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VSPVTHHRVLVDGVDTFYRTAGPVDAPIVLLPHGYPASSYVYRNLMAALGGRWRLIAPDLPGFGYSATPS AQEFAYTFAAYSAFLQSFVETLGLGRYVIWLHDYGSQFGFQLALAKPERVAGLIIQNGDIYEDAFGPKYD FLKESWNNPGPAARRRIAQHVTLHGFETEFRGELPDDVAERISPDLWTLHWSLMSTPERVANLIRLLEDQ PTTLGWFAAEQAYLREQHPRVLIVWGPHDGYMPEASARAYLRDLPDADIHLLGGGHWLLETHLDEVVPLI DAFLADVYARR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6151 | - | - | 100% (291) | alpha/beta hydrolase fold-1 |
| M. smegmatis MC2 155 | MSMEG_0117 | - | 6e-50 | 38.25% (285) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_6586 | - | 4e-16 | 26.99% (289) | alpha/beta hydrolase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2318 | - | 4e-15 | 35.61% (132) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_4848 | - | 1e-50 | 37.63% (287) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2296 | - | 4e-15 | 35.61% (132) | haloalkane dehalogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-07 | 29.17% (96) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0528c | - | 8e-12 | 33.33% (117) | epoxide hydrolase EphA |
| M. marinum M | MMAR_4428 | - | 1e-18 | 38.84% (121) | haloalkane dehalogenase |
| M. avium 104 | MAV_2130 | - | 5e-16 | 35.61% (132) | haloalkane dehalogenase |
| M. thermoresistible (build 8) | TH_2421 | - | 1e-14 | 39.13% (115) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3979 | dhaA | 1e-17 | 27.64% (275) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_4733 | - | 9e-53 | 37.37% (281) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4848|M.gilvum_PYR-GCK -----------------------------MTVVHHRIDTVDGHQVFYREA
Mvan_4733|M.vanbaalenii_PYR-1 ---------------------------MAETCTHYRTASIDGLDVFYREA
MSMEG_6151|M.smegmatis_MC2_155 ----------------------------MSPVTHHRVL-VDGVDTFYRTA
Mb2318|M.bovis_AF2122/97 ---------MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDE
Rv2296|M.tuberculosis_H37Rv ---------MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDE
MAV_2130|M.avium_104 MPVHAEELNMHVLRTPDSRFENLEDYPFVAHYLDVTARDTRPLRMHYLDE
MUL_3979|M.ulcerans_Agy99 ----------------------------------MKRVDVLDSAMSYIDV
TH_2421|M.thermoresistible__bu --------------------------------VRRSFVEARGVRFHVTES
MAB_0528c|M.abscessus_ATCC_199 -------------------------MTDAAVDIRERDIATNGVHLRIVEA
MMAR_4428|M.marinum_M ------------------MTRAQVARLLEQHRASGRRFTAAGIESFVLDS
MLBr_00862|M.leprae_Br4923 ----------------------MPATQSIHKVPHQFVESPDGVRLAIYQS
Mflv_4848|M.gilvum_PYR-GCK GDPDAPVIVLLHGFPTSSFMFRNLIPELADR-YRVIAPDYLGFGYSDAPT
Mvan_4733|M.vanbaalenii_PYR-1 GDRSNPTLLLLHGFPSSSHMFRNLITALADD-YHLVAPDHIGFGQSSMPS
MSMEG_6151|M.smegmatis_MC2_155 GPVDAPIVLLPHGYPASSYVYRNLMAALGGR-WRLIAPDLPGFGYSATPS
Mb2318|M.bovis_AF2122/97 GPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKP-
Rv2296|M.tuberculosis_H37Rv GPGDGPPIVLLHGEPTWSYLYRTMIPPLSAAGHRVLAPDLIGFGRSDKP-
MAV_2130|M.avium_104 GPIDGPPIVLLHGEPTWSYLYRTMITPLTDAGNRVLAPDLIGFGRSDKP-
MUL_3979|M.ulcerans_Agy99 GQGD--PIVFLHGNPTSSYLWRNVIPHLSDV-GRCLAPDLIGMGASGTS-
TH_2421|M.thermoresistible__bu GPADGRPVLALHGWPQHHWAYRDLLADPPAG-LRIIAPDLPGYGWSGPA-
MAB_0528c|M.abscessus_ATCC_199 GEPGQPAVILSHGFPELAYSWRHQIPALAAAGYHVIAPDQRGYGRSSMP-
MMAR_4428|M.marinum_M GARDAPPVICVHGVPASSFLYRKVVAAMAQRGLRGIAIDLPGLGLAERP-
MLBr_00862|M.leprae_Br4923 GQPEGPAIVLVHGFPDSHVLWDGVVPLLAKR-FRIVRYDNRGVGQSSVP-
* :: ** * : :. : : * * * : .
Mflv_4848|M.gilvum_PYR-GCK VEDFDYTFDALTDSVAGLLTQLGIRR-YAIYVQDYG--APVGWRLALRDP
Mvan_4733|M.vanbaalenii_PYR-1 VNQFTYSFDRLTDITEKLIDRLGLGR-FAIYIHDYG--APIGLRIASSRP
MSMEG_6151|M.smegmatis_MC2_155 AQEFAYTFAAYSAFLQSFVETLGLGR-YVIWLHDYG--SQFGFQLALAKP
Mb2318|M.bovis_AF2122/97 TRIEDYTYLRHVEWVTSWFENLDLHD-VTLFVQDWG--SLIGLRIAAEHG
Rv2296|M.tuberculosis_H37Rv TRIEDYTYLRHVEWVTSWFENLDLHD-VTLFVQDWG--SLIGLRIAAEHG
MAV_2130|M.avium_104 SRIEDYSYQRHVDWVVSWFEHLNLSD-VTLFVQDWG--SLIGLRIAAEQP
MUL_3979|M.ulcerans_Agy99 -PTFSYQFADHVRYLDAWFEAVGITENVVLVVHDWG--SALGFYRALRYP
TH_2421|M.thermoresistible__bu --PHRWAKEDVASDLLALMDELGLGR-TLLIGHDWG--GYIGFLMILRAP
MAB_0528c|M.abscessus_ATCC_199 AHIDDYNIEALSDDLLGILDDVGAGK-ATFVGHDWG--AVVTWHTALAVP
MMAR_4428|M.marinum_M -SDADYTWSGLGRWLGAAIDALGIGR-FHLVVHDIG--GPIGFDVANAAP
MLBr_00862|M.leprae_Br4923 KPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGAS
: . :. . :* * .
Mflv_4848|M.gilvum_PYR-GCK AAITAIITQ------NGNG-YNDGFVAEGWQPAWDYQREQTPETEAALRG
Mvan_4733|M.vanbaalenii_PYR-1 ERITGIITQ------SGNA-YTEGFTPF-WDRLFAHAKDRG-ANEDAVRD
MSMEG_6151|M.smegmatis_MC2_155 ERVAGLIIQ------NGDI-YEDAFGPK-YDFLKESWNNPGPAARRRIAQ
Mb2318|M.bovis_AF2122/97 DRIARLVVA------NGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVN
Rv2296|M.tuberculosis_H37Rv DRIARLVVA------NGFLPAAQGRTPLPFYVWRAFARYSPVLPAGRLVN
MAV_2130|M.avium_104 DRVGRLVVA------NGFLPTAQRRTPPAFYAWRAFARYSPVLPAGRIVS
MUL_3979|M.ulcerans_Agy99 EQIAGIAYM------DAPVQPRTWAGFTDYEPLMRALRTEQGERMALAEN
TH_2421|M.thermoresistible__bu ERFDGYIPL------NIAHPWVSTGTVLKHIWRFSYQPPMAAFGVPLQQR
MAB_0528c|M.abscessus_ATCC_199 ERVSGVVGLSVPFTRRSQVPPTQAWNKLFGDNFFYILYFQEPGVADADLN
MMAR_4428|M.marinum_M DRVLSMTLL------NTIIAVQRFHRPWPMEPFAHRAVGEMWLGLLRVPG
MLBr_00862|M.leprae_Br4923 DRVASFTSVSGP-SQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVL
.
Mflv_4848|M.gilvum_PYR-GCK ILTFETTRMQYTAGVPDP--SVVSPDTWHHDFALLSRPGNDRIQLKLFLD
Mvan_4733|M.vanbaalenii_PYR-1 YFTPETTKWQYTHGVPADRLDRIAPETWLLDQAGLDRKGNDAIQLQLFWD
MSMEG_6151|M.smegmatis_MC2_155 HVTLHGFETEFRGELPDDVAERISPDLWTLHWSLMSTPERVANLIRLLED
Mb2318|M.bovis_AF2122/97 FGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDD---------
Rv2296|M.tuberculosis_H37Rv FGTVHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDD---------
MAV_2130|M.avium_104 VGTVRRVSSKVRAGYDAPFPDKTYQAGARAFPQLVPTSPAD---------
MUL_3979|M.ulcerans_Agy99 VFVEKVVPGGVQRQLTEEEMAVYRKPYPTPQSRIPTLLWAREIPVE--GE
TH_2421|M.thermoresistible__bu TRVLERVVFGKGSALDAETAKVYADRFRDPVCARAGRDTYRTFLVR----
MAB_0528c|M.abscessus_ATCC_199 RDPATTMRRMMAGMARIDGATMIAPGPAGFVERMPDPGELPEWLSQDELD
MMAR_4428|M.marinum_M AFESIMRLVGVSSRVPSAEIACWKPLLFGDDGGRAFLEIMRG--------
MLBr_00862|M.leprae_Br4923 FSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTY
Mflv_4848|M.gilvum_PYR-GCK YSTNPKIYPALHDYLRASG------------------VPLLAVWGDKDPF
Mvan_4733|M.vanbaalenii_PYR-1 YQFNLDGYPKFQEYFRVHQ------------------PPLLVTWGRNDEI
MSMEG_6151|M.smegmatis_MC2_155 QPTTLGWFAAEQAYLREQH------------------PRVLIVWGPHDGY
Mb2318|M.bovis_AF2122/97 --PAVPANRAAWEALGRWD------------------KPFLAIFGYRDPI
Rv2296|M.tuberculosis_H37Rv --PAVPANRAAWEALGRWD------------------KPFLAIFGYRDPI
MAV_2130|M.avium_104 --PAIPANRKAWEALGRWE------------------KPFLAIFGARDPI
MUL_3979|M.ulcerans_Agy99 PADVQAMVQEYADFLSRSD------------------IPKLLIVAEPGAI
TH_2421|M.thermoresistible__bu ----EMPAAARNPEKRRAT------------------VPIRALFGTRDLA
MAB_0528c|M.abscessus_ATCC_199 HYITEFARTGFTGGLNWYRNFDRNWALTERLAGANVVVPSLFIAGAADPV
MMAR_4428|M.marinum_M FELTPEKQHNYIAAVQDTR------------------YPVQIVWGVRDTM
MLBr_00862|M.leprae_Br4923 PANYFRAFSGRRRGKGVPVVN----------------VPVQLIVNTMDRY
.
Mflv_4848|M.gilvum_PYR-GCK FGP-DGARAFAKDAVDSE---IHLIDGGHFLLESELTRVANLIRDFLERR
Mvan_4733|M.vanbaalenii_PYR-1 FGA-AGAEAFKRDLPDGE---FHLLDTGHFALETHGDEIAGHIRDFLGRQ
MSMEG_6151|M.smegmatis_MC2_155 MPE-ASARAYLRDLPDAD---IHLLGGGHWLLETHLDEVVPLIDAFLADV
Mb2318|M.bovis_AF2122/97 LGQ-ADG-PLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
Rv2296|M.tuberculosis_H37Rv LGQ-ADG-PLIKHIPGAAGQPHARIKASHFIQEDSGTELAERMLSWQQAT
MAV_2130|M.avium_104 LGH-ADS-PLIKHIPGAAGQPHARINASHFIQEDRGPELAERILSWQQAL
MUL_3979|M.ulcerans_Agy99 LHEGGSELDFARSWPNQR---EVKVAGRHFLQEDSPDAIGAAVRAFVLDV
TH_2421|M.thermoresistible__bu IHP--SLAAPETALADDYT--LETVDCSHFIVDERPDLVRARLVALAEET
MAB_0528c|M.abscessus_ATCC_199 LGFTDHAGSAKYRTDNRGD--LLIDGAGHWIQQERPLEVNAALLAFLREV
MMAR_4428|M.marinum_M LSWRRYG-AEARQLAGTQR--VTTLPAKHFLQEDFPEEIAAAVQRLAQSS
MLBr_00862|M.leprae_Br4923 VRP-YGYDATARWVPRLWR---RDIKAGHFSPMSHPQVMAAAVHDLADLV
. *: : :
Mflv_4848|M.gilvum_PYR-GCK L-------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 EGLIRE--------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 YARR----------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 L-------------------------------------------------
MUL_3979|M.ulcerans_Agy99 RERQDGADRA----------------------------------------
TH_2421|M.thermoresistible__bu A-------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 VH------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALARRGAEV
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MLBr_00862|M.leprae_Br4923 VVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGV
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERG
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MLBr_00862|M.leprae_Br4923 TGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTT
Mflv_4848|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 --------------------------------------------------
Mb2318|M.bovis_AF2122/97 --------------------------------------------------
Rv2296|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2130|M.avium_104 --------------------------------------------------
MUL_3979|M.ulcerans_Agy99 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_0528c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4428|M.marinum_M --------------------------------------------------
MLBr_00862|M.leprae_Br4923 ICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADT
Mflv_4848|M.gilvum_PYR-GCK -----------------------------------------
Mvan_4733|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_6151|M.smegmatis_MC2_155 -----------------------------------------
Mb2318|M.bovis_AF2122/97 -----------------------------------------
Rv2296|M.tuberculosis_H37Rv -----------------------------------------
MAV_2130|M.avium_104 -----------------------------------------
MUL_3979|M.ulcerans_Agy99 -----------------------------------------
TH_2421|M.thermoresistible__bu -----------------------------------------
MAB_0528c|M.abscessus_ATCC_199 -----------------------------------------
MMAR_4428|M.marinum_M -----------------------------------------
MLBr_00862|M.leprae_Br4923 ILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI