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QQTVRARVACLGEPLVLVSEAGDPHPAGAELNVAVGLAGLGVPASLLGRLGADEYGVLIRAALQQRGIDD SAVETDPARPTGSYSKVTGTDAAGERTTTSRYARAGSAASAMGPDFLDRDEVSAALGAAAIVHCSGITAA LSDTCRALMCRLLTDRPGIPGLVSFDVNWREQLWPDADPAVVLDLADRADLVLVGADEAARVAGTGDPVA LRRVLPSPATLVVKDGARRAVAVDRDGVTTEVPALRVDVVEPVGAGDAFAAGYLSGLVRGDDTATCLRRG HIGAAATLTVATDWAPPPPAGTLQRLLACSPPEWAATTVTTAGFALPEGM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3785 | - | - | 100% (331) | PfkB-family protein carbohydrate kinase |
| M. smegmatis MC2 155 | MSMEG_2908 | - | 5e-18 | 30.95% (294) | 2-keto-3-deoxy-gluconate kinase |
| M. smegmatis MC2 155 | MSMEG_5577 | - | 6e-14 | 28.41% (271) | fructokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1827 | - | 3e-18 | 31.13% (302) | ribokinase-like domain-containing protein |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0359 | - | 4e-10 | 28.43% (306) | putative fructokinase |
| M. marinum M | MMAR_4574 | pfkB | 6e-19 | 32.18% (317) | fructokinase, PfkB |
| M. avium 104 | MAV_1051 | - | 9e-18 | 30.77% (312) | kinase, PfkB family protein |
| M. thermoresistible (build 8) | TH_0601 | - | 6e-13 | 29.63% (270) | fructokinase |
| M. ulcerans Agy99 | MUL_4435 | pfkB | 2e-17 | 31.55% (317) | fructokinase, PfkB |
| M. vanbaalenii PYR-1 | Mvan_4916 | - | 8e-19 | 30.70% (329) | ribokinase-like domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4574|M.marinum_M -----MARGLVIGEALIDIVDGP--DPAEYVGGSPLNVAVGLARLGRDVD
MUL_4435|M.ulcerans_Agy99 -----MARGLVIGEALIDIVDGP--DPAEYVGGSPLNVAVGPARLGRDVD
MAV_1051|M.avium_104 -----MTRGLVIGESLIDIVED-----AEYVGGSPLNVAVGLGRLGRDVD
Mflv_1827|M.gilvum_PYR-GCK ------MRALVIGEALIDIVERGDEVT-EHVGGSPLNVAVGLARLGRDVD
Mvan_4916|M.vanbaalenii_PYR-1 ------MRALVIGEALIDIVERDGGVT-EHVGGSPLNVAVGLARLGRDVD
TH_0601|M.thermoresistible__bu ----MTARALVIGEALIDVVERDGRVLGEHVGGSPLNVAVGLARLGRDVD
MAB_0359|M.abscessus_ATCC_1997 --MADGGGILVCGETLVDLVPVAGGLRRPVPGGGPYNTAIAAAKLGAPTA
MSMEG_3785|M.smegmatis_MC2_155 MQQTVRARVACLGEPLVLVSEAG----DPHPAGAELNVAVGLAGLGVPAS
**.*: : .*. *.*:. . ** .
MMAR_4574|M.marinum_M LLTHIGRDARGRRIAEYIESSGVQLVSGSQTADRTPTATARIG-PDGSAT
MUL_4435|M.ulcerans_Agy99 LLTHIGRDARGRRIAEYIESSGVQLVSGSQTADRTPTATARIG-PDGSAT
MAV_1051|M.avium_104 FLTYLADDDHGRRIAAYLKDAGVQLVSESRAAERTATARSTIA-ADGSAD
Mflv_1827|M.gilvum_PYR-GCK FLTHIGTDDRGRRIAEYVESSGVHLVPGSTAAPRTATARAKLD-AAGSAS
Mvan_4916|M.vanbaalenii_PYR-1 FLTHIGTDARGQRITDFVESSGAQLVPGSRSAARTATARAVLD-ATGSAT
TH_0601|M.thermoresistible__bu FLTHIADDARGRRIADHLADSGVQLVPGSRTAKRTPTAVARLD-ATGAAD
MAB_0359|M.abscessus_ATCC_1997 LLTHVSHDAFGSRCVQDLAAAGVDESLVMRHDVPTTLAVADVD-EHGAAR
MSMEG_3785|M.smegmatis_MC2_155 LLGRLGADEYGVLIRAALQQRGIDDSAVETDPARPTGSYSKVTGTDAAGE
:* :. * * : * . .. : : : .:.
MMAR_4574|M.marinum_M YAFDLEWQIPDTP----------------PVAPPLLVHTGSIAAAREPGC
MUL_4435|M.ulcerans_Agy99 YAFDLEWQIPDTP----------------PVAPPLLVHTGSIAAAREPGC
MAV_1051|M.avium_104 YEFDLDWRLSGIP----------------PVAPPLFVHTGSIAAVRDPGC
Mflv_1827|M.gilvum_PYR-GCK YSFNIEWALTGTP----------------EVAPPLVVHTGSIAAVHEPGC
Mvan_4916|M.vanbaalenii_PYR-1 YSFDIDWQLSGTP----------------EVAPPLVVHTGSIAAVLEPGC
TH_0601|M.thermoresistible__bu YTFDIDWQLSGTP----------------EVAPPVVAHTGSIAAVLEPGC
MAB_0359|M.abscessus_ATCC_1997 YLFYWQGTSNDVAIQSF----------PDPVRTPVAIWAGSIASVLWRER
MSMEG_3785|M.smegmatis_MC2_155 RTTTSRYARAGSAASAMGPDFLDRDEVSAALGAAAIVHCSGITAALSDTC
. . : .. ..*::.
MMAR_4574|M.marinum_M LAVAALLDAYRAAAT--VSFDPNVRPSLSADPDLTRERIQRLVERSDIIK
MUL_4435|M.ulcerans_Agy99 LAVAALLDAYRAAAT--VSFDPNVRPSLRADPDLTRERIQRLVERSDIIK
MAV_1051|M.avium_104 LAVAALIDTYRVSAT--VTFDPNVRPSLIADRELAVSRIEHLVERSDIVK
Mflv_1827|M.gilvum_PYR-GCK LATKALIDAYHLSAT--FTFDPNIRAALITDADAARSRIDRLLEQADVVK
Mvan_4916|M.vanbaalenii_PYR-1 LATTALVDTYHLSAT--FTFDPNVRPALITDPDAARSRIDRLLERADVVK
TH_0601|M.thermoresistible__bu RAAAALIDTYHVSAT--TTFDPNVRPALITDDTGARARIDRFIERCDVVK
MAB_0359|M.abscessus_ATCC_1997 DELRAWIARHYADIP--LTFDVNVRPALISHRQTYAARIVPWLSVARVAR
MSMEG_3785|M.smegmatis_MC2_155 RALMCRLLTDRPGIPGLVSFDVNWREQLWPDADP--AVVLDLADRADLVL
. : . :** * * * .. : . . :
MMAR_4574|M.marinum_M ASAEDLHWIDPTQPPEQTARAWLACGP--AIVALTLGDQGAVAFCAAG--
MUL_4435|M.ulcerans_Agy99 ASAEDLHWIDPTQPPEQTARAWLACGP--AIVALTFGDQSAVAFCAAG--
MAV_1051|M.avium_104 VSAEDLHWIDPDRSPEQLAQTWLGLGP--AVVAVTMADRGAVGYCAAG--
Mflv_1827|M.gilvum_PYR-GCK ASHEDLHWIDPTRTPEQVAAAWLALGP--AIVVVTFGADGALAMCAAG--
Mvan_4916|M.vanbaalenii_PYR-1 ASSEDLHWIDPTRNPEQVATAWLALGP--SIVVVTFGAEGSVAMCADG--
TH_0601|M.thermoresistible__bu ASDEDLQWLEPGRSPEQVAQTWLRMGP--SLVAVTMGDRGAYAVCAAG--
MAB_0359|M.abscessus_ATCC_1997 ASTDDLEFLYPGVSVRDAVNAWLDAYPRIEIAVITCGAAGSLAFRRGEPS
MSMEG_3785|M.smegmatis_MC2_155 VGADEAARVAGTGDP--VALRRVLPSP--ATLVVKDGARRAVAVDRDG-V
.. :: : . : * .:. . : .
MMAR_4574|M.marinum_M PASVPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLGADRRTELRKIGVSA
MUL_4435|M.ulcerans_Agy99 PASMPAQPVRVVDTVGAGDAFMAGLLDTLWEQGLLDADRRTELRKIGVSA
MAV_1051|M.avium_104 TARVPTRAVRVVDTVGAGDSFMAGLLDALWEAGLLGGDRRGALRDIGIDT
Mflv_1827|M.gilvum_PYR-GCK SVRVPAGNVHVVDTVGAGDAFMTGLIDALWSADLLGADRRHHLARIDVDA
Mvan_4916|M.vanbaalenii_PYR-1 TVRVPAGNVDVVDTVGAGDAFMTGLIDALWSMDLLGAGRRARLAGIGTDA
TH_0601|M.thermoresistible__bu EVRVPARPVEVVDTVGAGDAFMAGLIDALWSLQLLGAERRRQLAGIAVEA
MAB_0359|M.abscessus_ATCC_1997 PLRIAAHKVSVVDTVGAGDTYTGAFLDGFYRHRLD---------------
MSMEG_3785|M.smegmatis_MC2_155 TTEVPALRVDVVEPVGAGDAFAAGYLSGLVRGDDTATCLRRGHIGAAATL
:.: * **:.*****:: . :. :
MMAR_4574|M.marinum_M LTSALEVAALTSALTVARAGADLPYRADLRQSR----------
MUL_4435|M.ulcerans_Agy99 LTSALEVAALTSALTVARAGADLPYRADLRQSR----------
MAV_1051|M.avium_104 LTSALDAASLSSALTIARAGADLPDRAAVQAALRR--------
Mflv_1827|M.gilvum_PYR-GCK LTTAVRAATLTSALTVAKSGADLPDRVERDTAPASDILS----
Mvan_4916|M.vanbaalenii_PYR-1 LTTAVRAATLTAALTVTRPGADLPDRVTRDAATASDILG----
TH_0601|M.thermoresistible__bu LQRVVETAALSSALTVARAGADLPDRATRDAAAAATERETGTY
MAB_0359|M.abscessus_ATCC_1997 LPEALRRAAVAAAITCTRPGAQPPDATELANELRRVTS-----
MSMEG_3785|M.smegmatis_MC2_155 TVATDWAPPPPAGTLQRLLACSPPEWAATTVTTAGFALPEGM-
. .. .:. ... * .