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VSLINFMAISPDVKLKAQSPESAGPPSRTRMIIVLGLLVALGPLTIDMYLPALPKIGEELSVSSSVAQLT LTGTLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGIARGLQGMGAAAGMVVAI AVVGDLYKDNAAATVMSRLMLVLGVAPVLAPSLGAAVLLHGSWHWVFAALVVVAAALLVMAVLALPETLP VDHRRPLKVRGIAATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFGLDQTAFALVFGAGAV ALIGTTQCNVILLKRFTPQQIMVWALAASSVFGLVFVALAAAGVGGVFGFVIPVWAILAAMGLVIPNAPA VALTRHPDAAGTAAALLGAVQFGGGAAIAPVVGVLGNDELAMAVVMAAGVIIALGALLVTGAHRNTEPAR VPDEAVAEPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2220 | - | - | 100% (430) | Bcr/CflA subfamily drug resistance transporter |
| M. gilvum PYR-GCK | Mflv_0301 | - | 2e-19 | 25.11% (462) | EmrB/QacA family drug resistance transporter |
| M. gilvum PYR-GCK | Mflv_2728 | - | 2e-17 | 26.22% (370) | major facilitator transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1908 | - | 4e-20 | 32.49% (237) | hypothetical protein Mb1908 |
| M. tuberculosis H37Rv | Rv1877 | - | 4e-20 | 32.49% (237) | integral membrane protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-16 | 25.40% (315) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1395 | - | 1e-137 | 62.76% (392) | Bcr/CflA family multidrug resistance transporter |
| M. marinum M | MMAR_3524 | - | 9e-34 | 27.87% (366) | hypothetical protein MMAR_3524 |
| M. avium 104 | MAV_3140 | - | 7e-16 | 25.11% (454) | drug efflux membrane protein |
| M. smegmatis MC2 155 | MSMEG_5047 | - | 1e-162 | 73.80% (416) | drug resistance transporter Bcr/CflA subfamily protein |
| M. thermoresistible (build 8) | TH_0755 | - | 1e-56 | 63.43% (175) | drug resistance transporter Bcr/CflA subfamily protein |
| M. ulcerans Agy99 | MUL_3826 | - | 1e-15 | 23.92% (372) | hypothetical protein MUL_3826 |
| M. vanbaalenii PYR-1 | Mvan_4475 | - | 0.0 | 89.90% (406) | Bcr/CflA subfamily drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1877|M.tuberculosis_H37Rv ----------------MAGP---TAPTTAPTAIRAGGPLLSPVR------
MUL_3826|M.ulcerans_Agy99 ----------------MMRPRATVAAATPTTDLAAGRALITPRR------
Mb1908|M.bovis_AF2122/97 ----------------MAGP---TAPTTAPTAIRAGGPLLSPVR------
Mflv_2220|M.gilvum_PYR-GCK ----------------MSLINFMAISPDVKLKAQSPESAGPPS-------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------MAPPG-------
MSMEG_5047|M.smegmatis_MC2_155 ----------------------------------------MPS-------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 ----------------MRALSTEVTSAPGKTTVDDPATDRTPAGSVSPPA
MMAR_3524|M.marinum_M ------------------------------------MKASAPSR------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_3140|M.avium_104 --------------------------MTDAATITGGWRELLGAR------
Rv1877|M.tuberculosis_H37Rv ----RNIIFTALVFGVLVAATGQTIVVPALPTIVAELGSTV-DQSWAVTS
MUL_3826|M.ulcerans_Agy99 ----RNFIFVALVLGILLSSLDQTIVAIALPTIVADLGEAG-RQSWVVTS
Mb1908|M.bovis_AF2122/97 ----RNIIFTALVFGVLVAATGQTIVVPALPTIVAELGSTV-DQSWAVTS
Mflv_2220|M.gilvum_PYR-GCK ----RTRMIIVLGLLVALGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
Mvan_4475|M.vanbaalenii_PYR-1 ----RTRMILVLGLLVALGPLTIDMYLPALPKIAEELSVSSSVAQLTLTG
MSMEG_5047|M.smegmatis_MC2_155 ----RTRMILVLGALITLGPLTIDMYLPALPKIGEELSVSSSVAQLTLTG
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TRLGRAWLITVLGAMVALGPLTIDMYLPALPDIGSDLHVNSTLTQLTLTG
MMAR_3524|M.marinum_M ------RIVAVLLCVVPLNQIPMDAYTPALPQMETSIGTTATALQSTVTV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MAV_3140|M.avium_104 ----YLRTSILLAGGVALYATNEFLTTSLLPNTIAEIGGSR-LYAWVTTL
Rv1877|M.tuberculosis_H37Rv YLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLAI
MUL_3826|M.ulcerans_Agy99 YLLASTIATALVGKLGDMFGRKRVFQVAVLLFVAGSVSCGLTQSMTMLVA
Mb1908|M.bovis_AF2122/97 YLLGGTVVVVVAGKLGDLLGRNRVLLGSVVVFVVGSVLCGLSQTMTMLAI
Mflv_2220|M.gilvum_PYR-GCK TLAGLAIGQLVIGPLSDSLGRRKPLFAGIVLHMVASLLCMFAPTITVLGI
Mvan_4475|M.vanbaalenii_PYR-1 TLAGLAIGQLVIGPLSDSLGRRRPLFAGIVLHMLASLLCLLAPNITVLGV
MSMEG_5047|M.smegmatis_MC2_155 TLAGLALGQLVVGSLSDSLGRRRPLLAGIVLHMAASVLCFLAPNIAVLGI
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 TLVGLGLGQLLVGPLSDSLGRRLPLIAGAILHIVASLAITIAPNIVVLGV
MMAR_3524|M.marinum_M FMIGMALSYLAVGIMSDSWGRKPVLMGCAAALTVTSLACAAANNVAMLLV
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
MAV_3140|M.avium_104 YLVGSVVAATMVNPMLLRVGARASYLLGLAVFGVASLVCGAAPDMHVLIA
Rv1877|M.tuberculosis_H37Rv SRALQGVGAGAISVTAYALAAEVVP-LRDRGRYQGVLGAVFGVNTVTGPL
MUL_3826|M.ulcerans_Agy99 SRALQGVGGGAITVTAIALIGEVVP-LRDRGRYQGILGAVIGIATIGGPL
Mb1908|M.bovis_AF2122/97 SRALQGVGAGAISVTAYALAAEVVP-LRDRGRYQGVLGAVFGVNTVTGPL
Mflv_2220|M.gilvum_PYR-GCK ARGLQGMGAAAGMVVAIAVVGDLYK-DNAAATVMSRLMLVLGVAPVLAPS
Mvan_4475|M.vanbaalenii_PYR-1 ARCLQGMGAAAGMVVAIAVVGDLYK-DNVAATVMSRLMLVLGVAPVLAPS
MSMEG_5047|M.smegmatis_MC2_155 ARGLQGMGASAAAVVAIAVVGDLYS-GNTAATVMSRLMLVLGVAPVLAPS
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 LRAVEGMGAAAAMVVAMAVVRDLYT-DKAAATVISRLTLVIGIAPILAPS
MMAR_3524|M.marinum_M LRFLQGGACSAFIVVAIAIAADCFE-GARLRSVNGLLGAAWSAAPILAPA
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
MAV_3140|M.avium_104 GRAMQGVAGGLLAGLGYAVINSALP-RWLWTRGSALVSAMWGVATVVGPA
Rv1877|M.tuberculosis_H37Rv LGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDY---L
MUL_3826|M.ulcerans_Agy99 LGGYFTDCLGWRWAFWINLPVSAVVICVATAAIPALAATTRPVIDY---A
Mb1908|M.bovis_AF2122/97 LGGWLTDYLSWRWAFWINVPVSIAVLTVAATAVPALARPPKPVIDY---L
Mflv_2220|M.gilvum_PYR-GCK LGAAVLLHGSWHWVFAALVVVAAALLVMAVLALPETLPVDHRRPLK---V
Mvan_4475|M.vanbaalenii_PYR-1 FGAAVLLHGSWHWVFAALVVVAGALLVMSVLALPETLPADHRRPLK---A
MSMEG_5047|M.smegmatis_MC2_155 LGAAVLLKASWHWVFVALVILAGLLLVMAALALPETLPTSHRRPLK---V
TH_0755|M.thermoresistible__bu ---------------------------MSEEPLGEXX-------------
MAB_1395|M.abscessus_ATCC_1997 LGAAVLVHGSWQNVFAALSCLGVLLLILAVVALPETLPPSARRPLR---A
MMAR_3524|M.marinum_M VGGFIVEYASWRYVFVLIAALSVVVGLAVTWALPETLDQESRTRFE---L
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAIL
MAV_3140|M.avium_104 TGGLFAQLGIWRWAFVVMAVLTALMALLVPVALARVDPAPAIPRMKVPVW
.:
Rv1877|M.tuberculosis_H37Rv GILVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGR
MUL_3826|M.ulcerans_Agy99 GIMFIGLSLAALTLATSLGGSVYAWGSAPIIGLFTAAGVTLAVFVWVETI
Mb1908|M.bovis_AF2122/97 GILVIAVATTALIMATSWGGTTYAWGSATIVGLLIGAAVALGFFVWLEGR
Mflv_2220|M.gilvum_PYR-GCK RGIAATYLELVRDARFVILVLVAALGMSGLFAYIAGASFVLQGRFGLDQT
Mvan_4475|M.vanbaalenii_PYR-1 RGIALTYLELLRDVRFVILVFVGALGMSGLFAYIAGASFVLQGRFGLDQT
MSMEG_5047|M.smegmatis_MC2_155 GGIMRTYGRLLHDARFVILVLVAALGMSGLFAYISAAPFVLQGRYGLDQQ
TH_0755|M.thermoresistible__bu -------------------------------XYISGAAFVLQDGYGLNQQ
MAB_1395|M.abscessus_ATCC_1997 GAILRTYRDLLRDKVFVVLVLVAGLSLSGLFAYISGASFVLQGQYGMNQQ
MMAR_3524|M.marinum_M GQTWQVLTATARNRVFLALAAIFGLLAGPQLSFGVAAPFLYQDEMGFSPS
MLBr_01562|M.leprae_Br4923 ATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENPV
MAV_3140|M.avium_104 SLLIIGVASLAVSVAQIPHNTAATFGLLAAGIMLVGLFVIVDWRMHAAIL
. .
Rv1877|M.tuberculosis_H37Rv AAAAILPPR-------LFGSPVFAVCCVLSFVVGFAMLGALTFVPIYLGY
MUL_3826|M.ulcerans_Agy99 AAQPILPIR-------LFAAPVFSVCCVLAFVVGFAMLGALIFVPTFMQY
Mb1908|M.bovis_AF2122/97 ARCGHPAAQ-------AVWQP--SICRVLR--------------PVLRGR
Mflv_2220|M.gilvum_PYR-GCK AFALVFGAG-------AVALIGTTQCNVIL--------------------
Mvan_4475|M.vanbaalenii_PYR-1 AFALVFGAG-------AIALIGTTQFNVVL--------------------
MSMEG_5047|M.smegmatis_MC2_155 MFAAVFAAG-------AVALIGSTQFNVVL--------------------
TH_0755|M.thermoresistible__bu AFALVFGAG-------AIALIGATQFNVVL--------------------
MAB_1395|M.abscessus_ATCC_1997 VFALAFGAG-------AIAFVAASQLNVVL--------------------
MMAR_3524|M.marinum_M AYGLIALVV-------GVAVLLGSFSTGML--------------------
MLBr_01562|M.leprae_Br4923 VPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIG----------LYIQDIL
MAV_3140|M.avium_104 PPSVFSPGPLKWIYLTMGVLMAAAMVNTYVPLFG------------QRLA
Rv1877|M.tuberculosis_H37Rv VDGASATASGLRTLPMVIGLLIASTGTGVLVGRTGRYKIFPVAGMALMAV
MUL_3826|M.ulcerans_Agy99 VNGVSATASGLRILPMVIGMLITSIGSGSMVGRTGRYKIFPVLGTALMTL
Mb1908|M.bovis_AF2122/97 IRDAGCTD-------------LRTDLSGVRGRRVG-----DRVRSAHVAD
Mflv_2220|M.gilvum_PYR-GCK ----------------------------LKRFTPQQIMVWALAASSVFGL
Mvan_4475|M.vanbaalenii_PYR-1 ----------------------------LKRFAPQQIMVWALVAASLSGA
MSMEG_5047|M.smegmatis_MC2_155 ----------------------------LRRFTPQAITVAALASATVVGA
TH_0755|M.thermoresistible__bu ----------------------------LRRFDPSTIVVTALAVASVLGF
MAB_1395|M.abscessus_ATCC_1997 ----------------------------LKRFEPQQIVRWCLSLALIPAV
MMAR_3524|M.marinum_M ----------------------------ATRMAFRRLAFADWTLYMVGAA
MLBr_01562|M.leprae_Br4923 GYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAML
MAV_3140|M.avium_104 HLTPIAAGFLGAALALGWTVSEIVSASPENPRTVGRVVMVAPLVAASGLA
Rv1877|M.tuberculosis_H37Rv AFLLMSQMD-EWTPPLLQSLYLVVLGAGIGLS-MQVLVLIVQNTSSFEDL
MUL_3826|M.ulcerans_Agy99 AFLLMSRTD-ESTSAAVQSVYLLILGSAIGMS-SQVLVIIVQNTSEFEDL
Mb1908|M.bovis_AF2122/97 GDRPADRLDRDGCPGRPDGPLQDLPGRGDGADGGCVPADVADGRVDATAA
Mflv_2220|M.gilvum_PYR-GCK VFVALAAAGVGGVFGFVIPVWAILAAMGLVIP--NAPAVALTRHPDAAGT
Mvan_4475|M.vanbaalenii_PYR-1 VFVALAAAHIGGLWGFVIPVWAILAAMGLVIP--NAPAVALTRHPDAAGT
MSMEG_5047|M.smegmatis_MC2_155 VFVGLTIADVGGLIGFLVPVMAILTAMGFVIP--NAPAVALSRHSEAAGT
TH_0755|M.thermoresistible__bu VFVGLAVTGVGGLAGFVLPVWGVLGAMGFVLP--NAPALALSRHPEASGT
MAB_1395|M.abscessus_ATCC_1997 VLLVLAGFGIGGLVGFVAPVWTLMALMGFVIP--NAPALALSRHGEAAGT
MMAR_3524|M.marinum_M LLLGSAPVVGVNPWAITLAVSLAVAGCGALVP--QAQAAALGAFSRNLGL
MLBr_01562|M.leprae_Br4923 YGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPV
MAV_3140|M.avium_104 LGAVARHGDGSAWTAALWAVALLVAGTGIGMAWPHLSARAMASVNDPAEG
. .
Rv1877|M.tuberculosis_H37Rv GVATSGVTFFRVVGASFGTATFGALFVNFLDRRLGSALTSGAVPVPAVPS
MUL_3826|M.ulcerans_Agy99 GVATSGVSLFRTIGGSFGAAIFGSLFVNFLNSRLASALTATEVAS----S
Mb1908|M.bovis_AF2122/97 AIAVPGRPRCRHRIVHAGARSHRAEHVVFRRPRRR-NIGCDLLPGG---R
Mflv_2220|M.gilvum_PYR-GCK AAALLG-------AVQFGGGAAIAPVVGVLG-------------------
Mvan_4475|M.vanbaalenii_PYR-1 AAALLG-------AVQFGMGAAIAPVVGVLG-------------------
MSMEG_5047|M.smegmatis_MC2_155 AAALLG-------AAQFGIGALVAPLVGALG-------------------
TH_0755|M.thermoresistible__bu AAALLG-------CGQFGLGAVISPLVGVLG-------------------
MAB_1395|M.abscessus_ATCC_1997 SAAVLG-------AAQFGVGAVIAPLVGALG-------------------
MMAR_3524|M.marinum_M VSGLFG-------TLTYLIIAAIMAIVGVSPE------------------
MLBr_01562|M.leprae_Br4923 SAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTG-------------PV
MAV_3140|M.avium_104 GAASAAINTVQLTSAAIGAGLAGVVVNTATG-------------------
Rv1877|M.tuberculosis_H37Rv PAVLHQLPQSMAAPIVRAYAESLTQVFLCAVSVTVVGFILALLLREVPLT
MUL_3826|M.ulcerans_Agy99 PEALHRQSPAVAAPIVHAYAGSLAQVFLCAAPVAAIGFVLALFMREVPLR
Mb1908|M.bovis_AF2122/97 RLVWYRNIRCVVRKLPGPKTRFRADVGRRACPGSAISGCLASAAPEHGRP
Mflv_2220|M.gilvum_PYR-GCK -----NDELAMAVVMAAGVIIALGALLVTG-AHRNTEPAR----------
Mvan_4475|M.vanbaalenii_PYR-1 -----NDELAMAVVMAAGVIVALTALLVTG-VHRNTAPAA----------
MSMEG_5047|M.smegmatis_MC2_155 -----NGALALSGVMTAGMAIALVALLLVGGSHADDETHDGNEDGPGSDD
TH_0755|M.thermoresistible__bu -----NSAPAMAAVMTGGVLIALVALLAAG-VRPGAEHRD----------
MAB_1395|M.abscessus_ATCC_1997 -----NNALAVAIVMMIGVVLALAGLAVVR--------------------
MMAR_3524|M.marinum_M -----RTQAPLGWLYVLCGALVFAALAWVTPRVQGEKPTPG---------
MLBr_01562|M.leprae_Br4923 KFMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVK
MAV_3140|M.avium_104 -----GDEMAAHLLFTVFTALSAAGVAVSYAATRATR-------------
:
Rv1877|M.tuberculosis_H37Rv DIHDDADDLGDGFGVPRAESPEDVLEIAVRRMLPNGVRLRDIATQPGCGL
MUL_3826|M.ulcerans_Agy99 DIHNRDHDAR----VPSGD---------------------------GSGQ
Mb1908|M.bovis_AF2122/97 DRAGICRVAHPG--VPLRG-------------------------------
Mflv_2220|M.gilvum_PYR-GCK VPDEAVAEPA----------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 VPGEAVAEPA----------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 VVAEAVAEPA----------------------------------------
TH_0755|M.thermoresistible__bu -TADMLVEHA----------------------------------------
MAB_1395|M.abscessus_ATCC_1997 ---NRVAA------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 EAVDAGEL------------------------------------------
MAV_3140|M.avium_104 -QAQPVGNVG----------------------------------------
Rv1877|M.tuberculosis_H37Rv GVAELWALLRIYQYQRLFEAVRLTDIGRHLHVPYQVFEPVFDRLVQTGYA
MUL_3826|M.ulcerans_Agy99 ---------------------------------------------QN---
Mb1908|M.bovis_AF2122/97 -------------------------------------------------L
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MAV_3140|M.avium_104 --------------------------------------------------
Rv1877|M.tuberculosis_H37Rv ARDGDILTLTPSGHRQVDSLAVLIRQWLLDHLAVAPGLKRQPDHQFEAAL
MUL_3826|M.ulcerans_Agy99 KLEGDLDTGQSVG---------------------APGK--EPDFGVDPAM
Mb1908|M.bovis_AF2122/97 GHGGRFHPGAVAAR--------------------------------GTAH
Mflv_2220|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5047|M.smegmatis_MC2_155 --------------------------------------------------
TH_0755|M.thermoresistible__bu --------------------------------------------------
MAB_1395|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3524|M.marinum_M --------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MAV_3140|M.avium_104 --------------------------------------------------
Rv1877|M.tuberculosis_H37Rv QHVTDAVLVQRDWYEDLGDLSESRQLAATT
MUL_3826|M.ulcerans_Agy99 GPVR--------------------------
Mb1908|M.bovis_AF2122/97 RHPR--------------------------
Mflv_2220|M.gilvum_PYR-GCK ------------------------------
Mvan_4475|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_5047|M.smegmatis_MC2_155 ------------------------------
TH_0755|M.thermoresistible__bu ------------------------------
MAB_1395|M.abscessus_ATCC_1997 ------------------------------
MMAR_3524|M.marinum_M ------------------------------
MLBr_01562|M.leprae_Br4923 ------------------------------
MAV_3140|M.avium_104 ------------------------------