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VWSYRIIAPYLFERTSIADKTPECLAEGQVLLRFQAAGVCGSDLPAFRGARGHLPGDDGHSAAAKDGFPI HEVAGEVIASRHRAHHQGDRVVGWASGFDGLMQRVIADGDGLAPYDPGLTPTQAVGLQPLACVLYACAQL PDLAGRHVAVIGQGSIGLLFSHAAKVAGARRVTGVDPIDRENLSATFGVDDAVRATSDRWVSQLGAGDRA DIVIEAVGHQVATLGHAIDAAAPGGTVFYFGVADDDAYPISMRTMLRNNLTLKSGVTQDRRRMLELAGKF AAEHPELLSGYLTHNFDVEDVQAAFELACRPVPERVKIAITA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0400 | - | - | 100% (322) | dehydrogenase |
| M. marinum M | MMAR_2790 | - | 2e-14 | 27.13% (328) | dehydrogenase |
| M. marinum M | MMAR_3163 | - | 2e-10 | 29.39% (262) | Zn-dependent alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1929 | - | 8e-14 | 29.61% (206) | dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4106 | - | 1e-135 | 73.29% (322) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1895 | - | 8e-15 | 29.15% (271) | dehydrogenase |
| M. leprae Br4923 | MLBr_00118 | - | 3e-05 | 23.87% (222) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_2041c | - | 2e-11 | 29.77% (262) | zinc-containing alcohol dehydrogenase |
| M. avium 104 | MAV_5122 | - | 1e-154 | 82.81% (320) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2564 | - | 1e-135 | 72.19% (320) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_0280 | - | 1e-130 | 71.25% (320) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. ulcerans Agy99 | MUL_2962 | - | 1e-13 | 26.83% (328) | dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2240 | - | 1e-133 | 71.12% (322) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv --MRAVVIDGAGSVRVNTQPD--PALPGPDGVVVAVTAAGICGSDLHFYE
MUL_2962|M.ulcerans_Agy99 --MRTVVIDGPGSIRVDNRPD--PALPGSDGVIVVVSAAGICGSDLHFYE
MMAR_0400|M.marinum_M --MWSYRIIAPYLFERTSIADKTPECLAEGQVLLRFQAAGVCGSDLPAFR
MAV_5122|M.avium_104 --MWCYRIVAPYRFEPTAIDDKTPECLADGQVLLRFSAAGVCGSDLPAFR
Mflv_4106|M.gilvum_PYR-GCK --MWSYRLVAPYTFERTEQPQRSPESLAENQVLLRFLAGGICGSDLPGFR
Mvan_2240|M.vanbaalenii_PYR-1 --MWSYRLVAPFIFEKADVPQRCPESLGDGQVLLRFLAAGICGSDLPGYR
TH_0280|M.thermoresistible__bu --MWAYRLTAPYRFDRIEVPEPDPDGLRDGQVLLRFLAAGVCGSDLPGFR
MSMEG_2564|M.smegmatis_MC2_155 --MWSYRLVAPYVFERSDLRAPSPDALTDGQVLLSFSAAGICGSDIPGFR
MAB_2041c|M.abscessus_ATCC_199 MIAEAMVLTGPRSLQR---RQMIIPDVGDRGAILRVEACGLCGTDHEQFT
MLBr_00118|M.leprae_Br4923 --MHAIVAESANQMVWREVPD---VTAGPGEVLIEVAASGVNRADVLQVA
Mb1929|M.bovis_AF2122/97 --------------------------------------------------
Rv1895|M.tuberculosis_H37Rv GEYPFTEPVALGHEAVGTIVEAGPQVRTVGVGDLVMVSSVAGCGVCPGCE
MUL_2962|M.ulcerans_Agy99 GEYPLAEPVALGHEAVGTVVEKGPDVHTVEVGDQVMVSSVAGCGACAGCA
MMAR_0400|M.marinum_M GARGHLP---------------GDDGHSAAAKDGFPIHEVAGEVIASRHR
MAV_5122|M.avium_104 GARGRLP---------------GDDGRSGPEKDGFPIHEVAGEVIASRHP
Mflv_4106|M.gilvum_PYR-GCK GARGRLA---------------FDTGRQAAEKDGFPIHEVVGEVLASRHL
Mvan_2240|M.vanbaalenii_PYR-1 GAKGRLA---------------GDTGACAAEMDGFPIHEIAGEVIASRHP
TH_0280|M.thermoresistible__bu GTQGRLP---------------GDTGVSTCEIPGFPIHEIAGEVIASRHP
MSMEG_2564|M.smegmatis_MC2_155 GTQGKLP---------------GDTGASAAQMPGFPIHEIAGEVLASRHP
MAB_2041c|M.abscessus_ATCC_199 GHLPAGFSFVPGHEIVG---IVEHVGAAAGQRWGVQAGQRVAVEVFRSCR
MLBr_00118|M.leprae_Br4923 GKYPHPP---------------GASAIIGMEVAGVVAAVSSGVTEWS---
Mb1929|M.bovis_AF2122/97 -----------MIFGAGVLGGAQADLLAVPAADFQ-------------VL
Rv1895|M.tuberculosis_H37Rv THDPVMCFSGPMIFGAGVLGGAQADLLAVPAADFQ-------------VL
MUL_2962|M.ulcerans_Agy99 TRDPAMCVSGPQIFGSGALGGAQADLLAVPATDFQ-------------VL
MMAR_0400|M.marinum_M AHH-------QGDRVVGWASGFDGLMQRVIADGDG-------------LA
MAV_5122|M.avium_104 AHR-------PGDRVVGWASGFDGLMERVVSDGDG-------------LA
Mflv_4106|M.gilvum_PYR-GCK AHT-------PGDRVVGWASGFDGLAEEVVADGEG-------------LA
Mvan_2240|M.vanbaalenii_PYR-1 AHR-------PGDRVVGWASGFDGLMEQVIADGDG-------------LV
TH_0280|M.thermoresistible__bu QHH-------PGDRVVGWASGFDGLQARVTADGDG-------------LA
MSMEG_2564|M.smegmatis_MC2_155 DHR-------VGDHVVGWASGFDGLMEQVIADGDG-------------LV
MAB_2041c|M.abscessus_ATCC_199 DCPECRRGEYRRCAVNGIATMFGFVDVEIGAGLWGGYATHVELPWDAMLL
MLBr_00118|M.leprae_Br4923 ----------VGQEVCALLAG-GGYAEYVAVPASQ-------------VM
. : :
Mb1929|M.bovis_AF2122/97 KIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGA--VGLCA
Rv1895|M.tuberculosis_H37Rv KIPEGITTEQALLLTDNLATGWAAAQRADISFGSAVAVIGLGA--VGLCA
MUL_2962|M.ulcerans_Agy99 KIPAAITTEQALLLTDNLATGWAAARRADIPFGATVAVIGLGA--VGLCA
MMAR_0400|M.marinum_M PYDPGLTPTQAVGLQP-LACVLYACAQLPDLAGRHVAVIGQGS--IGLLF
MAV_5122|M.avium_104 PYDPALSPAQAVGLQP-LACVLYACEQL-ELAGKHVAIIGQGS--IGLLF
Mflv_4106|M.gilvum_PYR-GCK SYDPSLDPAHAVALQP-LACVLYAVEQMPDLAGRHVAILGQGS--IGLLF
Mvan_2240|M.vanbaalenii_PYR-1 AYHGSLSPAHAVALQP-LACVLYAVEQLPDLTGRHVAVLGQGS--IGLLF
TH_0280|M.thermoresistible__bu RYDAALEPRHAVALQP-LACVLYAVEQLGDLTGRRVAVIGQGS--IGLLF
MSMEG_2564|M.smegmatis_MC2_155 SYDPALPPRLAVGLQP-LACVLCAVEQLPDLDGRHVAVIGQGS--IGLLF
MAB_2041c|M.abscessus_ATCC_199 PIAEDMDPVLATLFNPLGAGIQWGATLPDTKAGDVVAILGPGI--RGICA
MLBr_00118|M.leprae_Br4923 PIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTSGIGSHG
: : : . . : :: * *
Mb1929|M.bovis_AF2122/97 LRSAFIHGAATVFAVDR----VKGRLQRAATWGATPIPSPAAETILAATR
Rv1895|M.tuberculosis_H37Rv LRSAFIHGAATVFAVDR----VKGRLQRAATWGATPIPSPAAETILAATR
MUL_2962|M.ulcerans_Agy99 VRSALAQGAATVFAVDR----VQGRLQRAAEWGATAVASPAAEAIVAATS
MMAR_0400|M.marinum_M SHAAKVAGARRVTGVDP----IDRENLSATFGVDDAVRATSDRWVSQLGA
MAV_5122|M.avium_104 SYVAKAAGARRVTGVDP----IDRRDVARAFGVDDPVRATSDRWVSQLDP
Mflv_4106|M.gilvum_PYR-GCK SYVAKAAGAAHVTGVDP----VDRSAVGAAFGVDTVVRATSDRWVSHLGA
Mvan_2240|M.vanbaalenii_PYR-1 SHAAKAAGAAHVTGVDP----VDRDDVGPSFGVDTVVRATSDRWVSRLAP
TH_0280|M.thermoresistible__bu SYVAKAAGAAHVTGVDP----VDRELVGKEFGVDTVVRATSDRWIRHLGA
MSMEG_2564|M.smegmatis_MC2_155 SYVAKALGAARVTGVDP----LDRSAIAARFGIDTPVRATSDRWVTHLDP
MAB_2041c|M.abscessus_ATCC_199 AVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVDLPIDVSQDDAATALQR
MLBr_00118|M.leprae_Br4923 IQVARALGAKVAVTAGS----EEKLEFCRALGAQITINYRDEDFVARLQQ
* ** . .. . :
Mb1929|M.bovis_AF2122/97 GRG---ADSVIDAVGTDAS-MSDALNAVRPGGTVSVVGVHDLQPFP-LPA
Rv1895|M.tuberculosis_H37Rv GRG---ADSVIDAVGTDAS-MSDALNAVRPGGTVSVVGVHDLQPFP-VPA
MUL_2962|M.ulcerans_Agy99 GRG---ADSVIDAVDTDAS-MTDALNAVRAGGTVSVVGVHDLQPFP-LPA
MMAR_0400|M.marinum_M GDR---ADIVIEAVGHQVATLGHAIDAAAPGGTVFYFGVADDDAYP-ISM
MAV_5122|M.avium_104 ADR---ADVVIEAVGHQVATLAHAIDAAAPGGTVFYFGVADDDTYP-ISM
Mflv_4106|M.gilvum_PYR-GCK DDR---PDVVIEAVGHQVATLTHAVEAAAFGGFVFYFGVPDDDWYP-ISM
Mvan_2240|M.vanbaalenii_PYR-1 DAK---PDIVIEAVGHQVATLSHAVEAAAFGGTVFYFGVPDDDCYP-ISM
TH_0280|M.thermoresistible__bu DDR---ADVVIEAVGHQVATLNHAIEATAFGGTVFYFGVPDDDSYP-INM
MSMEG_2564|M.smegmatis_MC2_155 DDR---ADVVIEAVGHQVATLNHALTAAAFGGTVFYFGVPDDDSYP-ISM
MAB_2041c|M.abscessus_ATCC_199 ETGGRLADVVVDVTAKAPSAFADAVGLARPGGTIVVAGTRGGGGAPRFEP
MLBr_00118|M.leprae_Br4923 QNGG--ADVILDIMG--AAYLDRNIDALAIDGQLIVIGLQGGVKGELNLG
.* ::: : : : .* : * .
Mb1929|M.bovis_AF2122/97 LTCLLRSITLRMTMAPVQRTWPELIPLLQSGR----------LDVDGIFT
Rv1895|M.tuberculosis_H37Rv LTCLLRSITLRMTMAPVQRTWPELIPLLQSGR----------LDVDGIFT
MUL_2962|M.ulcerans_Agy99 LTCLLRSITLRLTIAPVQRTWSELIPLLESGR----------LDVDGIFT
MMAR_0400|M.marinum_M RTMLRNNLTLKSGVTQDRRRMLELAGKFAAEHP---------ELLSGYLT
MAV_5122|M.avium_104 RTMLRNNLTLKSGVTLDRRRMLELAGKFAAEHP---------WLLGAYLT
Mflv_4106|M.gilvum_PYR-GCK RTMLRNNLTLKAGVTLERRRVLRCADEFAAAHP---------GLLDRYLT
Mvan_2240|M.vanbaalenii_PYR-1 RTMLRNNLTLKSGVTIERRRVLAKADAFVQEHP---------GLLERYLT
TH_0280|M.thermoresistible__bu RAMLRNNLTLKSGVTLDRRRMLARADAFAREHS---------DLLTRYLT
MSMEG_2564|M.smegmatis_MC2_155 RTMLRNNLTLKSGVTTDRQRVLRRADTFAREHP---------HLLPGYVT
MAB_2041c|M.abscessus_ATCC_199 DLLVYKELHVVGALGVEYPAYRAALEILAMGRWP-------FDRITREST
MLBr_00118|M.leprae_Br4923 KVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIG
. : : : :
Mb1929|M.bovis_AF2122/97 TTLPLDEAAKGYATARA-RSGEELKVLLTP--------------------
Rv1895|M.tuberculosis_H37Rv TTLPLDEAAKGYATARA-RSGEELRFCLRPDSRDVLGAHETVDLYVHVRR
MUL_2962|M.ulcerans_Agy99 TSLPLDEAAKGYSIAGS-RSGNDVKVLLKV--------------------
MMAR_0400|M.marinum_M HNFDVEDVQAAFELACR-PVPERVKIAITA--------------------
MAV_5122|M.avium_104 HTFGVDEVQDAFELACR-PVADRIKIAIAG--------------------
Mflv_4106|M.gilvum_PYR-GCK HTFGVDDVQQAFELAAR-PVPGRVKIAIEAR-------------------
Mvan_2240|M.vanbaalenii_PYR-1 HTFGVDEAPAAFELASR-PVPGRIKIAIVA--------------------
TH_0280|M.thermoresistible__bu HTFGADEAQAAFELACR-PAPERIKIAIVG--------------------
MSMEG_2564|M.smegmatis_MC2_155 HTFGVDDVQAAFELACR-PVPDRVKIVVAR--------------------
MAB_2041c|M.abscessus_ATCC_199 GFAGLAQLLTSLADESA-RSSGALHNVFLPTP------------------
MLBr_00118|M.leprae_Br4923 ARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH---------
: . : .
Mb1929|M.bovis_AF2122/97 -----------------------
Rv1895|M.tuberculosis_H37Rv CQSVADLQLEGAADGVDGPSMLN
MUL_2962|M.ulcerans_Agy99 -----------------------
MMAR_0400|M.marinum_M -----------------------
MAV_5122|M.avium_104 -----------------------
Mflv_4106|M.gilvum_PYR-GCK -----------------------
Mvan_2240|M.vanbaalenii_PYR-1 -----------------------
TH_0280|M.thermoresistible__bu -----------------------
MSMEG_2564|M.smegmatis_MC2_155 -----------------------
MAB_2041c|M.abscessus_ATCC_199 -----------------------
MLBr_00118|M.leprae_Br4923 -----------------------