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MTAEDLQHRGMSTRLTVLFALAGAMAVGNLYYTQPLLHVIGVSLHTEVGHVGLLVTATQIGYSLGVLLLV PLGDSRDRRRLIPTLMLLSAAALTWCAVAPTLSALAVASLALGLTTVSGQLLTPLAGDLADDRSRGRVVG IVVSGLVTGILVSRIAGGVIAGAWGWRAVFAIAAAITAALALVLAAAVPRVPPTTRVAYPKLLGSVLALA VREPTVRVTLVLGALGFAMFTMFWTALTFLLSGAPYDFTAWQIGLVGVAGLVGALAAQGAGRLHDRGRNV AATGACWCLGLAAWAVAAVSHNLLIGIIVAAIVLDVSVQGLNILNQSRVFVVAQEARSRVNTAYVTANFV GGTGGSLAAAVLWSVGGWSAITVAGAAMSVLGCAVWAAARRGALRASRDVHTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2810 | - | - | 100% (403) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_0103 | - | 9e-20 | 26.02% (392) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_5047 | - | 2e-15 | 24.57% (407) | drug resistance transporter Bcr/CflA subfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0805c | emrB | 6e-10 | 32.34% (167) | multidrug resistance integral membrane efflux protein EmrB |
| M. gilvum PYR-GCK | Mflv_2220 | - | 3e-18 | 24.57% (403) | Bcr/CflA subfamily drug resistance transporter |
| M. tuberculosis H37Rv | Rv0783c | emrB | 6e-10 | 32.34% (167) | multidrug resistance integral membrane efflux protein EmrB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0022c | - | 9e-73 | 41.60% (375) | permease |
| M. marinum M | MMAR_0577 | - | 4e-13 | 26.18% (382) | integral membrane transport protein |
| M. avium 104 | MAV_1539 | - | 4e-21 | 26.97% (393) | major facilitator family protein transporter |
| M. thermoresistible (build 8) | TH_3988 | - | 1e-09 | 24.89% (237) | PUTATIVE putative MFS permease |
| M. ulcerans Agy99 | MUL_3826 | - | 1e-10 | 29.41% (170) | hypothetical protein MUL_3826 |
| M. vanbaalenii PYR-1 | Mvan_4890 | - | 8e-16 | 24.08% (382) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0805c|M.bovis_AF2122/97 MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTAGVCVL
Rv0783c|M.tuberculosis_H37Rv MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTAGVCVL
MSMEG_2810|M.smegmatis_MC2_155 ----------------------MTAEDLQHRGMSTRLTVLFALAG---AM
MAB_0022c|M.abscessus_ATCC_199 -----------------MKNSAQGPASGSARTLPRSVVALLAIAT---AT
MAV_1539|M.avium_104 -----------------MVMPNGPVAHQAGTRGYRRMTAALCGAG---LA
MUL_3826|M.ulcerans_Agy99 ----------MMRPRATVAAATPTTDLAAGRALITPRRRNFIFVA--LVL
Mflv_2220|M.gilvum_PYR-GCK ---------MSLINFMAISPDVKLKAQSPESAGPPSRTRMIIVLGLLVAL
Mvan_4890|M.vanbaalenii_PYR-1 -----------------MTDTLHRPSGPVSVAAPDPVVRRLAVVA--LAL
MMAR_0577|M.marinum_M -----------------MPESVTAPPELGIRHATPGLLALTIATC----L
TH_3988|M.thermoresistible__bu -----------MSESKASQDASAPAADPVDATARRTPWIAILAAALGIFV
Mb0805c|M.bovis_AF2122/97 ASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGW
Rv0783c|M.tuberculosis_H37Rv ASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGW
MSMEG_2810|M.smegmatis_MC2_155 AVGNLYYTQPLLHVIGVSLHTEVGHVGLLVTATQIGYSLGVLLLVPLG--
MAB_0022c|M.abscessus_ATCC_199 SVAVAYYSQPLLDAIGTDLGIPATVAPLIVTLTQLGFAASLFLILPLG--
MAV_1539|M.avium_104 SFAAMYCTQALLPALSAHHRIGPATAALTVSLTTGALALSIIPASVLS--
MUL_3826|M.ulcerans_Agy99 GILLSSLDQTIVAIALPTIVADLGEAG-RQSWVVTSYLLASTIATALVGK
Mflv_2220|M.gilvum_PYR-GCK GPLTIDMYLPALPKIGEELSVSSSVAQLTLTGTLAGLAIGQLVIGPLS--
Mvan_4890|M.vanbaalenii_PYR-1 GGFGIGTTEFVAMGLLPDIATGMGVSEPTAGHVISAYALGVVVGAPVIAA
MMAR_0577|M.marinum_M AITTEILPVGLLPAIGHTFGVRDAVTGLLVSLYAVLVALLAVPLTVVT--
TH_3988|M.thermoresistible__bu MITIEELPIGVLTLIGDDLGLSSGVVGLTVTIPGVLAGAVAVLTPTLIG-
Mb0805c|M.bovis_AF2122/97 AADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTP
Rv0783c|M.tuberculosis_H37Rv AADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTP
MSMEG_2810|M.smegmatis_MC2_155 --DSRDRRRLIPTLMLLSAAALTWCAVAPTLSALAVASLALGLTT-VSGQ
MAB_0022c|M.abscessus_ATCC_199 --DMLNRRRLIVGLSVLSALVLGLTALAPTGTWVLWLSPLVGAMA-VVAQ
MAV_1539|M.avium_104 --ERYGRTRVMLISGVASSVIGLLLPFSPSLGVLVFGRAVQGVALAGIPA
MUL_3826|M.ulcerans_Agy99 LGDMFGRKRVFQVAVLLFVAGSVSCGLTQSMTMLVASRALQGVGGGAITV
Mflv_2220|M.gilvum_PYR-GCK --DSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGIARGLQGMGAAAGMV
Mvan_4890|M.vanbaalenii_PYR-1 VTARMARRKLLLALMALFTIGNLASMLAPTYETLIAARFLAGLPHGAYFG
MMAR_0577|M.marinum_M --ARFPRKPLLLTTLLGYAVSNTLVAIAPTFAMVAAGRAVGGVTHALFFS
TH_3988|M.thermoresistible__bu ---RLDRRLALVSALLLVFVSAATSAIAPNLPVLLASRLFAGMAIGVFWA
: .: . : *
Mb0805c|M.bovis_AF2122/97 VSFAILAREAGPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAYGWRWIF
Rv0783c|M.tuberculosis_H37Rv VSFAILAREAGPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAYGWRWIF
MSMEG_2810|M.smegmatis_MC2_155 LLTPLAGDLADDRSRGRVVGIVVSGLVTGILVSRIAGGVIAGAWGWRAVF
MAB_0022c|M.abscessus_ATCC_199 LLVALTATLAPAEQRGRVVGTVMSGLLIGILLARTAAGLIADLAGWRAVY
MAV_1539|M.avium_104 VAMALLAEEVDASSLGSAMGRYIAGTTIGGLAGRIVPSVVVQVGTWRVAL
MUL_3826|M.ulcerans_Agy99 TAIALIGEVVPLRDRGRYQGILGAVIGIATIGGPLLGGYFTDCLGWRWAF
Mflv_2220|M.gilvum_PYR-GCK VAIAVVGDLYKDNAAATVMSRLMLVLGVAPVLAPSLGAAVLLHGSWHWVF
Mvan_4890|M.vanbaalenii_PYR-1 VAALVAAHLMGPQNRAKAVAHVLTGLTVATVLGVPIASWLGQSLGWRAAF
MMAR_0577|M.marinum_M LCIGYAPRLVGLADVGRALALVGGGVSAGIVVGVPLLTSVGTAVGWRGAF
TH_3988|M.thermoresistible__bu LLAVVVARVAHPDDLPKALTLAFGGVSVAVVLGVPFAAWIGAMVGWRWAF
. : . . *:
Mb0805c|M.bovis_AF2122/97 LVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLLLLSPGLATFLFGVSS
Rv0783c|M.tuberculosis_H37Rv LVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLLLLSPGLATFLFGVSS
MSMEG_2810|M.smegmatis_MC2_155 AIAAAITAALALVLAAAVPRVPPT------------TRVAYPKLLGSVLA
MAB_0022c|M.abscessus_ATCC_199 VTAATSMLAVAAALARRLPSEESAG-----------TTRNYIRLLGSVLD
MAV_1539|M.avium_104 LACSLITLAGTAVFAVLVPRSRFFT-----------PKPASVRAALRNLA
MUL_3826|M.ulcerans_Agy99 WINLPVSAVVICVATAAIPALAATTRPVIDYAGIMFIGLSLAALTLATSL
Mflv_2220|M.gilvum_PYR-GCK AALVVVAAALLVMAVLALPETLPVDHR----------RPLKVRGIAATYL
Mvan_4890|M.vanbaalenii_PYR-1 GLVVGVGLVTLTALWCWLPFQLKFMR----------------ATSPLTEL
MMAR_0577|M.marinum_M AVLAVLAAVLLLVVAKLLPPVSSES-------------------APPPAG
TH_3988|M.thermoresistible__bu VLVGALGLMVAVALTVLLPPVPVAER-----------------TTLGQLG
.*
Mb0805c|M.bovis_AF2122/97 SPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRLFQNRAVA
Rv0783c|M.tuberculosis_H37Rv SPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRLFQNRAVA
MSMEG_2810|M.smegmatis_MC2_155 LAVREPTVRVTLVLGALGFAMFTMFWTALTFLLSGAP-------------
MAB_0022c|M.abscessus_ATCC_199 LVYQQKVLRTRMLFGAIAFAQFSVLWTALTSLLSGEP-------------
MAV_1539|M.avium_104 GHLRNPVLAKLFAVGFVLMGGFVTVYNYLGYRLAARP-------------
MUL_3826|M.ulcerans_Agy99 G-GSVYAWGSAPIIGLFTAAGVTLAVFVWVETIAAQPILPIRLFAAPVFS
Mflv_2220|M.gilvum_PYR-GCK ELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFG------------
Mvan_4890|M.vanbaalenii_PYR-1 GALRRPQVWLALLVGMIGFGGMFAVYTYITTTMTDVAG------------
MMAR_0577|M.marinum_M TAKGRRRLAAVVSSNALTYTGQFTLYTFISAVLLAAGAR-----------
TH_3988|M.thermoresistible__bu AAWSIPAARTGVLVTLVMVTAHFTAYTYASPVLQDRIHIT----------
.
Mb0805c|M.bovis_AF2122/97 QANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAM
Rv0783c|M.tuberculosis_H37Rv QANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAM
MSMEG_2810|M.smegmatis_MC2_155 ---YDFTAWQIGLVG-------------------------VAGLVGALAA
MAB_0022c|M.abscessus_ATCC_199 ---YGYSEGVIGLFG-------------------------VIGAAGALGA
MAV_1539|M.avium_104 ---FGLAPSVVGLLF-------------------------LLYLVGTGTS
MUL_3826|M.ulcerans_Agy99 VCCVLAFVVGFAMLGALIFVPTFMQYVNGVSATASGLRILPMVIGMLITS
Mflv_2220|M.gilvum_PYR-GCK -----LDQTAFALVFG-------------------------AGAVALIGT
Mvan_4890|M.vanbaalenii_PYR-1 -MPRGLVPLALMMFG----------------------------LGMVLGN
MMAR_0577|M.marinum_M ---PAFIGPLLLMCG----------------------------VCSLAGL
TH_3988|M.thermoresistible__bu ---ESGVGPMLFVFG----------------------------IAGFLGN
. :
Mb0805c|M.bovis_AF2122/97 PIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLAI
Rv0783c|M.tuberculosis_H37Rv PIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLAI
MSMEG_2810|M.smegmatis_MC2_155 QGAGRLHDRGRNVAATGACWCLGLAAWAVAAVSHN------LLIGIIVAA
MAB_0022c|M.abscessus_ATCC_199 RFAGKLADSGRSATTTLGAAITMLVSWPALLFGGD------DLIALVLGI
MAV_1539|M.avium_104 VVAGRLADR-RGRPLVLGAALPIAVAGLLLTVPPS-------LAAIVAGV
MUL_3826|M.ulcerans_Agy99 IGSGSMVGR-TGRYKIFPVLGTALMTLAFLLMSRTDESTSAAVQSVYLLI
Mflv_2220|M.gilvum_PYR-GCK TQCNVILLKRFTPQQIMVWALAASSVFGLVFVALAAAGVG-GVFGFVIPV
Mvan_4890|M.vanbaalenii_PYR-1 LVGGRLADGSVVRALYLSLGALCGALALFVVASHN-------PWTALLVL
MMAR_0577|M.marinum_M WYVGATLDRNPRQTTVIIIVVVIGALLGLGASFPA-------LLPVVLAA
TH_3988|M.thermoresistible__bu FAAGPLLRRSMRATYVVLPIGVMVGVX-----------------------
.
Mb0805c|M.bovis_AF2122/97 MGMGMGCSMMPLSG-AAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSV
Rv0783c|M.tuberculosis_H37Rv MGMGMGCSMMPLSG-AAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSV
MSMEG_2810|M.smegmatis_MC2_155 IVLDVSVQGLNILNQSRVFVVAQEARSRVNTAYVTANFVGGTGGSLAAAV
MAB_0022c|M.abscessus_ATCC_199 LLLDFGVQAMHVTNQSQIYALPGDARSRITSAYMTAYFAGGALGSAAVSV
MAV_1539|M.avium_104 GVFTGGFFAAHTVASGWVGAVAQRDRAEASALYLFSYYLGGSVAGAFGGV
MUL_3826|M.ulcerans_Agy99 LGSAIGMSSQVLVIIVQNTSEFEDLGVATSGVSLFRTIGGSFGAAIFGSL
Mflv_2220|M.gilvum_PYR-GCK WAILAAMGLVIPNAPAVALTRHPDAAGTAAALLGAVQFGGGAAIAPVVGV
Mvan_4890|M.vanbaalenii_PYR-1 FLIGLTGSAVGPALQTRLMDVAHDAQTLAAALNHSALNIGNATGAWVGGL
MMAR_0577|M.marinum_M AVWNGAFGGIPSIYQAGAVRAQAATPEMAGAWVNATANLGIAAGAAIGAG
TH_3988|M.thermoresistible__bu -------------------XXGPNSRWRPDGTRM----------------
Mb0805c|M.bovis_AF2122/97 LLTYQFNHSEIIATAKKVALTPESGAGRGAAVDPSSLPRQTNFAAQLLHD
Rv0783c|M.tuberculosis_H37Rv LLTYQFNHSEIIATAKKVALTPESGAGRGAAVDPSSLPRQTNFAAQLLHD
MSMEG_2810|M.smegmatis_MC2_155 LWSVGGWSAITVAGAAMSVLGCAVWAAARR------GALRASRDVHTS--
MAB_0022c|M.abscessus_ATCC_199 AGSRWGWTGVCTVGAGFALLQLLTAALRPRESSQAIGALSVCSQDKNLWS
MAV_1539|M.avium_104 LYGVGGWSATVCFVVVLLMAGAALVALLVRDNGFRIGRRVVAGVASVK--
MUL_3826|M.ulcerans_Agy99 FVNFLNSRLASALTATEVASSPEALHRQSPAVAAPIVHAYAGSLAQVFLC
Mflv_2220|M.gilvum_PYR-GCK LGNDELAMAVVMAAGVIIALGALLVTGAHRNTEPARVPDEAVAEPA----
Mvan_4890|M.vanbaalenii_PYR-1 VIAAGLGYTAPAAAGAVLALAGLAVLTVSVLLQKRG--------------
MMAR_0577|M.marinum_M LLPTIGLAGLPWVAAALIAISLAVTLATGRGPTH----------------
TH_3988|M.thermoresistible__bu --------------------------------------------------
Mb0805c|M.bovis_AF2122/97 LSHAYAVVFVIATALVVSTLIPAAFLPKQQASHRRAPLLSA---------
Rv0783c|M.tuberculosis_H37Rv LSHAYAVVFVIATALVVSTLIPAAFLPKQQASHRRAPLLSA---------
MSMEG_2810|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0022c|M.abscessus_ATCC_199 LGESNS--------------------------------------------
MAV_1539|M.avium_104 --------------------------------------------------
MUL_3826|M.ulcerans_Agy99 AAPVAAIGFVLALFMREVPLRDIHNRDHDARVPSGDGSGQQNKLEGDLDT
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4890|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0577|M.marinum_M --------------------------------------------------
TH_3988|M.thermoresistible__bu --------------------------------------------------
Mb0805c|M.bovis_AF2122/97 -----------------------
Rv0783c|M.tuberculosis_H37Rv -----------------------
MSMEG_2810|M.smegmatis_MC2_155 -----------------------
MAB_0022c|M.abscessus_ATCC_199 -----------------------
MAV_1539|M.avium_104 -----------------------
MUL_3826|M.ulcerans_Agy99 GQSVGAPGKEPDFGVDPAMGPVR
Mflv_2220|M.gilvum_PYR-GCK -----------------------
Mvan_4890|M.vanbaalenii_PYR-1 -----------------------
MMAR_0577|M.marinum_M -----------------------
TH_3988|M.thermoresistible__bu -----------------------