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NAAKRAVKPVRDLVDADRELALLRELIQAASSGPGVEPLAAAAARMITAATGTDVCFVHVLDDSDRSLTL AGATPPFDSEVGKIRLPIGQGISGWVADHCEPVVISHDKEADPRYMPFESLRGRDFTSMVSVPMEAEPGG LVGVLNVHTVRRREFTPRDVELLVVIGRLIAGALHQARLHRQLVARERAHENFVEQVIEAQELERRRLAA DIHDGISQRLVTLSYRLDAAARAADDPRAVAEQLGKARELADLTLQEARAAISGLRPPVLDDLGLSGGLA SLARSIPQVDLDVDLADTRVPDHIELALYRIAQECLQNVVKHARATTARLTFAVEDGIARLEIVDDGIGF DTFEHPLGSDEMSGYGLLSMAERAEIVGGRLNIRSRPGAGTAVTATIPLPSHEPAPNLTKLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1493 | - | - | 100% (413) | sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_0980 | - | 2e-26 | 29.87% (385) | signal transduction histidine kinase |
| M. smegmatis MC2 155 | MSMEG_3448 | - | 3e-26 | 33.47% (239) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 3e-17 | 28.78% (271) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 0.0 | 85.46% (392) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv2027c | - | 9e-17 | 29.39% (245) | histidine kinase response regulator |
| M. leprae Br4923 | MLBr_00774 | mtrB | 4e-05 | 26.09% (161) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_4499 | - | 2e-22 | 32.91% (234) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4781 | - | 1e-19 | 30.74% (231) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 4e-20 | 30.30% (231) | hypothetical protein MAV_0874 |
| M. thermoresistible (build 8) | TH_4203 | - | 0.0 | 84.90% (404) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 8e-20 | 30.74% (231) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_1357 | - | 0.0 | 84.71% (399) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 ------------------------------------------MMNSRQRE
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_1493|M.smegmatis_MC2_155 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1357|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
Rv2027c|M.tuberculosis_H37Rv MTHPDRANVNPGSPPLRETLSQLRLRELLLEVQDRIEQIVEGRDRLDGLI
MLBr_00774|M.leprae_Br4923 ------------------------------------------------MI
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 ADRRQFAPSCRRQDESAGQSLGQRRTERSPNPSCANYGQLVGSCRLYGVP
Mb0868|M.bovis_AF2122/97 ------------------------------MPSYGNLGRLGG-RHEYGVL
MAV_0874|M.avium_104 --------------------------------------------------
MSMEG_1493|M.smegmatis_MC2_155 --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1357|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 ----MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSARLGIVAAVVLLV
Rv2027c|M.tuberculosis_H37Rv DAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEG
MLBr_00774|M.leprae_Br4923 FSSRRRIRGRWGRSGPMMRGMGALTRVVGVVWRRSLQLRVVALTFGLSLA
MMAR_4781|M.marinum_M -MVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVGTPRREWGA
MUL_0350|M.ulcerans_Agy99 VVVTSDAELARVRRTHQLRAYRIGSVLRIGVVLFMVAAMLVGTPRREWGA
Mb0868|M.bovis_AF2122/97 VAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQ
MAV_0874|M.avium_104 MAVAGDAELERVRAVHQMRSYRIGSVLRVGVVGLMVAAMIIGTARSEWPQ
MSMEG_1493|M.smegmatis_MC2_155 ----MNAAKRAVKPVRDL----VDADRELALLRELIQAASSGPGVEPLAA
TH_4203|M.thermoresistible__bu -----VTSGPHPDPVRDLSEQLLTADRELVLLRELIQAASRGPGVEPLAA
Mflv_5015|M.gilvum_PYR-GCK -------------MTRPL----LTADRELALLRELIQAASSGPGVEPLAA
Mvan_1357|M.vanbaalenii_PYR-1 -------------MSRPL----LTADRELALLRELIQAASSGPGVEPLAA
MAB_4499|M.abscessus_ATCC_1997 AESMLTIFLRTIAPTEHLAAVYLIGILVISVIWRLRLALAMSIASAIVFD
Rv2027c|M.tuberculosis_H37Rv IDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPM
MLBr_00774|M.leprae_Br4923 VILALGFVLTSQLTSRVLDVKVRVAIEQIERARTTVTGIVNGEETRSLDS
. : : .
MMAR_4781|M.marinum_M QT---------ALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPL
MUL_0350|M.ulcerans_Agy99 QT---------ALICVYAFAALWALALAFRRSRPMVSLDRFANIARYEPL
Mb0868|M.bovis_AF2122/97 QI---------VLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPF
MAV_0874|M.avium_104 ES---------VLILLYGIIALGAVALAFAPFRRWIGIGRLAGVGRLEPF
MSMEG_1493|M.smegmatis_MC2_155 AA---------ARMITAATGTDVCFVHVLDDSDRSLTLAGATPPFDSEVG
TH_4203|M.thermoresistible__bu AA---------ARMITAATASDVCFVHVLDDTERSLTLAGATPPFDKEVG
Mflv_5015|M.gilvum_PYR-GCK AS---------ARMITASTDSDVCFVHVLDDTERSLTLAGATPPFDSEVG
Mvan_1357|M.vanbaalenii_PYR-1 AA---------ARMITAATDSDVCFVHVLDDTERSLTLAGATPPFDSEVG
MAB_4499|M.abscessus_ATCC_1997 CIRN----WPKANPLSTESHNLITHLSFLAVTLTASALAALARAGTIEAE
Rv2027c|M.tuberculosis_H37Rv RTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDN
MLBr_00774|M.leprae_Br4923 SLQLARNTLTSKTDPTSGAGLVGAFDAVLIVPGDGPRTATTAGPVDQVPN
MMAR_4781|M.marinum_M AFT--AVDVLALTGFQLLSTD---------GIYSLLIMTLLPVLVALDIS
MUL_0350|M.ulcerans_Agy99 AFT--AVDVLALTGFQLLSTD---------GIYSLLIMTLLPVLVALDIS
Mb0868|M.bovis_AF2122/97 AFT--AVDVLILTGFQLLSTD---------GIYPLLIMILLPVLVGLDVS
MAV_0874|M.avium_104 AFT--VVDILALTIFQLLSTN---------GIYPLLIMAMLPVLLGLDVS
MSMEG_1493|M.smegmatis_MC2_155 KIR--LPIGQGISGWVADHCE---------PVVISHDKEADPRYMPFESL
TH_4203|M.thermoresistible__bu KIR--LPLGQGISGWVASHRE---------PVVITENKEADPRYLPFQSL
Mflv_5015|M.gilvum_PYR-GCK KIR--LPLGQGISGWVASHRQ---------PVVIRRDKESDPRYLPFQSL
Mvan_1357|M.vanbaalenii_PYR-1 KIR--LPLGQGISGWVASNRE---------PVVIRRDKESDPRYLPFRSL
MAB_4499|M.abscessus_ATCC_1997 RRR--REAAAIAQQQAALRRT---------ATLVASNVSPVELYAKVVEE
Rv2027c|M.tuberculosis_H37Rv ARL--FEESRTREAWIEATRD---------IGTQMLAGADPAMVFRLIAE
MLBr_00774|M.leprae_Br4923 SLRGFIKAGQAAYQYATVHTEGFSGPALIIGTPTSSQVTNLELYLIFPLK
.
MMAR_4781|M.marinum_M SRRAAVVLALTLVGFALALAQ------DPVVIRMNGWPEAIFRFGLYAFL
MUL_0350|M.ulcerans_Agy99 SRRAAVVLALTLVGFGLALAQ------DPVVIRMNGWPEAIFRFGLYAFL
Mb0868|M.bovis_AF2122/97 TRRAAVVLACTLVGFAVAVLG------DPVMLRAIGWPETIFRFALYAFL
MAV_0874|M.avium_104 SRRAAVVLIFSMLGFAIAVLQ------DPVMSSSVRLPEAGFRFLLYGFL
MSMEG_1493|M.smegmatis_MC2_155 RGRDFTSMVSVPMEAEPGGLV------GVLNVHTVRRREFTPRDVELLVV
TH_4203|M.thermoresistible__bu RGRDFTSMVSVPMETDPGGLV------GVLNVHTVERREFTRRDVDLLLV
Mflv_5015|M.gilvum_PYR-GCK RGRDFTSMVSVPMETDPGGLV------GVLNVHTVAERDFTDRDVELLLV
Mvan_1357|M.vanbaalenii_PYR-1 RGRDFTSMVSVPMETDPGGLV------GVLNVHTVAERDFGDRDVGLLLV
MAB_4499|M.abscessus_ATCC_1997 AARCFASPTAVLVQLMPGDEG------TIVAGHGTEESRTPPAGKRFPLL
Rv2027c|M.tuberculosis_H37Rv EALTLMAGAATLVAVPLDDEAPACEVDDLVIVEVAGEISPAVKQMTVAVS
MLBr_00774|M.leprae_Br4923 NEQATVTLVRGTMATGGMVLLVLLSGIALLVSRQVVVPVRSASRIAERFA
: : .
MMAR_4781|M.marinum_M --------------------------------------CATALMVVRSEE
MUL_0350|M.ulcerans_Agy99 --------------------------------------CATALMVVRSEE
Mb0868|M.bovis_AF2122/97 --------------------------------------CATALMVVRIEE
MAV_0874|M.avium_104 --------------------------------------CCAAFLVVRIEE
MSMEG_1493|M.smegmatis_MC2_155 --------------------------------------IGRLIAGALHQA
TH_4203|M.thermoresistible__bu --------------------------------------IGRLIAGGLHQA
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------IGRLIAGAMHQA
Mvan_1357|M.vanbaalenii_PYR-1 --------------------------------------IGRLIAGAMHQA
MAB_4499|M.abscessus_ATCC_1997 DSNNVARELRLTPAVCAPIVVDAK-------------HWGTLIVGSHTPA
Rv2027c|M.tuberculosis_H37Rv GTSIGGVFHDRTPRRFDRLDLAVDGPVEPGPALVLPLRAADTVAGVLVAL
MLBr_00774|M.leprae_Br4923 EG------------------------------------HLSERMPVRGED
MMAR_4781|M.marinum_M RHARSVATLSVIREELLAQTMT-----------------ASEVLQRRISE
MUL_0350|M.ulcerans_Agy99 RHARSVATLSVIREELLAQTMT-----------------ASEVLQRRISE
Mb0868|M.bovis_AF2122/97 RHTRSVAGLSALREELLAQTMT-----------------ASEVLQRRIAE
MAV_0874|M.avium_104 RHTRSVAGLSALREELLAQTMN-----------------ASDVSQRRISE
MSMEG_1493|M.smegmatis_MC2_155 RLHRQLVARERAHENFVEQVIE-----------------AQELERRRLAA
TH_4203|M.thermoresistible__bu RLHRQLVARERAHEIFVEQVIE-----------------AQELERRRLAA
Mflv_5015|M.gilvum_PYR-GCK RLHRQLVARERAHENFVEQVIE-----------------AQELERRRLAG
Mvan_1357|M.vanbaalenii_PYR-1 RLHRQLVARERAHEHFVEQVIE-----------------AQELERRRLAG
MAB_4499|M.abscessus_ATCC_1997 QRDQDIRAGVRDFADLVATAIANAATREELAASRARIVSASDTARRRLER
Rv2027c|M.tuberculosis_H37Rv RSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDRDRIAR
MLBr_00774|M.leprae_Br4923 DMARLAVSFNDMAESLSRQITQ---------------LEEFGNLQRRFTS
: : *:
MMAR_4781|M.marinum_M SIHDGPLQDVLAARQELIELRAAAPH------------DQRVSTALAGLQ
MUL_0350|M.ulcerans_Agy99 SIHDGPLQDVLAARQELIELRAAAPH------------DQRVSTALAGLQ
Mb0868|M.bovis_AF2122/97 AIHDGPLQDVLAARQELIELDAVTPG------------DERVGRALAGLQ
MAV_0874|M.avium_104 FIHDGPLQDILAVRQELVELDAAVPD------------DERIGRALAGLQ
MSMEG_1493|M.smegmatis_MC2_155 DIHDGISQRLVTLSYRLDAAARAAD--------DPRAVAEQLGKARELAD
TH_4203|M.thermoresistible__bu DIHDGISQRLVTLSYRLDAAIRAVD--------DPATVTEQLSKARELAD
Mflv_5015|M.gilvum_PYR-GCK DIHDGISQRLVTLSYRLDAAAQAAKSPA-----DHAALTEQLDRARELAD
Mvan_1357|M.vanbaalenii_PYR-1 DIHDGISQRLVTLSYRLDAAAQAATSPG-----DPDALHEQLDRARELAE
MAB_4499|M.abscessus_ATCC_1997 DLHDGAQQRLAYLRLKLGMVRAAVPAT-------DAELTQELNNLDTDLT
Rv2027c|M.tuberculosis_H37Rv DLHDHVIQRLFAVGLTLQGAAPRARVP---------AVRESIYSSIDDLQ
MLBr_00774|M.leprae_Br4923 DVSHELRTPLTTVRMAADLIYDHSSDLDPTLRRSTELMVSELDRFETLLN
: . : . :
MMAR_4781|M.marinum_M SASDLLR--QATFELHPAVLEQVGLGAAVEQLASFHAQRSG--IRITDDV
MUL_0350|M.ulcerans_Agy99 SASDLLR--QATFELHPAVLEQVGLGAAVEQLASFHAQRSG--IRITDDV
Mb0868|M.bovis_AF2122/97 SASERLR--QATFELHPAVLEQVGLGPAVKQLAASTAQRSG--IKISTDI
MAV_0874|M.avium_104 LASERLR--QATFELHPAVLEQVGLGAAVQQLAEFTAQRSG--IEISTDI
MSMEG_1493|M.smegmatis_MC2_155 LTLQEAR--AAISGLRPPVLDDLGLSGGLASLARSIPQVDL----DVDLA
TH_4203|M.thermoresistible__bu LTLEETR--AAISGLRPPVLDDLGLSGGLASLAQSVGQLDIGVDIEVDLA
Mflv_5015|M.gilvum_PYR-GCK LTLQEAR--AAISGLRPPVLDDLGLAGGLASLARSIPQIGI----ETDLD
Mvan_1357|M.vanbaalenii_PYR-1 LTLQEAR--AAISGLRPPVLDDLGLSGGLASLARTIPQVTI----DVDLV
MAB_4499|M.abscessus_ATCC_1997 AVTRELQ--EFSRGLHPAILS-KGLAPALRTLARRSLIPVR----TELEL
Rv2027c|M.tuberculosis_H37Rv EIIQEIR--SAIFDLHAGPSRATGLRHRLDKVIDQLAIPALHTTVQYTGP
MLBr_00774|M.leprae_Br4923 DLLEISRHDAGVAELSVEAVDLRVMVNNALGNVGHLAEEAGIELLVDMPV
: * :
MMAR_4781|M.marinum_M DYPIRDEIDPIVFGVARELLSNVVQHSRARNASVALGISDG----VCVLD
MUL_0350|M.ulcerans_Agy99 DYPIRDEIDPIVFGVARELLSNVVQHSRARNASVALGISDG----VCVLD
Mb0868|M.bovis_AF2122/97 DYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDE----KCVLD
MAV_0874|M.avium_104 DYSGRSAIDAVVFGVVRELLSNVVQHSRARTAAIMLGRTDG----TCVLH
MSMEG_1493|M.smegmatis_MC2_155 DTRVPDHIELALYRIAQECLQNVVKHARATTARLTFAVEDG----IARLE
TH_4203|M.thermoresistible__bu ETRLPDHIELALYRIAQECLQNVVKHARARTARLTYAVDRGEHGEVARLE
Mflv_5015|M.gilvum_PYR-GCK DTRLADHIELALYRIAQECLQNVVKHARASAARLTFAVD----DNTARLE
Mvan_1357|M.vanbaalenii_PYR-1 DTRLPDHIELALYRIAQECLQNVVKHARASRARLTFALDRGDHGDLARLE
MAB_4499|M.abscessus_ATCC_1997 DQKYGESIEIAAYYVVAEALANTAKHSQASEVVIRAHEADD----QIHIT
Rv2027c|M.tuberculosis_H37Rv LSVVDTVLANHAEAVLREAVSNAVRHANATSLAINVSVEDD-----VRVE
MLBr_00774|M.leprae_Br4923 DEVIAEVDARRVERILRNLIANAIDHSEHKPVRIRMAADED----TVAVT
: : : *. *: : :
MMAR_4781|M.marinum_M VADDGVGVSGE-----------TMARRLG---QGHIGLASHRARVDAAGG
MUL_0350|M.ulcerans_Agy99 VADDGVGVSGE-----------TMARRLG---QGHIGLASHRARVDAAGG
Mb0868|M.bovis_AF2122/97 VADDGVGVTGD-----------TMARRLG---EGHIGLASHRARVDAAGG
MAV_0874|M.avium_104 VVDDGVGFNQE-----------TVARRLG---EGHIGLASHRARVEAAGG
MSMEG_1493|M.smegmatis_MC2_155 IVDDGIGFD-------------TFEHPLGSDEMSGYGLLSMAERAEIVGG
TH_4203|M.thermoresistible__bu IVDDGVGFD-------------TFEHPLGGDDMSGYGLLSMAERAEIVGG
Mflv_5015|M.gilvum_PYR-GCK IADDGVGFD-------------TFEHPLGSDEMGGYGLLSMAERAEIVGG
Mvan_1357|M.vanbaalenii_PYR-1 IADDGIGFD-------------TLEHPLGGDEMGGYGLLSMAERAEIVGG
MAB_4499|M.abscessus_ATCC_1997 ISDDGIGGAK---------------------PRKGTGLIGLTDRVTALGG
Rv2027c|M.tuberculosis_H37Rv VVDDGVGISG---------------------DITESGLRNLRQRADDAGG
MLBr_00774|M.leprae_Br4923 VRDYGIGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISIEDARLHQG
: * *:* ** . *
MMAR_4781|M.marinum_M SLVFLNTP-TGTHVCVRIPLKG----------------------------
MUL_0350|M.ulcerans_Agy99 SLVFLNTP-TGTHVCVRIPLKG----------------------------
Mb0868|M.bovis_AF2122/97 VLVFLATP-RGTHVCVELPLKR----------------------------
MAV_0874|M.avium_104 ELVFLDVP-VGTHVCVEVPLRN----------------------------
MSMEG_1493|M.smegmatis_MC2_155 RLNIRSRPGAGTAVTATIPLPSHEPAPNLTKLP-----------------
TH_4203|M.thermoresistible__bu RLNIRSRPGAGTAVIATIPLP---PATR----------------------
Mflv_5015|M.gilvum_PYR-GCK RLNIRSRPGSGTTVTATIPLH----QGGA---------------------
Mvan_1357|M.vanbaalenii_PYR-1 RLNIRSRPGAGTTVTATIPLP----ANRE---------------------
MAB_4499|M.abscessus_ATCC_1997 RLDVHSASGRGTTMTAIIPLHQSD--------------------------
Rv2027c|M.tuberculosis_H37Rv EFTVENMPTGGTLLRWSAPLR-----------------------------
MLBr_00774|M.leprae_Br4923 RLEAWGEPGQGACFRLTLPLVRGHKVTTSPLPMKPILQPSPQASTAGQQH
: . *: . **
MMAR_4781|M.marinum_M ---------------
MUL_0350|M.ulcerans_Agy99 ---------------
Mb0868|M.bovis_AF2122/97 ---------------
MAV_0874|M.avium_104 ---------------
MSMEG_1493|M.smegmatis_MC2_155 ---------------
TH_4203|M.thermoresistible__bu ---------------
Mflv_5015|M.gilvum_PYR-GCK ---------------
Mvan_1357|M.vanbaalenii_PYR-1 ---------------
MAB_4499|M.abscessus_ATCC_1997 ---------------
Rv2027c|M.tuberculosis_H37Rv ---------------
MLBr_00774|M.leprae_Br4923 GTQRQRLREHAERSR