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VNCRPITLVTLLSWSSRWYARRVTSPSVSDWRAGGGWINTAAGKVFVRSGEGIAPTVLLLHGFPSSSFNF RSVIPYLAGQAWLTMDFLGFGLSDKPRPHRYSLLEQADLVQNVVAQNVTGPVVVLAHDMGTSVTTELLAR DLEGRLPFELQRVVLSNGSVILERASLRLIQKVLRGPLGPIAARLVNRGGFTRGFGKLFSAQHPLSAQEP EAQWELLTHNNGHRIAHLLISYLEERERYAQRWNNAVRDWPKPLGFVWGLDDPVATTNVLNGLRELRPNA GVIELPGLGHYPQVEDPKAYTQPALDLLVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3053 | - | - | 100% (310) | hydrolase |
| M. ulcerans Agy99 | MUL_2723 | - | 7e-18 | 28.67% (293) | hydrolase |
| M. ulcerans Agy99 | MUL_2888 | ephB | 1e-06 | 37.78% (90) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1865 | - | 1e-135 | 80.49% (287) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2749 | - | 3e-17 | 28.14% (295) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1834 | - | 1e-136 | 80.84% (287) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-07 | 35.42% (96) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4300 | - | 9e-27 | 28.17% (284) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_2711 | - | 1e-164 | 97.92% (288) | hydrolase |
| M. avium 104 | MAV_2139 | - | 3e-19 | 30.48% (292) | hydrolase, alpha/beta fold family protein, putative |
| M. smegmatis MC2 155 | MSMEG_2777 | - | 5e-29 | 29.43% (282) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4027 | - | 1e-106 | 65.12% (281) | PUTATIVE hydrolase |
| M. vanbaalenii PYR-1 | Mvan_3788 | - | 4e-17 | 28.62% (290) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2749|M.gilvum_PYR-GCK ---------------MDIFDEWHRGGTTFSWTSTTPANGGAQVDVFARRT
Mvan_3788|M.vanbaalenii_PYR-1 ---------------MDIFTDWQRDGTHFTWTSTTAANAGTEVEVFSRRC
MAV_2139|M.avium_104 ---------------MDIFAQWQGGGTELRWRSTTAANDGREVGVFSRRC
Mb1865|M.bovis_AF2122/97 ----------------------MTSPSVREWRDGGRWLPTAVGKVFVR-S
Rv1834|M.tuberculosis_H37Rv ----------------------MTSPSVREWRDGGRWLPTAVGKVFVR-S
MUL_3053|M.ulcerans_Agy99 MNCRPITLVTLLSWSSRWYARRVTSPSVSDWRAGGGWINTAAGKVFVR-S
MMAR_2711|M.marinum_M ----------------------MTSPSVSDWRAGGGWINTAAGKVFVR-S
TH_4027|M.thermoresistible__bu ---------------------------VARWRAEGRWIRTGVGSVFVR-S
MAB_4300|M.abscessus_ATCC_1997 -----------------------MDAELEEWKAAGHYFDYLGFDIFYRVE
MSMEG_2777|M.smegmatis_MC2_155 -----------------------MHDELQRWKDAGQYFDYLGFDIFYRVD
MLBr_00862|M.leprae_Br4923 -----------------------MPATQSIHKVPHQFVESPDGVRLAIYQ
:
Mflv_2749|M.gilvum_PYR-GCK GT--PGAPALVCVHGFPTAGVDYHALTRELADDFDIYVLDFPGYGLSGKP
Mvan_3788|M.vanbaalenii_PYR-1 GT--PGAPALVCVHGFPTSGIDYSALARELAAEFDIYVLDFPGYGLSGKP
MAV_2139|M.avium_104 GT--PGAPALVLVHGFPTSSIDYFALAGELSRDFDIHLIDFPGYGLSDKP
Mb1865|M.bovis_AF2122/97 GP--GDTPTMLLLHGYPSSSFDFRAVIPHLT-GQAWVTMDFLGFGLSDKP
Rv1834|M.tuberculosis_H37Rv GP--GDTPTMLLLHGYPSSSFDFRAVIPHLT-GQAWVTMDFLGFGLSDKP
MUL_3053|M.ulcerans_Agy99 GE--GIAPTVLLLHGFPSSSFNFRSVIPYLA-GQAWLTMDFLGFGLSDKP
MMAR_2711|M.marinum_M GE--GIAPTVLLLHGFPSSSFDFRSVIPYLA-GQAWLTMDFLGFGLSDKP
TH_4027|M.thermoresistible__bu AS--GRGSPVVLLHGYPSSSYDYRAVLPELG-DRGWVTFDFLGFGLSDKP
MAB_4300|M.abscessus_ATCC_1997 ----GSGPPLLLIHGYPFNSWDWALIWPTLVERFTVIAPDMIGMGFSDKP
MSMEG_2777|M.smegmatis_MC2_155 GVAPGTGPNLLLIHGYPFNSWDWSLIWPTLTQRFTVIAPDMIGMGFSDKP
MLBr_00862|M.leprae_Br4923 SGQ-PEGPAIVLVHGFPDSHVLWDGVVPLLAKRFRIVRYDNRGVGQSSVP
. :: :**:* : : * * * * *. *
Mflv_2749|M.gilvum_PYR-GCK PHPYVYSLYDDARLLVHAITDVWGLETFRMVTHDRGSSIGMIALGLLDDI
Mvan_3788|M.vanbaalenii_PYR-1 PSPYVYSLYDDARLLVHAVTERWRLTDYRMITHDRGSSVGMIALGMLAES
MAV_2139|M.avium_104 PEPYVYSLYDDARLLVHAITEVWRLSDYRMLTHDRGSSVGMIASGMLAAL
Mb1865|M.bovis_AF2122/97 -RPHRYSLLEQAHLVETVVAHTV-TGAVVVLAHDMGTSVTTELLARDLDG
Rv1834|M.tuberculosis_H37Rv -RPHRYSLLEQAHLVETVVAHTV-TGAVVVLAHDMGTSVTTELLARDLDG
MUL_3053|M.ulcerans_Agy99 -RPHRYSLLEQADLVQNVVAQNV-TGPVVVLAHDMGTSVTTELLARDLEG
MMAR_2711|M.marinum_M -RPHRYSLLEQADLVQNVVAQNV-TGPVVVLAHDMGTSVTTELLARDLEG
TH_4027|M.thermoresistible__bu -RPHRYSLFEQADLVQTVVRSVT-DEPVLLIAHDMGTSVATELMARDLQG
MAB_4300|M.abscessus_ATCC_1997 -VQYGYSVLDHADMHEALLSYLG-IERFHLLTHDLGNSVGQEMLARFEFE
MSMEG_2777|M.smegmatis_MC2_155 -VAYEYRVTDHADIHEALLAHLG-ITSTHILAHDLGDSVGQEMLARHEFG
MLBr_00862|M.leprae_Br4923 KPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGAS
* : * : :::** * .
Mflv_2749|M.gilvum_PYR-GCK G--------------------------------RRPLDLFMTNANIYLPL
Mvan_3788|M.vanbaalenii_PYR-1 G--------------------------------STPVDVFITNGNIYLPL
MAV_2139|M.avium_104 DPP------------------------------AAPVDLILTNANIYLPL
Mb1865|M.bovis_AF2122/97 RLP------------------------------FDLRRAVLSNGSVILER
Rv1834|M.tuberculosis_H37Rv RLP------------------------------FDLRRAVLSNGSVILER
MUL_3053|M.ulcerans_Agy99 RLP------------------------------FELQRVVLSNGSVILER
MMAR_2711|M.marinum_M RLP------------------------------FELQRAVLSNGSVILER
TH_4027|M.thermoresistible__bu QLP------------------------------FRLQRVVLSNGSVLLDR
MAB_4300|M.abscessus_ATCC_1997 QQSR---------------------------GRVPIDSVTWLNGGLFIEA
MSMEG_2777|M.smegmatis_MC2_155 GQAY---------------------------GGFQIESVTWLNGGLFNEA
MLBr_00862|M.leprae_Br4923 DRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLF
.
Mflv_2749|M.gilvum_PYR-GCK ANLTAFQVALLDDDTGRATAAATTPEMLAAGLGAA---TFMPRRTLQDPE
Mvan_3788|M.vanbaalenii_PYR-1 ANLTAFQVALLDEATGRATAAATTPAMLAAGLGAS---TFMPRRSPQDDE
MAV_2139|M.avium_104 ANLTAFQSALLDPSTARATAAATTPELLAAGMGAS---TFMPRRTLDDPE
Mb1865|M.bovis_AF2122/97 ASLRPIQKVLRSP-LGPVAARLVSRGGFTRGFGR----IFSPAHPLSAQE
Rv1834|M.tuberculosis_H37Rv ASLRPIQKVLRSP-LGPVAARLVSRGGFTRGFGR----IFSPAHPLSAQE
MUL_3053|M.ulcerans_Agy99 ASLRLIQKVLRGP-LGPIAARLVNRGGFTRGFGK----LFSAQHPLSAQE
MMAR_2711|M.marinum_M ASLRPIQKVLRGP-LGPIAARLVNRGGFTRGFGK----LFSAQHPLSAQE
TH_4027|M.thermoresistible__bu ASLRPIQKVLRGR-FGPVVSQLVNEPMFIRGLGK----VFSKQRPLSAAE
MAB_4300|M.abscessus_ATCC_1997 YRPRIAQTLMSRTPLGDLVSRFQGTPVTRRIMDAAVSEMFGPDTKPSPRL
MSMEG_2777|M.smegmatis_MC2_155 YRPRLMQKVMSRTPLGDILSPLQGSPLSRRVFESTLDQMFGVNTKPSREM
MLBr_00862|M.leprae_Br4923 SIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYP
: . : .
Mflv_2749|M.gilvum_PYR-GCK IAALAHCFAHNDG----------IRVLPDTVRYLHER-AADETGWLERLS
Mvan_3788|M.vanbaalenii_PYR-1 IAALAQCFAHNDG----------ISVLPDTVRYLHER-AADETGWLERLS
MAV_2139|M.avium_104 IAALAKCFAHNDG----------IRVLPDTIQYLNER-AADETRWLEALS
Mb1865|M.bovis_AF2122/97 AQAQWELLCYNDG----------NRIPHLLISYLDER-IRHAQRWHGAVR
Rv1834|M.tuberculosis_H37Rv AQAQWELLCYNDG----------NRIPHLLISYLDER-IRHAQRWHGAVR
MUL_3053|M.ulcerans_Agy99 PEAQWELLTHNNG----------HRIAHLLISYLEER-ERYAQRWNNAVR
MMAR_2711|M.marinum_M AEAQWELLTHNNG----------HRIAHLLISYLEER-ERYAQRWHNAVR
TH_4027|M.thermoresistible__bu GAAQWALMSYHDG----------HRIMHLLTAYLNER-VRYADRWHGAVA
MAB_4300|M.abscessus_ATCC_1997 LSLFQQVLEYNDG----------ARVTHQVGRFINDR-YDNRSRWVRAMR
MSMEG_2777|M.smegmatis_MC2_155 IEKFHQILDHNDG----------KRVLHKVGRFVTDR-YTHRNRWVRAMR
MLBr_00862|M.leprae_Br4923 ANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLW
. * : :: * :
Mflv_2749|M.gilvum_PYR-GCK TIPVDTTVIWGLHDAVAPLRVANHVWQTYVKPKPG---------------
Mvan_3788|M.vanbaalenii_PYR-1 TIDVDTTLIWGLHDTVAPLRVANHVWEHYLKSSPG---------------
MAV_2139|M.avium_104 TSDVDTTMVWGLHDNVAPLRVPNHVWQTYLKTKPG---------------
Mb1865|M.bovis_AF2122/97 DWPKPLGFVWGLDDPVATTNVLNGLRELRPS-------------------
Rv1834|M.tuberculosis_H37Rv DWPKPLGFVWGLDDPVATTNVLNGLRELRPS-------------------
MUL_3053|M.ulcerans_Agy99 DWPKPLGFVWGLDDPVATTNVLNGLRELRPN-------------------
MMAR_2711|M.marinum_M DWPKPLGFVWGLDDPVATTNVLNGLRELRPN-------------------
TH_4027|M.thermoresistible__bu DWPKPLGLLWGTDDPVATTDVLAGLRELRSD-------------------
MAB_4300|M.abscessus_ATCC_1997 ETAVPMRMIDGPIDPNSGLHMAERYLEVIHDP------------------
MSMEG_2777|M.smegmatis_MC2_155 ETSVPMRLIDGPSDPNSGRHMAQRYLEVIPDP------------------
MLBr_00862|M.leprae_Br4923 RRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTF
. . :
Mflv_2749|M.gilvum_PYR-GCK RNHYWVVPTADHYVQCDAPAELAQIIRMTADGADIDLQTLGNRPDGAVLV
Mvan_3788|M.vanbaalenii_PYR-1 RNRYWVVPGADHYVQCDAPGQLAGIIRLTAEGVPPGLPTLGDRPDGAVLV
MAV_2139|M.avium_104 RNRYWVIPGADHYLQCDAPAQLAEIVRLTARGEDVPLQTLGDRPDGAVLV
Mb1865|M.bovis_AF2122/97 -AAVVELPGLGHYPQAEAPKAYAEAALSLL---------VD---------
Rv1834|M.tuberculosis_H37Rv -AAVVELPGLGHYPQVEAPKAYAEAALSLL---------VD---------
MUL_3053|M.ulcerans_Agy99 -AGVIELPGLGHYPQVEDPKAYTQPALDLL---------VG---------
MMAR_2711|M.marinum_M -AGVIELPGLGHYPQVEDPKAYTQAALDLL---------VG---------
TH_4027|M.thermoresistible__bu -AEVIELAGVGHYPQIEVPEVFARAALELLGLN----RTIG---------
MAB_4300|M.abscessus_ATCC_1997 -DVVLLDDNIGHWPQIEAPEAVLTHFLEHIDRITP---------------
MSMEG_2777|M.smegmatis_MC2_155 -DVVMLADDIAHWPQIEAPDAVLAHFLEHIDRVVAL--------------
MLBr_00862|M.leprae_Br4923 GDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASG
: .
Mflv_2749|M.gilvum_PYR-GCK DRSDGDRL------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 DRSDGDDG------------------------------------------
MAV_2139|M.avium_104 DGGAS---------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPP
Mflv_2749|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2139|M.avium_104 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 EEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLS
Mflv_2749|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2139|M.avium_104 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTA
Mflv_2749|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2139|M.avium_104 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 KQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYAL
Mflv_2749|M.gilvum_PYR-GCK --------------------
Mvan_3788|M.vanbaalenii_PYR-1 --------------------
MAV_2139|M.avium_104 --------------------
Mb1865|M.bovis_AF2122/97 --------------------
Rv1834|M.tuberculosis_H37Rv --------------------
MUL_3053|M.ulcerans_Agy99 --------------------
MMAR_2711|M.marinum_M --------------------
TH_4027|M.thermoresistible__bu --------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------
MLBr_00862|M.leprae_Br4923 YGISRVLPQVLRSTARIRVI