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MTNQPYDVLAIGRSGVDVYPLQIGVGLEDVETFGKFLGGSAANVAVAAARLGHRSALISGVGDDPFGRYV RAELARLDVDNRFVATHPEFPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIKPEEIDAEAVHSARLFWATV TGLSEEPSRSAHFAAWGARERKPLTVLDLDYRPMFWDSPAAATEQVQKALAHVTVAVGNREECEIAVGQS NPHKAADALLDLGVELAIVKQGPRGVLGKTRHSSVTVPPNEVDVVNGLGAGDAFGGSLCHGLLQGWPLEK TLRYANAAGAIVAGRLECSTAMPTAAEVAALAEQTAAEAVNV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4016 | - | - | 100% (322) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4916 | - | 9e-12 | 26.86% (309) | ribokinase-like domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1394 | - | 1e-07 | 33.03% (109) | ribokinase-like domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2054c | pfkB | 4e-11 | 32.23% (121) | phosphofructokinase pfkB (phosphohexokinase) |
| M. gilvum PYR-GCK | Mflv_2602 | - | 1e-171 | 91.30% (322) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | Rv2029c | pfkB | 4e-11 | 32.23% (121) | phosphofructokinase PfkB (phosphohexokinase) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0359 | - | 2e-13 | 26.86% (309) | putative fructokinase |
| M. marinum M | MMAR_4574 | pfkB | 3e-10 | 24.64% (280) | fructokinase, PfkB |
| M. avium 104 | MAV_0347 | - | 3e-09 | 30.15% (262) | kinase, PfkB family protein |
| M. smegmatis MC2 155 | MSMEG_4661 | - | 1e-160 | 85.54% (325) | sugar kinase, ribokinase family protein |
| M. thermoresistible (build 8) | TH_0601 | - | 2e-12 | 26.81% (276) | fructokinase |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 2e-09 | 24.19% (277) | fructokinase, PfkB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4016|M.vanbaalenii_PYR-1 -----MTNQP---YDVLAIGRSG--VDVYPLQIGVGLEDVETFG--KFLG
Mflv_2602|M.gilvum_PYR-GCK ----MMIDQP---YDVLAIGRSG--VDVYPLQVGVGLEEVETFG--KFLG
MSMEG_4661|M.smegmatis_MC2_155 -----MTNSPTPQLDVLALGRCG--VDVYPLQIGVGLEEVESFG--KFLG
MMAR_4574|M.marinum_M -----MARG-------LVIGEAL--IDIVD---------GPDPA--EYVG
MUL_4435|M.ulcerans_Agy99 -----MARG-------LVIGEAL--IDIVD---------GPDPA--EYVG
TH_0601|M.thermoresistible__bu ----MTARA-------LVIGEAL--IDVVER-------DGRVLG--EHVG
MAB_0359|M.abscessus_ATCC_1997 -----MADGG----GILVCGETL--VDLVPV-------AGGLRR--PVPG
Mb2054c|M.bovis_AF2122/97 MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR--YDPG
Rv2029c|M.tuberculosis_H37Rv MTEPAAWDEGKPRIITLTMNPALDITTSVDVVRPTEKMRCGAPR--YDPG
MAV_0347|M.avium_104 ---------------MVVIGQIGRDLVLRTDRPPTAGESATVLRREELLG
:. . *
Mvan_4016|M.vanbaalenii_PYR-1 GSAANVAVAAARLGHRSALISGVGDDPFGRYVRAELARLDVDNRFVATHP
Mflv_2602|M.gilvum_PYR-GCK GSAANVAVAAARLGNRSALISGVGDDPFGRYVRAELARLDVDNRFVATHD
MSMEG_4661|M.smegmatis_MC2_155 GSAANVTVAAARLGNSAGLISGVGDDPFGRYVRNELARLGVDNRFVATYG
MMAR_4574|M.marinum_M GSPLNVAVGLARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQT
MUL_4435|M.ulcerans_Agy99 GSPLNVAVGPARLGRDVDLLTHIGRDARGRRIAEYIESSGVQ-LVSGSQT
TH_0601|M.thermoresistible__bu GSPLNVAVGLARLGRDVDFLTHIADDARGRRIADHLADSGVQ-LVPGSRT
MAB_0359|M.abscessus_ATCC_1997 GGPYNTAIAAAKLGAPTALLTHVSHDAFGSRCVQDLAAAGVD-ESLVMRH
Mb2054c|M.bovis_AF2122/97 GGGINVARIVHVLGGCSTALFPAG-GSTGSLLMALLGDAGVPFRVIPIAA
Rv2029c|M.tuberculosis_H37Rv GGGINVARIVHVLGGCSTALFPAG-GSTGSLLMALLGDAGVPFRVIPIAA
MAV_0347|M.avium_104 GKGANQAVGLAQLGVPVTLIGVVGDDQAGTSILQQAQRDGIDVSKVARRG
* * : ** : . . * .:
Mvan_4016|M.vanbaalenii_PYR-1 EFPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIKPEEIDAEAVHSARLFWA
Mflv_2602|M.gilvum_PYR-GCK EYPTPVTFCEIFPPDDFPLYFYRKPSAPDLQIHPAEIDVEAVRAARLYWS
MSMEG_4661|M.smegmatis_MC2_155 EYPTPVTFCEIFPPDNFPLYFYRKPSAPDLQIRAEQIDADAVRDARLYWS
MMAR_4574|M.marinum_M ADRTPTATARIGPDGSATYAFDLEWQIPDTP---------PVAPPLLVHT
MUL_4435|M.ulcerans_Agy99 ADRTPTATARIGPDGSATYAFDLEWQIPDTP---------PVAPPLLVHT
TH_0601|M.thermoresistible__bu AKRTPTAVARLDATGAADYTFDIDWQLSGTP---------EVAPPVVAHT
MAB_0359|M.abscessus_ATCC_1997 DVPTTLAVADVDEHGAARYLFYWQGTSNDVAIQSF---PDPVRTPVAIWA
Mb2054c|M.bovis_AF2122/97 STRESFTVNESRTAKQYRFVLPGPSLTVAEQ---------EQCLDELRGA
Rv2029c|M.tuberculosis_H37Rv STRESFTVNESRTAKQYRFVLPGPSLTVAEQ---------EQCLDELRGA
MAV_0347|M.avium_104 TTALLVDVVAAPPERMLLEDVPDSSLVRVADLD-------RSSSLFDTAD
.
Mvan_4016|M.vanbaalenii_PYR-1 TVTGLSEEPSRSAHFAAWGARERKPLTVLDLDYRPMFWDSPAAATEQVQK
Mflv_2602|M.gilvum_PYR-GCK TVTGLSEEPSRSAHFAAWESRGRRPLTVLDLDYRPMFWATPAAATEQVRK
MSMEG_4661|M.smegmatis_MC2_155 TVTGLCEEPSRSAHFAAWEARQRAPLTVLDLDYRPMFWESPAAATEVVQR
MMAR_4574|M.marinum_M GSIAAAREPGCLAVAALLDAYRAAATVSFDPNVRPSLSADPDLTRERIQR
MUL_4435|M.ulcerans_Agy99 GSIAAAREPGCLAVAALLDAYRAAATVSFDPNVRPSLRADPDLTRERIQR
TH_0601|M.thermoresistible__bu GSIAAVLEPGCRAAAALIDTYHVSATTTFDPNVRPALITDDTGARARIDR
MAB_0359|M.abscessus_ATCC_1997 GSIASVLWRERDELRAWIARHYADIPLTFDVNVRPALISHRQTYAARIVP
Mb2054c|M.bovis_AF2122/97 AASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISS
Rv2029c|M.tuberculosis_H37Rv AASAAFVVASGSLPPGVAADYYQRVADICRRSSTPLILDTSGGGLQHISS
MAV_0347|M.avium_104 TVSIQLQQPAATALEAAQRARQRGLRVVADGVPAPQVRADLLATLDVLRA
. * . :
Mvan_4016|M.vanbaalenii_PYR-1 ALAHVTVAVGNREECEIAVGQSNPH--KAADALLDLGV--ELAIVKQGPR
Mflv_2602|M.gilvum_PYR-GCK ALAHVTVAVGNREECEIAVGETSPH--KAADALLDLGV--ELAIVKQGPR
MSMEG_4661|M.smegmatis_MC2_155 ALQHVTIAVGNREECEIAVGETNPH--RAAEALLDLGV--ELAIVKQGPR
MMAR_4574|M.marinum_M LVERSDIIKASAEDLHWIDPTQPPE--QTARAWLACGP--AIVALTLGDQ
MUL_4435|M.ulcerans_Agy99 LVERSDIIKASAEDLHWIDPTQPPE--QTARAWLACGP--AIVALTFGDQ
TH_0601|M.thermoresistible__bu FIERCDVVKASDEDLQWLEPGRSPE--QVAQTWLRMGP--SLVAVTMGDR
MAB_0359|M.abscessus_ATCC_1997 WLSVARVARASTDDLEFLYPGVSVR--DAVNAWLDAYPRIEIAVITCGAA
Mb2054c|M.bovis_AF2122/97 GVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGR-AEVVVVSLGSQ
Rv2029c|M.tuberculosis_H37Rv GVFLLKASVRELRECVGSELLTEPEQLAAAHELIDRGR-AEVVVVSLGSQ
MAV_0347|M.avium_104 DATEASIIAG-------TEITTVEQAFELADHLLSGGP--ELVALAVPDV
. . : :. :
Mvan_4016|M.vanbaalenii_PYR-1 GVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLCHGLLQGWPLEKTL
Mflv_2602|M.gilvum_PYR-GCK GVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLCHGLLHGWSLEKTL
MSMEG_4661|M.smegmatis_MC2_155 GVLGKTRHS--SVTVPPNEVDVVNGLGAGDAFGGSLIHGLLHDWPLEKTL
MMAR_4574|M.marinum_M GAVAFCAAG--PASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLGADR
MUL_4435|M.ulcerans_Agy99 SAVAFCAAG--PASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLDADR
TH_0601|M.thermoresistible__bu GAYAVCAAG--EVRVPARPVEVVDTVGAGDAFMAGLIDALWSLQLLGAER
MAB_0359|M.abscessus_ATCC_1997 GSLAFRRGEPSPLRIAAHKVSVVDTVGAGDTYTGAFLDGFYRHRLD----
Mb2054c|M.bovis_AF2122/97 GALLATRHA--SHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKSV
Rv2029c|M.tuberculosis_H37Rv GALLATRHA--SHRFSSIPMTAVSGVGAGDAMVAAITVGLSRGWSLIKSV
MAV_0347|M.avium_104 GDLLTWRGG--SELFEFADVEVVDPTGAGDAFVAGLVAALREGAAP----
. . : .*. ****: ..: :
Mvan_4016|M.vanbaalenii_PYR-1 R-----------YANAAGAIVAGRLECSTAMPTAAEVAALAEQTAAEAVN
Mflv_2602|M.gilvum_PYR-GCK R-----------YANAAGAIVAGRLECSTAMPTAAEVAELAEQTAVEAVN
MSMEG_4661|M.smegmatis_MC2_155 R-----------YANAAGAIVASRLECSTAMPTAAEVAALAEQTASEAVN
MMAR_4574|M.marinum_M RTELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR------
MUL_4435|M.ulcerans_Agy99 RTELRKIGVSALTSALEVAALTSALTVARAGADLPYRADLRQSR------
TH_0601|M.thermoresistible__bu RRQLAGIAVEALQRVVETAALSSALTVARAGADLPDRATRDAAAAATERE
MAB_0359|M.abscessus_ATCC_1997 -----------LPEALRRAAVAAAITCTRPGAQPPDATELANELRRVTS-
Mb2054c|M.bovis_AF2122/97 R----------LGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQD
Rv2029c|M.tuberculosis_H37Rv R----------LGNAAGAAMLLTPGTAACNRDDVERFFELAAEPTEVGQD
MAV_0347|M.avium_104 ------------REAGRRAAAAAGATVQRLGGR-PDLTGLRA--------
*
Mvan_4016|M.vanbaalenii_PYR-1 V-------------
Mflv_2602|M.gilvum_PYR-GCK V-------------
MSMEG_4661|M.smegmatis_MC2_155 V-------------
MMAR_4574|M.marinum_M --------------
MUL_4435|M.ulcerans_Agy99 --------------
TH_0601|M.thermoresistible__bu TGTY----------
MAB_0359|M.abscessus_ATCC_1997 --------------
Mb2054c|M.bovis_AF2122/97 QYVWHPIVNPEASP
Rv2029c|M.tuberculosis_H37Rv QYVWHPIVNPEASP
MAV_0347|M.avium_104 --------------