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MELAEAVRARRSTRKFLPDKPVPHELIEEALTLAMRAPSNSNVQPWRVYFASGERRERLVAALTAEVRAR RPTSLGLPDAFQHLRSQLGALVYGSMGIARADTEARWAAQLRNWEFFGAPLAGVVCMHRDLGLVDSVGVG MFLQTFLLALTERGIGSCVQVSVAMCADVLRAELDIPDELTVLCGMSIGYADPAFPANHLDIPRNPVEQN VTFYS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2354 | - | - | 100% (215) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3462 | - | 4e-30 | 34.51% (226) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_6505 | - | 4e-28 | 35.43% (223) | NfnB protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3290 | fbiB | 3e-12 | 31.75% (189) | F420-0--gamma-glutamyl ligase |
| M. gilvum PYR-GCK | Mflv_4892 | - | 2e-08 | 28.40% (169) | nitroreductase |
| M. tuberculosis H37Rv | Rv3262 | fbiB | 3e-12 | 31.75% (189) | F420-0--gamma-glutamyl ligase |
| M. leprae Br4923 | MLBr_00758 | - | 9e-10 | 29.26% (188) | F420-0--gamma-glutamyl ligase |
| M. abscessus ATCC 19977 | MAB_2661c | - | 4e-27 | 34.98% (223) | putative nitroreductase |
| M. marinum M | MMAR_1739 | - | 4e-69 | 59.91% (212) | nitroreductase |
| M. avium 104 | MAV_4225 | - | 2e-10 | 30.15% (199) | F420-0--gamma-glutamyl ligase |
| M. thermoresistible (build 8) | TH_0777 | - | 1e-10 | 29.90% (204) | PROBABLE F420 BIOSYNTHESIS PROTEIN FBIB |
| M. ulcerans Agy99 | MUL_1982 | - | 1e-45 | 61.31% (137) | nitroreductase |
| M. vanbaalenii PYR-1 | Mvan_1213 | - | 1e-31 | 35.75% (221) | nitroreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3290|M.bovis_AF2122/97 MTG---------PEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLR
Rv3262|M.tuberculosis_H37Rv MTG---------PEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLR
MLBr_00758|M.leprae_Br4923 MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLR
MAV_4225|M.avium_104 MSP--------AGEHGTAAPIEILPVAGLPEFRPGDDLGAAVAKAAPWLR
TH_0777|M.thermoresistible__bu VSTAGGAGQTGSGDHGTAAAIELFPVTGLPQFCPGDDLTAAVAAAAPWLR
MMAR_1739|M.marinum_M --------------------------------------------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2661c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1213|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4892|M.gilvum_PYR-GCK --------------------------------------------------
Mb3290|M.bovis_AF2122/97 DGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDR
Rv3262|M.tuberculosis_H37Rv DGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDR
MLBr_00758|M.leprae_Br4923 DGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGR
MAV_4225|M.avium_104 DGDVVVVTSKAVSKCEGRLVPAPADPEERDRLRRKLVDEEAVRVLARKGR
TH_0777|M.thermoresistible__bu DNDVVVVTSKVVSKCEGRIIAAPADPEQRDALRRKLIDEEAVRVLARKGR
MMAR_1739|M.marinum_M --------------------------------------------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2661c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1213|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4892|M.gilvum_PYR-GCK --------------------------------------------------
Mb3290|M.bovis_AF2122/97 TLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLG
Rv3262|M.tuberculosis_H37Rv TLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLG
MLBr_00758|M.leprae_Br4923 TLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLG
MAV_4225|M.avium_104 TLITENRHGLVQAAAGVDGSNVGRDELALLPLDPDASAAALRARLRELLG
TH_0777|M.thermoresistible__bu TLITENALGLVQAAAGVDGSNVAATELALLPVDPDASAAALRAGLRQRLG
MMAR_1739|M.marinum_M ---------MYDLDETIRLRRSTRMFLP-RPVPRRLVQEALELAMCAPS-
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 ----------MELAEAVRARRSTRKFLPDKPVPHELIEEALTLAMRAPS-
MAB_2661c|M.abscessus_ATCC_199 ----------MDVYDAVASRRSVREFVD-RPVSPATLTRVLTAAARAPS-
Mvan_1213|M.vanbaalenii_PYR-1 ----------MDVYEAVRSRRAVRGFTD-EPVPQAVLERVLAAAAWAPS-
Mflv_4892|M.gilvum_PYR-GCK -----MTLNLSADEVLTTTRSVRKRLDFDRPVPREVLNECLEIALQAPTG
Mb3290|M.bovis_AF2122/97 VTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTE
Rv3262|M.tuberculosis_H37Rv VTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTE
MLBr_00758|M.leprae_Br4923 VNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTE
MAV_4225|M.avium_104 VEVAVLVTDTMGRAWRNGQTDAAVGAAGLAVLHGYSGAVDQHGNELLVTE
TH_0777|M.thermoresistible__bu VDVGVIITDTMGRAWRTGQTDFAIGAAGLTVLHGYAGSHDRHGNELFVTE
MMAR_1739|M.marinum_M --------------------------------------------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2661c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_1213|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4892|M.gilvum_PYR-GCK --------------------------------------------------
Mb3290|M.bovis_AF2122/97 VAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLF
Rv3262|M.tuberculosis_H37Rv VAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLF
MLBr_00758|M.leprae_Br4923 IAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLF
MAV_4225|M.avium_104 VAIADEIAAAADLVKGKLTAMPVAVVRGLSVTDDGSTARQLLRPGTEDLF
TH_0777|M.thermoresistible__bu VAVADEIAAAADLVKGKLTDVPVAVVRGLTLRDDGSTARTLVRPGQDDLF
MMAR_1739|M.marinum_M --------------NSNVQPWHVVFTSGAARDR-----------------
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 --------------NSNVQPWRVYFASGERRER-----------------
MAB_2661c|M.abscessus_ATCC_199 --------------GGNLQPWHVYVLSGARLAE-----------------
Mvan_1213|M.vanbaalenii_PYR-1 --------------GSNLQPWHIYVVTGAPLAQ-----------------
Mflv_4892|M.gilvum_PYR-GCK ---------------SNAQGWQFVFVDDPEKKK-----------------
Mb3290|M.bovis_AF2122/97 WLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHH
Rv3262|M.tuberculosis_H37Rv WLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHH
MLBr_00758|M.leprae_Br4923 WLGTTEALELGRQQAQLLRRSVRQFSDEPIAAELIETAVAEALTAPAPHH
MAV_4225|M.avium_104 WLGTAEAIELGRRQAQLLRRSVRRFSAEPVPAELVREAVAEALTAPAPHH
TH_0777|M.thermoresistible__bu WLGTEEAIRLGRSQAQLLRRSVRRFDSEPVPADLIEAAVAEALTAPAPHH
MMAR_1739|M.marinum_M ----------------------------------LVAAMLERARSEPPNV
MUL_1982|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2354|M.smegmatis_MC2_155 ----------------------------------LVAALTAEVRARRPTS
MAB_2661c|M.abscessus_ATCC_199 ----------------------------------LKERIARRVIAGDRGD
Mvan_1213|M.vanbaalenii_PYR-1 ----------------------------------MKKLATERVAAGDPWD
Mflv_4892|M.gilvum_PYR-GCK -------------------------------------ALADIYR------
Mb3290|M.bovis_AF2122/97 TRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQIL
Rv3262|M.tuberculosis_H37Rv TRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQIL
MLBr_00758|M.leprae_Br4923 TRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAIAQRVARGQIL
MAV_4225|M.avium_104 TRPVRFVWLQTPAVRTRLLDAMKDKWRADLAGDGRPAESIERRVARGQIL
TH_0777|M.thermoresistible__bu TRPVRFVWLQNWTARTRLLDRMKDRWRADLAGDGASPEAVERRVGRGQIL
MMAR_1739|M.marinum_M AR--------LPPAFTHLRSALGAQVYGAMGIARDDTQARQTAVLRNWEF
MUL_1982|M.ulcerans_Agy99 ----------MPPAFTHLRSALGAQVYGAMGIARDDTQARQTAVLRNWEF
MSMEG_2354|M.smegmatis_MC2_155 LG--------LPDAFQHLRSQLGALVYGSMGIARADTEARWAAQLRNWEF
MAB_2661c|M.abscessus_ATCC_199 ALEVAMYPQPLDSPYRERLYDFGHRRYGALGIDHDDHDARAAVRAGNWAC
Mvan_1213|M.vanbaalenii_PYR-1 EREYVMYPPVLKSPYHERRATFGRERYSALGIEREDWEARQRAAIANWDC
Mflv_4892|M.gilvum_PYR-GCK -------------IAADPYLEAEKPTFGDVR-DERTPLVVDSAKYLAEHL
:
Mb3290|M.bovis_AF2122/97 YDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVR
Rv3262|M.tuberculosis_H37Rv YDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVR
MLBr_00758|M.leprae_Br4923 YDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAVR
MAV_4225|M.avium_104 YDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVGLAVR
TH_0777|M.thermoresistible__bu YDAPELIVPFLVADGAHHYPDARRAAAEHTMFTVAGGAAVQALLVALAVR
MMAR_1739|M.marinum_M FRAPLGGIVSMHQELGLVD-------------SMGVGMFLQNLMLALTAR
MUL_1982|M.ulcerans_Agy99 FRAPLGGIVSMHQELGLVD-------------SMGVGMFLQNLMLALTAR
MSMEG_2354|M.smegmatis_MC2_155 FGAPLAGVVCMHRDLGLVD-------------SVGVGMFLQTFLLALTER
MAB_2661c|M.abscessus_ATCC_199 FGASTALFCYLDRDMPPPQ-------------WGDAGMYLQTIMLLLRAE
Mvan_1213|M.vanbaalenii_PYR-1 FGAPAALFCYIDRDLGRPQ-------------WSDLGMYLQTVMLLLRAE
Mflv_4892|M.gilvum_PYR-GCK HEAPVMLIPCLEGRPDGAPAGMSAG------FWGSLLPAVWSFMLALRSR
. *. . : : .:: * .
Mb3290|M.bovis_AF2122/97 GLGSCWIGSTIFAA--DLVRDELDLPVDWEPLGAIA-IGYADE------P
Rv3262|M.tuberculosis_H37Rv GLGSCWIGSTIFAA--DLVRDELDLPVDWEPLGAIA-IGYADE------P
MLBr_00758|M.leprae_Br4923 GLGSCWIGSTIFAD--DLVRAELELPADWEPLGAIA-IGYAHE------P
MAV_4225|M.avium_104 GLGSCWIGSTIFAA--DLVRAVLGLPADWEPLGAIA-IGYAAE------P
TH_0777|M.thermoresistible__bu EIGSCWVGSTIFAP--EVVRTELGLPDDWEPLGAVA-IGYPAE------P
MMAR_1739|M.marinum_M GLGTCVQVSIAGYP--EIVRKQVGIPSHLTILCGLA-IGYPDPDFAGNQL
MUL_1982|M.ulcerans_Agy99 GLGTCVQVSIAGYP--EIVRKQVGIPSHLTILCGLA-IGYPDPDFAGNQL
MSMEG_2354|M.smegmatis_MC2_155 GIGSCVQVSVAMCA--DVLRAELDIPDELTVLCGMS-IGYADPAFPANHL
MAB_2661c|M.abscessus_ATCC_199 GLDSCPQIAWAEYH--RTVAEVIAPPPQRVLYCGMS-IGYRNP--ETKAP
Mvan_1213|M.vanbaalenii_PYR-1 GLHSCPQMAWSQVR--STVAQVLSPPDELMLFCGMS-IGHEDT--SVGYV
Mflv_4892|M.gilvum_PYR-GCK GLGSAWTTLHLIGDGEKQAAEVLGIPFDKYSQGGLFPIAYTKG---TDFK
: :. : * . .: *.:
Mb3290|M.bovis_AF2122/97 SGLRDPVPAADLLILK
Rv3262|M.tuberculosis_H37Rv SGLRDPVPAADLLILK
MLBr_00758|M.leprae_Br4923 TDLREPVRVADLLLRK
MAV_4225|M.avium_104 AGPRDPADPGDLLIRK
TH_0777|M.thermoresistible__bu AGPRDPAPTEGLLVFR
MMAR_1739|M.marinum_M RVGRDDVAEHVVFLDD
MUL_1982|M.ulcerans_Agy99 RVGRDDVAEHVVFLDD
MSMEG_2354|M.smegmatis_MC2_155 DIPRNPVEQNVTFYS-
MAB_2661c|M.abscessus_ATCC_199 EMPRAALSETVTFL--
Mvan_1213|M.vanbaalenii_PYR-1 PTGRSALAETVTFVNG
Mflv_4892|M.gilvum_PYR-GCK KAKRLPAEQLTHWNTW
*