For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VWSYRLVAPYVFERSDLRAPSPDALTDGQVLLSFSAAGICGSDIPGFRGTQGKLPGDTGASAAQMPGFPI HEIAGEVLASRHPDHRVGDHVVGWASGFDGLMEQVIADGDGLVSYDPALPPRLAVGLQPLACVLCAVEQL PDLDGRHVAVIGQGSIGLLFSYVAKALGAARVTGVDPLDRSAIAARFGIDTPVRATSDRWVTHLDPDDRA DVVIEAVGHQVATLNHALTAAAFGGTVFYFGVPDDDSYPISMRTMLRNNLTLKSGVTTDRQRVLRRADTF AREHPHLLPGYVTHTFGVDDVQAAFELACRPVPDRVKIVVAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2564 | - | - | 100% (322) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_1370 | - | 2e-15 | 26.76% (355) | 2-deoxy-scyllo-inosamine dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2914 | - | 6e-13 | 31.67% (281) | L-idonate 5-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 8e-09 | 36.92% (130) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4106 | - | 1e-137 | 74.38% (320) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 6e-09 | 36.92% (130) | dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-05 | 29.75% (158) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2041c | - | 5e-10 | 29.35% (276) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0400 | - | 1e-135 | 72.19% (320) | dehydrogenase |
| M. avium 104 | MAV_5122 | - | 1e-136 | 73.52% (321) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_0280 | - | 1e-142 | 75.00% (320) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. ulcerans Agy99 | MUL_2962 | - | 4e-10 | 27.61% (268) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2240 | - | 1e-139 | 74.38% (320) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0400|M.marinum_M --MWSYRIIAPYLFERTSIADKTPECLAEGQVLLRFQAAGVCGSDLPAFR
MAV_5122|M.avium_104 --MWCYRIVAPYRFEPTAIDDKTPECLADGQVLLRFSAAGVCGSDLPAFR
Mflv_4106|M.gilvum_PYR-GCK --MWSYRLVAPYTFERTEQPQRSPESLAENQVLLRFLAGGICGSDLPGFR
Mvan_2240|M.vanbaalenii_PYR-1 --MWSYRLVAPFIFEKADVPQRCPESLGDGQVLLRFLAAGICGSDLPGYR
TH_0280|M.thermoresistible__bu --MWAYRLTAPYRFDRIEVPEPDPDGLRDGQVLLRFLAAGVCGSDLPGFR
MSMEG_2564|M.smegmatis_MC2_155 --MWSYRLVAPYVFERSDLRAPSPDALTDGQVLLSFSAAGICGSDIPGFR
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv --MRAVVIDGAGSVRVNTQPD--PALPGPDGVVVAVTAAGICGSDLHFYE
MUL_2962|M.ulcerans_Agy99 --MRTVVIDGPGSIRVDNRPD--PALPGSDGVIVVVSAAGICGSDLHFYE
MLBr_01784|M.leprae_Br4923 MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCHTDLTYRE
MAB_2041c|M.abscessus_ATCC_199 MIAEAMVLTGPRSLQR---RQMIIPDVGDRGAILRVEACGLCGTDHEQFT
MMAR_0400|M.marinum_M GARGHLP---------------GDDGHS---AAAKDGFPIHEVAGEVIAS
MAV_5122|M.avium_104 GARGRLP---------------GDDGRS---GPEKDGFPIHEVAGEVIAS
Mflv_4106|M.gilvum_PYR-GCK GARGRLA---------------FDTGRQ---AAEKDGFPIHEVVGEVLAS
Mvan_2240|M.vanbaalenii_PYR-1 GAKGRLA---------------GDTGAC---AAEMDGFPIHEIAGEVIAS
TH_0280|M.thermoresistible__bu GTQGRLP---------------GDTGVS---TCEIPGFPIHEIAGEVIAS
MSMEG_2564|M.smegmatis_MC2_155 GTQGKLP---------------GDTGAS---AAQMPGFPIHEIAGEVLAS
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv GEYPFTEPVALGHEAVGTIVEAGPQVRT---VGVGDLVMVSSVAGCGVCP
MUL_2962|M.ulcerans_Agy99 GEYPLAEPVALGHEAVGTVVEKGPDVHT---VEVGDQVMVSSVAGCGACA
MLBr_01784|M.leprae_Br4923 GGINDRYPFLLGHEAAGTVEVVGPGVTA---VEPGDFVILNWRAVCGQCR
MAB_2041c|M.abscessus_ATCC_199 GHLPAGFSFVPGHEIVGIVEHVGAAAGQRWGVQAGQRVAVEVFRSCRDCP
MMAR_0400|M.marinum_M RHRAHH----------------QGDRVVGWASGFDGLMQRVIADGDGLAP
MAV_5122|M.avium_104 RHPAHR----------------PGDRVVGWASGFDGLMERVVSDGDGLAP
Mflv_4106|M.gilvum_PYR-GCK RHLAHT----------------PGDRVVGWASGFDGLAEEVVADGEGLAS
Mvan_2240|M.vanbaalenii_PYR-1 RHPAHR----------------PGDRVVGWASGFDGLMEQVIADGDGLVA
TH_0280|M.thermoresistible__bu RHPQHH----------------PGDRVVGWASGFDGLQARVTADGDGLAR
MSMEG_2564|M.smegmatis_MC2_155 RHPDHR----------------VGDHVVGWASGFDGLMEQVIADGDGLVS
Mb1929|M.bovis_AF2122/97 -----------------------MIFGAGVLGGAQADLLAVPAADFQVLK
Rv1895|M.tuberculosis_H37Rv GCETHDP---------VMCFSGPMIFGAGVLGGAQADLLAVPAADFQVLK
MUL_2962|M.ulcerans_Agy99 GCATRDP---------AMCVSGPQIFGSGALGGAQADLLAVPATDFQVLK
MLBr_01784|M.leprae_Br4923 ACKRGRPSYCFDTFNAQQKMTLIDGTELTPALGIGAFADKTLVHSGQCTK
MAB_2041c|M.abscessus_ATCC_199 ECRRGEYRRCAVN--GIATMFGFVDVEIGAGLWGGYATHVELPWDAMLLP
.
MMAR_0400|M.marinum_M YDPGLTPTQAVGLQP-LACVL-YACAQLPDLAGRHVAVIGQGSIGLLFSH
MAV_5122|M.avium_104 YDPALSPAQAVGLQP-LACVL-YACEQL-ELAGKHVAIIGQGSIGLLFSY
Mflv_4106|M.gilvum_PYR-GCK YDPSLDPAHAVALQP-LACVL-YAVEQMPDLAGRHVAILGQGSIGLLFSY
Mvan_2240|M.vanbaalenii_PYR-1 YHGSLSPAHAVALQP-LACVL-YAVEQLPDLTGRHVAVLGQGSIGLLFSH
TH_0280|M.thermoresistible__bu YDAALEPRHAVALQP-LACVL-YAVEQLGDLTGRRVAVIGQGSIGLLFSY
MSMEG_2564|M.smegmatis_MC2_155 YDPALPPRLAVGLQP-LACVL-CAVEQLPDLDGRHVAVIGQGSIGLLFSY
Mb1929|M.bovis_AF2122/97 IPEGITTEQALLLTDNLATGW-AAAQRADISFGSAVAVIGLGAVGLCALR
Rv1895|M.tuberculosis_H37Rv IPEGITTEQALLLTDNLATGW-AAAQRADISFGSAVAVIGLGAVGLCALR
MUL_2962|M.ulcerans_Agy99 IPAAITTEQALLLTDNLATGW-AAARRADIPFGATVAVIGLGAVGLCAVR
MLBr_01784|M.leprae_Br4923 VDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAIS
MAB_2041c|M.abscessus_ATCC_199 IAEDMDPVLATLFNP-LGAGIQWGATLPDTKAGDVVAILGPGIRGICAAV
. * : : . . **::* * *
MMAR_0400|M.marinum_M AAKVAGARRVTGVDP---IDRENLSATFGVDD----AVRATSDRWVSQLG
MAV_5122|M.avium_104 VAKAAGARRVTGVDP---IDRRDVARAFGVDD----PVRATSDRWVSQLD
Mflv_4106|M.gilvum_PYR-GCK VAKAAGAAHVTGVDP---VDRSAVGAAFGVDT----VVRATSDRWVSHLG
Mvan_2240|M.vanbaalenii_PYR-1 AAKAAGAAHVTGVDP---VDRDDVGPSFGVDT----VVRATSDRWVSRLA
TH_0280|M.thermoresistible__bu VAKAAGAAHVTGVDP---VDRELVGKEFGVDT----VVRATSDRWIRHLG
MSMEG_2564|M.smegmatis_MC2_155 VAKALGAARVTGVDP---LDRSAIAARFGIDT----PVRATSDRWVTHLD
Mb1929|M.bovis_AF2122/97 SAFIHGAATVFAVDR---VKGRLQRAATWGAT----PIPSPAAETILAAT
Rv1895|M.tuberculosis_H37Rv SAFIHGAATVFAVDR---VKGRLQRAATWGAT----PIPSPAAETILAAT
MUL_2962|M.ulcerans_Agy99 SALAQGAATVFAVDR---VQGRLQRAAEWGAT----AVASPAAEAIVAAT
MLBr_01784|M.leprae_Br4923 GAALVGANRIIAVDI---DDTKLEWARTFGATHTVNALELEVVKTIQDLT
MAB_2041c|M.abscessus_ATCC_199 AAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATALQRET
* ** : .. . :
MMAR_0400|M.marinum_M AGDRADIVIEAVGHQVATLGHAIDAAAPGGTVFYFGVADDDA-YPISMRT
MAV_5122|M.avium_104 PADRADVVIEAVGHQVATLAHAIDAAAPGGTVFYFGVADDDT-YPISMRT
Mflv_4106|M.gilvum_PYR-GCK ADDRPDVVIEAVGHQVATLTHAVEAAAFGGFVFYFGVPDDDW-YPISMRT
Mvan_2240|M.vanbaalenii_PYR-1 PDAKPDIVIEAVGHQVATLSHAVEAAAFGGTVFYFGVPDDDC-YPISMRT
TH_0280|M.thermoresistible__bu ADDRADVVIEAVGHQVATLNHAIEATAFGGTVFYFGVPDDDS-YPINMRA
MSMEG_2564|M.smegmatis_MC2_155 PDDRADVVIEAVGHQVATLNHALTAAAFGGTVFYFGVPDDDS-YPISMRT
Mb1929|M.bovis_AF2122/97 RGRGADSVIDAVGTDAS-MSDALNAVRPGGTVSVVGVHDLQP-FPLPALT
Rv1895|M.tuberculosis_H37Rv RGRGADSVIDAVGTDAS-MSDALNAVRPGGTVSVVGVHDLQP-FPVPALT
MUL_2962|M.ulcerans_Agy99 SGRGADSVIDAVDTDAS-MTDALNAVRAGGTVSVVGVHDLQP-FPLPALT
MLBr_01784|M.leprae_Br4923 SGFGVDVVIDTVGRPET-WKQAFYARDLAGTVVLVGVPTPDMRLDMPLLD
MAB_2041c|M.abscessus_ATCC_199 GGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEPDL
* *::.. : .*. .* : *. .
MMAR_0400|M.marinum_M MLRNNLTLKS---GVTQDRRRMLELAGKFAAEHPELLSGYLTHN--FDVE
MAV_5122|M.avium_104 MLRNNLTLKS---GVTLDRRRMLELAGKFAAEHPWLLGAYLTHT--FGVD
Mflv_4106|M.gilvum_PYR-GCK MLRNNLTLKA---GVTLERRRVLRCADEFAAAHPGLLDRYLTHT--FGVD
Mvan_2240|M.vanbaalenii_PYR-1 MLRNNLTLKS---GVTIERRRVLAKADAFVQEHPGLLERYLTHT--FGVD
TH_0280|M.thermoresistible__bu MLRNNLTLKS---GVTLDRRRMLARADAFAREHSDLLTRYLTHT--FGAD
MSMEG_2564|M.smegmatis_MC2_155 MLRNNLTLKS---GVTTDRQRVLRRADTFAREHPHLLPGYVTHT--FGVD
Mb1929|M.bovis_AF2122/97 CLLRSITLRM---TMAPVQRTWPELIPLLQSGRLDVDG-IFTTT--LPLD
Rv1895|M.tuberculosis_H37Rv CLLRSITLRM---TMAPVQRTWPELIPLLQSGRLDVDG-IFTTT--LPLD
MUL_2962|M.ulcerans_Agy99 CLLRSITLRL---TIAPVQRTWSELIPLLESGRLDVDG-IFTTS--LPLD
MLBr_01784|M.leprae_Br4923 FFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLGK-FVSER--IGLG
MAB_2041c|M.abscessus_ATCC_199 LVYKELHVVG---ALGVEYPAYRAALEILAMGRWPFDRITRESTGFAGLA
. . : : .
MMAR_0400|M.marinum_M DVQAAFELACRPVPERVKIAITA---------------------------
MAV_5122|M.avium_104 EVQDAFELACRPVADRIKIAIAG---------------------------
Mflv_4106|M.gilvum_PYR-GCK DVQQAFELAARPVPGRVKIAIEAR--------------------------
Mvan_2240|M.vanbaalenii_PYR-1 EAPAAFELASRPVPGRIKIAIVA---------------------------
TH_0280|M.thermoresistible__bu EAQAAFELACRPAPERIKIAIVG---------------------------
MSMEG_2564|M.smegmatis_MC2_155 DVQAAFELACRPVPDRVKIVVAR---------------------------
Mb1929|M.bovis_AF2122/97 EAAKGYATARARSGEELKVLLTP---------------------------
Rv1895|M.tuberculosis_H37Rv EAAKGYATARARSGEELRFCLRPDSRDVLGAHETVDLYVHVRRCQSVADL
MUL_2962|M.ulcerans_Agy99 EAAKGYSIAGSRSGNDVKVLLKV---------------------------
MLBr_01784|M.leprae_Br4923 DVEEAFHKIHGGKVLRSVVML-----------------------------
MAB_2041c|M.abscessus_ATCC_199 QLLTSLADESARSSGALHNVFLPTP-------------------------
: . .
MMAR_0400|M.marinum_M ----------------
MAV_5122|M.avium_104 ----------------
Mflv_4106|M.gilvum_PYR-GCK ----------------
Mvan_2240|M.vanbaalenii_PYR-1 ----------------
TH_0280|M.thermoresistible__bu ----------------
MSMEG_2564|M.smegmatis_MC2_155 ----------------
Mb1929|M.bovis_AF2122/97 ----------------
Rv1895|M.tuberculosis_H37Rv QLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 ----------------
MLBr_01784|M.leprae_Br4923 ----------------
MAB_2041c|M.abscessus_ATCC_199 ----------------