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MATGELSGARRSLARQSVVIALLAAAVDVGIFASSGIFRVAFAAACAMTVLLVLADLALALPAHATAAVA IVQVVIRLAVCWLLSRHGLAAGIGDVGILVAGYRVGAWLPTRVALLVVPLLAAGVSGAAVINGAGRTWRE VVLIAVSNAVVPWLVGRYTAAGRAYVDQLERHQQQQQAALERALADEREAIARDLHDVISHHVSAVGIHA GAARLALGTDPDAVARSLAAVESASRSAMMDLRRQLDLLHGADSAGERQPGLANVSHLVDTVRQAGLSVE LELPDAMPALSQSLDVTVYRIVQELLTNALRHGDGTARLQVRRTINEVIIDTSNPIADGRFSGESPGRGR AGVRRRAELFGGIMRDGSDDGLRWRTVVSIPVPPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2813 | - | - | 100% (385) | sensor kinase |
| M. smegmatis MC2 155 | MSMEG_0854 | - | 2e-11 | 27.52% (218) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_1493 | - | 1e-09 | 25.09% (279) | sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 2e-08 | 24.68% (231) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_0967 | - | 3e-09 | 28.30% (265) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 2e-08 | 24.68% (231) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1521 | - | 9e-25 | 30.56% (288) | hypothetical protein MAB_1521 |
| M. marinum M | MMAR_1517 | devS | 4e-06 | 23.65% (203) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_5281 | - | 4e-28 | 32.53% (292) | histidine kinase domain-containing protein |
| M. thermoresistible (build 8) | TH_4203 | - | 5e-10 | 26.15% (260) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 2e-06 | 23.65% (203) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_5523 | - | 3e-28 | 30.34% (323) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAV_5281|M.avium_104 --------------------------------------------------
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2813|M.smegmatis_MC2_155 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MMAR_1517|M.marinum_M GRDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRDK
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAV_5281|M.avium_104 --------------------------------------------------
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2813|M.smegmatis_MC2_155 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
MMAR_1517|M.marinum_M RVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MAV_5281|M.avium_104 -MLRAAICHLREQLRRRGELIPVGLTWASLIAVDAA--------------
Mvan_5523|M.vanbaalenii_PYR-1 -------------------MMPGGFSWPIVVSIDVT--------------
MAB_1521|M.abscessus_ATCC_1997 ------MDRFRETALRRRALVPYEFPWTVPVVMYGS--------------
MSMEG_2813|M.smegmatis_MC2_155 ------------MATGELSGARRSLARQSVVI------------------
TH_4203|M.thermoresistible__bu -VTSGPHPDPVRDLSEQLLTADRELVLLRELIQAAS--------------
Mflv_0967|M.gilvum_PYR-GCK MMVQAPARTLVAAMISGPRYLVSMWPWRALLWTVFG--------------
:
Mb3156c|M.bovis_AF2122/97 GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
Rv3132c|M.tuberculosis_H37Rv GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
MMAR_1517|M.marinum_M GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MAV_5281|M.avium_104 ----------LLLGGTIGTLQRPAADLPVSLTAFAIALSPTVAFFVFNMK
Mvan_5523|M.vanbaalenii_PYR-1 ----------LFIVSAVAILQRPESQWWIAILGLAVAYSPYLVFFAVDIS
MAB_1521|M.abscessus_ATCC_1997 ----------TLLIVGCAVAQRGFTRPWVLLLAAGLALAPILIFIIAGRK
MSMEG_2813|M.smegmatis_MC2_155 ----------ALLAAAVDVGIFASSGIFRVAFAAACAMTVLLVLADLALA
TH_4203|M.thermoresistible__bu ------------RGPGVEPLAAAAARMITAATASDVCFVHVLDDTERSLT
Mflv_0967|M.gilvum_PYR-GCK ----------GVLGTVLIVGLPLILVMGVSRSARTAVWAPLLEIECARLS
Mb3156c|M.bovis_AF2122/97 AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
Rv3132c|M.tuberculosis_H37Rv AAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEA
MMAR_1517|M.marinum_M AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEA
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEA
MAV_5281|M.avium_104 MTPG------------------------------------------PLWA
Mvan_5523|M.vanbaalenii_PYR-1 VSPAVEAL--------------------------------------ALGL
MAB_1521|M.abscessus_ATCC_1997 LN--------------------------------------------TFWT
MSMEG_2813|M.smegmatis_MC2_155 LPAHATAA--------------------------------------VAIV
TH_4203|M.thermoresistible__bu LAGATPPFDKEVG------------------------------KIRLPLG
Mflv_0967|M.gilvum_PYR-GCK LIDEAAAERARSDVN-----------------------------AARAQQ
Mb3156c|M.bovis_AF2122/97 LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGA
Rv3132c|M.tuberculosis_H37Rv LKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVAGA
MMAR_1517|M.marinum_M LKLTSADAALVAVPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGT
MUL_2422|M.ulcerans_Agy99 LKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVAGT
MAV_5281|M.avium_104 TWTASTALTLFVTSTPIRADFAPALLVLMVLVVATLASVVGGLLAAAS--
Mvan_5523|M.vanbaalenii_PYR-1 AWMLAISIWLFGMSAPIEGDFAPVLLGLVTGVIGSMTSMRGGMLAAVT--
MAB_1521|M.abscessus_ATCC_1997 VACGLSAVALFLTWPPNVVDAAPFLLMFTVGEVGAMASVRVGLAATSA--
MSMEG_2813|M.smegmatis_MC2_155 QVVIRLAVCWLLSRHGLAAGIGDVGILVAGYRVGAWLPTRVALLVVPLLA
TH_4203|M.thermoresistible__bu QGISGWVASHREPVVITENKEADPRYLPFQSLRGRDFTSMVSVPMETD--
Mflv_0967|M.gilvum_PYR-GCK RLPTLRQAGYMVLTAMFTGPWGVVLVGFSAILIGVMVAAPWLVRPGEPIN
. . .
Mb3156c|M.bovis_AF2122/97 VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
Rv3132c|M.tuberculosis_H37Rv VLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLS
MMAR_1517|M.marinum_M ALAEVLLDSAPRQVDKIAVEGVDELGDTGPALVLPLRATDAVAGVVVLLH
MUL_2422|M.ulcerans_Agy99 ALAEVLLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVLLH
MAV_5281|M.avium_104 ----------------------------AAALLLTAAALHRLDAIVLYLG
Mvan_5523|M.vanbaalenii_PYR-1 ----------------------------AAGILGAAVAMDRVDTPWLYLS
MAB_1521|M.abscessus_ATCC_1997 ----------------------------CAALLVVAEQLHHLGIFSLYMM
MSMEG_2813|M.smegmatis_MC2_155 AG-------------------------VSGAAVINGAGRTWREVVLIAVS
TH_4203|M.thermoresistible__bu -----------------------------PGGLVGVLNVHTVERREFTRR
Mflv_0967|M.gilvum_PYR-GCK VG------------------------LWLIDSSGEAWAAVTLGIALLVLA
.
Mb3156c|M.bovis_AF2122/97 QGGPGAFTDEQLEMMAAFADQAALAWQLA---TSQRRMRELDVLTDRDRI
Rv3132c|M.tuberculosis_H37Rv QGGPGAFTDEQLEMMAAFADQAALAWQLA---TSQRRMRELDVLTDRDRI
MMAR_1517|M.marinum_M PSSPESVTEEQLEMMAAFADQAALALQLA---TSQRRMRELDVMTERDRI
MUL_2422|M.ulcerans_Agy99 PSSPESVTEEQLEMMAAFADQAALALQLA---TSQRRMRELDVVTERDRI
MAV_5281|M.avium_104 -----FIVVA-WLLGYLMRTQRLLVAEQI---EAQQMLAEHAAADERRRI
Mvan_5523|M.vanbaalenii_PYR-1 -----FIGIG-WLVGYLMRIQQELLLEQR---EAQQKLAEHAAVDERRRI
MAB_1521|M.abscessus_ATCC_1997 -----FFVLCGWMMGHILQLQQRLILQER---AQQARIQEQAASDERRRI
MSMEG_2813|M.smegmatis_MC2_155 ------NAVVPWLVGRYTAAGRAYVDQLERHQQQQQAALERALADEREAI
TH_4203|M.thermoresistible__bu DVDLLLVIGRLIAGGLHQARLHRQLVARERAHEIFVEQVIEAQELERRRL
Mflv_0967|M.gilvum_PYR-GCK AYLVGAYAAAVAQITVAALVDPHALQREVARLEHSRTALLDAVEQERRRI
:* :
Mb3156c|M.bovis_AF2122/97 ARDLHDHVIQRLFAIGLALQGAVPHERNP----EVQQRLSDVVDDLQDVI
Rv3132c|M.tuberculosis_H37Rv ARDLHDHVIQRLFAIGLALQGAVPHERNP----EVQQRLSDVVDDLQDVI
MMAR_1517|M.marinum_M ARDLHDHVIQRLFAIGLALQGSVPRTREP----KVQQRLSEVIDDLQGVI
MUL_2422|M.ulcerans_Agy99 ARDLHDHVIQRLFAIGLALQGSVPRTREP----KVQQRLSEVIDDLQGVI
MAV_5281|M.avium_104 AREVHDVIAHSLSITLLHVTGARRALQQDRDVDDAVEALEQAERLGRQAM
Mvan_5523|M.vanbaalenii_PYR-1 AREVHDVIAHSLTVTLLHVTGARRGLQEDRDVDEAVEALEQAERLGRQAM
MAB_1521|M.abscessus_ATCC_1997 AREIHDVIAHSLSVTMLHLTGARRALQEDHDVDDAVAGLVDAERLGRQAM
MSMEG_2813|M.smegmatis_MC2_155 ARDLHDVISHHVSAVGIHAGAARLALGTDP--DAVARSLAAVESASRSAM
TH_4203|M.thermoresistible__bu AADIHDGISQRLVTLSYRLDAAIRAVDDP---ATVTEQLSKARELADLTL
Mflv_0967|M.gilvum_PYR-GCK ESDLHDRVQHRLVALALTLGIAENAHGDS----AAGRLAADAHGQVDDIA
::** : : : : . .
Mb3156c|M.bovis_AF2122/97 QEIRTTIYDLHGASQGITRLR-------QRIDAAVAQFADSGLRTSVQFV
Rv3132c|M.tuberculosis_H37Rv QEIRTTIYDLHGASQGITRLR-------QRIDAAVAQFADSGLRTSVQFV
MMAR_1517|M.marinum_M QEIRTTIFDLHGSSQGVTRLR-------QRIDAAVAAFGSSGLRTTVQFI
MUL_2422|M.ulcerans_Agy99 QEIRTTIFDLHGSSQGVTRLR-------QRIDAAVAAFGSSGLRTTVQFI
MAV_5281|M.avium_104 ADIRRTVGLLDNWPTKAAPT--TPEPGLDDVASLVDGFRRAGLAVTLCVE
Mvan_5523|M.vanbaalenii_PYR-1 ADIRRTVGLLD---DAVGKV--TPEPGVGDIAMLVDDFVRAGLAVRFESS
MAB_1521|M.abscessus_ATCC_1997 SDIRGTVGLLSAGPGGVEPMRLAPEPGIADIPGLVADFTAAGMSVESHIY
MSMEG_2813|M.smegmatis_MC2_155 MDLRRQLDLLHGADSAGERQP-----GLANVSHLVDTVRQAGLSVELELP
TH_4203|M.thermoresistible__bu EETRAAISGLRPPVLDDLGLS-------GGLASLAQSVGQLDIGVDIEVD
Mflv_0967|M.gilvum_PYR-GCK AELRSVLLGILPRALTEHGLV-------AAATDLIGRYP-VAVEADFGAT
: * : : : .
Mb3156c|M.bovis_AF2122/97 GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDD-----LC
Rv3132c|M.tuberculosis_H37Rv GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDD-----LC
MMAR_1517|M.marinum_M GPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDD-----LC
MUL_2422|M.ulcerans_Agy99 GPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDD-----LC
MAV_5281|M.avium_104 GPADHVSPAVGLALYRITQESLANIAKHAPESKAGVVLDISPA-----SA
Mvan_5523|M.vanbaalenii_PYR-1 GRHDRISGAAGLALYRIAQESLANIAKHAPDAVSELSLTVSPS-----EA
MAB_1521|M.abscessus_ATCC_1997 GSGEAVSAGVGLALYRVAQESLANIAKHSPRSSAAVLLDITGS-----AA
MSMEG_2813|M.smegmatis_MC2_155 DAMPALSQSLDVTVYRIVQELLTNALRHG-DGTARLQVRRTIN-----EV
TH_4203|M.thermoresistible__bu LAETRLPDHIELALYRIAQECLQNVVKHARARTARLTYAVDRGEHGEVAR
Mflv_0967|M.gilvum_PYR-GCK EIPARLPGPVEHTAYLVLNEALTNSAKHASAGHVTITADRRDG----LWW
: : .* : * :*. :
Mb3156c|M.bovis_AF2122/97 IEVTDNGRGLPDEFT--------GSGLTNLRQRAEQAGGEFTLASVPGAS
Rv3132c|M.tuberculosis_H37Rv IEVTDNGRGLPDEFT--------GSGLTNLRQRAEQAGGEFTLASVPGAS
MMAR_1517|M.marinum_M IEVSDNGRGMPKTYT--------SSGLTNLRRRAQEAGGQFTIESPAAGG
MUL_2422|M.ulcerans_Agy99 IEVSDNGRGMPKTYT--------SSGLTNLRRRAQEAGGQFTIESPAAGG
MAV_5281|M.avium_104 RLAVTNILPAAVVAARSPE----GRGLRGMRQRVELLGGAIDVG--PTRD
Mvan_5523|M.vanbaalenii_PYR-1 VLTVTNRLPVPVAAANCAD----GRGMRGMRQRVQQLGGTVNAG--PDGD
MAB_1521|M.abscessus_ATCC_1997 SLTVSNDLAAGLRPDVCSG----G-GLTGMRQRIEMLGGVFHAG--RAED
MSMEG_2813|M.smegmatis_MC2_155 IIDTSNPIADGRFSGESP-----GRGRAGVRRRAELFGGIMRDGS-DDGL
TH_4203|M.thermoresistible__bu LEIVDDGVGFDTFEHPLGGDDMSGYGLLSMAERAEIVGGRLNIRS-RPGA
Mflv_0967|M.gilvum_PYR-GCK LVIRDDGRGGATIQP--------GRGLATLAARVEAVNGTLTVTS-PAGG
: . * : * : .* .
Mb3156c|M.bovis_AF2122/97 GTVLRWSAPLSQ-----------------
Rv3132c|M.tuberculosis_H37Rv GTVLRWSAPLSQ-----------------
MMAR_1517|M.marinum_M GTLLRWSAPLIQ-----------------
MUL_2422|M.ulcerans_Agy99 GTLLRWSAPLIQ-----------------
MAV_5281|M.avium_104 GWSVCAEIPLQESDGSWRPWWCGKA----
Mvan_5523|M.vanbaalenii_PYR-1 GWVVHATIPLDDESCVLR--GCGG-----
MAB_1521|M.abscessus_ATCC_1997 GWTVSASVPLESNGTDCRSRRRKVLWRHD
MSMEG_2813|M.smegmatis_MC2_155 RWRTVVSIPVPPS----------------
TH_4203|M.thermoresistible__bu GTAVIATIPLPPATR--------------
Mflv_0967|M.gilvum_PYR-GCK PTEVGMRCPV-------------------
*: