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VVIGQIGRDLVLRTDRPPTAGESATVLRREELLGGKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQA QRDGIDVSKVARRGTTALLVDVVAAPPERMLLEDVPDSSLVRVADLDRSSSLFDTADTVSIQLQQPAATA LEAAQRARQRGLRVVADGVPAPQVRADLLATLDVLRADATEASIIAGTEITTVEQAFELADHLLSGGPEL VALAVPDVGDLLTWRGGSELFEFADVEVVDPTGAGDAFVAGLVAALREGAAPREAGRRAAAAAGATVQRL GGRPDLTGLRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0347 | - | - | 100% (292) | kinase, PfkB family protein |
| M. avium 104 | MAV_1743 | - | 3e-20 | 30.56% (288) | kinase, pfkB family protein |
| M. avium 104 | MAV_1051 | - | 1e-09 | 28.68% (258) | kinase, PfkB family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2462 | rbsK | 5e-17 | 30.41% (296) | ribokinase RBSK |
| M. gilvum PYR-GCK | Mflv_2643 | - | 5e-18 | 31.71% (287) | ribokinase |
| M. tuberculosis H37Rv | Rv2436 | rbsK | 3e-17 | 30.74% (296) | ribokinase RBSK |
| M. leprae Br4923 | MLBr_00873 | - | 2e-07 | 23.70% (270) | putative carbohydrate kinase |
| M. abscessus ATCC 19977 | MAB_1617c | - | 3e-14 | 25.89% (282) | ribokinase RbsK |
| M. marinum M | MMAR_4574 | pfkB | 6e-12 | 29.57% (257) | fructokinase, PfkB |
| M. smegmatis MC2 155 | MSMEG_4585 | rbsK | 1e-19 | 29.15% (295) | ribokinase |
| M. thermoresistible (build 8) | TH_1517 | rbsK | 3e-14 | 31.29% (163) | RIBOKINASE RBSK |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 5e-11 | 29.41% (238) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_3935 | - | 2e-15 | 28.82% (288) | ribokinase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4585|M.smegmatis_MC2_155 ----------MGAARVCVVGSINADLTF----------TVANLPRPGQTV
TH_1517|M.thermoresistible__bu -----------VAARVCVVGSVNLDLTF----------NVDALPERGETV
Mflv_2643|M.gilvum_PYR-GCK -----------MATRLCVVGSVNADLTF----------TVDALPRPGETV
Mvan_3935|M.vanbaalenii_PYR-1 -----------MATRLSVVGSANVDLTF----------SVTALPRPGETV
Mb2462|M.bovis_AF2122/97 MANASETNVGPMAPRVCVVGSVNMDLTF----------VVDALPRPGETV
Rv2436|M.tuberculosis_H37Rv MANASETNVGPMAPRVCVVGSVNMDLTF----------VVDALPRPGETV
MAB_1617c|M.abscessus_ATCC_199 -----------------------MDLTL----------RVEELPAPGATV
MMAR_4574|M.marinum_M ------------MARGLVIGEALIDIVD----------GPDPAEYVGGSP
MUL_4435|M.ulcerans_Agy99 ------------MARGLVIGEALIDIVD----------GPDPAEYVGGSP
MAV_0347|M.avium_104 ---------------MVVIGQIGRDLVL----------RTDRPPTAGESA
MLBr_00873|M.leprae_Br4923 -------------MTIAVTGSIATDHLMRFPGRFSEQLLVDNLHKVSLSF
* . :
MSMEG_4585|M.smegmatis_MC2_155 LASSLASAPGGKGGNQAVAAARAGAATSLVAAVGDDAAAESLRAHLRANG
TH_1517|M.thermoresistible__bu LAHSMSSAPGGKGGNQAVAAARAGADVELIAALGDDAAGERLRSHLRDNG
Mflv_2643|M.gilvum_PYR-GCK LADALACAPGGKGGNQAVAAARAGADVQLVAALGTDASAEQLRDHLRANS
Mvan_3935|M.vanbaalenii_PYR-1 LASALSSTPGGKGGNQAVAAARAGAQVQLVAALGTDAAAEQLKAHLKANA
Mb2462|M.bovis_AF2122/97 LAASLTRTPGGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANA
Rv2436|M.tuberculosis_H37Rv LAASLTRTPGGKGANQAVAAARAGAQVQFSGAFGDDPAAAQLRAHLRANA
MAB_1617c|M.abscessus_ATCC_199 LATSAMPAPGGKGANQAVAAARAGASVQFIGAVGSDGAAPMLRSHLADNN
MMAR_4574|M.marinum_M LNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTADRT
MUL_4435|M.ulcerans_Agy99 LNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQLVSGSQTADRT
MAV_0347|M.avium_104 TVLRREELLGGKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQAQRDG
MLBr_00873|M.leprae_Br4923 LVDDLVIHRGGVAGNMAYAIGVLGGDVALIGAVGDDFADYR--DWLQNHG
* : . . : . .
MSMEG_4585|M.smegmatis_MC2_155 VDEDA-VVSLAGPSGSAAIVVDAAGENHIVVAPGANALLDVDAP------
TH_1517|M.thermoresistible__bu VGLDG-VTTVAGPSGSAVIVVDSDAENTIVVAPGANAALTIDAEGDGADD
Mflv_2643|M.gilvum_PYR-GCK VGLDA-VVAVPGPSGTAAILVDAGAENCIVVAPGANAHLSLASP------
Mvan_3935|M.vanbaalenii_PYR-1 VGLDG-VTAVPGPSGSAAILVDAAGENCIVVAPGANGHLSLSSP------
Mb2462|M.bovis_AF2122/97 VGLDR-TVTVPGPSGTAIIVVDASAENTVLVAPGANAHLTPVPS------
Rv2436|M.tuberculosis_H37Rv VGLDR-TVTVPGPSGTAIIVVDASAENTVLVAPGANAHLTPVPS------
MAB_1617c|M.abscessus_ATCC_199 VGLDG-LVEVDGPSGMATITVEDSGENCIVVAPGANTTFTLDEK------
MMAR_4574|M.marinum_M PTATA-RIGPDG-SATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPGC
MUL_4435|M.ulcerans_Agy99 PTATA-RIGPDG-SATYAFDLEWQIPDTPPVAPPLLVHTGSIAAAREPGC
MAV_0347|M.avium_104 IDVS--KVARRGTTALLVDVVAAPPERMLLEDVPDSSLVRVADLD-----
MLBr_00873|M.leprae_Br4923 VNCDSVLISKTAHTARFVCTTDLDMAQIGSFYTGAMSEARNIKLVD----
. :.
MSMEG_4585|M.smegmatis_MC2_155 --AARAAIGSADVVLLQLEISPTTAIAAAQQARDAGALVMLNASP--VGT
TH_1517|M.thermoresistible__bu SASAGAIIAASDVVLMQLEIPAATAVAAAXXXRXAG-----------VG-
Mflv_2643|M.gilvum_PYR-GCK --VVRSAIADADVVLLSLEIPIDTAVAAARAGRYAGATVMLN-----ASP
Mvan_3935|M.vanbaalenii_PYR-1 --AVREVVADSDVVLLSLEIPIDTAVTAARIGRSAGATVVLN-----ASP
Mb2462|M.bovis_AF2122/97 ------AVANCDVLLTQLEIPVATALAAARAAQSADAVVMVNASP--AGQ
Rv2436|M.tuberculosis_H37Rv ------AVANCDVLLTQLEIPVATALAAARAAQSADAVVMVNASP--AGQ
MAB_1617c|M.abscessus_ATCC_199 --VHKDIICSHDVLLCQLEIPVRVALTAARWAAEAGKQFVLNASP--VPE
MMAR_4574|M.marinum_M LAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQRLVE-----RSD
MUL_4435|M.ulcerans_Agy99 LAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQRLVE-----RSD
MAV_0347|M.avium_104 --RSSSLFDTADTVSIQLQQPAATALEAAQRARQRGLRVVADGVP--APQ
MLBr_00873|M.leprae_Br4923 ---AIATIGTPELVIIGANDP-AAMLGYTQECRKLGLAFAADPSQQLARL
: :
MSMEG_4585|M.smegmatis_MC2_155 AAHHLLALSHLTDVVVVNE---------TEAAEWHWP-------VRHLVI
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK TPREVGTLAAHVDVVVVNE---------TEADAWRDGDRIL---VPHLVV
Mvan_3935|M.vanbaalenii_PYR-1 ASAQASALADLADVVVVNE---------TESDGWLDGDRPR---VPHLVI
Mb2462|M.bovis_AF2122/97 DRSSLQDLAAIADVVIANE---------HEANDWPSP-------PTHFVI
Rv2436|M.tuberculosis_H37Rv DRSSLQDLAAIADVVIANE---------HEANDWPSP-------PTHFVI
MAB_1617c|M.abscessus_ATCC_199 RSPDLAELAFRASVVVVNE---------TEARSWLYP-------SRHLVT
MMAR_4574|M.marinum_M IIKASAEDLHWIDPTQPPE---------QTARAWLACG------PAIVAL
MUL_4435|M.ulcerans_Agy99 IIKASAEDLHWIDPTQPPE---------QTARAWLACG------PAIVAL
MAV_0347|M.avium_104 VRADLLATLDVLRADATEASIIAGTEITTVEQAFELADHLLSGGPELVAL
MLBr_00873|M.leprae_Br4923 SGEEIRNLIDGATYLFTND---YEWDLLLSKTGWSEADVMAQ--IQLRVT
MSMEG_4585|M.smegmatis_MC2_155 TRGARGASYVSDDERFDVP--ALRVRAVDTTGAGDVFAG-VLAAGWPAG-
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK THGARGATCVG-QCHLEVP--APAVEAVDTTGAGDVFAG-VLAANWEQG-
Mvan_3935|M.vanbaalenii_PYR-1 TRGARGATYVG-ETRLEFP--APAVEAVDTTGAGDVFAG-VLAANWPRG-
Mb2462|M.bovis_AF2122/97 TLGVRGARYVGADGVFEVP--APTVTPVDTAGAGDVFAG-VLAANWPRNP
Rv2436|M.tuberculosis_H37Rv TLGVRGARYVGADGVFEVP--APTVTPVDTAGAGDVFAG-VLAANWPRNP
MAB_1617c|M.abscessus_ATCC_199 TLGDEGSRYRSPQGQITVP--SYPVRPLDTTGAGDVFAG-VLAAWWPQG-
MMAR_4574|M.marinum_M TLGDQGAVAFCAAGPASVP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-
MUL_4435|M.ulcerans_Agy99 TFGDQSAVAFCAAGPASMP--AQPVRVVDTVGAGDAFMAGLLDTLWEQG-
MAV_0347|M.avium_104 AVPDVGDLLTWRGGSELFE--FADVEVVDPTGAGDAFVAGLVAALREGA-
MLBr_00873|M.leprae_Br4923 TLGAKGVDLVEPDGTRVHVSVVPEAGQVDPTGVGDAFRAGFLTGRSAGLS
MSMEG_4585|M.smegmatis_MC2_155 -----HEHALQRACAAGALATLVRGAGDCAPSAADIDAVLTP--------
TH_1517|M.thermoresistible__bu --------------------------------------------------
Mflv_2643|M.gilvum_PYR-GCK -----VEFAMARACAAGALATLVPGAGDCAPSREAVEDVLDAL-------
Mvan_3935|M.vanbaalenii_PYR-1 -----ADYALARACAAGALSTLVHGAGDCAPYSEAVEDVLEAS-------
Mb2462|M.bovis_AF2122/97 GSPAERLRALRRACAAGVLATLVSGAGDCAPAAAAIDAALRANRHNGS--
Rv2436|M.tuberculosis_H37Rv GSPAERLRALRRACAAGALATLVSGVGDCAPAAAAIDAALRANRHNGS--
MAB_1617c|M.abscessus_ATCC_199 -----AETALRRANVAGALATLRAGAGNCAPTGARIELSLKGS-------
MMAR_4574|M.marinum_M LLGADRRTELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR
MUL_4435|M.ulcerans_Agy99 LLDADRRTELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR
MAV_0347|M.avium_104 -----APREAGRRAAAAAGATVQRLGGRPDLTGLRA--------------
MLBr_00873|M.leprae_Br4923 LERSAQLGSLVAVLVLESTGTQQWGWDRDVAVARLAGAYGEEAAAEITVV
MSMEG_4585|M.smegmatis_MC2_155 --
TH_1517|M.thermoresistible__bu --
Mflv_2643|M.gilvum_PYR-GCK --
Mvan_3935|M.vanbaalenii_PYR-1 --
Mb2462|M.bovis_AF2122/97 --
Rv2436|M.tuberculosis_H37Rv --
MAB_1617c|M.abscessus_ATCC_199 --
MMAR_4574|M.marinum_M --
MUL_4435|M.ulcerans_Agy99 --
MAV_0347|M.avium_104 --
MLBr_00873|M.leprae_Br4923 LS