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MDAELEEWKAAGHYFDYLGFDIFYRVEGSGPPLLLIHGYPFNSWDWALIWPTLVERFTVIAPDMIGMGFS DKPVQYGYSVLDHADMHEALLSYLGIERFHLLTHDLGNSVGQEMLARFEFEQQSRGRVPIDSVTWLNGGL FIEAYRPRIAQTLMSRTPLGDLVSRFQGTPVTRRIMDAAVSEMFGPDTKPSPRLLSLFQQVLEYNDGARV THQVGRFINDRYDNRSRWVRAMRETAVPMRMIDGPIDPNSGLHMAERYLEVIHDPDVVLLDDNIGHWPQI EAPEAVLTHFLEHIDRITP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4300 | - | - | 100% (299) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3034 | - | 3e-17 | 29.63% (270) | hydrolase |
| M. abscessus ATCC 19977 | MAB_0139c | - | 3e-08 | 30.21% (96) | alpha/beta fold family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1865 | - | 1e-28 | 30.63% (284) | hydrolase |
| M. gilvum PYR-GCK | Mflv_3952 | - | 9e-17 | 45.00% (100) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv1834 | - | 4e-29 | 30.63% (284) | hydrolase |
| M. leprae Br4923 | MLBr_00862 | ephD | 8e-08 | 33.33% (99) | short chain dehydrogenase |
| M. marinum M | MMAR_2711 | - | 2e-26 | 28.17% (284) | hydrolase |
| M. avium 104 | MAV_3609 | - | 3e-17 | 45.00% (100) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_2777 | - | 1e-128 | 69.77% (301) | alpha/beta hydrolase fold |
| M. thermoresistible (build 8) | TH_4027 | - | 3e-28 | 28.82% (288) | PUTATIVE hydrolase |
| M. ulcerans Agy99 | MUL_3053 | - | 8e-27 | 28.17% (284) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2445 | - | 2e-16 | 44.00% (100) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3952|M.gilvum_PYR-GCK ------------------MTARTPN--LRPVRELT-PTLRYCTIHGYRRA
Mvan_2445|M.vanbaalenii_PYR-1 ------------------MTERKPN--LRPVRELT-PTLKFCTIHGYRRA
MAV_3609|M.avium_104 ------------------MTERKRKNTLRPVREVSAPRLEFRTIHGYRRA
MAB_4300|M.abscessus_ATCC_1997 -----------------------MDAELEEWKAAG-HYFDYLGFDIFYRV
MSMEG_2777|M.smegmatis_MC2_155 -----------------------MHDELQRWKDAG-QYFDYLGFDIFYRV
MMAR_2711|M.marinum_M ----------------------MTSPSVSDWRAGG-GWINTAAGKVFVRS
MUL_3053|M.ulcerans_Agy99 MNCRPITLVTLLSWSSRWYARRVTSPSVSDWRAGG-GWINTAAGKVFVRS
Mb1865|M.bovis_AF2122/97 ----------------------MTSPSVREWRDGG-RWLPTAVGKVFVRS
Rv1834|M.tuberculosis_H37Rv ----------------------MTSPSVREWRDGG-RWLPTAVGKVFVRS
TH_4027|M.thermoresistible__bu ---------------------------VARWRAEG-RWIRTGVGSVFVRS
MLBr_00862|M.leprae_Br4923 ---------------------MPATQSIHKVPHQFVESPDGVRLAIYQSG
: :
Mflv_3952|M.gilvum_PYR-GCK YR-IAGSGPAILLIHGIGDNSTTWAGVQTQLAQRFTVIAPDLLGHGKSDK
Mvan_2445|M.vanbaalenii_PYR-1 FR-VAGSGPAILLIHGIGDNSTTWSTVQTQLAQRFTVIAPDLLGHGRSDK
MAV_3609|M.avium_104 YR-IAGSGPAILLIHGIGDNSTTWNTVQAKLAQRFTVIAPDLLGHGQSDK
MAB_4300|M.abscessus_ATCC_1997 E----GSGPPLLLIHGYPFNSWDWALIWPTLVERFTVIAPDMIGMGFSDK
MSMEG_2777|M.smegmatis_MC2_155 DGVAPGTGPNLLLIHGYPFNSWDWSLIWPTLTQRFTVIAPDMIGMGFSDK
MMAR_2711|M.marinum_M G---EGIAPTVLLLHGFPSSSFDFRSVIPYLAGQA-WLTMDFLGFGLSDK
MUL_3053|M.ulcerans_Agy99 G---EGIAPTVLLLHGFPSSSFNFRSVIPYLAGQA-WLTMDFLGFGLSDK
Mb1865|M.bovis_AF2122/97 G---PGDTPTMLLLHGYPSSSFDFRAVIPHLTGQA-WVTMDFLGFGLSDK
Rv1834|M.tuberculosis_H37Rv G---PGDTPTMLLLHGYPSSSFDFRAVIPHLTGQA-WVTMDFLGFGLSDK
TH_4027|M.thermoresistible__bu A---SGRGSPVVLLHGYPSSSYDYRAVLPELGDRG-WVTFDFLGFGLSDK
MLBr_00862|M.leprae_Br4923 QP----EGPAIVLVHGFPDSHVLWDGVVPLLAKRFRIVRYDNRGVGQSSV
. ::*:** . : : . * : : * * * *.
Mflv_3952|M.gilvum_PYR-GCK PR--ADYSVAAYANGMRDLLSVLNIDS-ATVVGHSLGGG-----------
Mvan_2445|M.vanbaalenii_PYR-1 PR--ADYSVAAYANGMRDLLSVLDIDD-VTVIGHSLGGG-----------
MAV_3609|M.avium_104 PR--ADYSVAAYANGMRDLLAVLDIER-VTIVGHSLGGG-----------
MAB_4300|M.abscessus_ATCC_1997 PVQ-YGYSVLDHADMHEALLSYLGIER-FHLLTHDLG-------------
MSMEG_2777|M.smegmatis_MC2_155 PVA-YEYRVTDHADIHEALLAHLGITS-THILAHDLG-------------
MMAR_2711|M.marinum_M PRP-HRYSLLEQADLVQNVVAQNVTGP-VVVLAHDMG-------------
MUL_3053|M.ulcerans_Agy99 PRP-HRYSLLEQADLVQNVVAQNVTGP-VVVLAHDMG-------------
Mb1865|M.bovis_AF2122/97 PRP-HRYSLLEQAHLVETVVAHTVTGA-VVVLAHDMG-------------
Rv1834|M.tuberculosis_H37Rv PRP-HRYSLLEQAHLVETVVAHTVTGA-VVVLAHDMG-------------
TH_4027|M.thermoresistible__bu PRP-HRYSLFEQADLVQTVVRSVTDEP-VLLIAHDMG-------------
MLBr_00862|M.leprae_Br4923 PKPVSAYTMTRFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGA
* * : *. :: :: *. *
Mflv_3952|M.gilvum_PYR-GCK -----VAMQFAYQFPQLVDRLILVGAGGVTKDVNIALRAASLPMGTEALA
Mvan_2445|M.vanbaalenii_PYR-1 -----VAMQFAYQFPQLVNRLILVGAGGVTKDVNIALRLASLPMGSEALA
MAV_3609|M.avium_104 -----VAMQFAYQFPHLVERLILVGAGGVTKDVNFVLRWASLPLGSEAIA
MAB_4300|M.abscessus_ATCC_1997 --------------NSVGQEMLARFEFEQQSRGRVPIDSVTWLNGGLFIE
MSMEG_2777|M.smegmatis_MC2_155 --------------DSVGQEMLARHEFGGQAYGGFQIESVTWLNGGLFNE
MMAR_2711|M.marinum_M --------------TSVTTELLARDLEGRLP---FELQRAVLSNGSVILE
MUL_3053|M.ulcerans_Agy99 --------------TSVTTELLARDLEGRLP---FELQRVVLSNGSVILE
Mb1865|M.bovis_AF2122/97 --------------TSVTTELLARDLDGRLP---FDLRRAVLSNGSVILE
Rv1834|M.tuberculosis_H37Rv --------------TSVTTELLARDLDGRLP---FDLRRAVLSNGSVILE
TH_4027|M.thermoresistible__bu --------------TSVATELMARDLQGQLP---FRLQRVVLSNGSVLLD
MLBr_00862|M.leprae_Br4923 SDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVL
: .
Mflv_3952|M.gilvum_PYR-GCK LLRLPLLLPTLR--LLGRVGGPLLGNTRIGRDIPNMLRILADLPEPTASS
Mvan_2445|M.vanbaalenii_PYR-1 LLRLPLVLPALQ--VLGRVSGTVFGSTGVGRDIPDMLRILADLPEPTASS
MAV_3609|M.avium_104 LLRLPLVLPAVQ--LMGRVLGTALGSTGLGRDLPNVLRILDDLPEPTASA
MAB_4300|M.abscessus_ATCC_1997 AYRPRIAQTLMSRTPLGDLVSRFQGTPVTRRIMDAAVSEMFGPDTKPSPR
MSMEG_2777|M.smegmatis_MC2_155 AYRPRLMQKVMSRTPLGDILSPLQGSPLSRRVFESTLDQMFGVNTKPSRE
MMAR_2711|M.marinum_M RASLRPIQKVLR-GPLGPIAARLVN----RGGFTRGFGKLFSAQHPLSAQ
MUL_3053|M.ulcerans_Agy99 RASLRLIQKVLR-GPLGPIAARLVN----RGGFTRGFGKLFSAQHPLSAQ
Mb1865|M.bovis_AF2122/97 RASLRPIQKVLR-SPLGPVAARLVS----RGGFTRGFGRIFSPAHPLSAQ
Rv1834|M.tuberculosis_H37Rv RASLRPIQKVLR-SPLGPVAARLVS----RGGFTRGFGRIFSPAHPLSAQ
TH_4027|M.thermoresistible__bu RASLRPIQKVLR-GRFGPVVSQLVN----EPMFIRGLGKVFSKQRPLSAA
MLBr_00862|M.leprae_Br4923 FSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTY
: . : .
Mflv_3952|M.gilvum_PYR-GCK AFARTLRSVVDWRG----------QVVTMLDRCYLTQS-VPVQLIWGSQD
Mvan_2445|M.vanbaalenii_PYR-1 AFARTLRAVVDWRG----------QVVTMLDRCYLTQS-VPVQLIWGDCD
MAV_3609|M.avium_104 AFSRTLRAVVDWRG----------QIVTMLDRCYLTEA-IPVQIVWGTKD
MAB_4300|M.abscessus_ATCC_1997 LLSLFQQVLEYNDG----------ARVTHQVGRFINDR-YDNRSRWVRAM
MSMEG_2777|M.smegmatis_MC2_155 MIEKFHQILDHNDG----------KRVLHKVGRFVTDR-YTHRNRWVRAM
MMAR_2711|M.marinum_M EAEAQWELLTHNNG----------HRIAHLLISYLEER-ERYAQRWHNAV
MUL_3053|M.ulcerans_Agy99 EPEAQWELLTHNNG----------HRIAHLLISYLEER-ERYAQRWNNAV
Mb1865|M.bovis_AF2122/97 EAQAQWELLCYNDG----------NRIPHLLISYLDER-IRHAQRWHGAV
Rv1834|M.tuberculosis_H37Rv EAQAQWELLCYNDG----------NRIPHLLISYLDER-IRHAQRWHGAV
TH_4027|M.thermoresistible__bu EGAAQWALMSYHDG----------HRIMHLLTAYLNER-VRYADRWHGAV
MLBr_00862|M.leprae_Br4923 PANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRL
* : :: *
Mflv_3952|M.gilvum_PYR-GCK SVIPVSHAEMAHTAMPGSRLEIFEGAGHFPFHDE----------------
Mvan_2445|M.vanbaalenii_PYR-1 AVIPVSHGEMAHAAMPGSRLEVFEGSGHFPFHDD----------------
MAV_3609|M.avium_104 VVVPVRHAWMAHAAMPGSRLEIFEGSGHFPFHDD----------------
MAB_4300|M.abscessus_ATCC_1997 RETAVPMRMIDGPIDPNSGLHMAERYLEVIHDPD----------------
MSMEG_2777|M.smegmatis_MC2_155 RETSVPMRLIDGPSDPNSGRHMAQRYLEVIPDPD----------------
MMAR_2711|M.marinum_M RDWPKPLGFVWGLDDPVATTNVLNGLRELRPNAG----------------
MUL_3053|M.ulcerans_Agy99 RDWPKPLGFVWGLDDPVATTNVLNGLRELRPNAG----------------
Mb1865|M.bovis_AF2122/97 RDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAA----------------
Rv1834|M.tuberculosis_H37Rv RDWPKPLGFVWGLDDPVATTNVLNGLRELRPSAA----------------
TH_4027|M.thermoresistible__bu ADWPKPLGLLWGTDDPVATTDVLAGLRELRSDAE----------------
MLBr_00862|M.leprae_Br4923 WRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDT
. * ..
Mflv_3952|M.gilvum_PYR-GCK -------PDRFVELVEKFIDSTEPAVYDQEYLRTLLRTGTSENTLSGDVD
Mvan_2445|M.vanbaalenii_PYR-1 -------PDRFVEVVEKFIDTSEPAVYDHEYLRGLLRAGISEGTISGPAD
MAV_3609|M.avium_104 -------PARFIDVVERFIDSTEPAAYDQEALRRLLRSGGGAQAVTGPAP
MAB_4300|M.abscessus_ATCC_1997 -------VVLLDDNIGHWPQIEAPEAVLTHFLEHIDRITP----------
MSMEG_2777|M.smegmatis_MC2_155 -------VVMLADDIAHWPQIEAPDAVLAHFLEHIDRVVAL---------
MMAR_2711|M.marinum_M -------VIELPG-LGHYPQVEDPKAYTQAALDLL-----VG--------
MUL_3053|M.ulcerans_Agy99 -------VIELPG-LGHYPQVEDPKAYTQPALDLL-----VG--------
Mb1865|M.bovis_AF2122/97 -------VVELPG-LGHYPQAEAPKAYAEAALSLL-----VD--------
Rv1834|M.tuberculosis_H37Rv -------VVELPG-LGHYPQVEAPKAYAEAALSLL-----VD--------
TH_4027|M.thermoresistible__bu -------VIELAG-VGHYPQIEVPEVFARAALELLGLNRTIG--------
MLBr_00862|M.leprae_Br4923 FGDTLVSVTGAGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVAS
: : . : :
Mflv_3952|M.gilvum_PYR-GCK TQVAVLDAIGADERSAT---------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 TRVAVLDAMGADERSAT---------------------------------
MAV_3609|M.avium_104 TRVAVLSAMGSDERSAT---------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTP
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 PEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSL
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 SAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPT
Mflv_3952|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2445|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3609|M.avium_104 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2777|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2711|M.marinum_M --------------------------------------------------
MUL_3053|M.ulcerans_Agy99 --------------------------------------------------
Mb1865|M.bovis_AF2122/97 --------------------------------------------------
Rv1834|M.tuberculosis_H37Rv --------------------------------------------------
TH_4027|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 AKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYA
Mflv_3952|M.gilvum_PYR-GCK ---------------------
Mvan_2445|M.vanbaalenii_PYR-1 ---------------------
MAV_3609|M.avium_104 ---------------------
MAB_4300|M.abscessus_ATCC_1997 ---------------------
MSMEG_2777|M.smegmatis_MC2_155 ---------------------
MMAR_2711|M.marinum_M ---------------------
MUL_3053|M.ulcerans_Agy99 ---------------------
Mb1865|M.bovis_AF2122/97 ---------------------
Rv1834|M.tuberculosis_H37Rv ---------------------
TH_4027|M.thermoresistible__bu ---------------------
MLBr_00862|M.leprae_Br4923 LYGISRVLPQVLRSTARIRVI