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VTEREIDVLVAGRVYSDLVFTGVNAPAPGEEVYADGFAISPGGAANRAVAAARLGAHTALVTELGDDPIG CIVARSLQKEPNLDLRYAVQHPGYQIPISVAITDGHDRSFVTYEHSGHLPSWPEDIPVRVAHVGLGRGPV PAEAAHLRAQGTLLVGGVGWDPSGEWSEELLDHLAGVDVLIVNEIEALLYTRAATVEEALEVLAGAVETA VITLGPDGAIAAQGATRLRVPAIAVEAVDPTGAGDAFTAAFMVATAWEWELADRLRLASACATCSVRGAG GARSAPHPADIADLLADCCADPDWTPVREWAGRHRQSTVPATPGALTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0504 | - | - | 100% (328) | carbohydrate kinase |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 1e-20 | 32.23% (301) | ribokinase |
| M. smegmatis MC2 155 | MSMEG_4661 | - | 7e-15 | 26.67% (315) | sugar kinase, ribokinase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 8e-17 | 33.33% (300) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 4e-20 | 32.31% (294) | ribokinase |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 2e-16 | 33.00% (300) | ribokinase RBSK |
| M. leprae Br4923 | MLBr_00873 | - | 5e-05 | 30.16% (126) | putative carbohydrate kinase |
| M. abscessus ATCC 19977 | MAB_1617c | - | 3e-12 | 26.95% (282) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 4e-08 | 26.62% (278) | fructokinase, PfkB |
| M. avium 104 | MAV_1743 | - | 3e-15 | 31.69% (284) | kinase, pfkB family protein |
| M. thermoresistible (build 8) | TH_0601 | - | 4e-08 | 27.94% (247) | fructokinase |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 4e-07 | 25.09% (275) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_4016 | - | 2e-20 | 26.71% (322) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPG
MAV_1743|M.avium_104 ---------------------MNLDLSLAVDALPRPGETVLASSLRQAPG
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTFTVDALPRPGETVLADALACAPG
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTLRVEELPAPGATVLATSAMPAPG
MMAR_4574|M.marinum_M -----------------------MARGLVIGEALIDIVD--GPDPAEYVG
MUL_4435|M.ulcerans_Agy99 -----------------------MARGLVIGEALIDIVD--GPDPAEYVG
TH_0601|M.thermoresistible__bu ----------------------MTARALVIGEALIDVVERDGRVLGEHVG
MSMEG_0504|M.smegmatis_MC2_155 --------MTEREIDVLVAGRVYSDLVFTGVNAPAPGEEVYADGFAISPG
Mvan_4016|M.vanbaalenii_PYR-1 --------MTNQPYDVLAIG----RSGVDVYPLQIGVGLEDVETFGKFLG
MLBr_00873|M.leprae_Br4923 ---MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSFLVDDLVIHRG
. *
Mb2462|M.bovis_AF2122/97 GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRAN-AVGLDRTVTV
Rv2436|M.tuberculosis_H37Rv GKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRAN-AVGLDRTVTV
MAV_1743|M.avium_104 GKGGNQAVAAARAGARVQFVGAVGDDAAAGQLRAHLQAN-GVGLDGAVEI
Mflv_2643|M.gilvum_PYR-GCK GKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRAN-SVGLDAVVAV
MAB_1617c|M.abscessus_ATCC_199 GKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADN-NVGLDGLVEV
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESS-GVQLVSGSQT
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESS-GVQLVSGSQT
TH_0601|M.thermoresistible__bu GSPLNVAVGLARLGRDVDFLTHIADDARGRRIADHLADS-GVQLVPGSRT
MSMEG_0504|M.smegmatis_MC2_155 G-AANRAVAAARLGAHTALVTELGDDPIGCIVARSLQKEPNLDLRYAVQH
Mvan_4016|M.vanbaalenii_PYR-1 GSAANVAVAAARLGHRSALISGVGDDPFGRYVRAELARLDVDNRFVATHP
MLBr_00873|M.leprae_Br4923 GVAGNMAYAIGVLGGDVALIGAVGDDFAD--YRDWLQNHGVNCDSVLISK
* * * . . * : .. * :
Mb2462|M.bovis_AF2122/97 PGPSGTAIIVVDASAENTVLVAPGANAHLTP----VPSAVANCDVLLTQL
Rv2436|M.tuberculosis_H37Rv PGPSGTAIIVVDASAENTVLVAPGANAHLTP----VPSAVANCDVLLTQL
MAV_1743|M.avium_104 PGPSGTAIVVVDANAENTIVVAPGANGRFTLNDERARAVLAGCDVMLTQL
Mflv_2643|M.gilvum_PYR-GCK PGPSGTAAILVDAGAENCIVVAPGANAHLSLASPVVRSAIADADVVLLSL
MAB_1617c|M.abscessus_ATCC_199 DGPSGMATITVEDSGENCIVVAPGANTTFTLDEKVHKDIICSHDVLLCQL
MMAR_4574|M.marinum_M ADRTPTATARIGPDGSATYAFDLEWQIPDTP---PVAPPLLVHTGSIAAA
MUL_4435|M.ulcerans_Agy99 ADRTPTATARIGPDGSATYAFDLEWQIPDTP---PVAPPLLVHTGSIAAA
TH_0601|M.thermoresistible__bu AKRTPTAVARLDATGAADYTFDIDWQLSGTP---EVAPPVVAHTGSIAAV
MSMEG_0504|M.smegmatis_MC2_155 PGYQIPISVAITDGHDRSFVTYEHSGHLPSWP---EDIPVRVAHVGLGRG
Mvan_4016|M.vanbaalenii_PYR-1 EFPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIKPEEIDAEAVHSARLFWA
MLBr_00873|M.leprae_Br4923 TAHTARFVCTTDLDMAQIGSFYTGAMSEARNIKLVDAIATIGTPELVIIG
:
Mb2462|M.bovis_AF2122/97 EI------PVATALAAARAAQSADAVVMVNASPAG-------QDRSSLQD
Rv2436|M.tuberculosis_H37Rv EI------PVATALAAARAAQSADAVVMVNASPAG-------QDRSSLQD
MAV_1743|M.avium_104 EI------PVATAVAAARHARSGGAVVVVNASPAG-------RDPDSLSE
Mflv_2643|M.gilvum_PYR-GCK EI------PIDTAVAAARAGRYAGATVMLNASPTP-------REVG---T
MAB_1617c|M.abscessus_ATCC_199 EI------PVRVALTAARWAAEAGKQFVLNASPVP-------ERSPDLAE
MMAR_4574|M.marinum_M RE------PGCLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQR
MUL_4435|M.ulcerans_Agy99 RE------PGCLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQR
TH_0601|M.thermoresistible__bu LE------PGCRAAAALIDTYHVSATTTFDPNVRPALITDDTGARARIDR
MSMEG_0504|M.smegmatis_MC2_155 PV------PAEAAHLRAQGTLLVGG---VGWDPSG-------EWSEELLD
Mvan_4016|M.vanbaalenii_PYR-1 TVTGLSEEPSRSAHFAAWGARERKPLTVLDLDYRPMFWDSPAAATEQVQK
MLBr_00873|M.leprae_Br4923 AN------DPAAMLGYTQECRKLGLAFAADPSQQLAR-----LSGEEIRN
. .
Mb2462|M.bovis_AF2122/97 LAAIADVVIAN-------------EHEANDWPSPP----THFVITLGVRG
Rv2436|M.tuberculosis_H37Rv LAAIADVVIAN-------------EHEANDWPSPP----THFVITLGVRG
MAV_1743|M.avium_104 LAAAADVVITN-------------EEEASEWPWRP----RHLVVTLGSHG
Mflv_2643|M.gilvum_PYR-GCK LAAHVDVVVVN-------------ETEADAWRDGDRILVPHLVVTHGARG
MAB_1617c|M.abscessus_ATCC_199 LAFRASVVVVN-------------ETEARSWLYPS----RHLVTTLGDEG
MMAR_4574|M.marinum_M LVERSDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALTLGDQG
MUL_4435|M.ulcerans_Agy99 LVERSDIIKASAEDLHWIDPTQPPEQTARAWLACG---PAIVALTFGDQS
TH_0601|M.thermoresistible__bu FIERCDVVKASDEDLQWLEPGRSPEQVAQTWLRMG---PSLVAVTMGDRG
MSMEG_0504|M.smegmatis_MC2_155 HLAGVDVLIVNEIEALLYTRAATVEEALEVLAGAV----ETAVITLGPDG
Mvan_4016|M.vanbaalenii_PYR-1 ALAHVTVAVGNREECEIAVGQSNPHKAADALLDLG---VELAIVKQGPRG
MLBr_00873|M.leprae_Br4923 LIDGATYLFTNDYEWDLLLSKTG-WSEADVMAQIQ-----LRVTTLGAKG
. . * .
Mb2462|M.bovis_AF2122/97 ARYVGADGVFEVP--APTVTPVDTAGAGDVFAG--VLAANWPRNPGSPAE
Rv2436|M.tuberculosis_H37Rv ARYVGADGVFEVP--APTVTPVDTAGAGDVFAG--VLAANWPRNPGSPAE
MAV_1743|M.avium_104 ARYVGADGEYSVP--SPDVDAVDTTGAGDVFAG--VLAANWPLEPGSPDQ
Mflv_2643|M.gilvum_PYR-GCK ATCVG-QCHLEVP--APAVEAVDTTGAGDVFAG--VLAANWEQG------
MAB_1617c|M.abscessus_ATCC_199 SRYRSPQGQITVP--SYPVRPLDTTGAGDVFAG--VLAAWWPQG------
MMAR_4574|M.marinum_M AVAFCAAGPASVP--AQPVRVVDTVGAGDAFMAG-LLDTLWEQGLLG-AD
MUL_4435|M.ulcerans_Agy99 AVAFCAAGPASMP--AQPVRVVDTVGAGDAFMAG-LLDTLWEQGLLD-AD
TH_0601|M.thermoresistible__bu AYAVCAAGEVRVP--ARPVEVVDTVGAGDAFMAG-LIDALWSLQLLG-AE
MSMEG_0504|M.smegmatis_MC2_155 AIAAQGATRLRVP--AIAVEAVDPTGAGDAFTAAFMVATAWEWELADRLR
Mvan_4016|M.vanbaalenii_PYR-1 VLGKTRHSSVTVP--PNEVDVVNGLGAGDAFGGS-LCHGLLQGWPLEKTL
MLBr_00873|M.leprae_Br4923 VDLVEPDGTRVHVSVVPEAGQVDPTGVGDAFRAG-FLTGRSAGLSLERSA
. :: *.**.* . .
Mb2462|M.bovis_AF2122/97 RLRALRRACAAGV--------LATLVSGAGDCAPAAAAIDAALRANRHNG
Rv2436|M.tuberculosis_H37Rv RLRALRRACAAGA--------LATLVSGVGDCAPAAAAIDAALRANRHNG
MAV_1743|M.avium_104 RRLALRRACAAGA--------LATLVPGAGDCAPRAEEIERALRGKS---
Mflv_2643|M.gilvum_PYR-GCK VEFAMARACAAGA--------LATLVPGAGDCAPSREAVEDVLDAL----
MAB_1617c|M.abscessus_ATCC_199 AETALRRANVAGA--------LATLRAGAGNCAPTGARIELSLKGS----
MMAR_4574|M.marinum_M RRTELRKIGVSAL--------TSALEVAALTSALTVARAGADLPYRADLR
MUL_4435|M.ulcerans_Agy99 RRTELRKIGVSAL--------TSALEVAALTSALTVARAGADLPYRADLR
TH_0601|M.thermoresistible__bu RRRQLAGIAVEAL--------QRVVETAALSSALTVARAGADLPDRATRD
MSMEG_0504|M.smegmatis_MC2_155 LASACATCSVRGAGGARSAPHPADIADLLADCCADPDWTPVREWAGRHRQ
Mvan_4016|M.vanbaalenii_PYR-1 RYANAAGAIVAGR------LECSTAMPTAAEVAALAEQTAAEAVNV----
MLBr_00873|M.leprae_Br4923 QLGSLVAVLVLES---------TGTQQWGWDRDVAVARLAGAYGEEAAAE
.
Mb2462|M.bovis_AF2122/97 S------------
Rv2436|M.tuberculosis_H37Rv S------------
MAV_1743|M.avium_104 -------------
Mflv_2643|M.gilvum_PYR-GCK -------------
MAB_1617c|M.abscessus_ATCC_199 -------------
MMAR_4574|M.marinum_M QSR----------
MUL_4435|M.ulcerans_Agy99 QSR----------
TH_0601|M.thermoresistible__bu AAAAATERETGTY
MSMEG_0504|M.smegmatis_MC2_155 STVPATPGALTS-
Mvan_4016|M.vanbaalenii_PYR-1 -------------
MLBr_00873|M.leprae_Br4923 ITVVLS-------