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VTMPELDGVEHRYVDLGDDVTIHVADAGPASGPAVMLVHGFPQNWWEWRALIGPLAADGYRVLCPDLRGA GWSSAPRSSYRKDEMADDLAGVLDRLGVRSVDLVAHDWGGPVAFIMMLRHPEKVTGFFGVNTSAPFVKRS LSTIRNVWRFWYQIPISLPVIGPRVISTPDSRFVRLLGSWVGGGYTLPEEDVRLYLECMRQPGHAEAGSR WYRSFQTREMLSWMRGEYDGARVHVPVRWLSGTEDPVLTPDLLDGYAERIDDFQLELVDGVGHWIVDQRP DLVLDRVRAFLRRET*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5163 | - | - | 100% (296) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_0539 | - | 1e-28 | 30.43% (299) | hydrolase, alpha/beta fold family protein |
| M. avium 104 | MAV_2275 | - | 1e-17 | 35.16% (182) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 7e-23 | 44.63% (121) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1960 | - | 7e-38 | 34.59% (266) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0134 | ephF | 1e-144 | 79.05% (296) | epoxide hydrolase EphF |
| M. leprae Br4923 | MLBr_00862 | ephD | 4e-19 | 33.15% (178) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 1e-56 | 40.85% (284) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 1e-140 | 76.69% (296) | epoxide hydrolase EphF |
| M. smegmatis MC2 155 | MSMEG_3287 | - | 1e-28 | 28.94% (273) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2421 | - | 8e-45 | 37.91% (277) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4778 | ephF | 1e-139 | 76.35% (296) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 6e-38 | 31.62% (291) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5163|M.avium_104 --MVTMPELDGVEHRYVDLGDDVTIHVADAGP-ASGPAVMLVHGFPQNWW
Rv0134|M.tuberculosis_H37Rv --MIALPALEGVEHRHVDVAEGVRIHVADAGP-ADGPAVMLVHGFPQNWW
MMAR_0342|M.marinum_M --MSTLPALDGVEHRFVDLDGGITIHVADAGP-ADGPAVMLVHGFPENWW
MUL_4778|M.ulcerans_Agy99 --MSTLPALDGVEHRFVDLDGGITIHVADAGP-ADGPAVMLVHGFPENWW
Mflv_1960|M.gilvum_PYR-GCK ----------------MTVRG-VDFHITEAGP-EDGRPVLALHGWPQHHW
Mvan_4764|M.vanbaalenii_PYR-1 -MTDQPPPIDGVRRHFVTARG-VNFHVTEAGP-EDGRPVLALHGWPQHHW
TH_2421|M.thermoresistible__bu -----------VRRSFVEARG-VRFHVTESGP-ADGRPVLALHGWPQHHW
MAB_4522c|M.abscessus_ATCC_199 MTQRSMPVLDGVEHQYVQAGD-VKIHVAVAGP-QDGRAVVLLHGWPENWW
Mb1973|M.bovis_AF2122/97 ---------MSQVHRILNCRGTRIHAVADSPPDQQGPLVVLLHGFPESWY
MSMEG_3287|M.smegmatis_MC2_155 --------------MDSYRRGNLEFEVSEAGP-SDGATVILLHGFPQRNS
MLBr_00862|M.leprae_Br4923 --MPATQSIHKVPHQFVESPDGVRLAIYQSGQ-PEGPAIVLVHGFPDSHV
: : .* :: :**:*:
MAV_5163|M.avium_104 EWRALIGPLAAD----------GYRVLCPDLRGAGWSS--APRSSYRKDE
Rv0134|M.tuberculosis_H37Rv EWRDLIGPLAAD----------GNRVLCPDLRGAGWSS--APRSRYTKTE
MMAR_0342|M.marinum_M EWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKKE
MUL_4778|M.ulcerans_Agy99 EWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKKE
Mflv_1960|M.gilvum_PYR-GCK AYRDLLGDPP-----------PGLRIIAPDLPGYGWSG--PPPHRWAKED
Mvan_4764|M.vanbaalenii_PYR-1 VYRSLLADPPTSAGASSRLPEPGLRIIAPDLPGYGWSG--PAPHKWAKED
TH_2421|M.thermoresistible__bu AYRDLLADPP-----------AGLRIIAPDLPGYGWSG--PAPHRWAKED
MAB_4522c|M.abscessus_ATCC_199 MWHKVIPALAA----------AGYRVHAMDLRGAGWSE--VAPAGYEKEQ
Mb1973|M.bovis_AF2122/97 SWRHQIPALAG----------AGYRVVAIDQRGYGRSSKYRVQKAYRIKE
MSMEG_3287|M.smegmatis_MC2_155 SWEPIVGRLTAH----------GFRCLAPNQRGYSPGARPPRRRDYRVGE
MLBr_00862|M.leprae_Br4923 LWDGVVPLLAKR-----------FRIVRYDNRGVGQSSVPKPVSAYTMTR
: : . * : * . . :
MAV_5163|M.avium_104 MADDLAGVLDRLGVRS-VDLVAHDWG--GPVAFIMMLRHPEKVTGFFGVN
Rv0134|M.tuberculosis_H37Rv MADDLAAVLDGLGVAK-VKLVAHDWG--GPVAFIMMLRHPEKVTGFFGVN
MMAR_0342|M.marinum_M MADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGMN
MUL_4778|M.ulcerans_Agy99 MADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGMN
Mflv_1960|M.gilvum_PYR-GCK VVTDLVALVDALGLDR-FLLVGHDWG--GYIGHLLALRIPERIDAYLALN
Mvan_4764|M.vanbaalenii_PYR-1 VVSDLVALMDAMGLDR-VLLIGHDWG--GYIGHLLAMRVPERIDGYLALN
TH_2421|M.thermoresistible__bu VASDLLALMDELGLGR-TLLIGHDWG--GYIGFLMILRAPERFDGYIPLN
MAB_4522c|M.abscessus_ATCC_199 FASDVLAAADALGLES-FDLVGHDWG--GWTAQLVALKAQSRIRRLVVLN
Mb1973|M.bovis_AF2122/97 LVGDVVGVLDSYGAEQ-AFVVGHDWG--APVAWTFAWLHPDRCAGVVGIS
MSMEG_3287|M.smegmatis_MC2_155 LVEDVVALIDASGADR-VHLVGHDWG--AAVAWGVASYVPARLATLSALS
MLBr_00862|M.leprae_Br4923 FADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVS
.. *. . * . ::.**** . : :.
MAV_5163|M.avium_104 TSAPFV------------------KRSLSTIRNVWRFW-YQIPISLPVIG
Rv0134|M.tuberculosis_H37Rv TVAPWV------------------KRDLGMLRNMWRFW-YQIPMSLPVIG
MMAR_0342|M.marinum_M TAAPWF------------------PRDLGMVRDIWRFW-YQIPIMLPVIG
MUL_4778|M.ulcerans_Agy99 TAAPWF------------------PRDLGMVRDIWRFW-YQIPILLPVIG
Mflv_1960|M.gilvum_PYR-GCK IAHPWV------------------PPKV-MAPHLWRFLLYQPVVASAGVP
Mvan_4764|M.vanbaalenii_PYR-1 IAHPWV------------------PPKV-MAPHLWRFLQYQPLVAFAGVP
TH_2421|M.thermoresistible__bu IAHPWV------------------STGT-VLKHIWRFS-YQPPMAAFGVP
MAB_4522c|M.abscessus_ATCC_199 IPPVWQ------------------QPGR-VARYAHKLA-YQLVVGAPVVG
Mb1973|M.bovis_AF2122/97 VPFAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEI
MSMEG_3287|M.smegmatis_MC2_155 VPHPQA------------------FLRAMTTSRQGLASWYMYLNQLPRLP
MLBr_00862|M.leprae_Br4923 GPSQDQLVDYILSG----LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLV
:
MAV_5163|M.avium_104 PRVISTPDSRFVRLLGSWVGGGYTLPEEDVRLYLECMRQPGHAEAG----
Rv0134|M.tuberculosis_H37Rv PRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAG----
MMAR_0342|M.marinum_M PRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAG----
MUL_4778|M.ulcerans_Agy99 PRVIADPKARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAG----
Mflv_1960|M.gilvum_PYR-GCK LQTRTRYLEKVVFRAAAPK-----LDAATVGTYAERFRDPVVARTA----
Mvan_4764|M.vanbaalenii_PYR-1 LQRHTSFLKR-AYKLAAPK-----LDPQTVRVYSERFRDPVVARTA----
TH_2421|M.thermoresistible__bu LQQRTRVLERVVFGKGS-A-----LDAETAKVYADRFRDPVCARAG----
MAB_4522c|M.abscessus_ATCC_199 PLSHLSPTLWWFIRRSG-------MPKESVDFFRSCFRDRDRRVAG----
Mb1973|M.bovis_AF2122/97 EEDLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCM
MSMEG_3287|M.smegmatis_MC2_155 ERLMLGRDGGAARMVRTLQRSG--QTREIAERDARAMAEPGALTAA----
MLBr_00862|M.leprae_Br4923 PMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRA
. :
MAV_5163|M.avium_104 ------------SRWYRSFQTREMLSWMRGEYDGARV-HVPVRWLSGTE-
Rv0134|M.tuberculosis_H37Rv ------------SRWYRTFQTREMLRWLRGEYNDARV-DVPVRWLHGTG-
MMAR_0342|M.marinum_M ------------SRWYRTFQSSEALPWMRGEYADARV-DVPVRWLHGTE-
MUL_4778|M.ulcerans_Agy99 ------------SRWYRTFQSSEALPWMRGEYADARV-DVPVRWLHGTD-
Mflv_1960|M.gilvum_PYR-GCK ------------RDTYRTFLTREIPKGVRDG-ERRWS-TVPTRVLFGRS-
Mvan_4764|M.vanbaalenii_PYR-1 ------------RDTYRTFLLREAPAAIRNG-ERRRS-KVPTRALFGRD-
TH_2421|M.thermoresistible__bu ------------RDTYRTFLVREMPAAARNP-EKRRA-TVPIRALFGTR-
MAB_4522c|M.abscessus_ATCC_199 ------------SKIYRSMVGKEFANLARGPYDDQKL-TMPVRVLFGLD-
Mb1973|M.bovis_AF2122/97 AEGARLKDAFVYPETMPAWFTEADLDFYTGEFERSGF-GGPLSFYHNIDN
MSMEG_3287|M.smegmatis_MC2_155 ------------LNWYRAMFLSTSDPRAKHKVAKRKI-TVPTLYVWSDR-
MLBr_00862|M.leprae_Br4923 FSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKA
* .
MAV_5163|M.avium_104 ----------DPVLTPDLLDG------------------------YAERI
Rv0134|M.tuberculosis_H37Rv ----------DPVITPDLLDG------------------------YAERA
MMAR_0342|M.marinum_M ----------DPVLTPQLLRG------------------------YEDHI
MUL_4778|M.ulcerans_Agy99 ----------DPVLTPQLLRG------------------------YEDHI
Mflv_1960|M.gilvum_PYR-GCK ----------DTAIHPDLAAA------------------------ETARA
Mvan_4764|M.vanbaalenii_PYR-1 ----------DAAIHPSLAAA------------------------ETARA
TH_2421|M.thermoresistible__bu ----------DLAIHPSLAAP------------------------ETALA
MAB_4522c|M.abscessus_ATCC_199 ----------DVAVHPSLLDG------------------------FKDHA
Mb1973|M.bovis_AF2122/97 DWHDLADQQGKPLTPPALFIGGQYDVGTIWGAQA-------IERAHEVMP
MSMEG_3287|M.smegmatis_MC2_155 ----------DIAITEKPARET-----------------------ANYVA
MLBr_00862|M.leprae_Br4923 G-------HFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
.
MAV_5163|M.avium_104 DDFQLELVDGVGHWIVDQRPDLVLDRVRAFLRRET---------------
Rv0134|M.tuberculosis_H37Rv SDFEVELVDGVGHWIVEQRPELVLDRVRAFLAAGTEQRD-----------
MMAR_0342|M.marinum_M SDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET---------------
MUL_4778|M.ulcerans_Agy99 SDFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET---------------
Mflv_1960|M.gilvum_PYR-GCK DDYTI-DVVDGGHFILDEQPDLVRAKLIAVADEFPERPVR----------
Mvan_4764|M.vanbaalenii_PYR-1 DDYTI-DVVDGGHFILDEQPELVRAKLIALAEEFPAR-------------
TH_2421|M.thermoresistible__bu DDYTL-ETVDCSHFIVDERPDLVRARLVALAEETA---------------
MAB_4522c|M.abscessus_ATCC_199 DDLNITEVPNCGHFIVDEQPELVVKWLSEVLAEPAP--------------
Mb1973|M.bovis_AF2122/97 NYRGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP--------------
MSMEG_3287|M.smegmatis_MC2_155 GPYRFETLHGVSHWIPEERPDEVADLLLEWFAAHPV--------------
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
. . * : .
MAV_5163|M.avium_104 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
MAV_5163|M.avium_104 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
MAV_5163|M.avium_104 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
MAV_5163|M.avium_104 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_3287|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
MAV_5163|M.avium_104 ---------------------
Rv0134|M.tuberculosis_H37Rv ---------------------
MMAR_0342|M.marinum_M ---------------------
MUL_4778|M.ulcerans_Agy99 ---------------------
Mflv_1960|M.gilvum_PYR-GCK ---------------------
Mvan_4764|M.vanbaalenii_PYR-1 ---------------------
TH_2421|M.thermoresistible__bu ---------------------
MAB_4522c|M.abscessus_ATCC_199 ---------------------
Mb1973|M.bovis_AF2122/97 ---------------------
MSMEG_3287|M.smegmatis_MC2_155 ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI