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VVMPNGPVAHQAGTRGYRRMTAALCGAGLASFAAMYCTQALLPALSAHHRIGPATAALTVSLTTGALALS IIPASVLSERYGRTRVMLISGVASSVIGLLLPFSPSLGVLVFGRAVQGVALAGIPAVAMALLAEEVDASS LGSAMGRYIAGTTIGGLAGRIVPSVVVQVGTWRVALLACSLITLAGTAVFAVLVPRSRFFTPKPASVRAA LRNLAGHLRNPVLAKLFAVGFVLMGGFVTVYNYLGYRLAARPFGLAPSVVGLLFLLYLVGTGTSVVAGRL ADRRGRPLVLGAALPIAVAGLLLTVPPSLAAIVAGVGVFTGGFFAAHTVASGWVGAVAQRDRAEASALYL FSYYLGGSVAGAFGGVLYGVGGWSATVCFVVVLLMAGAALVALLVRDNGFRIGRRVVAGVASVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1539 | - | - | 100% (414) | major facilitator family protein transporter |
| M. avium 104 | MAV_4987 | - | 6e-11 | 20.91% (397) | sugar transporter family protein |
| M. avium 104 | MAV_4712 | - | 1e-10 | 27.55% (392) | transporter, major facilitator family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0197 | - | 3e-12 | 23.06% (360) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4405 | - | 7e-13 | 24.52% (367) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv0191 | - | 3e-12 | 23.06% (360) | integral membrane protein |
| M. leprae Br4923 | MLBr_00556 | - | 9e-05 | 23.15% (324) | putative integral membrane drug transport protein |
| M. abscessus ATCC 19977 | MAB_2706c | - | 1e-145 | 67.51% (394) | putative transporter |
| M. marinum M | MMAR_0434 | - | 3e-14 | 23.95% (405) | integral membrane protein |
| M. smegmatis MC2 155 | MSMEG_0103 | - | 5e-87 | 45.43% (383) | major facilitator family protein transporter |
| M. thermoresistible (build 8) | TH_3412 | - | 6e-09 | 24.63% (410) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_1084 | - | 2e-14 | 23.95% (405) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_4890 | - | 1e-14 | 24.07% (403) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1539|M.avium_104 ----------MVMPNG--PVAHQAGTRGYRRMTAALCGAGLASFAAMYCT
MAB_2706c|M.abscessus_ATCC_199 MATAASTEGTTTVRNGVDPSPHQTGTAGYRRLTGALFAAGLATFAALYGT
MSMEG_0103|M.smegmatis_MC2_155 --------MVTAQPEPAVWQGHTRGSSDYRRLLAALFCAGVATFAQLYSP
Mb0197|M.bovis_AF2122/97 ----------MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILP
Rv0191|M.tuberculosis_H37Rv ----------MTAPTGTSATTTRPWTPRIATQLSVLACAAFIYVTAEILP
MMAR_0434|M.marinum_M ----------MTSEARTATTAARPWTPRVAAQLSVLAAAAFIYVTAEILP
MUL_1084|M.ulcerans_Agy99 ----------MTSEARTATTAARPWTPRVAAQLSVLAAAAFIYVTAEILP
Mvan_4890|M.vanbaalenii_PYR-1 -------MTDTLHRPSGPVSVAAPDPVVRRLAVVALALGGFGIGTTEFVA
Mflv_4405|M.gilvum_PYR-GCK -------------MSSTKEGDCPTTKQRLPREVWVLVVANVVVALGYGVV
TH_3412|M.thermoresistible__bu -----------------MTQCAVRAGAREWAGLGVLAVPTVLLGLDVTVL
MLBr_00556|M.leprae_Br4923 ----------------------MSTRAGRRVAISAGSLAVLLGALDTYVV
. .
MAV_1539|M.avium_104 QALLPALSAHHRIGPATAA---LTVSLTTGALALSIIPASVLSERYGRTR
MAB_2706c|M.abscessus_ATCC_199 QAVLPALSADLGVSPASAA---LTVSVTTGMLALSIIPASALSERFGRTR
MSMEG_0103|M.smegmatis_MC2_155 QAVLPLIASDLGTGAAHAA---LAISAATIGLAFGVLPWAALADRVGRVQ
Mb0197|M.bovis_AF2122/97 VGALSAIARNLRVSVVLVG---TLLSWYALVAAVTTVPLVRWTAHWPRRR
Rv0191|M.tuberculosis_H37Rv VGALSAIARNLRVSVVLVG---TLLSWYALVAAVTTVPLVRWTAHWPRRR
MMAR_0434|M.marinum_M VGALSAIARNLHISVVLVG---TLLSWYALVAALTTVPLVRWTAHWPRRH
MUL_1084|M.ulcerans_Agy99 VGALSAIARNLHISVVLVG---TLLSWYALVAALTTVPLVRWTAHWPRRH
Mvan_4890|M.vanbaalenii_PYR-1 MGLLPDIATGMGVSEPTAG---HVISAYALGVVVGAPVIAAVTARMARRK
Mflv_4405|M.gilvum_PYR-GCK APVLPQYARHFGVSIAAAT---FVITAFAVMRLVGAPPAGFLVQRLGERR
TH_3412|M.thermoresistible__bu YLVLPAVAADLAPSPVQTL---WIMDAYGFFIAGFLITMGTLGDRIGRRR
MLBr_00556|M.leprae_Br4923 VTIMRDIMHDVGIPVNQMQRITWIVTMYLLGYIAAMPLLSRASDRFGRKL
: : : .
MAV_1539|M.avium_104 VMLISGVASSVIGLLLPFS---PSLGVLVFGRAVQGVALAGIPAVAMALL
MAB_2706c|M.abscessus_ATCC_199 VMLVSAIATTIIGLLLPAS---PTFAVLLIGRAAEGAALAGIPAVAMAFL
MSMEG_0103|M.smegmatis_MC2_155 VITVSVVVATVLGLLVPFA---PTYALLLCGRFVEGLALAGVPAVAVAYL
Mb0197|M.bovis_AF2122/97 ALVVSLVCLTVSQLVSALA---PNFAVLAAGRVLCAVTHGLLWAVIAPIA
Rv0191|M.tuberculosis_H37Rv ALVVSLVCLTVSQLVSALA---PNFAVLAAGRVLCAVTHGLLWAVIAPIA
MMAR_0434|M.marinum_M ALMVSLVCLTISQLISALA---PNFAVLAAGRALCAITHGLLWSVIAPIA
MUL_1084|M.ulcerans_Agy99 ALMVSLVCLTISQLISALA---PNFAVLAAGRALCAITHGLLWSVIAPIA
Mvan_4890|M.vanbaalenii_PYR-1 LLLALMALFTIGNLASMLA---PTYETLIAARFLAGLPHGAYFGVAALVA
Mflv_4405|M.gilvum_PYR-GCK VYTSGLIIVAVSTGACAFA---ETYWQLLLFRSLGGVGSAMFTVSALGLM
TH_3412|M.thermoresistible__bu LLTIGVTAFAGASVLAALA---PSAELLIVARALLGVAGATLMPSTLSLI
MLBr_00556|M.leprae_Br4923 LLQVSLAGFAIGSVMTALAGQFGDFHMLIAGRTIQGVASGALLPITLALG
: : * * . .
MAV_1539|M.avium_104 A-EEVDASSLGSAMGRYIAGTTIGGLAGRIVPSVVVQVGT-WRVALLACS
MAB_2706c|M.abscessus_ATCC_199 A-EEVHPGSLGSAMGRYIAGTTVGGLAGRLVASSVLDVSN-WRIALLGSG
MSMEG_0103|M.smegmatis_MC2_155 T-EEINAGHAARAAGTYVAGTTIGGLAGRLVTGPVAEFAG-WRVGVLTVA
Mb0197|M.bovis_AF2122/97 T-RLVPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWG-WRLAAVCVT
Rv0191|M.tuberculosis_H37Rv T-RLVPPSHAGRATTSIYIGTSLALVVGSPLTAAMSLMWG-WRLAAVCVT
MMAR_0434|M.marinum_M T-RLVPPSHAGRATTSIYIGTSLALVIGSPLTAALSLMWG-WRLAAVCVT
MUL_1084|M.ulcerans_Agy99 T-RLVPPSHAGRATTSIYIGTSLALVIGSPLTAALSLMWG-WRLAAVCVT
Mvan_4890|M.vanbaalenii_PYR-1 A-HLMGPQNRAKAVAHVLTGLTVATVLGVPIASWLGQSLG-WRAAFGLVV
Mflv_4405|M.gilvum_PYR-GCK I-RISPADARGRVAGLFSSGFMIGSVGG-PILGSLTAGFG-LAAPFLIYG
TH_3412|M.thermoresistible__bu SNMFVDAAQRALAIGVWATMFAVGMAAGPVVGGALVDRFW-WGAAFLLAV
MLBr_00556|M.leprae_Br4923 A-DLWAQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLFSDWRYVFWINI
. . :. * :
MAV_1539|M.avium_104 -------------------------------------------------L
MAB_2706c|M.abscessus_ATCC_199 -------------------------------------------------A
MSMEG_0103|M.smegmatis_MC2_155 -------------------------------------------------L
Mb0197|M.bovis_AF2122/97 -------------------------------------------------G
Rv0191|M.tuberculosis_H37Rv -------------------------------------------------G
MMAR_0434|M.marinum_M -------------------------------------------------V
MUL_1084|M.ulcerans_Agy99 -------------------------------------------------V
Mvan_4890|M.vanbaalenii_PYR-1 -------------------------------------------------G
Mflv_4405|M.gilvum_PYR-GCK -------------------------------------------------A
TH_3412|M.thermoresistible__bu PVAAAVLLGARLLPEYADPQAGRLDLRSVALSLLAILAAIYAVKHVAVHG
MLBr_00556|M.leprae_Br4923 PLTAIAMLMIQVSLSAHDRGDELEKVDVVG--------------GVLLAI
MAV_1539|M.avium_104 ITLAGTAVFAVLVPRSRFFTPKP------------------ASVRAALRN
MAB_2706c|M.abscessus_ATCC_199 MTLVCTVLFAALLPKSQFFVPKK------------------VRVGTTLRI
MSMEG_0103|M.smegmatis_MC2_155 LCGMAALAFVKLAPAAQGFTPAR------------------THWDLGRRL
Mb0197|M.bovis_AF2122/97 AAAAVALAARLALPEMVLRADQL------------------EHVGRRA--
Rv0191|M.tuberculosis_H37Rv AAAAVALAARLALPEMVLRADQL------------------EHVGRRA--
MMAR_0434|M.marinum_M AAAVVTVAARLLLPEMVLSADQL------------------QYVGPRS--
MUL_1084|M.ulcerans_Agy99 AAAVVTVAARLLLPEMVLSADQL------------------QHVGPRS--
Mvan_4890|M.vanbaalenii_PYR-1 VGLVTLTALWCWLPFQLKFMRAT------------------SPLTELG--
Mflv_4405|M.gilvum_PYR-GCK ALLVAATVVFVSLRNSAVVGQAD------------------DDVQVPIPF
TH_3412|M.thermoresistible__bu VDGVAVAACALAAAAATVFVHRQ------------------RRLDAPLLD
MLBr_00556|M.leprae_Br4923 ALGLVVIGLYNPQPDSKQVLPSYGVPVLVGGIVATVAFAVWERCARTRLI
MAV_1539|M.avium_104 LAGHLRNPVLAKLFAVGFVLMGGFVTVYNYLGYRLAARPFGLAPSVVGLL
MAB_2706c|M.abscessus_ATCC_199 LGVHLRNPVLLIMFGLAFLLMGGFVTVYNYLGYRLVAPPFGLPTAIAGLL
MSMEG_0103|M.smegmatis_MC2_155 LT-NLRSPRQLALFAQGFLLMGGFVAVYNFLGFRLSAAPFNLPQTVVSLV
Mb0197|M.bovis_AF2122/97 --RHHRNPRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLL
Rv0191|M.tuberculosis_H37Rv --RHHRNPRLVKVSVLTMIAVTGHFVSYTYIVVIIRDVVGVRGPNLAWLL
MMAR_0434|M.marinum_M --RHHRNRALIIVSLITMVGVTGHFVSYTYIVVIIRQVVGVRGPSLAWLL
MUL_1084|M.ulcerans_Agy99 --RHHRNRALIIVSLITMVGVTGHFVSYTYIVVIIRQVVGVRGPSLAWLL
Mvan_4890|M.vanbaalenii_PYR-1 ---ALRRPQVWLALLVGMIGFGGMFAVYTYITTTMTDVAGMPRGLVPLAL
Mflv_4405|M.gilvum_PYR-GCK RTVFRHRAYKAALFSNFATGWASFGLRIALVPLFVVEVLGEGPGAAGLAL
TH_3412|M.thermoresistible__bu VTLFADR-AFTAALTVLLIGLIGVGGTMYLVTQFLQLVEGLTPVRAGWWM
MLBr_00556|M.leprae_Br4923 DPAGVHIRPFLSALGASVAAGAALMVTLVNVELFGQGVLGMDQTQAAGLL
. : :
MAV_1539|M.avium_104 FLLYLVGTGTSVVAGRLADRRGRPLVLGAALPIAVAGLLLT------VPP
MAB_2706c|M.abscessus_ATCC_199 FLLYLAGTMSSAVAGRLADRRGRGSVLIAAIVITAAGLALT------IPN
MSMEG_0103|M.smegmatis_MC2_155 FLAYLAGTWASARAGAEATRFGRKPVLLVSIATMIAGVAVT------MST
Mb0197|M.bovis_AF2122/97 AAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLT------ALA
Rv0191|M.tuberculosis_H37Rv AAYGVAGLVSVPLVARPLDRWPKGAVIVGMTGLTAAFTLLT------ALA
MMAR_0434|M.marinum_M AAYGVAGVVAVALVARPLDRRPKGTIIFCVAGLTFAFVLLT------ALA
MUL_1084|M.ulcerans_Agy99 AAYGVAGVVAVALVARPLDRRPKGTIIFCVAGLTFAFVLLT------ALA
Mvan_4890|M.vanbaalenii_PYR-1 MMFGLGMVLGNLVGGRLADGSVVRALYLSLGALCGALALFV------VAS
Mflv_4405|M.gilvum_PYR-GCK TAFAVGNIAVVIPSGHLSDRLGRRKLLIFGLMLAAVSTALV------GFT
TH_3412|M.thermoresistible__bu GPPALAMFVAAIGAPLIARRVRPGVVMAATLGVSVLGYAVL------ASA
MLBr_00556|M.leprae_Br4923 VWFLIALPIGAVLGGWGATKAGDRTMTFVGLLITAGGYWLISHWPVDLLN
: : .
MAV_1539|M.avium_104 S---------LAAIVAGVGVFTGGFFAAHTVASGWVGAVAQRDRAE-ASA
MAB_2706c|M.abscessus_ATCC_199 S---------LLTVIVGVGVFTAGFFAAHTVASGWVGAVAQRDRAE-ASA
MSMEG_0103|M.smegmatis_MC2_155 N---------AVVVLVGLVIATAGFFGAHAIASGWVGAEAGDSKAQ-ASA
Mb0197|M.bovis_AF2122/97 FGERHTAATALLG-TGAIVLWGALATAVSPMLQSAAMRSGGDDPDG-ASG
Rv0191|M.tuberculosis_H37Rv FGERHTAATALLG-TGAIVLWGALATAVSPMLQSAAMRSGGDDPDG-ASG
MMAR_0434|M.marinum_M FGGHLAPMTALVVGTGAIVLWGAAATAVSPMLQSAAMRSGADDPDG-ASG
MUL_1084|M.ulcerans_Agy99 FGGHLAPMTALVVGTGAIVLWGAAVTAVSPMLQSAAMRSGADDPDG-ASG
Mvan_4890|M.vanbaalenii_PYR-1 HN--------PWTALLVLFLIGLTGSAVGPALQTRLMDVAHDAQTL-AAA
Mflv_4405|M.gilvum_PYR-GCK TS-------LPVFLVAAVIAGAATGIFVSPQQAAVADVVGNKSRGGPAVA
TH_3412|M.thermoresistible__bu GRG------DGPAVVVAFAFVYLGLGAIAALGTDIVVGAAPAAKSGSAAA
MLBr_00556|M.leprae_Br4923 YRRSIFGLFSVPTMYADLLVAGLGLGLVIGPLSSATLRVVPTAQHGIASA
. * .
MAV_1539|M.avium_104 LYLFSYYLGGSVAGAFGGVLYGVGGWSATVCFVVVLLMAGAALVALLVRD
MAB_2706c|M.abscessus_ATCC_199 LYLFSYYLGSSVAGAVGGLAYQAGGWGLTVLFVGALLAIALVLAALMVLR
MSMEG_0103|M.smegmatis_MC2_155 LYNLFYYGGSSAVGWLGGLAFDAAGWSAVAGTVMGLAALAGLIAFALAR-
Mb0197|M.bovis_AF2122/97 LYVTAFQIGIMAGALLGGLLYER---SLAMMLTASAGLMGVALFGMTVSQ
Rv0191|M.tuberculosis_H37Rv LYVTAFQIGIMAGALLGGLLYER---SLAMMLTASAGLMGVALFGMTVSQ
MMAR_0434|M.marinum_M LYVTAFQVGIMAGSLIGGLLYER---SVAMMLTASAGLMGVALVGMTSAR
MUL_1084|M.ulcerans_Agy99 LYVTAFQVGIMAGSLIGGLLYER---SVAMMLTASAGLMGVALVGMTSAR
Mvan_4890|M.vanbaalenii_PYR-1 LNHSALNIGNATGAWVGGLVIAAG-LGYTAPAAAGAVLALAGLAVLTVSV
Mflv_4405|M.gilvum_PYR-GCK TFQMMADFGSIGGSLLVGLIAQYTSYGWAFLVSGIILAVAAIGWFFAPET
TH_3412|M.thermoresistible__bu MSETVQELGIAVGVALLGSVTAAVYRSRMTGPEGVAEGVGGPDAERLAES
MLBr_00556|M.leprae_Br4923 AVVVARMTGMLIGVAALTAWGLYRFNQILAGLSTAVPPDATLIERAAAVA
*
MAV_1539|M.avium_104 NGFRIGRRVVAGVASVK---------------------------------
MAB_2706c|M.abscessus_ATCC_199 N--RFGHINAPE--------------------------------------
MSMEG_0103|M.smegmatis_MC2_155 --------------------------------------------------
Mb0197|M.bovis_AF2122/97 HLFENPTLSPGDG-------------------------------------
Rv0191|M.tuberculosis_H37Rv HLFENPTLSPGDG-------------------------------------
MMAR_0434|M.marinum_M RVFEAPVAVAGATSHNQ---------------------------------
MUL_1084|M.ulcerans_Agy99 RVFEAPVAVAGATSHNQ---------------------------------
Mvan_4890|M.vanbaalenii_PYR-1 LLQKRG--------------------------------------------
Mflv_4405|M.gilvum_PYR-GCK RPTPSTEHTPGRPLGPEAGGEVP---------------------------
TH_3412|M.thermoresistible__bu LPAAVSVADRVPGEAVRLAQDAFAAGVNIAALIGGAAVVVVAVVCATALR
MLBr_00556|M.leprae_Br4923 DQAKRAYTMMYSDIFMITAIVCVIGALLGLLISSRKEHASEPKVPE----
MAV_1539|M.avium_104 ------
MAB_2706c|M.abscessus_ATCC_199 ------
MSMEG_0103|M.smegmatis_MC2_155 ------
Mb0197|M.bovis_AF2122/97 ------
Rv0191|M.tuberculosis_H37Rv ------
MMAR_0434|M.marinum_M ------
MUL_1084|M.ulcerans_Agy99 ------
Mvan_4890|M.vanbaalenii_PYR-1 ------
Mflv_4405|M.gilvum_PYR-GCK ------
TH_3412|M.thermoresistible__bu HLRPLD
MLBr_00556|M.leprae_Br4923 ------