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HDVAIIGVGLHPFGRFEGKTAMHMGVDAITAAVADAGVSWNDIQFGVGGSWTVANPDAIVGMVGLSGIPF TNVFNACATAASATKACADGIRLGDYDIGIAVGLDKHPRGAFTEDPGLVGMPSWYAENGQYLTTQFFGMK ANRYLHEHGISHRTLAKVVNKNLRNGALNPNAFRRKPMDEDAILDSPMLNYPLTQYMFCSPDEGAAAVVM CRADIAHRYTNKPVFVRAVEVRTRKYGAYEVNTTFAPVDEDVAPTVYASRGAFEKAGIEPSDVDVIQLQD TDAGAEIIHMAEAGFCADGDQEKLIADGATEIGGAMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQA GDRQIPGEPKVGFAQLYGAPGTAGATILTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1999 | - | - | 100% (381) | thiolase |
| M. vanbaalenii PYR-1 | Mvan_4139 | - | e-168 | 72.75% (378) | thiolase |
| M. vanbaalenii PYR-1 | Mvan_3366 | - | 1e-45 | 32.07% (396) | lipid-transfer protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1653c | - | 1e-45 | 32.07% (396) | lipid-transfer protein |
| M. gilvum PYR-GCK | Mflv_4345 | - | 0.0 | 96.59% (381) | thiolase |
| M. tuberculosis H37Rv | Rv1627c | - | 1e-45 | 32.07% (396) | lipid-transfer protein |
| M. leprae Br4923 | MLBr_02158 | - | 6e-22 | 45.00% (120) | hypothetical protein MLBr_02158 |
| M. abscessus ATCC 19977 | MAB_2619 | - | 3e-48 | 33.08% (396) | lipid-transfer protein |
| M. marinum M | MMAR_0142 | ltp1_1 | 2e-43 | 30.90% (411) | lipid-transfer protein Ltp1_1 |
| M. avium 104 | MAV_1596 | - | 0.0 | 86.88% (381) | putative thiolase |
| M. smegmatis MC2 155 | MSMEG_2236 | - | 0.0 | 87.60% (379) | putative thiolase |
| M. thermoresistible (build 8) | TH_0532 | - | 1e-175 | 74.74% (380) | putative thiolase |
| M. ulcerans Agy99 | MUL_4955 | ltp1_1 | 6e-44 | 31.14% (411) | lipid-transfer protein Ltp1_1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1999|M.vanbaalenii_PYR-1 ------MHDVAIIGVGLHPFGRFEGKTAMHMGVDAITAAVADAGVSWNDI
Mflv_4345|M.gilvum_PYR-GCK ------MHDVAIIGVGLHPFGRFEGKTAMQMGVDAITAAVADAGVSWNDI
MAV_1596|M.avium_104 ------MNDVAIIGVGLHPFGRFEGKSAMEMAVDAIQLAVADAGVEWKDI
MSMEG_2236|M.smegmatis_MC2_155 -----MSHDVAIIGVGIHPFGRFEGKTAMQMGVDAIFAAVADAGVDWKDI
TH_0532|M.thermoresistible__bu ---MSNENSVAIIGVGLHPFGRFD-KTAMEMGAEAIAAALADAGLEWKDI
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 MRMS-APEPVYILGAGMHPWGKWG-NDFTEYGVVAARAALRDAGVDWRHV
Rv1627c|M.tuberculosis_H37Rv MRMS-APEPVYILGAGMHPWGKWG-NDFTEYGVVAARAALRDAGVDWRHV
MAB_2619|M.abscessus_ATCC_1997 --MSRTPDPVYILGAGMHPWGKWG-RDFTEYGVAAARTALQDAELDWRQI
MMAR_0142|M.marinum_M --MS-ASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMADI
MUL_4955|M.ulcerans_Agy99 --MS-ASDEIWILGIRMTKFGKHPDLDTVDLAAQAAMSALDDAGVSMADI
Mvan_1999|M.vanbaalenii_PYR-1 QFGVGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKAC
Mflv_4345|M.gilvum_PYR-GCK QFGVGGSWTVANPD------AIVGMLGLSGIPFTNVFNACATAASATKTC
MAV_1596|M.avium_104 QAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASAAKAC
MSMEG_2236|M.smegmatis_MC2_155 GAATGGSWTVANPD------AIVGMVGLSGIPFTNVFNACATAASATKVC
TH_0532|M.thermoresistible__bu QFGYGGSYEISNPD------AVTRLVGLTGITFTNVFNACATAASAIQET
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
Rv1627c|M.tuberculosis_H37Rv QLVAGADTIRNGYPGFVAGATFAQKLGWTGVPVSSSYAACASGSQALQSA
MAB_2619|M.abscessus_ATCC_1997 QFVAGADTIRNGYPGFIAGSTFAQKLGWNGVPISSTYAACASGSQALQSA
MMAR_0142|M.marinum_M GVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALRTA
MUL_4955|M.ulcerans_Agy99 GVLAAGNLMAANAG---IGQQLQKQIGQTGIPVYNVANACATGATALRTA
Mvan_1999|M.vanbaalenii_PYR-1 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
Mflv_4345|M.gilvum_PYR-GCK ADGIRLGDYDIGIAVGLDKHPRGAFTEDPG-LVGMPSWYAENGQYLTTQF
MAV_1596|M.avium_104 ADGIRLGDYDIGIAIGLDKHPRGAFTEDPA-LVGMPRWYAENGQYLTTQF
MSMEG_2236|M.smegmatis_MC2_155 ADGIRLGDYDIGIAVGLDKHPRGAFTEDPA-LVGMPKWYAENGQYLTTQF
TH_0532|M.thermoresistible__bu ADTIRLGKYDIGIAIGMDKHPRGAFTDDPA-KLALPQWYAQNGQFVTTKF
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
Rv1627c|M.tuberculosis_H37Rv RAQILAGFCDVALVIGADTTPKGFFAPVGGERKGDPD-WQRFHLIGATNT
MAB_2619|M.abscessus_ATCC_1997 RAQILAGFCDVALVIGADTTPKGFFAPVGGERKADPD-WQRFHLIGATNP
MMAR_0142|M.marinum_M IMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAVAP
MUL_4955|M.ulcerans_Agy99 IMAVKAGEVDYGMAVGVEKLSGAGLLGGGGKKKSDADVWTPAGRYGAVAP
Mvan_1999|M.vanbaalenii_PYR-1 FG-------------MKANRYLHEHG-ISHRTLAKVVNKNLRNGALNPNA
Mflv_4345|M.gilvum_PYR-GCK FG-------------MKANRYLHTHH-VSHRTLAKVVNKNLRNGALNPNA
MAV_1596|M.avium_104 FG-------------MKANRYLHQHG-ISQRTLAKVAAKNFRNGARNPNA
MSMEG_2236|M.smegmatis_MC2_155 FG-------------MKANRYLHDHN-ISRRTLARVAAKNFRNGALNPNA
TH_0532|M.thermoresistible__bu FG-------------MKANRYLHDHG-ISQETLARVANKNFRNGSLNPNA
MLBr_02158|M.leprae_Br4923 --------------------------------MCSVASRFLRTRS-----
Mb1653c|M.bovis_AF2122/97 VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
Rv1627c|M.tuberculosis_H37Rv VY-----------FALLARRRMDLYG-ATVEDFAQVKVKNSRHGLDNPNA
MAB_2619|M.abscessus_ATCC_1997 VY-----------FALLARRRMDLFG-ATVEDFAQVKVKNSRHGLNNPNA
MMAR_0142|M.marinum_M VDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNPLA
MUL_4955|M.ulcerans_Agy99 VDGRIGTETMPGVFAQIGTEYGHKYGGTSFELFAKISEKNHAHSTLNPLA
:. : :
Mvan_1999|M.vanbaalenii_PYR-1 FRRKPMDEDAILDSPMLNYPLTQYMFCSPDEGAAAVVMCR-ADIAHRYTN
Mflv_4345|M.gilvum_PYR-GCK FRRKPMDEDAILNSPMLNYPLTQYMFCSPDEGAAAVVMCR-ADLAHKYTN
MAV_1596|M.avium_104 FRRKPIPEDEILNSPMLNYPLTQYMFCAPDEGAAAVVMCR-ADIAHRYSA
MSMEG_2236|M.smegmatis_MC2_155 FRRKPISEDDILNSTMLNYPLTQYMFCAPDEGAAAVVMCR-ADIAHRYTD
TH_0532|M.thermoresistible__bu FRRKEISVEDILNSPVLNYPLTQYMFCAPDEGAAAVIMCR-GDIAHRFTD
MLBr_02158|M.leprae_Br4923 --------------------LTQCMFCALNKGAFAVIVCL-GDIAHKFTD
Mb1653c|M.bovis_AF2122/97 RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVAS-KSFTEKHLG
Rv1627c|M.tuberculosis_H37Rv RYRKENSIDDVLASPVVSDPLRLLDICATSDGAAALIVAS-KSFTEKHLG
MAB_2619|M.abscessus_ATCC_1997 RFRKESSVADVLASPVVSDPLRLLDICATSDGAAALIVAS-ADFAKKHLG
MMAR_0142|M.marinum_M AYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNGETLKSLSAR
MUL_4955|M.ulcerans_Agy99 AYQKRFTLEQIMNDVMIAYPNTRPMCSANCDGAAAAIVCNGETLKSLSAR
.: .** * ::. :
Mvan_1999|M.vanbaalenii_PYR-1 KPVFVRAVEVRTRKYGAYEVNTTFAPVDEDVAP-TVYASR---------G
Mflv_4345|M.gilvum_PYR-GCK KPVFVRAVEVRTRKYGAYEVNTTFAPVDEDVAP-TVYASR---------A
MAV_1596|M.avium_104 KPVYLRAVEVRTRRYGAYEVNTTFAPVDEDVAP-TVYAAR---------A
MSMEG_2236|M.smegmatis_MC2_155 KPVYLKAVEVRTRRYGAYEVNTTCAPVEEDVAP-TVYAAR---------A
TH_0532|M.thermoresistible__bu KPVYVRASEIRTRRYGAYEVHATSAPLEEDVAP-TVYAAR---------A
MLBr_02158|M.leprae_Br4923 KTVHVHVTEIRTRRYGAYEVHATFAPLVEDASPKRCTIAK---------A
Mb1653c|M.bovis_AF2122/97 SVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDA
Rv1627c|M.tuberculosis_H37Rv SVAGVPSVRAISTVTPKYPQHLPELPDIATDSTAAVPAPERVFKDQILDA
MAB_2619|M.abscessus_ATCC_1997 SVDGVPSVRAVATITPKYPQHLPELPDIATDSTAVVPAPERVFKDQIVDA
MMAR_0142|M.marinum_M QRRRAVKVSASVLTTDPYEPGCQVLPNVNTLTRNAAKT------------
MUL_4955|M.ulcerans_Agy99 QRRRAVKVSASVLTTDPYEPGCQVLPNVNTLTRNAAKT------------
. * * :
Mvan_1999|M.vanbaalenii_PYR-1 AFEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGDQEKLIADGAT
Mflv_4345|M.gilvum_PYR-GCK AFEKAGIEPSDVDVIQLQDTDAGA-EIIHMAEAGFCADGEQEKLIADGAT
MAV_1596|M.avium_104 AFEKAGVAPQDVDVIQLQDTDAGA-EIIHMAECGFCADGEQEKLLADGVT
MSMEG_2236|M.smegmatis_MC2_155 AFEKAGVAPEDVDVIQLQDTDAGA-EIIHMAECGFCAHGDQEKLLADGAT
TH_0532|M.thermoresistible__bu AYEAAGIGPEDVDIAQLQDTDAGA-EVIHMAETGLCADGEQEKLLAEGAT
MLBr_02158|M.leprae_Br4923 VYRGRQASDLRTSTSPSCRTSVPAPEVIQMDETVLCADGEQEKLASW---
Mb1653c|M.bovis_AF2122/97 AYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGAT
Rv1627c|M.tuberculosis_H37Rv AYAEAGIGPEDLSLAEVYDLSTAL-ELDWYEHLGLCPKGEAEALLRSGAT
MAB_2619|M.abscessus_ATCC_1997 AYAEAGIGPEDISLAEVYDLSTAL-ELDWYEHLGLCAKGEGEQLLRSGAT
MMAR_0142|M.marinum_M AYEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGAP
MUL_4955|M.ulcerans_Agy99 AYEQAGVGPSDLDLVELHDCFATA-ELVHYDNLMLCEQGGAADFFESGAP
.: . . *: . :* .* :
Mvan_1999|M.vanbaalenii_PYR-1 EIGGAMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGEPK
Mflv_4345|M.gilvum_PYR-GCK EIGGTMPVNTDGGLLANGEPIGASGLRQLHEIVRQLRGQAGDRQIPGDPK
MAV_1596|M.avium_104 EITGAMPINTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVAGEPR
MSMEG_2236|M.smegmatis_MC2_155 EIGGSLPVNTDGGLIANGEPIGASGLRQIHELVRQLRGEAGDRQVPGEPK
TH_0532|M.thermoresistible__bu EINGSLPINTDGGLIANGEPIGASGLRQIHELVRQLRGQAGDRQVPGNPK
MLBr_02158|M.leprae_Br4923 --------------------------------------------------
Mb1653c|M.bovis_AF2122/97 TLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AK
Rv1627c|M.tuberculosis_H37Rv TLGGRVPVNPSGGLACFGEAIPAQAIAQVCELTWQLRGQATGRQVAD-AK
MAB_2619|M.abscessus_ATCC_1997 TVGGRVPVNASGGLACFGEAIPAQAIAQVCELTWQLRGQAGDRQVEG-AR
MMAR_0142|M.marinum_M WRDGSTPVNVSGGLQSKGHPIAATGIANVWEICHHLRGEAGDRQIDN-AK
MUL_4955|M.ulcerans_Agy99 WRHGSTPVNVSGGLQSKGHPIAATGIANVWEICHQLRGEAGDRQIDN-AK
Mvan_1999|M.vanbaalenii_PYR-1 VGFAQLYGAPGTAGATILTT---
Mflv_4345|M.gilvum_PYR-GCK VGFAQLYGAPGTAGATILTT---
MAV_1596|M.avium_104 VGFAQLYGAPGTAAATILTT---
MSMEG_2236|M.smegmatis_MC2_155 VGFAQLYGAPGTAGATILTR---
TH_0532|M.thermoresistible__bu VGFAQLYGAPGTAAATVLTT---
MLBr_02158|M.leprae_Br4923 -----------------------
Mb1653c|M.bovis_AF2122/97 VGVTANQGLFGHGSSVIVAR---
Rv1627c|M.tuberculosis_H37Rv VGVTANQGLFGHGSSVIVAR---
MAB_2619|M.abscessus_ATCC_1997 VGITANQGLFGNGSSVIVAR---
MMAR_0142|M.marinum_M VGLAHVIGLGSACGVHILERSAA
MUL_4955|M.ulcerans_Agy99 VGLAHVIGLGSACGVHILERSAA