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MDRFRETALRRRALVPYEFPWTVPVVMYGSTLLIVGCAVAQRGFTRPWVLLLAAGLALAPILIFIIAGRK LNTFWTVACGLSAVALFLTWPPNVVDAAPFLLMFTVGEVGAMASVRVGLAATSACAALLVVAEQLHHLGI FSLYMMFFVLCGWMMGHILQLQQRLILQERAQQARIQEQAASDERRRIAREIHDVIAHSLSVTMLHLTGA RRALQEDHDVDDAVAGLVDAERLGRQAMSDIRGTVGLLSAGPGGVEPMRLAPEPGIADIPGLVADFTAAG MSVESHIYGSGEAVSAGVGLALYRVAQESLANIAKHSPRSSAAVLLDITGSAASLTVSNDLAAGLRPDVC SGGGLTGMRQRIEMLGGVFHAGRAEDGWTVSASVPLESNGTDCRSRRRKVLWRHD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1521 | - | - | 100% (405) | hypothetical protein MAB_1521 |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-08 | 26.24% (221) | putative two-component system sensor kinase |
| M. abscessus ATCC 19977 | MAB_3890c | - | 2e-06 | 23.18% (220) | histidine kinase response regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 2e-11 | 27.49% (211) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_5015 | - | 5e-16 | 27.57% (243) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 2e-11 | 27.49% (211) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_0133 | - | 2e-12 | 32.03% (231) | two-component sensor histidine kinase |
| M. avium 104 | MAV_5281 | - | 1e-84 | 46.55% (391) | histidine kinase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2813 | - | 1e-24 | 30.56% (288) | sensor kinase |
| M. thermoresistible (build 8) | TH_4203 | - | 5e-13 | 27.57% (243) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 7e-08 | 25.99% (227) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_5523 | - | 2e-79 | 42.78% (381) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5015|M.gilvum_PYR-GCK -------------------------------------------MTRPLLT
TH_4203|M.thermoresistible__bu -------------------------------VTSGPHPDPVRDLSEQLLT
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAV_5281|M.avium_104 ------------------------------------MLRAAICHLREQLR
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 -----------------------------------------MDRFRETAL
MSMEG_2813|M.smegmatis_MC2_155 -------------------------------------------------M
MMAR_0133|M.marinum_M -----------------------------------------------MLA
Mflv_5015|M.gilvum_PYR-GCK ADRELALLRELIQAASSGPGVEPLAAASARMITASTDSDVCFVHVLDDTE
TH_4203|M.thermoresistible__bu ADRELVLLRELIQAASRGPGVEPLAAAAARMITAATASDVCFVHVLDDTE
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAV_5281|M.avium_104 RRGELIPVGLTWASLIAVDAALLLGGTIGTLQRPAADLPVSLTAFAIALS
Mvan_5523|M.vanbaalenii_PYR-1 ----MMPGGFSWPIVVSIDVTLFIVSAVAILQRPESQWWIAILGLAVAYS
MAB_1521|M.abscessus_ATCC_1997 RRRALVPYEFPWTVPVVMYGSTLLIVGCAVAQRGFTRPWVLLLAAGLALA
MSMEG_2813|M.smegmatis_MC2_155 ATGELSGARRSLARQSVVIALLAAAVDVGIFASSG----IFRVAFAAACA
MMAR_0133|M.marinum_M LLDRTAALRHGADVVHRRLGADLAAGAN----RIAEDDTMEVVAVVGGRT
Mflv_5015|M.gilvum_PYR-GCK RSLTLAGATPPFDSEVGKIRLPLGQGISGWVASHRQPVVIRRDKESDPRY
TH_4203|M.thermoresistible__bu RSLTLAGATPPFDKEVGKIRLPLGQGISGWVASHREPVVITENKEADPRY
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRL-DDVSAHPAS
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRL-DDVSAHPAS
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRL-EDISQHPAS
MAV_5281|M.avium_104 PTVAFFVFNMKMTPG------PLWATWTASTALTLFVTSTPIRADFAPAL
Mvan_5523|M.vanbaalenii_PYR-1 PYLVFFAVDISVSPAV--EALALGLAWMLAISIWLFGMSAPIEGDFAPVL
MAB_1521|M.abscessus_ATCC_1997 PILIFIIAGRKLN--------TFWTVACGLSAVALFLTWPPNVVDAAPFL
MSMEG_2813|M.smegmatis_MC2_155 MTVLLVLADLALALPAHATAAVAIVQVVIRLAVCWLLSRHGLAAGIGDVG
MMAR_0133|M.marinum_M EELNGLVIGPQE-------------GLGGQAAVLRRTVAVHDYCMSRDIT
:
Mflv_5015|M.gilvum_PYR-GCK LPFQSLRGRDFTSMVSVPMETDPGGLVGVLNVHTVAERDFTDRDVELLLV
TH_4203|M.thermoresistible__bu LPFQSLRGRDFTSMVSVPMETDPGGLVGVLNVHTVERREFTRRDVDLLLV
Mb3156c|M.bovis_AF2122/97 IGFPPYHP-PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQA
Rv3132c|M.tuberculosis_H37Rv IGFPPYHP-PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQA
MUL_2422|M.ulcerans_Agy99 IGFPSHHP-PMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQA
MAV_5281|M.avium_104 LVLMVLVVATLASVVGG--LLAAASAAALLLTAAALHR--LDAIVLYLGF
Mvan_5523|M.vanbaalenii_PYR-1 LGLVTGVIGSMTSMRGG--MLAAVTAAGILGAAVAMDR--VDTPWLYLSF
MAB_1521|M.abscessus_ATCC_1997 LMFTVGEVGAMASVRVG--LAATSACAALLVVAEQLHH--LGIFSLYMMF
MSMEG_2813|M.smegmatis_MC2_155 ILVAGYRVGAWLPTRVALLVVPLLAAGVSGAAVINGAGRTWREVVLIAVS
MMAR_0133|M.marinum_M HDFDHAVRAEGLRAAMVAPIVRAHRLYGLLYAARRSPVAWTDRDRAELLS
. .
Mflv_5015|M.gilvum_PYR-GCK IGRLIAGAMHQARLHRQLVARER---------------------------
TH_4203|M.thermoresistible__bu IGRLIAGGLHQARLHRQLVARER---------------------------
Mb3156c|M.bovis_AF2122/97 LAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAA
Rv3132c|M.tuberculosis_H37Rv LAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAA
MUL_2422|M.ulcerans_Agy99 LAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAE
MAV_5281|M.avium_104 IVVA-WLLGYLMRTQRLLVAEQI---------------------------
Mvan_5523|M.vanbaalenii_PYR-1 IGIG-WLVGYLMRIQQELLLEQR---------------------------
MAB_1521|M.abscessus_ATCC_1997 FVLCGWMMGHILQLQQRLILQER---------------------------
MSMEG_2813|M.smegmatis_MC2_155 NAVVPWLVGRYTAAGRAYVDQLERHQ------------------------
MMAR_0133|M.marinum_M LARQAAVAMEVADSAREMAEVAAFG-------------------------
.
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 EALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVA
Rv3132c|M.tuberculosis_H37Rv EALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTIPVA
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTIAVA
MAV_5281|M.avium_104 --------------------------------------------------
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2813|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK --------------------------------------------------
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 GAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVV
Rv3132c|M.tuberculosis_H37Rv GAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVV
MUL_2422|M.ulcerans_Agy99 GTALAEVLLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVL
MAV_5281|M.avium_104 --------------------------------------------------
Mvan_5523|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1521|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2813|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0133|M.marinum_M --------------------------------------------------
Mflv_5015|M.gilvum_PYR-GCK ---------------AHENFVEQVIEAQELE--------------RRRLA
TH_4203|M.thermoresistible__bu ---------------AHEIFVEQVIEAQELE--------------RRRLA
Mb3156c|M.bovis_AF2122/97 LSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIA
Rv3132c|M.tuberculosis_H37Rv LSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIA
MUL_2422|M.ulcerans_Agy99 LHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDRIA
MAV_5281|M.avium_104 --------------EAQQMLAEHAAAD-----------------ERRRIA
Mvan_5523|M.vanbaalenii_PYR-1 --------------EAQQKLAEHAAVD-----------------ERRRIA
MAB_1521|M.abscessus_ATCC_1997 --------------AQQARIQEQAASD-----------------ERRRIA
MSMEG_2813|M.smegmatis_MC2_155 --------------QQQQAALERALAD-----------------EREAIA
MMAR_0133|M.marinum_M --------------------------------------------ERQRLA
* :*
Mflv_5015|M.gilvum_PYR-GCK GDIHDGISQRLVTLSYRLDAAAQAAKSPADHAALTEQLDRARELADLTLQ
TH_4203|M.thermoresistible__bu ADIHDGISQRLVTLSYRLDAAIRAVDDP---ATVTEQLSKARELADLTLE
Mb3156c|M.bovis_AF2122/97 RDLHDHVIQRLFAIGLALQGAVPHERNP----EVQQRLSDVVDDLQDVIQ
Rv3132c|M.tuberculosis_H37Rv RDLHDHVIQRLFAIGLALQGAVPHERNP----EVQQRLSDVVDDLQDVIQ
MUL_2422|M.ulcerans_Agy99 RDLHDHVIQRLFAIGLALQGSVPRTREP----KVQQRLSEVIDDLQGVIQ
MAV_5281|M.avium_104 REVHDVIAHSLSITLLHVTGARRALQQDRDVDDAVEALEQAERLGRQAMA
Mvan_5523|M.vanbaalenii_PYR-1 REVHDVIAHSLTVTLLHVTGARRGLQEDRDVDEAVEALEQAERLGRQAMA
MAB_1521|M.abscessus_ATCC_1997 REIHDVIAHSLSVTMLHLTGARRALQEDHDVDDAVAGLVDAERLGRQAMS
MSMEG_2813|M.smegmatis_MC2_155 RDLHDVISHHVSAVGIHAGAARLALGTDP--DAVARSLAAVESASRSAMM
MMAR_0133|M.marinum_M IRLHDSVGATLFSLRVALMSAQEETEPG----RREELLSDALVLTERATS
:** : : .: * . .
Mflv_5015|M.gilvum_PYR-GCK EARAAISGLRPPVLDDLGLA-------GGLASLARSIPQ-IGI----ETD
TH_4203|M.thermoresistible__bu ETRAAISGLRPPVLDDLGLS-------GGLASLAQSVGQ-LDIGVDIEVD
Mb3156c|M.bovis_AF2122/97 EIRTTIYDLHGASQGITRLR-------QRIDAAVAQFAD-SGLRTSVQFV
Rv3132c|M.tuberculosis_H37Rv EIRTTIYDLHGASQGITRLR-------QRIDAAVAQFAD-SGLRTSVQFV
MUL_2422|M.ulcerans_Agy99 EIRTTIFDLHGSSQGVTRLR-------QRIDAAVAAFGS-SGLRTTVQFI
MAV_5281|M.avium_104 DIRRTVGLLDNWPTKAAPT--TPEPGLDDVASLVDGFRR-AGLAVTLCVE
Mvan_5523|M.vanbaalenii_PYR-1 DIRRTVGLLD---DAVGKV--TPEPGVGDIAMLVDDFVR-AGLAVRFESS
MAB_1521|M.abscessus_ATCC_1997 DIRGTVGLLSAGPGGVEPMRLAPEPGIADIPGLVADFTA-AGMSVESHIY
MSMEG_2813|M.smegmatis_MC2_155 DLRRQLDLLHGADSAGERQP-----GLANVSHLVDTVRQ-AGLSVELELP
MMAR_0133|M.marinum_M ELRAQTLSLHDLPEDKALAV--------TLEGDCRDFATRTGTAAELVVL
: * * : . .
Mflv_5015|M.gilvum_PYR-GCK LDDTRLADHIELALYRIAQECLQNVVKHARASAARLTFAVDDN----TAR
TH_4203|M.thermoresistible__bu LAETRLPDHIELALYRIAQECLQNVVKHARARTARLTYAVDRGEHGEVAR
Mb3156c|M.bovis_AF2122/97 GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDD-----LC
Rv3132c|M.tuberculosis_H37Rv GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDD-----LC
MUL_2422|M.ulcerans_Agy99 GPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDD-----LC
MAV_5281|M.avium_104 GPADHVSPAVGLALYRITQESLANIAKHAPESKAGVVLDISPA----SAR
Mvan_5523|M.vanbaalenii_PYR-1 GRHDRISGAAGLALYRIAQESLANIAKHAPDAVSELSLTVSPS----EAV
MAB_1521|M.abscessus_ATCC_1997 GSGEAVSAGVGLALYRVAQESLANIAKHSPRSSAAVLLDITGS----AAS
MSMEG_2813|M.smegmatis_MC2_155 DAMPALSQSLDVTVYRIVQELLTNALRHG-DGTARLQVRRTIN----EVI
MMAR_0133|M.marinum_M GDLPLLDSARTDALRRTAREALLNVEKHAGAHSVVVSLYRAEDG----VG
: .:* : * :*. :
Mflv_5015|M.gilvum_PYR-GCK LEIADDGVGFDTFEHPLGSDEMGGYGLLSMAERAEIVGGRLNIRSRPGS-
TH_4203|M.thermoresistible__bu LEIVDDGVGFDTFEHPLGGDDMSGYGLLSMAERAEIVGGRLNIRSRPGA-
Mb3156c|M.bovis_AF2122/97 IEVTDNGRGLP--------DEFTGSGLTNLRQRAEQAGGEFTLASVPGAS
Rv3132c|M.tuberculosis_H37Rv IEVTDNGRGLP--------DEFTGSGLTNLRQRAEQAGGEFTLASVPGAS
MUL_2422|M.ulcerans_Agy99 IEVSDNGRGMP--------KTYTSSGLTNLRRRAQEAGGQFTIESPAAGG
MAV_5281|M.avium_104 LAVTNILPAAVV-----AARSPEGRGLRGMRQRVELLGGAIDVG--PTRD
Mvan_5523|M.vanbaalenii_PYR-1 LTVTNRLPVPVA-----AANCADGRGMRGMRQRVQQLGGTVNAG--PDGD
MAB_1521|M.abscessus_ATCC_1997 LTVSNDLAAGLR-----PDVCSGG-GLTGMRQRIEMLGGVFHAG--RAED
MSMEG_2813|M.smegmatis_MC2_155 IDTSNPIADGRFS------GESPGRGRAGVRRRAELFGGIMRDGS-DDGL
MMAR_0133|M.marinum_M LTVADDGTAPDIAS-----EHRRGLGLRATVERIERVGGWLSCTANEEGG
: : . * .* : ** .
Mflv_5015|M.gilvum_PYR-GCK GTTVTATIPLHQGGA--------------
TH_4203|M.thermoresistible__bu GTAVIATIPLPPATR--------------
Mb3156c|M.bovis_AF2122/97 GTVLRWSAPLSQ-----------------
Rv3132c|M.tuberculosis_H37Rv GTVLRWSAPLSQ-----------------
MUL_2422|M.ulcerans_Agy99 GTLLRWSAPLIQ-----------------
MAV_5281|M.avium_104 GWSVCAEIPLQESDGSWRPWWCGKA----
Mvan_5523|M.vanbaalenii_PYR-1 GWVVHATIPLDDESCVLR--GCGG-----
MAB_1521|M.abscessus_ATCC_1997 GWTVSASVPLESNGTDCRSRRRKVLWRHD
MSMEG_2813|M.smegmatis_MC2_155 RWRTVVSIPVPPS----------------
MMAR_0133|M.marinum_M GTVQAWVPAARAFRPVGP-----------
.