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SHDVAIIGVGIHPFGRFEGKTAMQMGVDAIFAAVADAGVDWKDIGAATGGSWTVANPDAIVGMVGLSGIP FTNVFNACATAASATKVCADGIRLGDYDIGIAVGLDKHPRGAFTEDPALVGMPKWYAENGQYLTTQFFGM KANRYLHDHNISRRTLARVAAKNFRNGALNPNAFRRKPISEDDILNSTMLNYPLTQYMFCAPDEGAAAVV MCRADIAHRYTDKPVYLKAVEVRTRRYGAYEVNTTCAPVEEDVAPTVYAARAAFEKAGVAPEDVDVIQLQ DTDAGAEIIHMAECGFCAHGDQEKLLADGATEIGGSLPVNTDGGLIANGEPIGASGLRQIHELVRQLRGE AGDRQVPGEPKVGFAQLYGAPGTAGATILTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2236 | - | - | 100% (382) | putative thiolase |
| M. smegmatis MC2 155 | MSMEG_4778 | - | e-171 | 75.07% (381) | putative thiolase |
| M. smegmatis MC2 155 | MSMEG_3844 | - | 1e-46 | 32.67% (401) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1653c | - | 6e-46 | 31.91% (398) | lipid-transfer protein |
| M. gilvum PYR-GCK | Mflv_4345 | - | 0.0 | 86.81% (379) | thiolase |
| M. tuberculosis H37Rv | Rv1627c | - | 6e-46 | 31.91% (398) | lipid-transfer protein |
| M. leprae Br4923 | MLBr_02158 | - | 3e-21 | 44.17% (120) | hypothetical protein MLBr_02158 |
| M. abscessus ATCC 19977 | MAB_2619 | - | 3e-48 | 33.33% (402) | lipid-transfer protein |
| M. marinum M | MMAR_0142 | ltp1_1 | 8e-47 | 32.27% (409) | lipid-transfer protein Ltp1_1 |
| M. avium 104 | MAV_1596 | - | 0.0 | 90.24% (379) | putative thiolase |
| M. thermoresistible (build 8) | TH_0532 | - | 1e-179 | 78.10% (379) | putative thiolase |
| M. ulcerans Agy99 | MUL_4955 | ltp1_1 | 2e-47 | 32.52% (409) | lipid-transfer protein Ltp1_1 |
| M. vanbaalenii PYR-1 | Mvan_1999 | - | 0.0 | 87.60% (379) | thiolase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2236|M.smegmatis_MC2_155 -----MSHDVAIIGVGIHPFGRFEGKTAMQMGVDAIFAAVADAGVDWKDI
MAV_1596|M.avium_104 ------MNDVAIIGVGLHPFGRFEGKSAMEMAVDAIQLAVADAGVEWKDI
Mflv_4345|M.gilvum_PYR-GCK ------MHDVAIIGVGLHPFGRFEGKTAMQMGVDAITAAVADAGVSWNDI
Mvan_1999|M.vanbaalenii_PYR-1 ------MHDVAIIGVGLHPFGRFEGKTAMHMGVDAITAAVADAGVSWNDI
TH_0532|M.thermoresistible__bu ---MSNENSVAIIGVGLHPFGRFD-KTAMEMGAEAIAAALADAGLEWKDI
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 MRMS-APEPVYILGAGMHPWGKWG-NDFTEYGVVAARAALRDAGVDWRHV
Rv1627c|M.tuberculosis_H37Rv MRMS-APEPVYILGAGMHPWGKWG-NDFTEYGVVAARAALRDAGVDWRHV
MAB_2619|M.abscessus_ATCC_1997 --MSRTPDPVYILGAGMHPWGKWG-RDFTEYGVAAARTALQDAELDWRQI
MMAR_0142|M.marinum_M --MS-ASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMADI
MUL_4955|M.ulcerans_Agy99 --MS-ASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMADI
MSMEG_2236|M.smegmatis_MC2_155 GAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKVC
MAV_1596|M.avium_104 QAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASAAKAC
Mflv_4345|M.gilvum_PYR-GCK QFGVGGSWTVANPD------AIVGMLGLSGIPFTNVFNACATAASATKTC
Mvan_1999|M.vanbaalenii_PYR-1 QFGVGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKAC
TH_0532|M.thermoresistible__bu QFGYGGSYEISNPD------AVTRLVGLTGITFTNVFNACATAASAIQET
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
Rv1627c|M.tuberculosis_H37Rv QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
MAB_2619|M.abscessus_ATCC_1997 QFVAGADTIRNGYPGFIAGSTFAQKLGWNGVPISSTYAACASGSQALQSA
MMAR_0142|M.marinum_M GVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALRTA
MUL_4955|M.ulcerans_Agy99 GVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALRTA
MSMEG_2236|M.smegmatis_MC2_155 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPA-LVGMPKWYAENGQYLTTQF
MAV_1596|M.avium_104 ADGIRLGDYDIGIAIGLDKHPRGAFTEDPA-LVGMPRWYAENGQYLTTQF
Mflv_4345|M.gilvum_PYR-GCK ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
Mvan_1999|M.vanbaalenii_PYR-1 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
TH_0532|M.thermoresistible__bu ADTIRLGKYDIGIAIGMDKHPRGAFTDDPA-KLALPQWYAQNGQFVTTKF
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
Rv1627c|M.tuberculosis_H37Rv RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
MAB_2619|M.abscessus_ATCC_1997 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKADPD-WQRFHLIGATNP
MMAR_0142|M.marinum_M IMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAVAP
MUL_4955|M.ulcerans_Agy99 IMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAVAP
MSMEG_2236|M.smegmatis_MC2_155 FG-------------MKANRYLHDHN-ISRRTLARVAAKNFRNGALNPNA
MAV_1596|M.avium_104 FG-------------MKANRYLHQHG-ISQRTLAKVAAKNFRNGARNPNA
Mflv_4345|M.gilvum_PYR-GCK FG-------------MKANRYLHTHH-VSHRTLAKVVNKNLRNGALNPNA
Mvan_1999|M.vanbaalenii_PYR-1 FG-------------MKANRYLHEHG-ISHRTLAKVVNKNLRNGALNPNA
TH_0532|M.thermoresistible__bu FG-------------MKANRYLHDHG-ISQETLARVANKNFRNGSLNPNA
MLBr_02158|M.leprae_Br4923 --------------------------------MCSVASRFLRTRS-----
Mb1653c|M.bovis_AF2122/97 VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
Rv1627c|M.tuberculosis_H37Rv VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
MAB_2619|M.abscessus_ATCC_1997 VY-----------FALLARRRMDLFG-ATVEDFAQVKVKNSRHGLNNPNA
MMAR_0142|M.marinum_M VDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNPLA
MUL_4955|M.ulcerans_Agy99 VDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNPLA
:. : :
MSMEG_2236|M.smegmatis_MC2_155 FRRKPISEDDILNSTMLNYPLTQYMFCAPDEGAAAVVMCR-ADIAHRYTD
MAV_1596|M.avium_104 FRRKPIPEDEILNSPMLNYPLTQYMFCAPDEGAAAVVMCR-ADIAHRYSA
Mflv_4345|M.gilvum_PYR-GCK FRRKPMDEDAILNSPMLNYPLTQYMFCSPDEGAAAVVMCR-ADLAHKYTN
Mvan_1999|M.vanbaalenii_PYR-1 FRRKPMDEDAILDSPMLNYPLTQYMFCSPDEGAAAVVMCR-ADIAHRYTN
TH_0532|M.thermoresistible__bu FRRKEISVEDILNSPVLNYPLTQYMFCAPDEGAAAVIMCR-GDIAHRFTD
MLBr_02158|M.leprae_Br4923 --------------------LTQCMFCALNKGAFAVIVCL-GDIAHKFTD
Mb1653c|M.bovis_AF2122/97 RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVAS-KSFTEKHLG
Rv1627c|M.tuberculosis_H37Rv RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVAS-KSFTEKHLG
MAB_2619|M.abscessus_ATCC_1997 RFRKESSVADVLASPVVSDPLRLLDICATSDGAAALIVAS-ADFAKKHLG
MMAR_0142|M.marinum_M AYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNGETLKSLSAR
MUL_4955|M.ulcerans_Agy99 AYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNGETLKSLSAR
.: .** * ::. :
MSMEG_2236|M.smegmatis_MC2_155 KPVYLKAVEVRTRRYGAYEVNTTCAPVEEDVAP-TVYAAR---------A
MAV_1596|M.avium_104 KPVYLRAVEVRTRRYGAYEVNTTFAPVDEDVAP-TVYAAR---------A
Mflv_4345|M.gilvum_PYR-GCK KPVFVRAVEVRTRKYGAYEVNTTFAPVDEDVAP-TVYASR---------A
Mvan_1999|M.vanbaalenii_PYR-1 KPVFVRAVEVRTRKYGAYEVNTTFAPVDEDVAP-TVYASR---------G
TH_0532|M.thermoresistible__bu KPVYVRASEIRTRRYGAYEVHATSAPLEEDVAP-TVYAAR---------A
MLBr_02158|M.leprae_Br4923 KTVHVHVTEIRTRRYGAYEVHATFAPLVEDASPKRCTIAK---------A
Mb1653c|M.bovis_AF2122/97 SVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDA
Rv1627c|M.tuberculosis_H37Rv SVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDA
MAB_2619|M.abscessus_ATCC_1997 SVDGVPSVRAVATITPKYPQHLPELPDIATDSTAVVPAPERVFKDQIVDA
MMAR_0142|M.marinum_M QRRRAVKVSASVLTTDPYEPGCQVLPNVNTLTRNAAKT------------
MUL_4955|M.ulcerans_Agy99 QRRRAVKVSASVLTTDPYEPGCQVLPNVNTLTRNAAKT------------
. * * :
MSMEG_2236|M.smegmatis_MC2_155 AFEKAGVAPEDVDVIQLQDTDAGA-EIIHMAECGFCAHGDQEKLLADGAT
MAV_1596|M.avium_104 AFEKAGVAPQDVDVIQLQDTDAGA-EIIHMAECGFCADGEQEKLLADGVT
Mflv_4345|M.gilvum_PYR-GCK AFEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGEQEKLIADGAT
Mvan_1999|M.vanbaalenii_PYR-1 AFEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGDQEKLIADGAT
TH_0532|M.thermoresistible__bu AYEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGEQEKLLAEGAT
MLBr_02158|M.leprae_Br4923 VYRGRQASDLRTSTSPSCRTSVPAPEVIQMDETVLCADGEQEKLASW---
Mb1653c|M.bovis_AF2122/97 AYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGAT
Rv1627c|M.tuberculosis_H37Rv AYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGAT
MAB_2619|M.abscessus_ATCC_1997 AYAEAGIGPEDISLAEVYDLSTAL-ELDWYEHLGLCAKGEGEQLLRSGAT
MMAR_0142|M.marinum_M AYEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGAP
MUL_4955|M.ulcerans_Agy99 AYEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGAP
.: . . *: . :* .* :
MSMEG_2236|M.smegmatis_MC2_155 EIGGSLPVNTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVPGEPK
MAV_1596|M.avium_104 EITGAMPINTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVAGEPR
Mflv_4345|M.gilvum_PYR-GCK EIGGTMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGDPK
Mvan_1999|M.vanbaalenii_PYR-1 EIGGAMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGEPK
TH_0532|M.thermoresistible__bu EINGSLPINTDGGLIANGEPIGASGLRQIHELVRQLRGQAGDRQVPGNPK
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 TLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AK
Rv1627c|M.tuberculosis_H37Rv TLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AK
MAB_2619|M.abscessus_ATCC_1997 TVGGRVPVNASGGLACFGEAIPAQAIAQVCELTWQLRGQAGDRQVEG-AR
MMAR_0142|M.marinum_M WRDGSTPVNVSGGLQSKGHPIAATGIANVWEICHHLRGEAGDRQIDN-AK
MUL_4955|M.ulcerans_Agy99 WRHGSTPVNVSGGLQSKGHPIAATGIANVWEICHQLRGEAGDRQIDN-AK
MSMEG_2236|M.smegmatis_MC2_155 VGFAQLYGAPGTAGATILTR---
MAV_1596|M.avium_104 VGFAQLYGAPGTAAATILTT---
Mflv_4345|M.gilvum_PYR-GCK VGFAQLYGAPGTAGATILTT---
Mvan_1999|M.vanbaalenii_PYR-1 VGFAQLYGAPGTAGATILTT---
TH_0532|M.thermoresistible__bu VGFAQLYGAPGTAAATVLTT---
MLBr_02158|M.leprae_Br4923 -----------------------
Mb1653c|M.bovis_AF2122/97 VGVTANQGLFGHGSSVIVAR---
Rv1627c|M.tuberculosis_H37Rv VGVTANQGLFGHGSSVIVAR---
MAB_2619|M.abscessus_ATCC_1997 VGITANQGLFGNGSSVIVAR---
MMAR_0142|M.marinum_M VGLAHVIGLGSACGVHILERSAA
MUL_4955|M.ulcerans_Agy99 VGLAHVIGLGSACGVHILERSAA