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NDVAIIGVGLHPFGRFEGKSAMEMAVDAIQLAVADAGVEWKDIQAATGGSWTVANPDAIVGMVGLSGIPF TNVFNACATAASAAKACADGIRLGDYDIGIAIGLDKHPRGAFTEDPALVGMPRWYAENGQYLTTQFFGMK ANRYLHQHGISQRTLAKVAAKNFRNGARNPNAFRRKPIPEDEILNSPMLNYPLTQYMFCAPDEGAAAVVM CRADIAHRYSAKPVYLRAVEVRTRRYGAYEVNTTFAPVDEDVAPTVYAARAAFEKAGVAPQDVDVIQLQD TDAGAEIIHMAECGFCADGEQEKLLADGVTEITGAMPINTDGGLIANGEPIGASGLRQIHELVRQLRGEA GDRQVAGEPRVGFAQLYGAPGTAAATILTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1596 | - | - | 100% (381) | putative thiolase |
| M. avium 104 | MAV_0989 | - | e-175 | 76.78% (379) | putative thiolase |
| M. avium 104 | MAV_2573 | - | e-133 | 59.26% (378) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1653c | - | 8e-46 | 31.31% (396) | lipid-transfer protein |
| M. gilvum PYR-GCK | Mflv_4345 | - | 0.0 | 85.56% (381) | thiolase |
| M. tuberculosis H37Rv | Rv1627c | - | 8e-46 | 31.31% (396) | lipid-transfer protein |
| M. leprae Br4923 | MLBr_02158 | - | 6e-22 | 45.00% (120) | hypothetical protein MLBr_02158 |
| M. abscessus ATCC 19977 | MAB_2619 | - | 1e-48 | 32.75% (400) | lipid-transfer protein |
| M. marinum M | MMAR_2430 | - | 3e-44 | 31.41% (398) | nonspecific lipid-transfer protein |
| M. smegmatis MC2 155 | MSMEG_2236 | - | 0.0 | 90.24% (379) | putative thiolase |
| M. thermoresistible (build 8) | TH_0532 | - | 1e-177 | 77.37% (380) | putative thiolase |
| M. ulcerans Agy99 | MUL_4955 | ltp1_1 | 7e-45 | 31.91% (398) | lipid-transfer protein Ltp1_1 |
| M. vanbaalenii PYR-1 | Mvan_1999 | - | 0.0 | 86.88% (381) | thiolase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1596|M.avium_104 ------MNDVAIIGVGLHPFGRFEGKSAMEMAVDAIQLAVADAGVEWKDI
MSMEG_2236|M.smegmatis_MC2_155 -----MSHDVAIIGVGIHPFGRFEGKTAMQMGVDAIFAAVADAGVDWKDI
Mflv_4345|M.gilvum_PYR-GCK ------MHDVAIIGVGLHPFGRFEGKTAMQMGVDAITAAVADAGVSWNDI
Mvan_1999|M.vanbaalenii_PYR-1 ------MHDVAIIGVGLHPFGRFEGKTAMHMGVDAITAAVADAGVSWNDI
TH_0532|M.thermoresistible__bu ---MSNENSVAIIGVGLHPFGRFD-KTAMEMGAEAIAAALADAGLEWKDI
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 MRMS-APEPVYILGAGMHPWGKWGN-DFTEYGVVAARAALRDAGVDWRHV
Rv1627c|M.tuberculosis_H37Rv MRMS-APEPVYILGAGMHPWGKWGN-DFTEYGVVAARAALRDAGVDWRHV
MMAR_2430|M.marinum_M --MS-APEPLYILGAGMHPWGKWGN-DFTEYGVAAARAALREAGLEWRQI
MAB_2619|M.abscessus_ATCC_1997 --MSRTPDPVYILGAGMHPWGKWGR-DFTEYGVAAARTALQDAELDWRQI
MUL_4955|M.ulcerans_Agy99 --MS-ASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMADI
MAV_1596|M.avium_104 QAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASAAKAC
MSMEG_2236|M.smegmatis_MC2_155 GAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKVC
Mflv_4345|M.gilvum_PYR-GCK QFGVGGSWTVANPD------AIVGMLGLSGIPFTNVFNACATAASATKTC
Mvan_1999|M.vanbaalenii_PYR-1 QFGVGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKAC
TH_0532|M.thermoresistible__bu QFGYGGSYEISNPD------AVTRLVGLTGITFTNVFNACATAASAIQET
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
Rv1627c|M.tuberculosis_H37Rv QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
MMAR_2430|M.marinum_M QLVAGADTIRNGYPGFVAGATFAQKLGWNGVPVSSSYAACASGSQALQSA
MAB_2619|M.abscessus_ATCC_1997 QFVAGADTIRNGYPGFIAGSTFAQKLGWNGVPISSTYAACASGSQALQSA
MUL_4955|M.ulcerans_Agy99 GVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALRTA
MAV_1596|M.avium_104 ADGIRLGDYDIGIAIGLDKHPRGAFTEDPA-LVGMPRWYAENGQYLTTQF
MSMEG_2236|M.smegmatis_MC2_155 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPA-LVGMPKWYAENGQYLTTQF
Mflv_4345|M.gilvum_PYR-GCK ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
Mvan_1999|M.vanbaalenii_PYR-1 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
TH_0532|M.thermoresistible__bu ADTIRLGKYDIGIAIGMDKHPRGAFTDDPA-KLALPQWYAQNGQFVTTKF
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
Rv1627c|M.tuberculosis_H37Rv RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
MMAR_2430|M.marinum_M RAQILAGFCDVALVVGADTTPKGFFAPVGGERKNDPD-WQRFHLIGATNP
MAB_2619|M.abscessus_ATCC_1997 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKADPD-WQRFHLIGATNP
MUL_4955|M.ulcerans_Agy99 IMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAVAP
MAV_1596|M.avium_104 FG-------------MKANRYLHQHG-ISQRTLAKVAAKNFRNGARNPNA
MSMEG_2236|M.smegmatis_MC2_155 FG-------------MKANRYLHDHN-ISRRTLARVAAKNFRNGALNPNA
Mflv_4345|M.gilvum_PYR-GCK FG-------------MKANRYLHTHH-VSHRTLAKVVNKNLRNGALNPNA
Mvan_1999|M.vanbaalenii_PYR-1 FG-------------MKANRYLHEHG-ISHRTLAKVVNKNLRNGALNPNA
TH_0532|M.thermoresistible__bu FG-------------MKANRYLHDHG-ISQETLARVANKNFRNGSLNPNA
MLBr_02158|M.leprae_Br4923 --------------------------------MCSVASRFLRTRS-----
Mb1653c|M.bovis_AF2122/97 VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
Rv1627c|M.tuberculosis_H37Rv VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
MMAR_2430|M.marinum_M VY-----------FALLARRRMDLYG-ATLEDFAQVKVKNSRHGLQNPNA
MAB_2619|M.abscessus_ATCC_1997 VY-----------FALLARRRMDLFG-ATVEDFAQVKVKNSRHGLNNPNA
MUL_4955|M.ulcerans_Agy99 VDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNPLA
:. : :
MAV_1596|M.avium_104 FRRKPIPEDEILNSPMLNYPLTQYMFCAPDEGAAAVVMCRADIAHRYSAK
MSMEG_2236|M.smegmatis_MC2_155 FRRKPISEDDILNSTMLNYPLTQYMFCAPDEGAAAVVMCRADIAHRYTDK
Mflv_4345|M.gilvum_PYR-GCK FRRKPMDEDAILNSPMLNYPLTQYMFCSPDEGAAAVVMCRADLAHKYTNK
Mvan_1999|M.vanbaalenii_PYR-1 FRRKPMDEDAILDSPMLNYPLTQYMFCSPDEGAAAVVMCRADIAHRYTNK
TH_0532|M.thermoresistible__bu FRRKEISVEDILNSPVLNYPLTQYMFCAPDEGAAAVIMCRGDIAHRFTDK
MLBr_02158|M.leprae_Br4923 --------------------LTQCMFCALNKGAFAVIVCLGDIAHKFTDK
Mb1653c|M.bovis_AF2122/97 RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVASKSFTEKHLGS
Rv1627c|M.tuberculosis_H37Rv RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVASKSFTEKHLGS
MMAR_2430|M.marinum_M RYRKEVSVEDVLASQVVAEPLRLLDICATSDGAAALIVASAKFAREHLGS
MAB_2619|M.abscessus_ATCC_1997 RFRKESSVADVLASPVVSDPLRLLDICATSDGAAALIVASADFAKKHLGS
MUL_4955|M.ulcerans_Agy99 AYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNG----ETLKS
.: .** * ::. . .
MAV_1596|M.avium_104 PVYLRAVEVRTRRYG---------AYEVNTTFAPVDEDVAP-TVYAARAA
MSMEG_2236|M.smegmatis_MC2_155 PVYLKAVEVRTRRYG---------AYEVNTTCAPVEEDVAP-TVYAARAA
Mflv_4345|M.gilvum_PYR-GCK PVFVRAVEVRTRKYG---------AYEVNTTFAPVDEDVAP-TVYASRAA
Mvan_1999|M.vanbaalenii_PYR-1 PVFVRAVEVRTRKYG---------AYEVNTTFAPVDEDVAP-TVYASRGA
TH_0532|M.thermoresistible__bu PVYVRASEIRTRRYG---------AYEVHATSAPLEEDVAP-TVYAARAA
MLBr_02158|M.leprae_Br4923 TVHVHVTEIRTRRYG---------AYEVHATFAPLVEDASPKRCTIAKAV
Mb1653c|M.bovis_AF2122/97 VAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDAA
Rv1627c|M.tuberculosis_H37Rv VAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDAA
MMAR_2430|M.marinum_M LDGVPSVRAVSTVTPRYPQHLPELPDIATDSTAVVPAPERVFKDQILDAA
MAB_2619|M.abscessus_ATCC_1997 VDGVPSVRAVATITPKYPQHLPELPDIATDSTAVVPAPERVFKDQIVDAA
MUL_4955|M.ulcerans_Agy99 LSARQRRRAVKVSAS-------VLTTDPYEPGCQVLPNVNTLTRNAAKTA
. . . . : .
MAV_1596|M.avium_104 FEKAGVAPQDVDVIQLQDTDAGA-EIIHMAECGFCADGEQEKLLADGVTE
MSMEG_2236|M.smegmatis_MC2_155 FEKAGVAPEDVDVIQLQDTDAGA-EIIHMAECGFCAHGDQEKLLADGATE
Mflv_4345|M.gilvum_PYR-GCK FEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGEQEKLIADGATE
Mvan_1999|M.vanbaalenii_PYR-1 FEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGDQEKLIADGATE
TH_0532|M.thermoresistible__bu YEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGEQEKLLAEGATE
MLBr_02158|M.leprae_Br4923 YRGRQASDLRTSTSPSCRTSVPAPEVIQMDETVLCADGEQEKLASW----
Mb1653c|M.bovis_AF2122/97 YAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGATT
Rv1627c|M.tuberculosis_H37Rv YAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGATT
MMAR_2430|M.marinum_M YTEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGATT
MAB_2619|M.abscessus_ATCC_1997 YAEAGIGPEDISLAEVYDLSTAL-ELDWYEHLGLCAKGEGEQLLRSGATT
MUL_4955|M.ulcerans_Agy99 YEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGAPW
: . . *: . :* .* :
MAV_1596|M.avium_104 ITGAMPINTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVAGEPRV
MSMEG_2236|M.smegmatis_MC2_155 IGGSLPVNTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVPGEPKV
Mflv_4345|M.gilvum_PYR-GCK IGGTMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGDPKV
Mvan_1999|M.vanbaalenii_PYR-1 IGGAMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGEPKV
TH_0532|M.thermoresistible__bu INGSLPINTDGGLIANGEPIGASGLRQIHELVRQLRGQAGDRQVPGNPKV
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 LGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AKV
Rv1627c|M.tuberculosis_H37Rv LGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AKV
MMAR_2430|M.marinum_M IGGRVPVNPSGGLACFGEAIPAQAIAQVCELNWQLRGQATGRQVEN-ARV
MAB_2619|M.abscessus_ATCC_1997 VGGRVPVNASGGLACFGEAIPAQAIAQVCELTWQLRGQAGDRQVEG-ARV
MUL_4955|M.ulcerans_Agy99 RHGSTPVNVSGGLQSKGHPIAATGIANVWEICHQLRGEAGDRQIDN-AKV
MAV_1596|M.avium_104 GFAQLYGAPGTAAATILTT---
MSMEG_2236|M.smegmatis_MC2_155 GFAQLYGAPGTAGATILTR---
Mflv_4345|M.gilvum_PYR-GCK GFAQLYGAPGTAGATILTT---
Mvan_1999|M.vanbaalenii_PYR-1 GFAQLYGAPGTAGATILTT---
TH_0532|M.thermoresistible__bu GFAQLYGAPGTAAATVLTT---
MLBr_02158|M.leprae_Br4923 ----------------------
Mb1653c|M.bovis_AF2122/97 GVTANQGLFGHGSSVIVAR---
Rv1627c|M.tuberculosis_H37Rv GVTANQGLFGHGSSVIVAR---
MMAR_2430|M.marinum_M GVTANQGLFGHGSSVIVAR---
MAB_2619|M.abscessus_ATCC_1997 GITANQGLFGNGSSVIVAR---
MUL_4955|M.ulcerans_Agy99 GLAHVIGLGSACGVHILERSAA