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STFDVVALGEPLIEVSTRGKITHGVDCGFAVSGDVVNTATAAVAAGARVAVVARVSDDELGTAVIDHLAG LGVHTGHIRRDRGFQGIYVQHSDPKGDRQFCYARSGSAGSRLAPEDLPDDVLESAGAVVVSGITASLSST TRATVLAAAGRATRFVYDPNFRPRLTTAEDARALLLEIAPRCALITPSAPHECAALLGTSEAAEAAARLR TAGAAAVAVTCGAAGVHVDAETTYWQGAFAAPSVVDQTGAGDVFTGTVAARLALGDETSDAVRIGAAAAS LAVGGVGGSGGIAPLEAVRAHAEVLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2908 | - | - | 100% (307) | 2-keto-3-deoxy-gluconate kinase |
| M. smegmatis MC2 155 | MSMEG_3785 | - | 5e-18 | 30.95% (294) | PfkB-family protein carbohydrate kinase |
| M. smegmatis MC2 155 | MSMEG_0504 | - | 2e-10 | 31.72% (268) | carbohydrate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2602 | - | 1e-09 | 23.20% (306) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0359 | - | 2e-08 | 26.92% (260) | putative fructokinase |
| M. marinum M | MMAR_4574 | pfkB | 8e-07 | 26.35% (296) | fructokinase, PfkB |
| M. avium 104 | MAV_0347 | - | 4e-10 | 26.69% (281) | kinase, PfkB family protein |
| M. thermoresistible (build 8) | TH_0601 | - | 5e-10 | 28.12% (256) | fructokinase |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 2e-05 | 25.34% (296) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_4016 | - | 5e-12 | 24.44% (315) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2602|M.gilvum_PYR-GCK -MMIDQPYDVLAIGRSGVDVYPLQVGVGLEEVETFGKFLGGSAANVAVAA
Mvan_4016|M.vanbaalenii_PYR-1 --MTNQPYDVLAIGRSGVDVYPLQIGVGLEDVETFGKFLGGSAANVAVAA
MMAR_4574|M.marinum_M ---MARG---LVIGEALIDIVD---------GPDPAEYVGGSPLNVAVGL
MUL_4435|M.ulcerans_Agy99 ---MARG---LVIGEALIDIVD---------GPDPAEYVGGSPLNVAVGP
TH_0601|M.thermoresistible__bu --MTARA---LVIGEALIDVVER-------DGRVLGEHVGGSPLNVAVGL
MAB_0359|M.abscessus_ATCC_1997 ---MADGGGILVCGETLVDLVPV-------AGGLRRPVPGGGPYNTAIAA
MAV_0347|M.avium_104 MVVIGQIGRDLVLRTDRPPTAGES-----ATVLRREELLGGKGANQAVGL
MSMEG_2908|M.smegmatis_MC2_155 ----MSTFDVVALGEPLIEVSTRG---KITHGVDCGFAVSGDVVNTATAA
:. .* * * .
Mflv_2602|M.gilvum_PYR-GCK ARLGNRSALISGVGDDPFGRYVRAELARLDVDNRFVATHDEYPTPVTFCE
Mvan_4016|M.vanbaalenii_PYR-1 ARLGHRSALISGVGDDPFGRYVRAELARLDVDNRFVATHPEFPTPVTFCE
MMAR_4574|M.marinum_M ARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQTADRTPTATAR
MUL_4435|M.ulcerans_Agy99 ARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQTADRTPTATAR
TH_0601|M.thermoresistible__bu ARLGRDVDFLTHIADDARGRRIADHLADSGVQ-LVPGSRTAKRTPTAVAR
MAB_0359|M.abscessus_ATCC_1997 AKLGAPTALLTHVSHDAFGSRCVQDLAAAGVD-ESLVMRHDVPTTLAVAD
MAV_0347|M.avium_104 AQLGVPVTLIGVVGDDQAGTSILQQAQRDGID---VSKVARRGTTALLVD
MSMEG_2908|M.smegmatis_MC2_155 VAAGARVAVVARVSDDELGTAVIDHLAGLGVHTGHIRRDRGFQG-IYVQH
. * .: :. * * .:.
Mflv_2602|M.gilvum_PYR-GCK IFPPDDFPLYFYRKPSAPDLQIHPAEIDVEAVRAARLYWSTVTGLSEEPS
Mvan_4016|M.vanbaalenii_PYR-1 IFPPDDFPLYFYRKPSAPDLQIKPEEIDAEAVHSARLFWATVTGLSEEPS
MMAR_4574|M.marinum_M IGPDGSATYAFDLEWQIPDTP---------PVAPPLLVHTGSIAAAREPG
MUL_4435|M.ulcerans_Agy99 IGPDGSATYAFDLEWQIPDTP---------PVAPPLLVHTGSIAAAREPG
TH_0601|M.thermoresistible__bu LDATGAADYTFDIDWQLSGTP---------EVAPPVVAHTGSIAAVLEPG
MAB_0359|M.abscessus_ATCC_1997 VDEHGAARYLFYWQGTSNDVAIQSF---PDPVRTPVAIWAGSIASVLWRE
MAV_0347|M.avium_104 VVAAPPERMLLEDVPDSSLVRVADLD----RSSSLFDTADTVSIQLQQPA
MSMEG_2908|M.smegmatis_MC2_155 SDPKGDRQFCYARSGSAGSRLAPEDLPDDVLESAGAVVVSGITASLSSTT
.
Mflv_2602|M.gilvum_PYR-GCK RSAHFAAWESRGRRPLTVLDLDYRPMFWATPAAATEQVRKALAHVTVAVG
Mvan_4016|M.vanbaalenii_PYR-1 RSAHFAAWGARERKPLTVLDLDYRPMFWDSPAAATEQVQKALAHVTVAVG
MMAR_4574|M.marinum_M CLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQRLVERSDIIKA
MUL_4435|M.ulcerans_Agy99 CLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQRLVERSDIIKA
TH_0601|M.thermoresistible__bu CRAAAALIDTYHVSATTTFDPNVRPALITDDTGARARIDRFIERCDVVKA
MAB_0359|M.abscessus_ATCC_1997 RDELRAWIARHYADIPLTFDVNVRPALISHRQTYAARIVPWLSVARVARA
MAV_0347|M.avium_104 ATALEAAQRARQRGLRVVADGVPAPQVRADLLATLDVLRADATEASIIAG
MSMEG_2908|M.smegmatis_MC2_155 RATVLAAAG---RATRFVYDPNFRPRLTTAEDARALLLEIAPRCALITPS
* * * . : : .
Mflv_2602|M.gilvum_PYR-GCK NREECEIAVGETSPHKAADALLDLGV--ELAIVKQGPRGVLGKTRHS--S
Mvan_4016|M.vanbaalenii_PYR-1 NREECEIAVGQSNPHKAADALLDLGV--ELAIVKQGPRGVLGKTRHS--S
MMAR_4574|M.marinum_M SAEDLHWIDPTQPPEQTARAWLACGP--AIVALTLGDQGAVAFCAAG--P
MUL_4435|M.ulcerans_Agy99 SAEDLHWIDPTQPPEQTARAWLACGP--AIVALTFGDQSAVAFCAAG--P
TH_0601|M.thermoresistible__bu SDEDLQWLEPGRSPEQVAQTWLRMGP--SLVAVTMGDRGAYAVCAAG--E
MAB_0359|M.abscessus_ATCC_1997 STDDLEFLYPGVSVRDAVNAWLDAYPRIEIAVITCGAAGSLAFRRGEPSP
MAV_0347|M.avium_104 -----TEITTVEQAFELADHLLSGGP--ELVALAVPDVGDLLTWRGG--S
MSMEG_2908|M.smegmatis_MC2_155 APHECAALLGTSEAAEAAARLRTAGA--AAVAVTCGAAGVHVDAETT--Y
. . . : .
Mflv_2602|M.gilvum_PYR-GCK VTVPPNEVDVVNGLGAGDAFGGSLCHGLLHGWSLEKTLR-----------
Mvan_4016|M.vanbaalenii_PYR-1 VTVPPNEVDVVNGLGAGDAFGGSLCHGLLQGWPLEKTLR-----------
MMAR_4574|M.marinum_M ASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLGADRRTELRKIGVSAL
MUL_4435|M.ulcerans_Agy99 ASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLDADRRTELRKIGVSAL
TH_0601|M.thermoresistible__bu VRVPARPVEVVDTVGAGDAFMAGLIDALWSLQLLGAERRRQLAGIAVEAL
MAB_0359|M.abscessus_ATCC_1997 LRIAAHKVSVVDTVGAGDTYTGAFLDGFYRHRLD---------------L
MAV_0347|M.avium_104 ELFEFADVEVVDPTGAGDAFVAGLVAALREGAAP----------------
MSMEG_2908|M.smegmatis_MC2_155 WQGAFAAPSVVDQTGAGDVFTGTVAARLALGDET----------------
**: ****.: . . :
Mflv_2602|M.gilvum_PYR-GCK YANAAGAIVAGRLECSTAMPTAAEVAELAEQTAVEAVNV---
Mvan_4016|M.vanbaalenii_PYR-1 YANAAGAIVAGRLECSTAMPTAAEVAALAEQTAAEAVNV---
MMAR_4574|M.marinum_M TSALEVAALTSALTVARAGADLPYRADLRQSR----------
MUL_4435|M.ulcerans_Agy99 TSALEVAALTSALTVARAGADLPYRADLRQSR----------
TH_0601|M.thermoresistible__bu QRVVETAALSSALTVARAGADLPDRATRDAAAAATERETGTY
MAB_0359|M.abscessus_ATCC_1997 PEALRRAAVAAAITCTRPGAQPPDATELANELRRVTS-----
MAV_0347|M.avium_104 REAGRRAAAAAGATVQRLGGR-PDLTGLRA------------
MSMEG_2908|M.smegmatis_MC2_155 SDAVRIGAAAASLAVGGVGGSGGIAPLEAVRAHAEVLA----
. :. .