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MIDQPYDVLAIGRSGVDVYPLQVGVGLEEVETFGKFLGGSAANVAVAAARLGNRSALISGVGDDPFGRYV RAELARLDVDNRFVATHDEYPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIHPAEIDVEAVRAARLYWSTV TGLSEEPSRSAHFAAWESRGRRPLTVLDLDYRPMFWATPAAATEQVRKALAHVTVAVGNREECEIAVGET SPHKAADALLDLGVELAIVKQGPRGVLGKTRHSSVTVPPNEVDVVNGLGAGDAFGGSLCHGLLHGWSLEK TLRYANAAGAIVAGRLECSTAMPTAAEVAELAEQTAVEAVNV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2602 | - | - | 100% (323) | ribokinase-like domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1827 | - | 1e-08 | 24.37% (279) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 2e-11 | 33.88% (121) | phosphofructokinase pfkB (phosphohexokinase) |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 2e-11 | 33.88% (121) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0359 | - | 4e-15 | 27.97% (311) | putative fructokinase |
| M. marinum M | MMAR_4574 | pfkB | 3e-10 | 26.02% (246) | fructokinase, PfkB |
| M. avium 104 | MAV_1051 | - | 3e-11 | 24.84% (314) | kinase, PfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4661 | - | 1e-159 | 87.34% (316) | sugar kinase, ribokinase family protein |
| M. thermoresistible (build 8) | TH_0601 | - | 2e-12 | 25.91% (274) | fructokinase |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 3e-09 | 25.20% (246) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_4016 | - | 1e-171 | 91.30% (322) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2602|M.gilvum_PYR-GCK ----MMIDQP---YDVLAIGRSG-----VDVYPLQVGVGLEEVETFGKFL
Mvan_4016|M.vanbaalenii_PYR-1 -----MTNQP---YDVLAIGRSG-----VDVYPLQIGVGLEDVETFGKFL
MSMEG_4661|M.smegmatis_MC2_155 -----MTNSPTPQLDVLALGRCG-----VDVYPLQIGVGLEEVESFGKFL
MMAR_4574|M.marinum_M -----MARG-------LVIGEAL-----IDIVDGPD---------PAEYV
MUL_4435|M.ulcerans_Agy99 -----MARG-------LVIGEAL-----IDIVDGPD---------PAEYV
MAV_1051|M.avium_104 -----MTRG-------LVIGESL-----IDIVED------------AEYV
TH_0601|M.thermoresistible__bu ----MTARA-------LVIGEAL-----IDVVERDGRV-------LGEHV
MAB_0359|M.abscessus_ATCC_1997 -----MADGG----GILVCGETL-----VDLVPVAGGL-------RRPVP
Mb2054c|M.bovis_AF2122/97 MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCG---APRYDP
Rv2029c|M.tuberculosis_H37Rv MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCG---APRYDP
*. . :*:
Mflv_2602|M.gilvum_PYR-GCK GGSAANVAVAAARLGNRSALISGVGDDPFGRYVRAELARLDVDNRFVATH
Mvan_4016|M.vanbaalenii_PYR-1 GGSAANVAVAAARLGHRSALISGVGDDPFGRYVRAELARLDVDNRFVATH
MSMEG_4661|M.smegmatis_MC2_155 GGSAANVTVAAARLGNSAGLISGVGDDPFGRYVRNELARLGVDNRFVATY
MMAR_4574|M.marinum_M GGSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQ
MUL_4435|M.ulcerans_Agy99 GGSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQ
MAV_1051|M.avium_104 GGSPLNVAVGLGRLGRDVDFLTYLADDDHGRRIAAYLKDAGVQ-LVSESR
TH_0601|M.thermoresistible__bu GGSPLNVAVGLARLGRDVDFLTHIADDARGRRIADHLADSGVQ-LVPGSR
MAB_0359|M.abscessus_ATCC_1997 GGGPYNTAIAAAKLGAPTALLTHVSHDAFGSRCVQDLAAAGVD-ESLVMR
Mb2054c|M.bovis_AF2122/97 GGGGINVARIVHVLGGCSTALFPAG-GSTGSLLMALLGDAGVPFRVIPIA
Rv2029c|M.tuberculosis_H37Rv GGGGINVARIVHVLGGCSTALFPAG-GSTGSLLMALLGDAGVPFRVIPIA
**. *.: ** : . . * : .*
Mflv_2602|M.gilvum_PYR-GCK DEYPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIHPAEIDVEAVRAARLYW
Mvan_4016|M.vanbaalenii_PYR-1 PEFPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIKPEEIDAEAVHSARLFW
MSMEG_4661|M.smegmatis_MC2_155 GEYPTPVTFCEIFPPDNFPLYFYRKPSAPDLQIRAEQIDADAVRDARLYW
MMAR_4574|M.marinum_M TADRTPTATARIGPDGSATYAFDLEWQIPDTP---------PVAPPLLVH
MUL_4435|M.ulcerans_Agy99 TADRTPTATARIGPDGSATYAFDLEWQIPDTP---------PVAPPLLVH
MAV_1051|M.avium_104 AAERTATARSTIAADGSADYEFDLDWRLSGIP---------PVAPPLFVH
TH_0601|M.thermoresistible__bu TAKRTPTAVARLDATGAADYTFDIDWQLSGTP---------EVAPPVVAH
MAB_0359|M.abscessus_ATCC_1997 HDVPTTLAVADVDEHGAARYLFYWQGTSNDVAIQSF---PDPVRTPVAIW
Mb2054c|M.bovis_AF2122/97 ASTRESFTVNESRTAKQYRFVLPGPSLTVAEQ---------EQCLDELRG
Rv2029c|M.tuberculosis_H37Rv ASTRESFTVNESRTAKQYRFVLPGPSLTVAEQ---------EQCLDELRG
. : :
Mflv_2602|M.gilvum_PYR-GCK STVTGLSEEPSRSAHFAAWESRGRRPLTVLDLDYRPMFWATPAAATEQVR
Mvan_4016|M.vanbaalenii_PYR-1 ATVTGLSEEPSRSAHFAAWGARERKPLTVLDLDYRPMFWDSPAAATEQVQ
MSMEG_4661|M.smegmatis_MC2_155 STVTGLCEEPSRSAHFAAWEARQRAPLTVLDLDYRPMFWESPAAATEVVQ
MMAR_4574|M.marinum_M TGSIAAAREPGCLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQ
MUL_4435|M.ulcerans_Agy99 TGSIAAAREPGCLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQ
MAV_1051|M.avium_104 TGSIAAVRDPGCLAVAALIDTYRVSATVTFDPNVRPSLIADRELAVSRIE
TH_0601|M.thermoresistible__bu TGSIAAVLEPGCRAAAALIDTYHVSATTTFDPNVRPALITDDTGARARID
MAB_0359|M.abscessus_ATCC_1997 AGSIASVLWRERDELRAWIARHYADIPLTFDVNVRPALISHRQTYAARIV
Mb2054c|M.bovis_AF2122/97 AAASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHIS
Rv2029c|M.tuberculosis_H37Rv AAASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHIS
: . . . * : :
Mflv_2602|M.gilvum_PYR-GCK KALAHVTVAVGNREECEIAVGETSPH--KAADALLDLGV--ELAIVKQGP
Mvan_4016|M.vanbaalenii_PYR-1 KALAHVTVAVGNREECEIAVGQSNPH--KAADALLDLGV--ELAIVKQGP
MSMEG_4661|M.smegmatis_MC2_155 RALQHVTIAVGNREECEIAVGETNPH--RAAEALLDLGV--ELAIVKQGP
MMAR_4574|M.marinum_M RLVERSDIIKASAEDLHWIDPTQPPE--QTARAWLACGP--AIVALTLGD
MUL_4435|M.ulcerans_Agy99 RLVERSDIIKASAEDLHWIDPTQPPE--QTARAWLACGP--AIVALTFGD
MAV_1051|M.avium_104 HLVERSDIVKVSAEDLHWIDPDRSPE--QLAQTWLGLGP--AVVAVTMAD
TH_0601|M.thermoresistible__bu RFIERCDVVKASDEDLQWLEPGRSPE--QVAQTWLRMGP--SLVAVTMGD
MAB_0359|M.abscessus_ATCC_1997 PWLSVARVARASTDDLEFLYPGVSVR--DAVNAWLDAYPRIEIAVITCGA
Mb2054c|M.bovis_AF2122/97 SGVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGR-AEVVVVSLGS
Rv2029c|M.tuberculosis_H37Rv SGVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGR-AEVVVVSLGS
: . : . . : :. :. .
Mflv_2602|M.gilvum_PYR-GCK RGVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLCHGLLHGWSLEKT
Mvan_4016|M.vanbaalenii_PYR-1 RGVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLCHGLLQGWPLEKT
MSMEG_4661|M.smegmatis_MC2_155 RGVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLIHGLLHDWPLEKT
MMAR_4574|M.marinum_M QGAVAFCAAG--PASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLGAD
MUL_4435|M.ulcerans_Agy99 QSAVAFCAAG--PASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLDAD
MAV_1051|M.avium_104 RGAVGYCAAG--TARVPTRAVRVVDTVGAGDSFMAGLLDALWEAGLLGGD
TH_0601|M.thermoresistible__bu RGAYAVCAAG--EVRVPARPVEVVDTVGAGDAFMAGLIDALWSLQLLGAE
MAB_0359|M.abscessus_ATCC_1997 AGSLAFRRGEPSPLRIAAHKVSVVDTVGAGDTYTGAFLDGFYRHRLD---
Mb2054c|M.bovis_AF2122/97 QGALLATRHA--SHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKS
Rv2029c|M.tuberculosis_H37Rv QGALLATRHA--SHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKS
. ... : .*. :****: ..: :
Mflv_2602|M.gilvum_PYR-GCK LR--------YANAAGAIVAGRLECSTAMPTAAEVAELAEQTAVEAVNV-
Mvan_4016|M.vanbaalenii_PYR-1 LR--------YANAAGAIVAGRLECSTAMPTAAEVAALAEQTAAEAVNV-
MSMEG_4661|M.smegmatis_MC2_155 LR--------YANAAGAIVASRLECSTAMPTAAEVAALAEQTASEAVNV-
MMAR_4574|M.marinum_M RRT---ELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MUL_4435|M.ulcerans_Agy99 RRT---ELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR--
MAV_1051|M.avium_104 RRG---ALRDIGIDTLTSALDAASLSSALTIARAGADLPDRAAVQAALRR
TH_0601|M.thermoresistible__bu RRR---QLAGIAVEALQRVVETAALSSALTVARAGADLPDRATRDAAAAA
MAB_0359|M.abscessus_ATCC_1997 ---------------LPEALRRAAVAAAITCTRPGAQPPDATELANELRR
Mb2054c|M.bovis_AF2122/97 VRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVN
Rv2029c|M.tuberculosis_H37Rv VRLGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQDQYVWHPIVN
. : : :
Mflv_2602|M.gilvum_PYR-GCK --------
Mvan_4016|M.vanbaalenii_PYR-1 --------
MSMEG_4661|M.smegmatis_MC2_155 --------
MMAR_4574|M.marinum_M --------
MUL_4435|M.ulcerans_Agy99 --------
MAV_1051|M.avium_104 --------
TH_0601|M.thermoresistible__bu TERETGTY
MAB_0359|M.abscessus_ATCC_1997 VTS-----
Mb2054c|M.bovis_AF2122/97 PEASP---
Rv2029c|M.tuberculosis_H37Rv PEASP---