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TAAHEVITTVVDHGSWTSWDSPVTDEDLDPVYARDLAHARAVTGLDEAVITGAAYVQGHRIALLACDFRF LGGSIGIAAGERLTAAIRRATAEKLPLLALPTSGGTRMQEGAAAFLQMVKITAAVVDHKAAHLPYLVYLR HPTTGGVFASWGSLGHITFAEPGAMIGFLGPRVYQALYDAPFPEGVQTAENLEACGLIDGVLPLDRLPEV VDRALSVMMRARRTTQAPATAKVSVGVDVPAWQSVCASRREDRPGVRELLHHAAGDVLALSGTGQGETDP GLLLALARFGHLPCVVLGQDRRGQTPQTPLGPGALRQARRGMRLAADLDLPLVTVIDTAGAALSKEAEEG GLAGEIARCIAEMVSLPVPTVSVLLGQGTGGGALALVPADRVLAAQHGWLSPLPPEGASAILHRDTAHAA EMAEQQGVRSTDLFEHGLVDRIIAEHPDAASEPEMFSRRTGAAIQAELWALTGEDPARRLAERARRFDRI GRRHHLLAQAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2169 | accD | - | 100% (502) | acetyl-CoA carboxylase, carboxyl transferase, beta subunit |
| M. smegmatis MC2 155 | MSMEG_5642 | - | e-166 | 64.52% (482) | acetyl-coenzyme a carboxylase carboxyl transferase |
| M. smegmatis MC2 155 | MSMEG_4329 | - | 1e-09 | 23.02% (417) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0928c | accD3 | 1e-165 | 63.69% (482) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_1754 | - | 1e-159 | 62.24% (482) | carboxyl transferase |
| M. tuberculosis H37Rv | Rv0904c | accD3 | 1e-165 | 63.69% (482) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. leprae Br4923 | MLBr_01657 | - | 7e-10 | 21.55% (478) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_1876c | - | 8e-11 | 23.83% (428) | propionyl-CoA carboxylase beta chain 6 |
| M. marinum M | MMAR_4626 | accD3 | 1e-162 | 62.45% (482) | acetyl-coenzyme A carboxylase carboxyl transferase (subunit |
| M. avium 104 | MAV_2190 | - | 3e-12 | 23.50% (468) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_0091 | accD3 | 1e-162 | 62.37% (489) | PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE |
| M. ulcerans Agy99 | MUL_0237 | accD3 | 1e-161 | 62.24% (482) | acetyl-coenzyme a carboxylase carboxyl transferase (subunit |
| M. vanbaalenii PYR-1 | Mvan_4993 | - | 1e-161 | 62.66% (482) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0928c|M.bovis_AF2122/97 MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADE
Rv0904c|M.tuberculosis_H37Rv MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADE
MMAR_4626|M.marinum_M MSRITTDQLRDAVLDEGSFISWDTPPLEVPISESYARDLADARAATGRDE
MUL_0237|M.ulcerans_Agy99 MSRITTDQLRDAVLDEDSFISWDTPPLEVPISESYARDLADVRAATGRDE
Mflv_1754|M.gilvum_PYR-GCK MSRIGALALRDAVLDEGSFLSWDRPPIPVVTSAEYRAELAAAADATGLDE
Mvan_4993|M.vanbaalenii_PYR-1 MSRIRALALRDALLDEGSFVSWDGPPLAVPTSAEYRRELAEAEAATGLDE
TH_0091|M.thermoresistible__bu MSRIGAVQFVETVLDTGSFVSWDDPPLAIPADEDYRRELTDAAAVTGLDE
MSMEG_2169|M.smegmatis_MC2_155 MT--AAHEVITTVVDHGSWTSWDSPVTDEDLDPVYARDLAHARAVTGLDE
MLBr_01657|M.leprae_Br4923 MTITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATG---
MAV_2190|M.avium_104 MTITAPETVGESLDPRDPLLRLSNFFDDGSVALLHERDRSGVLAAAG---
MAB_1876c|M.abscessus_ATCC_199 MTILAPEAIDESLDPRDPLLRLNTFFDDGSVELLHERDRSGVLAAAG---
*: . . :: .. . : : : . .:*
Mb0928c|M.bovis_AF2122/97 SVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPL
Rv0904c|M.tuberculosis_H37Rv SVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPL
MMAR_4626|M.marinum_M SVLTGEGRVLGRRVAVVVCEFDFLAGSIGVAAAERITAAVERATRQRLPL
MUL_0237|M.ulcerans_Agy99 SVLTGEGRVLGRRVAVVACEFDFLAGSIGVAAAERITAAMERATSQRLPL
Mflv_1754|M.gilvum_PYR-GCK SVVTGEGRVFGRRVALIACEFDFLAGSIGVAAAERITAAVQRATAEGLPL
Mvan_4993|M.vanbaalenii_PYR-1 SVLTGEGRVFGRRVALIACEFDFLAGSIGVAAAERIIAAVQKATAERLPL
TH_0091|M.thermoresistible__bu AVLTGEGTIFGRRVALVACEFDFLAGSIGVAAAERIVAAVQRATAERLPL
MSMEG_2169|M.smegmatis_MC2_155 AVITGAAYVQGHRIALLACDFRFLGGSIGIAAGERLTAAIRRATAEKLPL
MLBr_01657|M.leprae_Br4923 -------TVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAYDTAIEEQSPI
MAV_2190|M.avium_104 -------TVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAYDTAIEEQSPI
MAB_1876c|M.abscessus_ATCC_199 -------TVNGVRTIAFCTDGTVMGGAMGVEGCRHIVNAYDTAIEEQSPI
: * * . : .:.*::*: . :: * * : *:
Mb0928c|M.bovis_AF2122/97 LASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGV
Rv0904c|M.tuberculosis_H37Rv LASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGV
MMAR_4626|M.marinum_M LASPSSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGV
MUL_0237|M.ulcerans_Agy99 LASPSSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGV
Mflv_1754|M.gilvum_PYR-GCK LASPSSGGTRMQEGTVAFLQMVKIAAAVELHKKGNLPYLVYLRHPTTGGV
Mvan_4993|M.vanbaalenii_PYR-1 LASPSSGGTRMQEGTVAFLQMVKIAAAVELHKKAHLPYLVYLRHPTTGGV
TH_0091|M.thermoresistible__bu VASPSSGGTRMQEGTVAFLQMVKIAAAVQLHKLAHLSYLVYLRHPTTGGV
MSMEG_2169|M.smegmatis_MC2_155 LALPTSGGTRMQEGAAAFLQMVKITAAVVDHKAAHLPYLVYLRHPTTGGV
MLBr_01657|M.leprae_Br4923 VGIWHSGGARLAEG-VRALHAVGQVFEAMIRASGYIPQISVVVGFAAGG-
MAV_2190|M.avium_104 VGIWHSGGARLAEG-VKALHAVGLVFEAMIRASGYIPQISVVVGFAAGG-
MAB_1876c|M.abscessus_ATCC_199 VGIWHSGGARLAEG-VKALHAVGLVFEAMIRASGYIPQISVVVGFAAGG-
:. ***:*: ** . *: * . : . :. : : ::**
Mb0928c|M.bovis_AF2122/97 FASWG-SLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHG
Rv0904c|M.tuberculosis_H37Rv FASWG-SLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHG
MMAR_4626|M.marinum_M FASWG-SLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGIQTAENLQRHG
MUL_0237|M.ulcerans_Agy99 FASWG-SLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGVQTAENLQRHG
Mflv_1754|M.gilvum_PYR-GCK FASWG-SLGHVTAAEPDALIGFLGPRVYEHLYGERFPSGVQTSENLQRHG
Mvan_4993|M.vanbaalenii_PYR-1 FASWG-SLGHVTAAEPGALIGFLGPRVYEHLYGEPFPAGIQTAENLHRHG
TH_0091|M.thermoresistible__bu FASWG-SLGHITIAEPNALIGFLGPRVYQHLYGEPFPPGVQTAENLHRHG
MSMEG_2169|M.smegmatis_MC2_155 FASWG-SLGHITFAEPGAMIGFLGPRVYQALYDAPFPEGVQTAENLEACG
MLBr_01657|M.leprae_Br4923 -AAYGPALTDVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGGPETHHKK
MAV_2190|M.avium_104 -AAYGPALTDVVVMAPESRVFVTGPDVVRSVTGEDVDMASLGGPETHHKK
MAB_1876c|M.abscessus_ATCC_199 -AAYGPALTDVIIMAPESRVFVTGPDVVRSVTGEDVDMATLGGPDAHHKK
*::* :* .: * . : . ** * . : . . . . : .
Mb0928c|M.bovis_AF2122/97 IIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPA--PVPDVPTWDSVV
Rv0904c|M.tuberculosis_H37Rv IIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPA--PVPDVPTWDSVV
MMAR_4626|M.marinum_M VIDGVVTLDELRRTLDRALTVLTDAPAPAPAAPAPT--AIPDVPAWTSVL
MUL_0237|M.ulcerans_Agy99 VIDGVVTLDELRRTLDRALTVLTDAPAPAPAAPAPP--AIPDVAAWTSVL
Mflv_1754|M.gilvum_PYR-GCK VIDAVVPLEVLRATVDRTLKVVADAPGPPPAAPEPE--VLPDIPAWDSVE
Mvan_4993|M.vanbaalenii_PYR-1 VVDAVIPPGILRATLDRALRVVSDAPDVPPAAPDAE--PLPDVPAWESVE
TH_0091|M.thermoresistible__bu VIDSVVPLPRLRSELDRALRVLVDEPGTPPAPPDVDT-SQPDVPAWDSVI
MSMEG_2169|M.smegmatis_MC2_155 LIDGVLPLDRLPEVVDRALSVMMRARRTTQAPATAKVSVGVDVPAWQSVC
MLBr_01657|M.leprae_Br4923 SGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPES
MAV_2190|M.avium_104 SGVCHIVADDELDAYERGRRLVGLFCQQGHFDRTKAEAGDTDIHALLPES
MAB_1876c|M.abscessus_ATCC_199 SGVCHIVADDELDAYARGRKLVGFFCQQGVFDRGRAEADHTDLRALLPES
: * :: :: : .
Mb0928c|M.bovis_AF2122/97 ASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAAT-TLLALARFGGQPTVV
Rv0904c|M.tuberculosis_H37Rv ASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAAT-TLLALARFGGQPTVV
MMAR_4626|M.marinum_M ASRRPDRPGVEHLLRYGATDRVLLSGTGYGDAAT-TLLALARMAGQPMVV
MUL_0237|M.ulcerans_Agy99 ASRRPDRPGVEHLLRYGATDRVLLSGTGYGDAAT-TLLALARMAGQPMVV
Mflv_1754|M.gilvum_PYR-GCK ISRRPDRPGVSFLLRHGATERVLLSGTGQGESAT-MMLALARFGNQPAVV
Mvan_4993|M.vanbaalenii_PYR-1 ISRRPDRPGVSALLRYGTTDRVLLSGTGQGEAAT-TLLALARFGGQPAVV
TH_0091|M.thermoresistible__bu ASRRPDRPGVGYLLRHGATDTVLLSGSGGGEAAT-TLLALARFGGQPAVV
MSMEG_2169|M.smegmatis_MC2_155 ASRREDRPGVRELLHHAAGDVLALSGTGQGETDPGLLLALARFGHLPCVV
MLBr_01657|M.leprae_Br4923 SRRAYDVHPVVTAILDENTPFDEFQAN----WAPSMVVGLGRLSGRTVGV
MAV_2190|M.avium_104 ARRAYDVRPIVTAILDDETPFDEFQAN----WAPSMVIGLGRLSGRTVGV
MAB_1876c|M.abscessus_ATCC_199 AKRAYDVHPIVNALLDGDDPFEEFQGK----WAPSMVIGLGRLAGRTVGV
* * : : :... . ::.*.*:. . *
Mb0928c|M.bovis_AF2122/97 LGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAA
Rv0904c|M.tuberculosis_H37Rv LGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAA
MMAR_4626|M.marinum_M LGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPALSAD
MUL_0237|M.ulcerans_Agy99 LGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPALSAD
Mflv_1754|M.gilvum_PYR-GCK LGQQ-RVVGG--LVGPAALREARRGMALAASLKLPLVLVIDTAGPALSTE
Mvan_4993|M.vanbaalenii_PYR-1 LGQQ-RVVGG--LVGPAALREARRGMALAAGLKLPLVLVIDTAGPALSTE
TH_0091|M.thermoresistible__bu LGQQ-RVIGA--MVGPAALREARRGMALAADLQLPLVLVIDTAGPALTAE
MSMEG_2169|M.smegmatis_MC2_155 LGQDRRGQTPQTPLGPGALRQARRGMRLAADLDLPLVTVIDTAGAALSKE
MLBr_01657|M.leprae_Br4923 LANNPLRLGG--CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVD
MAV_2190|M.avium_104 LANNPLRLGG--CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVD
MAB_1876c|M.abscessus_ATCC_199 LANNPLRLGG--CLNSESAEKAARFVRLCNAFGIPLIVLVDVPGYLPGVG
*.:: :.. : .:* * : *. : :**: ::*..*
Mb0928c|M.bovis_AF2122/97 AEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----ADRV
Rv0904c|M.tuberculosis_H37Rv AEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----ADRV
MMAR_4626|M.marinum_M AEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----ADRV
MUL_0237|M.ulcerans_Agy99 AEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----ADRV
Mflv_1754|M.gilvum_PYR-GCK AEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----ADRV
Mvan_4993|M.vanbaalenii_PYR-1 AEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----ADRV
TH_0091|M.thermoresistible__bu AEQGGLASEIAHCLAELVTLDTATLSVLLGQGSGGPALAMVP----ADRV
MSMEG_2169|M.smegmatis_MC2_155 AEEGGLAGEIARCIAEMVSLPVPTVSVLLGQGTGGGALALVP----ADRV
MLBr_01657|M.leprae_Br4923 QEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKV
MAV_2190|M.avium_104 QEWGGVVRRGAKLLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLNATKV
MAB_1876c|M.abscessus_ATCC_199 QEWGGVVRRGAKLLHAFGEATVPRVTLVTRKIYGGAYIAMNSRSLGATKV
* **:. . *: : : .. :::: : ** :*: . * :*
Mb0928c|M.bovis_AF2122/97 LAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTI
Rv0904c|M.tuberculosis_H37Rv LAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTI
MMAR_4626|M.marinum_M LAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIVDVI
MUL_0237|M.ulcerans_Agy99 LAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIVDVI
Mflv_1754|M.gilvum_PYR-GCK LAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSVDLLRDGIVDAV
Mvan_4993|M.vanbaalenii_PYR-1 LAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSADLLRNGIVDAI
TH_0091|M.thermoresistible__bu LAARHGWLAPLPPEGVSAIVHRDLDHAPELAARQGIRSVDLLRHGIVDAI
MSMEG_2169|M.smegmatis_MC2_155 LAAQHGWLSPLPPEGASAILHRDTAHAAEMAEQQGVRSTDLFEHGLVDRI
MLBr_01657|M.leprae_Br4923 FAWPDAEVAVMGAKAAVGILHKRKLAAAPNDEREALHDDLAAEHERIAGG
MAV_2190|M.avium_104 FAWPDAEVAVMGAKAAVGILHKKKLAAAPEHEREALHDQLAAEHEKIAGG
MAB_1876c|M.abscessus_ATCC_199 FAWPDAEVAVMGAKAAVGILHKKQLAAAAPEEREALHEELALEHERIAGG
:* .. :: : .:.. .*:.: *. :.::. :
Mb0928c|M.bovis_AF2122/97 VPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIG-
Rv0904c|M.tuberculosis_H37Rv VPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIG-
MMAR_4626|M.marinum_M VPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRSIG-
MUL_0237|M.ulcerans_Agy99 VPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRSIG-
Mflv_1754|M.gilvum_PYR-GCK VPEHPDAADEPRAFVERLSATIAVELHRLRFAPEAERSASRLERYRRIG-
Mvan_4993|M.vanbaalenii_PYR-1 VPEHPDAADEPQAFTQRLSATIAVELHRLRTVPDEQRLAARLERYRRIG-
TH_0091|M.thermoresistible__bu VDERPDAADEPMEFTARLADSIAVELHRLREMPAESRLETRLARYRRIG-
MSMEG_2169|M.smegmatis_MC2_155 IAEHPDAASEPEMFSRRTGAAIQAELWALTGEDPARRLAERARRFDRIGR
MLBr_01657|M.leprae_Br4923 VDSAIDIG--------VVDEKINPAHTRSKLTEALAQSPVRRGRHKNIP-
MAV_2190|M.avium_104 VDSAIEIG--------VVDEKIDPAHTRSKLTEALAQAPARRGRHKNIP-
MAB_1876c|M.abscessus_ATCC_199 VDRAIEIG--------VVDEEIEPSQTRAVLTRALAEAPSRRGRHKNIP-
: : . * . * *. *
Mb0928c|M.bovis_AF2122/97 ----LPRD-
Rv0904c|M.tuberculosis_H37Rv ----LPRD-
MMAR_4626|M.marinum_M ----LPRDR
MUL_0237|M.ulcerans_Agy99 ----LPRDR
Mflv_1754|M.gilvum_PYR-GCK ----LA---
Mvan_4993|M.vanbaalenii_PYR-1 ----LP---
TH_0091|M.thermoresistible__bu ----LPR--
MSMEG_2169|M.smegmatis_MC2_155 RHHLLAQAG
MLBr_01657|M.leprae_Br4923 ----L----
MAV_2190|M.avium_104 ----L----
MAB_1876c|M.abscessus_ATCC_199 ----L----
*