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VGQVLDIAPLRSLVAVADCGGFHRAAAVLHLTQSAVSQHVRRLEGVVGGPIVQRSGRGMAFTELGHRVVA HARRILAAHDAALADLGAAEEKTLLIGATEHGADVMLPGLNDALAECLPDWRVRFRLDRNVALADAIEHG TVDVAVMLDGSGWDRVNASGMVPLKWISARNFGCDGEPLPVVVYSEPCTLREPAFAALEKLEVDYQIVAE CADLSGLIAAVRSGLGIALLPMIGRLPDGLTVADTMPEANRASVFVRGRAGVDSGLLATVDTAVRELLND DRPSGTMVAKTSVKVSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2544 | - | - | 100% (297) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_3972 | - | 4e-40 | 35.27% (275) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 2e-14 | 27.06% (303) | LysR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0384 | - | 4e-09 | 29.79% (141) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1833 | - | 9e-12 | 26.12% (245) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0377 | - | 4e-09 | 29.79% (141) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-12 | 28.10% (242) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3179c | - | 3e-90 | 59.57% (277) | LysR family transcriptional regulator |
| M. marinum M | MMAR_2756 | oxyR | 4e-11 | 27.27% (242) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_0094 | - | 1e-111 | 71.33% (279) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 1e-12 | 33.10% (145) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 8e-11 | 26.79% (280) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 2e-12 | 25.60% (250) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2544|M.smegmatis_MC2_155 -----------MGQVLDIAPLRSLVAVADCGGFHRAAAVLHLTQSAVSQH
MAV_0094|M.avium_104 -----------MGQVLDIAPLRSLVAVADCGGFHRAAAALHLSQSAVSQH
MAB_3179c|M.abscessus_ATCC_199 ----------MASSTFDIAPLRSLAAVADCGGFHRAAAVLHLTQSAVSQH
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
Mb0384|M.bovis_AF2122/97 ---------------MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMH
Rv0377|M.tuberculosis_H37Rv ---------------MTPAQLRAYSAVVRLGSVRAAAAELGLSDAGVSMH
Mflv_1833|M.gilvum_PYR-GCK ---------------MDTHRLKYFLRIAEEGSITRAASLLGMAQPALSRQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
* :. . ** * : : :*
MSMEG_2544|M.smegmatis_MC2_155 VRRLEGVVGGPIVQRSGRGMAFTELGHRVVAHARRILAAHDAALADLGAA
MAV_0094|M.avium_104 LRRIEAVVGEPIVQRSGRGVVFTEVGQKALRHARTILAAHDTALDDLGAT
MAB_3179c|M.abscessus_ATCC_199 VRKLETAIGEPVVRRYGRGVVFTDRGARLLVHARRILAAHDAAVDDLVAG
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
Mb0384|M.bovis_AF2122/97 VAALRKELDDPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEA
Rv0377|M.tuberculosis_H37Rv VAALRKELDDPLFTRTGAGLAFTPGGLRLASRAVEILGLQQQTAIEVTEA
Mflv_1833|M.gilvum_PYR-GCK LQLLEEDLGVALFRRNRRGVELTDAGERLRSSTAAPLRQLELAVQYAAFP
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :. :. :. * : .* * :
MSMEG_2544|M.smegmatis_MC2_155 EE---KTLLIGATEHGADVMLPGLNDALAECLPDWRVRFRLDRNVALADA
MAV_0094|M.avium_104 EN---KVLTIGATEHGADVMLAGLSGALRDRLPDLRVRFRLDRNVSLADS
MAB_3179c|M.abscessus_ATCC_199 QE---RALVLGVTEHGADLILPSITSALRSHLPDWSVRVRFDRNLYLAES
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTERLLTA
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTERLLTA
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVEDQTEHLLTA
Mb0384|M.bovis_AF2122/97 AHG-RRLLRIAASSAFAEHAAPGLIELFSSRADDLSVELSVHPTSRFREL
Rv0377|M.tuberculosis_H37Rv AHG-RRLLRIAASSAFAEHAAPGLIELFSSRADDLSVELSVHPTSRFREL
Mflv_1833|M.gilvum_PYR-GCK LARLKRAMLIGIPESAIDVLAAPLMTRLGSAFPDAQFAVTVGSTDHLVEA
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLPDVKLDLREMVTAAQIEG
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYPSTSFTLRQLYPDALTDA
.. : . .
MSMEG_2544|M.smegmatis_MC2_155 IEHGTVDVAVMLDGSG----WDRVNASGMVPLKWISAR----------NF
MAV_0094|M.avium_104 IDRGLVDVAIMLDGAG----LDRANASGLVRLQWVSAR----------TL
MAB_3179c|M.abscessus_ATCC_199 VDRGIMDLAVILDGSG----LDRANAVGTVPLQWVAAR----------GY
MMAR_2756|M.marinum_M LREGSLDTALIALPAD----YGGLTEIPIYEEDFVLALPPGHPMADRHGV
MUL_2998|M.ulcerans_Agy99 LREGSLDTALIALPAD----YGGLTEIPIYEEDFVLALPPGHPMADRHGV
MLBr_02041|M.leprae_Br4923 LREGALDAAMIALPVE----TAGIAEIPIYDEDFVLALPPGHPLSGKRRV
Mb0384|M.bovis_AF2122/97 ICSRAVDIAIGPASESSIGSDGSIFLRPFLKYQIITVVAP--------NS
Rv0377|M.tuberculosis_H37Rv ICSRAVDIAIGPASESSIGSDGSIFLRPFLKYQIITVVAP--------NS
Mflv_1833|M.gilvum_PYR-GCK MLKGSVDIALINPVPD-----DRVFYREILTEEFVLVGGPDSPLEPEKPL
Mvan_1027|M.vanbaalenii_PYR-1 LMTGELDLGMARPPLK----RPGLVSRPLLHEQLLAALPEGHPLADMTRE
TH_3504|M.thermoresistible__bu VFDGTVQLGLRRGVVP----TPELATAVIGYHRVRVAFVDSHPLAARESV
: :: .: .
MSMEG_2544|M.smegmatis_MC2_155 GCD-GEPLPVVVYSEPCTLR-------EPAFAALEKLEVDYQIVAE-CAD
MAV_0094|M.avium_104 TIAPKDPLPLVIFSEPCTLR-------EPAFAILDSHRIDYEIAAE-CGD
MAB_3179c|M.abscessus_ATCC_199 KPNPIEPLRVMTFTEPCTLR-------APMFSALHTLGNQYQIVGE-SPD
MMAR_2756|M.marinum_M PVAALSELPLLLLDEGHCLR-------DQALDVCQNAGVRAELADTRAAS
MUL_2998|M.ulcerans_Agy99 PVAALSELPLLLLDEGHCLR-------DQALDVCQNAGVRAEHADTRADS
MLBr_02041|M.leprae_Br4923 PTTALAQLPLLLLDEGHCLR-------DQTLDICRKSGVQAELANTRAAS
Mb0384|M.bovis_AF2122/97 PLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPESQQRIFQSD
Rv0377|M.tuberculosis_H37Rv PLAAGIPMPALLRHQQWMLGPSAGSVDGEIATMLRGLAIPESQQRIFQSD
Mflv_1833|M.gilvum_PYR-GCK QFADLVELPLVVPRSTTGLG-------QALYNAALRAKVTIDYRIT-TDS
Mvan_1027|M.vanbaalenii_PYR-1 LTLIDLDGQDFVMYSPVQAR-----YFNELLISTFTIAGTTPRYVQYVTQ
TH_3504|M.thermoresistible__bu DITELAREQVALWAPPGTSYYS-----DFLMGACRRAGFEPDYVVSRVQG
MSMEG_2544|M.smegmatis_MC2_155 LSGLIAAVRSG-----LGIALLPMIG------RLPDGLTVADTMPEANRA
MAV_0094|M.avium_104 LSGLYAAVRSG-----LGVALLPMIG------KFPDGLGPAEGLPPANNA
MAB_3179c|M.abscessus_ATCC_199 LSGLYAGLRSG-----LGMALLPIIG------WLPDGIAPVDAMPAANLA
MMAR_2756|M.marinum_M LATAVQCVNGG-----LGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRI
MUL_2998|M.ulcerans_Agy99 LATAVQCVNGG-----LGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRI
MLBr_02041|M.leprae_Br4923 LATAVQCVTGG-----LGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRI
Mb0384|M.bovis_AF2122/97 AAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLA
Rv0377|M.tuberculosis_H37Rv AAALEEVMRVGGATLAIGFAVAKDLAAGRLVHVTGPGLDRAGEWCVATLA
Mflv_1833|M.gilvum_PYR-GCK TRVMVCLIESG-----LAYGVLPLSACGREFAESRLRYSRICEPVLTQQL
Mvan_1027|M.vanbaalenii_PYR-1 VHTMLVLVRSG-----IGIALVPASAAT--LHPEGVVFRTIGAFRERPVE
TH_3504|M.thermoresistible__bu AATVAAPLTTG------GIAFVTAAAG-----PTMNGRVQVVDLTPPLLV
: * . . .
MSMEG_2544|M.smegmatis_MC2_155 SVFVRGRAGVDSGLLATVDTAVRELLNDDRPSGTMVAKTSVKVSA-----
MAV_0094|M.avium_104 SILVRGRTGIDPALLSTVDTAVRDLLATAT--------------------
MAB_3179c|M.abscessus_ATCC_199 TLSVVGRRGLDPVAFNAVKDAAREALSGESAAIA----------------
MMAR_2756|M.marinum_M GLVYRASSGRD-EAYRQLAAIMGESISNEQQVRLVN--------------
MUL_2998|M.ulcerans_Agy99 GLVYRASSGRD-EAYRQLAAIMGESISNEQQVRLVN--------------
MLBr_02041|M.leprae_Br4923 GLAFRSASGRS-ASYRQIAKIIGELISTEHHVRLVA--------------
Mb0384|M.bovis_AF2122/97 PSARQPAVSELVGFISTPRCIQAMIRGSGVGVTRFRPKVHVTLWS-----
Rv0377|M.tuberculosis_H37Rv PSARQPAVSELVGFISTPRCIQAMIPGSGVGVTRFRPKVHVTLWS-----
Mflv_1833|M.gilvum_PYR-GCK GVAATEQLDLPRELVVKVGNALREEIAALIRSGSWRADLLSPEPWSPRRV
Mvan_1027|M.vanbaalenii_PYR-1 LDAVWRGDSTNPALLRVLKDVLPQQEWTT---------------------
TH_3504|M.thermoresistible__bu PVQALWQRHTLSAIRDRILEGLG---------------------------