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SRIGALALRDAVLDEGSFLSWDRPPIPVVTSAEYRAELAAAADATGLDESVVTGEGRVFGRRVALIACEF DFLAGSIGVAAAERITAAVQRATAEGLPLLASPSSGGTRMQEGTVAFLQMVKIAAAVELHKKGNLPYLVY LRHPTTGGVFASWGSLGHVTAAEPDALIGFLGPRVYEHLYGERFPSGVQTSENLQRHGVIDAVVPLEVLR ATVDRTLKVVADAPGPPPAAPEPEVLPDIPAWDSVEISRRPDRPGVSFLLRHGATERVLLSGTGQGESAT MMLALARFGNQPAVVLGQQRVVGGLVGPAALREARRGMALAASLKLPLVLVIDTAGPALSTEAEEGGLAG EIARCLAELVTLDTPTVSVLLGQGSGGPALAMVPADRVLAALHGWLAPLPPEGASAIVFRDVDHAPELAA AQGIRSVDLLRDGIVDAVVPEHPDAADEPRAFVERLSATIAVELHRLRFAPEAERSASRLERYRRIGLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1754 | - | - | 100% (490) | carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_4774 | - | 2e-15 | 24.22% (483) | carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_1170 | - | 2e-14 | 23.93% (397) | carboxyl transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0928c | accD3 | 0.0 | 76.83% (492) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. tuberculosis H37Rv | Rv0904c | accD3 | 0.0 | 76.83% (492) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. leprae Br4923 | MLBr_00731 | accD5 | 6e-16 | 23.14% (471) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 1e-16 | 24.34% (419) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_4626 | accD3 | 0.0 | 76.07% (489) | acetyl-coenzyme A carboxylase carboxyl transferase (subunit |
| M. avium 104 | MAV_4250 | - | 1e-13 | 23.03% (482) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_5642 | - | 0.0 | 83.03% (489) | acetyl-coenzyme a carboxylase carboxyl transferase |
| M. thermoresistible (build 8) | TH_0091 | accD3 | 0.0 | 76.94% (490) | PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE |
| M. ulcerans Agy99 | MUL_0237 | accD3 | 0.0 | 75.66% (489) | acetyl-coenzyme a carboxylase carboxyl transferase (subunit |
| M. vanbaalenii PYR-1 | Mvan_4993 | - | 0.0 | 87.53% (489) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0928c|M.bovis_AF2122/97 -------------------MSRITTDQLRHAVLDRGSFVSWDSEPLAVPV
Rv0904c|M.tuberculosis_H37Rv -------------------MSRITTDQLRHAVLDRGSFVSWDSEPLAVPV
MMAR_4626|M.marinum_M -------------------MSRITTDQLRDAVLDEGSFISWDTPPLEVPI
MUL_0237|M.ulcerans_Agy99 -------------------MSRITTDQLRDAVLDEDSFISWDTPPLEVPI
Mflv_1754|M.gilvum_PYR-GCK -------------------MSRIGALALRDAVLDEGSFLSWDRPPIPVVT
Mvan_4993|M.vanbaalenii_PYR-1 -------------------MSRIRALALRDALLDEGSFVSWDGPPLAVPT
MSMEG_5642|M.smegmatis_MC2_155 -------------------MSRIGALALRDAVLDEGSFRSWDTAPLDVGA
TH_0091|M.thermoresistible__bu -------------------MSRIGAVQFVETVLDTGSFVSWDDPPLAIPA
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
MAV_4250|M.avium_104 MTSVTDHTA---EPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEK
MAB_0181|M.abscessus_ATCC_1997 -------------------MPPHTTAEKLADLRERIALTREPGDAKAIAR
: : : . .
Mb0928c|M.bovis_AF2122/97 ADSYARELAAARAATGAD---------------------------ESVQT
Rv0904c|M.tuberculosis_H37Rv ADSYARELAAARAATGAD---------------------------ESVQT
MMAR_4626|M.marinum_M SESYARDLADARAATGRD---------------------------ESVLT
MUL_0237|M.ulcerans_Agy99 SESYARDLADVRAATGRD---------------------------ESVLT
Mflv_1754|M.gilvum_PYR-GCK SAEYRAELAAAADATGLD---------------------------ESVVT
Mvan_4993|M.vanbaalenii_PYR-1 SAEYRRELAEAEAATGLD---------------------------ESVLT
MSMEG_5642|M.smegmatis_MC2_155 DDEYRRELAEASAKTGLD---------------------------ESVLT
TH_0091|M.thermoresistible__bu DEDYRRELTDAAAVTGLD---------------------------EAVLT
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVT
MAV_4250|M.avium_104 VHAKGKLTARERILALLDEDSFVELDALARHRSKNFGLENNRPLGDGVIT
MAB_0181|M.abscessus_ATCC_1997 RDKKGIPSARARIDALLDKGSFLELDAFARTPG-----DANAPYTDGVVT
: : * :.* *
Mb0928c|M.bovis_AF2122/97 GEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASP
Rv0904c|M.tuberculosis_H37Rv GEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASP
MMAR_4626|M.marinum_M GEGRVLGRRVAVVVCEFDFLAGSIGVAAAERITAAVERATRQRLPLLASP
MUL_0237|M.ulcerans_Agy99 GEGRVLGRRVAVVACEFDFLAGSIGVAAAERITAAMERATSQRLPLLASP
Mflv_1754|M.gilvum_PYR-GCK GEGRVFGRRVALIACEFDFLAGSIGVAAAERITAAVQRATAEGLPLLASP
Mvan_4993|M.vanbaalenii_PYR-1 GEGRVFGRRVALIACEFDFLAGSIGVAAAERIIAAVQKATAERLPLLASP
MSMEG_5642|M.smegmatis_MC2_155 GEGTVFGRRVAVVACEFDFLAGSIGVAAAERITAAVQRATAERLPLLASP
TH_0091|M.thermoresistible__bu GEGTIFGRRVALVACEFDFLAGSIGVAAAERIVAAVQRATAERLPLVASP
MLBr_00731|M.leprae_Br4923 GYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MAV_4250|M.avium_104 GYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MAB_0181|M.abscessus_ATCC_1997 GLGRIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGIN
* * : ** *.:. : . **:* ..:: : * *::.
Mb0928c|M.bovis_AF2122/97 SSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASW
Rv0904c|M.tuberculosis_H37Rv SSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASW
MMAR_4626|M.marinum_M SSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASW
MUL_0237|M.ulcerans_Agy99 SSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASW
Mflv_1754|M.gilvum_PYR-GCK SSGGTRMQEGTVAFLQMVKIAAAVELHKKGNLPYLVYLRHPTTGGVFASW
Mvan_4993|M.vanbaalenii_PYR-1 SSGGTRMQEGTVAFLQMVKIAAAVELHKKAHLPYLVYLRHPTTGGVFASW
MSMEG_5642|M.smegmatis_MC2_155 SSGGTRMQEGTVAFLQMVKIAAAVELHKQAHLPYLVYLRHPTTGGVFASW
TH_0091|M.thermoresistible__bu SSGGTRMQEGTVAFLQMVKIAAAVQLHKLAHLSYLVYLRHPTTGGVFASW
MLBr_00731|M.leprae_Br4923 DGAGARIQEGVVSLGLYSRIFRNNILAS-GVIPQISLIMGAAAGGHVYSP
MAV_4250|M.avium_104 DGAGARIQEGVVSLGLYSRIFRNNILAS-GVIPQISLIMGAAAGGHVYSP
MAB_0181|M.abscessus_ATCC_1997 DSAGARIQDTATSLAWYAELGRRHELLR-GTVPEISIILGKCAGGAVYSP
...*:*:*: ..:: .: * . :. : : :** . *
Mb0928c|M.bovis_AF2122/97 GSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGV
Rv0904c|M.tuberculosis_H37Rv GSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGV
MMAR_4626|M.marinum_M GSLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGIQTAENLQRHGVIDGV
MUL_0237|M.ulcerans_Agy99 GSLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGVQTAENLQRHGVIDGV
Mflv_1754|M.gilvum_PYR-GCK GSLGHVTAAEPDALIGFLGPRVYEHLYGERFPSGVQTSENLQRHGVIDAV
Mvan_4993|M.vanbaalenii_PYR-1 GSLGHVTAAEPGALIGFLGPRVYEHLYGEPFPAGIQTAENLHRHGVVDAV
MSMEG_5642|M.smegmatis_MC2_155 GSLGHVTAAEPGALIGFLGPRVYEHLYGEPFPSGVQTAENLHAHGVIDGV
TH_0091|M.thermoresistible__bu GSLGHITIAEPNALIGFLGPRVYQHLYGEPFPPGVQTAENLHRHGVIDSV
MLBr_00731|M.leprae_Br4923 ALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAH
MAV_4250|M.avium_104 ALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTLH
MAB_0181|M.abscessus_ATCC_1997 IQTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQR-GNIH
. :. . . : : ** * : : .: .. . . :
Mb0928c|M.bovis_AF2122/97 VALDRLRPMLDRALTVLIDAPEP----------LPAPQTPA-PVPDVPTW
Rv0904c|M.tuberculosis_H37Rv VALDRLRPMLDRALTVLIDAPEP----------LPAPQTPA-PVPDVPTW
MMAR_4626|M.marinum_M VTLDELRRTLDRALTVLTDAPAP----------APAAPAPT-AIPDVPAW
MUL_0237|M.ulcerans_Agy99 VTLDELRRTLDRALTVLTDAPAP----------APAAPAPP-AIPDVAAW
Mflv_1754|M.gilvum_PYR-GCK VPLEVLRATVDRTLKVVADAPGP----------PPAAPEPE-VLPDIPAW
Mvan_4993|M.vanbaalenii_PYR-1 IPPGILRATLDRALRVVSDAPDV----------PPAAPDAE-PLPDVPAW
MSMEG_5642|M.smegmatis_MC2_155 VPLALLRETLDRTLRVVADPPGP----------APAVIETE-DLPDVPAW
TH_0091|M.thermoresistible__bu VPLPRLRSELDRALRVLVDEPGT----------PPAPPDVDTSQPDVPAW
MLBr_00731|M.leprae_Br4923 YVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLE
MAV_4250|M.avium_104 YVASGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLE
MAB_0181|M.abscessus_ATCC_1997 KVVEDEAAAFQYVRDYLSFLPSNTFDYP-----PIVNPGLEPEITEDDLY
.: . : * .
Mb0928c|M.bovis_AF2122/97 DSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQP
Rv0904c|M.tuberculosis_H37Rv DSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQP
MMAR_4626|M.marinum_M TSVLASRRPDRPGVEHLLRYGATDRVLLSGTGYGDAATTLLALARMAGQP
MUL_0237|M.ulcerans_Agy99 TSVLASRRPDRPGVEHLLRYGATDRVLLSGTGYGDAATTLLALARMAGQP
Mflv_1754|M.gilvum_PYR-GCK DSVEISRRPDRPGVSFLLRHGATERVLLSGTGQGESATMMLALARFGNQP
Mvan_4993|M.vanbaalenii_PYR-1 ESVEISRRPDRPGVSALLRYGTTDRVLLSGTGQGEAATTLLALARFGGQP
MSMEG_5642|M.smegmatis_MC2_155 DSVIASRRPDRPGVGFLLRHGATDQVLLSGTERGEAATTLLALARFGGQP
TH_0091|M.thermoresistible__bu DSVIASRRPDRPGVGYLLRHGATDTVLLSGSGGGEAATTLLALARFGGQP
MLBr_00731|M.leprae_Br4923 LDTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRP
MAV_4250|M.avium_104 LDTLIPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRP
MAB_0181|M.abscessus_ATCC_1997 LDTFIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHP
.. . :: : : : . : .:.*. .:*
Mb0928c|M.bovis_AF2122/97 TVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPAL
Rv0904c|M.tuberculosis_H37Rv TVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPAL
MMAR_4626|M.marinum_M MVVLGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPAL
MUL_0237|M.ulcerans_Agy99 MVVLGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPAL
Mflv_1754|M.gilvum_PYR-GCK AVVLGQQRVVGGL---VGPAALREARRGMALAASLKLPLVLVIDTAGPAL
Mvan_4993|M.vanbaalenii_PYR-1 AVVLGQQRVVGGL---VGPAALREARRGMALAAGLKLPLVLVIDTAGPAL
MSMEG_5642|M.smegmatis_MC2_155 AVVLGQRRIVGGL---VGPGALREARRGMALAAGLQLPLVLVIDTAGPAL
TH_0091|M.thermoresistible__bu AVVLGQQRVIGAM---VGPAALREARRGMALAADLQLPLVLVIDTAGPAL
MLBr_00731|M.leprae_Br4923 VGIVANQPIQFAG--CLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLP
MAV_4250|M.avium_104 VGIVANQPTQFAG--CLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLP
MAB_0181|M.abscessus_ATCC_1997 VGVIANQPLQMAG--AVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALP
::.:: . :. : :* : . :*:::::*..*
Mb0928c|M.bovis_AF2122/97 SAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----A
Rv0904c|M.tuberculosis_H37Rv SAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----A
MMAR_4626|M.marinum_M SADAEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----A
MUL_0237|M.ulcerans_Agy99 SADAEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----A
Mflv_1754|M.gilvum_PYR-GCK STEAEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----A
Mvan_4993|M.vanbaalenii_PYR-1 STEAEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----A
MSMEG_5642|M.smegmatis_MC2_155 STEAEQGGLAGEIARCLAELVTLDTPTVSVLMGQGSGGPALAMVP----A
TH_0091|M.thermoresistible__bu TAEAEQGGLASEIAHCLAELVTLDTATLSVLLGQGSGGPALAMVP----A
MLBr_00731|M.leprae_Br4923 GTEQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGC
MAV_4250|M.avium_104 GTGQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGC
MAB_0181|M.abscessus_ATCC_1997 GVSEEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSA
. * .*: . .: : ...:::: :. ** .* . .
Mb0928c|M.bovis_AF2122/97 DRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIV
Rv0904c|M.tuberculosis_H37Rv DRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIV
MMAR_4626|M.marinum_M DRVLAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIV
MUL_0237|M.ulcerans_Agy99 DRVLAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIV
Mflv_1754|M.gilvum_PYR-GCK DRVLAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSVDLLRDGIV
Mvan_4993|M.vanbaalenii_PYR-1 DRVLAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSADLLRNGIV
MSMEG_5642|M.smegmatis_MC2_155 DRVLAASNGWLAPLPPEGASAIVYRDTEHAPELAAAQGVRAVDLLRHGIV
TH_0091|M.thermoresistible__bu DRVLAARHGWLAPLPPEGVSAIVHRDLDHAPELAARQGIRSVDLLRHGIV
MLBr_00731|M.leprae_Br4923 DVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYE
MAV_4250|M.avium_104 DVNIAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGEDVDALRLQLQQEYE
MAB_0181|M.abscessus_ATCC_1997 DLNYVWPTARIAVIGAEGAAQLLVKRFPDPTAP---EVQKIRADFIEGYN
* . . :* : ..*. :: : . : :
Mb0928c|M.bovis_AF2122/97 DTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRR
Rv0904c|M.tuberculosis_H37Rv DTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRR
MMAR_4626|M.marinum_M DVIVPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRS
MUL_0237|M.ulcerans_Agy99 DVIVPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRS
Mflv_1754|M.gilvum_PYR-GCK DAVVPEHPDAADEPRAFVERLSATIAVELHRLRFAPEAERSASRLERYRR
Mvan_4993|M.vanbaalenii_PYR-1 DAIVPEHPDAADEPQAFTQRLSATIAVELHRLRTVPDEQRLAARLERYRR
MSMEG_5642|M.smegmatis_MC2_155 DVVVAEKPDAADEPRAFTARLSTAIAAELHNLRAVPDDERLQTRLQRYRR
TH_0091|M.thermoresistible__bu DAIVDERPDAADEPMEFTARLADSIAVELHRLREMPAESRLETRLARYRR
MLBr_00731|M.leprae_Br4923 DTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPK-KHGN
MAV_4250|M.avium_104 DTLVNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPPK-KHGN
MAB_0181|M.abscessus_ATCC_1997 KNLATPWIAAERGYIDGVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGL
. :. * . : *: ::
Mb0928c|M.bovis_AF2122/97 IGLPRD-
Rv0904c|M.tuberculosis_H37Rv IGLPRD-
MMAR_4626|M.marinum_M IGLPRDR
MUL_0237|M.ulcerans_Agy99 IGLPRDR
Mflv_1754|M.gilvum_PYR-GCK IGLA---
Mvan_4993|M.vanbaalenii_PYR-1 IGLP---
MSMEG_5642|M.smegmatis_MC2_155 IGL----
TH_0091|M.thermoresistible__bu IGLPR--
MLBr_00731|M.leprae_Br4923 IPL----
MAV_4250|M.avium_104 IPL----
MAB_0181|M.abscessus_ATCC_1997 TPI----
: