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MHDELQRWKDAGQYFDYLGFDIFYRVDGVAPGTGPNLLLIHGYPFNSWDWSLIWPTLTQRFTVIAPDMIG MGFSDKPVAYEYRVTDHADIHEALLAHLGITSTHILAHDLGDSVGQEMLARHEFGGQAYGGFQIESVTWL NGGLFNEAYRPRLMQKVMSRTPLGDILSPLQGSPLSRRVFESTLDQMFGVNTKPSREMIEKFHQILDHND GKRVLHKVGRFVTDRYTHRNRWVRAMRETSVPMRLIDGPSDPNSGRHMAQRYLEVIPDPDVVMLADDIAH WPQIEAPDAVLAHFLEHIDRVVAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2777 | - | - | 100% (304) | alpha/beta hydrolase fold |
| M. smegmatis MC2 155 | MSMEG_0117 | - | 4e-15 | 40.57% (106) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_6151 | - | 2e-11 | 25.73% (307) | alpha/beta hydrolase fold-1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1865 | - | 2e-32 | 31.58% (285) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 2e-14 | 41.90% (105) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1834 | - | 8e-33 | 31.58% (285) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-08 | 30.88% (136) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4300 | - | 1e-128 | 69.77% (301) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2711 | - | 1e-28 | 29.08% (282) | hydrolase |
| M. avium 104 | MAV_5163 | - | 4e-17 | 27.59% (290) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_4027 | - | 4e-28 | 28.62% (290) | PUTATIVE hydrolase |
| M. ulcerans Agy99 | MUL_3053 | - | 3e-29 | 29.43% (282) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 2e-14 | 46.51% (86) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3952|M.gilvum_PYR-GCK --------------------MTARTPNLRPVRELTPTLRYCTIHGYRRAY
Mvan_2445|M.vanbaalenii_PYR-1 --------------------MTERKPNLRPVRELTPTLKFCTIHGYRRAF
MSMEG_2777|M.smegmatis_MC2_155 -----------------------MHDELQRWKDAGQYFDYLGFDIFYRVD
MAB_4300|M.abscessus_ATCC_1997 -----------------------MDAELEEWKAAGHYFDYLGFDIFYRVE
MMAR_2711|M.marinum_M ----------------------MTSPSVSDWRAGGGWINTAAGKVFVRSG
MUL_3053|M.ulcerans_Agy99 MNCRPITLVTLLSWSSRWYARRVTSPSVSDWRAGGGWINTAAGKVFVRSG
Mb1865|M.bovis_AF2122/97 ----------------------MTSPSVREWRDGGRWLPTAVGKVFVRSG
Rv1834|M.tuberculosis_H37Rv ----------------------MTSPSVREWRDGGRWLPTAVGKVFVRSG
TH_4027|M.thermoresistible__bu ---------------------------VARWRAEGRWIRTGVGSVFVRSA
MAV_5163|M.avium_104 ------------------------MVTMPELDGVEHRYVDLGDDVTIHVA
MLBr_00862|M.leprae_Br4923 ------------------------MPATQSIHKVPHQFVESPDGVRLAIY
Mflv_3952|M.gilvum_PYR-GCK R-IAGSGPAILLIHGIGDNSTTWAGVQ-TQLAQRFTVIAPDLLGHGKSDK
Mvan_2445|M.vanbaalenii_PYR-1 R-VAGSGPAILLIHGIGDNSTTWSTVQ-TQLAQRFTVIAPDLLGHGRSDK
MSMEG_2777|M.smegmatis_MC2_155 GVAPGTGPNLLLIHGYPFNSWDWSLIW-PTLTQRFTVIAPDMIGMGFSDK
MAB_4300|M.abscessus_ATCC_1997 ----GSGPPLLLIHGYPFNSWDWALIW-PTLVERFTVIAPDMIGMGFSDK
MMAR_2711|M.marinum_M ---EGIAPTVLLLHGFPSSSFDFRSVI-PYLAGQA-WLTMDFLGFGLSDK
MUL_3053|M.ulcerans_Agy99 ---EGIAPTVLLLHGFPSSSFNFRSVI-PYLAGQA-WLTMDFLGFGLSDK
Mb1865|M.bovis_AF2122/97 ---PGDTPTMLLLHGYPSSSFDFRAVI-PHLTGQA-WVTMDFLGFGLSDK
Rv1834|M.tuberculosis_H37Rv ---PGDTPTMLLLHGYPSSSFDFRAVI-PHLTGQA-WVTMDFLGFGLSDK
TH_4027|M.thermoresistible__bu ---SGRGSPVVLLHGYPSSSYDYRAVL-PELGDRG-WVTFDFLGFGLSDK
MAV_5163|M.avium_104 DAGPASGPAVMLVHGFPQNWWEWRALIGPLAADGYRVLCPDLRGAGWSSA
MLBr_00862|M.leprae_Br4923 QSGQPEGPAIVLVHGFPDSHVLWDGVV-PLLAKRFRIVRYDNRGVGQSSV
. ::*:** . : : . : * * * *.
Mflv_3952|M.gilvum_PYR-GCK PR--ADYSVAAYANGMRDLLSVLNID-SATVVGHSLGGGVAMQFAYQFPQ
Mvan_2445|M.vanbaalenii_PYR-1 PR--ADYSVAAYANGMRDLLSVLDID-DVTVIGHSLGGGVAMQFAYQFPQ
MSMEG_2777|M.smegmatis_MC2_155 PVA-YEYRVTDHADIHEALLAHLGIT-STHILAHDLG-----------DS
MAB_4300|M.abscessus_ATCC_1997 PVQ-YGYSVLDHADMHEALLSYLGIE-RFHLLTHDLG-----------NS
MMAR_2711|M.marinum_M PRP-HRYSLLEQADLVQNVVAQNVTG-PVVVLAHDMG-----------TS
MUL_3053|M.ulcerans_Agy99 PRP-HRYSLLEQADLVQNVVAQNVTG-PVVVLAHDMG-----------TS
Mb1865|M.bovis_AF2122/97 PRP-HRYSLLEQAHLVETVVAHTVTG-AVVVLAHDMG-----------TS
Rv1834|M.tuberculosis_H37Rv PRP-HRYSLLEQAHLVETVVAHTVTG-AVVVLAHDMG-----------TS
TH_4027|M.thermoresistible__bu PRP-HRYSLFEQADLVQTVVRSVTDE-PVLLIAHDMG-----------TS
MAV_5163|M.avium_104 PR--SSYRKDEMADDLAGVLDRLGVR-SVDLVAHDWG-----------GP
MLBr_00862|M.leprae_Br4923 PKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGA
* * *. :: :: *. *
Mflv_3952|M.gilvum_PYR-GCK LVDRLILVGAGGVTKDVNIALRAASLPM---------------GTEALAL
Mvan_2445|M.vanbaalenii_PYR-1 LVNRLILVGAGGVTKDVNIALRLASLPM---------------GSEALAL
MSMEG_2777|M.smegmatis_MC2_155 VGQEMLARHEFGGQAYGGFQIESVTWLN---------------GGLFNEA
MAB_4300|M.abscessus_ATCC_1997 VGQEMLARFEFEQQSRGRVPIDSVTWLN---------------GGLFIEA
MMAR_2711|M.marinum_M VTTELLARDLEGRLP---FELQRAVLSN---------------GSVILER
MUL_3053|M.ulcerans_Agy99 VTTELLARDLEGRLP---FELQRVVLSN---------------GSVILER
Mb1865|M.bovis_AF2122/97 VTTELLARDLDGRLP---FDLRRAVLSN---------------GSVILER
Rv1834|M.tuberculosis_H37Rv VTTELLARDLDGRLP---FDLRRAVLSN---------------GSVILER
TH_4027|M.thermoresistible__bu VATELMARDLQGQLP---FRLQRVVLSN---------------GSVLLDR
MAV_5163|M.avium_104 VAFIMMLRHPEKVTGFFGVNTSAPFVKR---------------SLSTIRN
MLBr_00862|M.leprae_Br4923 SDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVL
.
Mflv_3952|M.gilvum_PYR-GCK LRLPLLLPTLR--LLGRVGGPLLGNTRIGRDIPNMLRILADLPEPTASSA
Mvan_2445|M.vanbaalenii_PYR-1 LRLPLVLPALQ--VLGRVSGTVFGSTGVGRDIPDMLRILADLPEPTASSA
MSMEG_2777|M.smegmatis_MC2_155 YRPRLMQKVMSRTPLGDILSPLQGSPLSRRVFESTLDQMFGVNTKPSREM
MAB_4300|M.abscessus_ATCC_1997 YRPRIAQTLMSRTPLGDLVSRFQGTPVTRRIMDAAVSEMFGPDTKPSPRL
MMAR_2711|M.marinum_M ASLRPIQKVLR-GPLGPIAARLVN----RGGFTRGFGKLFSAQHPLSAQE
MUL_3053|M.ulcerans_Agy99 ASLRLIQKVLR-GPLGPIAARLVN----RGGFTRGFGKLFSAQHPLSAQE
Mb1865|M.bovis_AF2122/97 ASLRPIQKVLR-SPLGPVAARLVS----RGGFTRGFGRIFSPAHPLSAQE
Rv1834|M.tuberculosis_H37Rv ASLRPIQKVLR-SPLGPVAARLVS----RGGFTRGFGRIFSPAHPLSAQE
TH_4027|M.thermoresistible__bu ASLRPIQKVLR-GRFGPVVSQLVN----EPMFIRGLGKVFSKQRPLSAAE
MAV_5163|M.avium_104 VWRFWYQIPISLPVIGPRVISTPD-----SRFVRLLGSWVGGGYTLPEED
MLBr_00862|M.leprae_Br4923 FSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTY
: :.
Mflv_3952|M.gilvum_PYR-GCK FARTLRSVVDW---RGQVVTMLDRCYLTQSVP---------VQLIWGSQD
Mvan_2445|M.vanbaalenii_PYR-1 FARTLRAVVDW---RGQVVTMLDRCYLTQSVP---------VQLIWGDCD
MSMEG_2777|M.smegmatis_MC2_155 IEKFHQILDHN---DGKRVLHKVGRFVTDRYT---------HRNRWVRAM
MAB_4300|M.abscessus_ATCC_1997 LSLFQQVLEYN---DGARVTHQVGRFINDRYD---------NRSRWVRAM
MMAR_2711|M.marinum_M AEAQWELLTHN---NGHRIAHLLISYLEERER---------YAQRWHNAV
MUL_3053|M.ulcerans_Agy99 PEAQWELLTHN---NGHRIAHLLISYLEERER---------YAQRWNNAV
Mb1865|M.bovis_AF2122/97 AQAQWELLCYN---DGNRIPHLLISYLDERIR---------HAQRWHGAV
Rv1834|M.tuberculosis_H37Rv AQAQWELLCYN---DGNRIPHLLISYLDERIR---------HAQRWHGAV
TH_4027|M.thermoresistible__bu GAAQWALMSYH---DGHRIMHLLTAYLNERVR---------YADRWHGAV
MAV_5163|M.avium_104 VRLYLECMRQPG--HAEAGSRWYRSFQTREML---------SWMRGEYDG
MLBr_00862|M.leprae_Br4923 PANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRL
. .
Mflv_3952|M.gilvum_PYR-GCK SVIPVSHAEMAHTAMPGSRLEIFEGAGHFPFHDE----------------
Mvan_2445|M.vanbaalenii_PYR-1 AVIPVSHGEMAHAAMPGSRLEVFEGSGHFPFHDD----------------
MSMEG_2777|M.smegmatis_MC2_155 RETSVPMRLIDGPSDPNSGRHMAQRYLEVIPDPD----------------
MAB_4300|M.abscessus_ATCC_1997 RETAVPMRMIDGPIDPNSGLHMAERYLEVIHDPD----------------
MMAR_2711|M.marinum_M RDWPKPLGFVWGLDDPVATTNVLNGLRELRPNAG----------------
MUL_3053|M.ulcerans_Agy99 RDWPKPLGFVWGLDDPVATTNVLNGLRELRPNAG----------------
Mb1865|M.bovis_AF2122/97 RDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAA----------------
Rv1834|M.tuberculosis_H37Rv RDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAA----------------
TH_4027|M.thermoresistible__bu ADWPKPLGLLWGTDDPVATTDVLAGLRELRSDAE----------------
MAV_5163|M.avium_104 ARVHVPVRWLSGTEDPVLTPDLLDGYAERIDDFQ----------------
MLBr_00862|M.leprae_Br4923 WRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
. * .
Mflv_3952|M.gilvum_PYR-GCK -------PDRFVELVEKFIDSTEPAVYDQEYLRTLLRTGTSENTLSGDVD
Mvan_2445|M.vanbaalenii_PYR-1 -------PDRFVEVVEKFIDTSEPAVYDHEYLRGLLRAGISEGTISGPAD
MSMEG_2777|M.smegmatis_MC2_155 -------VVMLADDIAHWPQIEAPDAVLAHFLEHIDRVVAL---------
MAB_4300|M.abscessus_ATCC_1997 -------VVLLDDNIGHWPQIEAPEAVLTHFLEHIDRITP----------
MMAR_2711|M.marinum_M -------VIELPG-LGHYPQVEDPKAYTQAALDLL-----VG--------
MUL_3053|M.ulcerans_Agy99 -------VIELPG-LGHYPQVEDPKAYTQPALDLL-----VG--------
Mb1865|M.bovis_AF2122/97 -------VVELPG-LGHYPQAEAPKAYAEAALSLL-----VD--------
Rv1834|M.tuberculosis_H37Rv -------VVELPG-LGHYPQVEAPKAYAEAALSLL-----VD--------
TH_4027|M.thermoresistible__bu -------VIELAG-VGHYPQIEVPEVFARAALELLGLNRTIG--------
MAV_5163|M.avium_104 -------LELVDG-VGHWIVDQRPDLVLDRVRAFLRRET-----------
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
: : . :
Mflv_3952|M.gilvum_PYR-GCK TQVAVLDAIGADERSAT---------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 TRVAVLDAMGADERSAT---------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
Mflv_3952|M.gilvum_PYR-GCK ---------------------
Mvan_2445|M.vanbaalenii_PYR-1 ---------------------
MSMEG_2777|M.smegmatis_MC2_155 ---------------------
MAB_4300|M.abscessus_ATCC_1997 ---------------------
MMAR_2711|M.marinum_M ---------------------
MUL_3053|M.ulcerans_Agy99 ---------------------
Mb1865|M.bovis_AF2122/97 ---------------------
Rv1834|M.tuberculosis_H37Rv ---------------------
TH_4027|M.thermoresistible__bu ---------------------
MAV_5163|M.avium_104 ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI