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VSRIGALALRDAVLDEGSFRSWDTAPLDVGADDEYRRELAEASAKTGLDESVLTGEGTVFGRRVAVVACE FDFLAGSIGVAAAERITAAVQRATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAVELHKQAHLPYLV YLRHPTTGGVFASWGSLGHVTAAEPGALIGFLGPRVYEHLYGEPFPSGVQTAENLHAHGVIDGVVPLALL RETLDRTLRVVADPPGPAPAVIETEDLPDVPAWDSVIASRRPDRPGVGFLLRHGATDQVLLSGTERGEAA TTLLALARFGGQPAVVLGQRRIVGGLVGPGALREARRGMALAAGLQLPLVLVIDTAGPALSTEAEQGGLA GEIARCLAELVTLDTPTVSVLMGQGSGGPALAMVPADRVLAASNGWLAPLPPEGASAIVYRDTEHAPELA AAQGVRAVDLLRHGIVDVVVAEKPDAADEPRAFTARLSTAIAAELHNLRAVPDDERLQTRLQRYRRIGL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5642 | - | - | 100% (489) | acetyl-coenzyme a carboxylase carboxyl transferase |
| M. smegmatis MC2 155 | MSMEG_2169 | accD | e-166 | 64.52% (482) | acetyl-CoA carboxylase, carboxyl transferase, beta subunit |
| M. smegmatis MC2 155 | MSMEG_1813 | - | 4e-16 | 24.84% (455) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0928c | accD3 | 0.0 | 78.86% (492) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_1754 | - | 0.0 | 83.03% (489) | carboxyl transferase |
| M. tuberculosis H37Rv | Rv0904c | accD3 | 0.0 | 78.86% (492) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. leprae Br4923 | MLBr_00102 | accD4 | 5e-14 | 23.63% (419) | putative acyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 1e-15 | 24.11% (423) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_4626 | accD3 | 0.0 | 77.91% (489) | acetyl-coenzyme A carboxylase carboxyl transferase (subunit |
| M. avium 104 | MAV_4250 | - | 1e-13 | 22.74% (453) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_0091 | accD3 | 0.0 | 80.04% (491) | PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE |
| M. ulcerans Agy99 | MUL_0237 | accD3 | 0.0 | 77.51% (489) | acetyl-coenzyme a carboxylase carboxyl transferase (subunit |
| M. vanbaalenii PYR-1 | Mvan_4993 | - | 0.0 | 83.64% (489) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0928c|M.bovis_AF2122/97 ----------------------MSRITTDQLRHAVLDR-----------G
Rv0904c|M.tuberculosis_H37Rv ----------------------MSRITTDQLRHAVLDR-----------G
MMAR_4626|M.marinum_M ----------------------MSRITTDQLRDAVLDE-----------G
MUL_0237|M.ulcerans_Agy99 ----------------------MSRITTDQLRDAVLDE-----------D
Mflv_1754|M.gilvum_PYR-GCK ----------------------MSRIGALALRDAVLDE-----------G
Mvan_4993|M.vanbaalenii_PYR-1 ----------------------MSRIRALALRDALLDE-----------G
MSMEG_5642|M.smegmatis_MC2_155 ----------------------MSRIGALALRDAVLDE-----------G
TH_0091|M.thermoresistible__bu ----------------------MSRIGAVQFVETVLDT-----------G
MLBr_00102|M.leprae_Br4923 ----------------MIMKSTAEKLAELRVRLELANEPGGEKAAAKRDK
MAB_0181|M.abscessus_ATCC_1997 ----------------MPPHTTAEKLADLRERIALTREPGDAKAIARRDK
MAV_4250|M.avium_104 MTSVTDHTAEPAAEHSIDIHTTAGKLAELHKRREESLHPVGEEAVEKVHA
::
Mb0928c|M.bovis_AF2122/97 SFVSWDSEPLAVPVADSYARELAAARAATG----------ADESVQTGEG
Rv0904c|M.tuberculosis_H37Rv SFVSWDSEPLAVPVADSYARELAAARAATG----------ADESVQTGEG
MMAR_4626|M.marinum_M SFISWDTPPLEVPISESYARDLADARAATG----------RDESVLTGEG
MUL_0237|M.ulcerans_Agy99 SFISWDTPPLEVPISESYARDLADVRAATG----------RDESVLTGEG
Mflv_1754|M.gilvum_PYR-GCK SFLSWDRPPIPVVTSAEYRAELAAAADATG----------LDESVVTGEG
Mvan_4993|M.vanbaalenii_PYR-1 SFVSWDGPPLAVPTSAEYRRELAEAEAATG----------LDESVLTGEG
MSMEG_5642|M.smegmatis_MC2_155 SFRSWDTAPLDVGADDEYRRELAEASAKTG----------LDESVLTGEG
TH_0091|M.thermoresistible__bu SFVSWDDPPLAIPADEDYRRELTDAAAVTG----------LDEAVLTGEG
MLBr_00102|M.leprae_Br4923 KNIPSARARIYALVDPGTFLEIGALTRTPG-----DPNALYGDGVVTGHG
MAB_0181|M.abscessus_ATCC_1997 KGIPSARARIDALLDKGSFLELDAFARTPG-----DANAPYTDGVVTGLG
MAV_4250|M.avium_104 KGKLTARERILALLDEDSFVELDALARHRSKNFGLENNRPLGDGVITGYG
. : :: . :.* ** *
Mb0928c|M.bovis_AF2122/97 RVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSG
Rv0904c|M.tuberculosis_H37Rv RVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSG
MMAR_4626|M.marinum_M RVLGRRVAVVVCEFDFLAGSIGVAAAERITAAVERATRQRLPLLASPSSG
MUL_0237|M.ulcerans_Agy99 RVLGRRVAVVACEFDFLAGSIGVAAAERITAAMERATSQRLPLLASPSSG
Mflv_1754|M.gilvum_PYR-GCK RVFGRRVALIACEFDFLAGSIGVAAAERITAAVQRATAEGLPLLASPSSG
Mvan_4993|M.vanbaalenii_PYR-1 RVFGRRVALIACEFDFLAGSIGVAAAERIIAAVQKATAERLPLLASPSSG
MSMEG_5642|M.smegmatis_MC2_155 TVFGRRVAVVACEFDFLAGSIGVAAAERITAAVQRATAERLPLLASPSSG
TH_0091|M.thermoresistible__bu TIFGRRVALVACEFDFLAGSIGVAAAERIVAAVQRATAERLPLVASPSSG
MLBr_00102|M.leprae_Br4923 LINGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSG
MAB_0181|M.abscessus_ATCC_1997 RIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSA
MAV_4250|M.avium_104 TIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGA
: ** * :. : . *::* ..:: : . *::. ...
Mb0928c|M.bovis_AF2122/97 GTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSL
Rv0904c|M.tuberculosis_H37Rv GTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSL
MMAR_4626|M.marinum_M GTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASWGSL
MUL_0237|M.ulcerans_Agy99 GTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASWGSL
Mflv_1754|M.gilvum_PYR-GCK GTRMQEGTVAFLQMVKIAAAVELHKKGNLPYLVYLRHPTTGGVFASWGSL
Mvan_4993|M.vanbaalenii_PYR-1 GTRMQEGTVAFLQMVKIAAAVELHKKAHLPYLVYLRHPTTGGVFASWGSL
MSMEG_5642|M.smegmatis_MC2_155 GTRMQEGTVAFLQMVKIAAAVELHKQAHLPYLVYLRHPTTGGVFASWGSL
TH_0091|M.thermoresistible__bu GTRMQEGTVAFLQMVKIAAAVQLHKLAHLSYLVYLRHPTTGGVFASWGSL
MLBr_00102|M.leprae_Br4923 GARIQDAVTSLAWYAELGRRHELLS-GIVPQISIVLGKCAGGAVYSPIQT
MAB_0181|M.abscessus_ATCC_1997 GARIQDTATSLAWYAELGRRHELLR-GTVPEISIILGKCAGGAVYSPIQT
MAV_4250|M.avium_104 GARIQEGVVSLGLYSRIFRNNILAS-GVIPQISLIMGAAAGGHVYSPALT
*:*:*: ..:: .: * . :. : : :** . *
Mb0928c|M.bovis_AF2122/97 GHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENL--RRHGIIDGVV
Rv0904c|M.tuberculosis_H37Rv GHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENL--RRHGIIDGVV
MMAR_4626|M.marinum_M GHVTVAEPGALIGFLGPRVYELLYDEPFPAGIQTAENL--QRHGVIDGVV
MUL_0237|M.ulcerans_Agy99 GHVTVAEPGALIGFLGPRVYELLYDEPFPAGVQTAENL--QRHGVIDGVV
Mflv_1754|M.gilvum_PYR-GCK GHVTAAEPDALIGFLGPRVYEHLYGERFPSGVQTSENL--QRHGVIDAVV
Mvan_4993|M.vanbaalenii_PYR-1 GHVTAAEPGALIGFLGPRVYEHLYGEPFPAGIQTAENL--HRHGVVDAVI
MSMEG_5642|M.smegmatis_MC2_155 GHVTAAEPGALIGFLGPRVYEHLYGEPFPSGVQTAENL--HAHGVIDGVV
TH_0091|M.thermoresistible__bu GHITIAEPNALIGFLGPRVYQHLYGEPFPPGVQTAENL--HRHGVIDSVV
MLBr_00102|M.leprae_Br4923 DLVVAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDS-QAKYGNIHQVV
MAB_0181|M.abscessus_ATCC_1997 DLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADV-QAQRGNIHKVV
MAV_4250|M.avium_104 DFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTLHYVA
. :. . . : . ** * : : .: .. . . * :. *
Mb0928c|M.bovis_AF2122/97 ALDRLRPMLDRALTVLIDAPEPLPAP----QTPA--PVPDVPTWDSVVAS
Rv0904c|M.tuberculosis_H37Rv ALDRLRPMLDRALTVLIDAPEPLPAP----QTPA--PVPDVPTWDSVVAS
MMAR_4626|M.marinum_M TLDELRRTLDRALTVLTDAPAPAPAA----PAPT--AIPDVPAWTSVLAS
MUL_0237|M.ulcerans_Agy99 TLDELRRTLDRALTVLTDAPAPAPAA----PAPP--AIPDVAAWTSVLAS
Mflv_1754|M.gilvum_PYR-GCK PLEVLRATVDRTLKVVADAPGPPPAA----PEPE--VLPDIPAWDSVEIS
Mvan_4993|M.vanbaalenii_PYR-1 PPGILRATLDRALRVVSDAPDVPPAA----PDAE--PLPDVPAWESVEIS
MSMEG_5642|M.smegmatis_MC2_155 PLALLRETLDRTLRVVADPPGPAPAV----IETE--DLPDVPAWDSVIAS
TH_0091|M.thermoresistible__bu PLPRLRSELDRALRVLVDEPGTPPAP----PDVDT-SQPDVPAWDSVIAS
MLBr_00102|M.leprae_Br4923 ESEAAAFGYVRDFLSFLPPNCFDKAP---IVNPG--LEPEIMAHDLELDS
MAB_0181|M.abscessus_ATCC_1997 EDEAAAFQYVRDYLSFLPSNTFDYPP---IVNPG--LEPEITEDDLYLDT
MAV_4250|M.avium_104 SGEQDAFDWVRDLLSYLPPNNATDPPRYAEPHPAGAIEDNLTDEDLELDT
* . :: :
Mb0928c|M.bovis_AF2122/97 RRPDRPGVRQLLRHGAT---DRVLLSGTDQGEAATTLLALARFGGQPTVV
Rv0904c|M.tuberculosis_H37Rv RRPDRPGVRQLLRHGAT---DRVLLSGTDQGEAATTLLALARFGGQPTVV
MMAR_4626|M.marinum_M RRPDRPGVEHLLRYGAT---DRVLLSGTGYGDAATTLLALARMAGQPMVV
MUL_0237|M.ulcerans_Agy99 RRPDRPGVEHLLRYGAT---DRVLLSGTGYGDAATTLLALARMAGQPMVV
Mflv_1754|M.gilvum_PYR-GCK RRPDRPGVSFLLRHGAT---ERVLLSGTGQGESATMMLALARFGNQPAVV
Mvan_4993|M.vanbaalenii_PYR-1 RRPDRPGVSALLRYGTT---DRVLLSGTGQGEAATTLLALARFGGQPAVV
MSMEG_5642|M.smegmatis_MC2_155 RRPDRPGVGFLLRHGAT---DQVLLSGTERGEAATTLLALARFGGQPAVV
TH_0091|M.thermoresistible__bu RRPDRPGVGYLLRHGAT---DTVLLSGSGGGEAATTLLALARFGGQPAVV
MLBr_00102|M.leprae_Br4923 IVPDSDNTAYDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTVGV
MAB_0181|M.abscessus_ATCC_1997 FIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPVGV
MAV_4250|M.avium_104 LIPDSPNQPYDMHEVITRILDDDEFLEIQGGYAQNIVVGFGRIDGRPVGI
** . : : : . : . .*. .:. :
Mb0928c|M.bovis_AF2122/97 LGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAA
Rv0904c|M.tuberculosis_H37Rv LGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAA
MMAR_4626|M.marinum_M LGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPALSAD
MUL_0237|M.ulcerans_Agy99 LGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPALSAD
Mflv_1754|M.gilvum_PYR-GCK LGQQRVVGGL---VGPAALREARRGMALAASLKLPLVLVIDTAGPALSTE
Mvan_4993|M.vanbaalenii_PYR-1 LGQQRVVGGL---VGPAALREARRGMALAAGLKLPLVLVIDTAGPALSTE
MSMEG_5642|M.smegmatis_MC2_155 LGQRRIVGGL---VGPGALREARRGMALAAGLQLPLVLVIDTAGPALSTE
TH_0091|M.thermoresistible__bu LGQQRVIGAM---VGPAALREARRGMALAADLQLPLVLVIDTAGPALTAE
MLBr_00102|M.leprae_Br4923 VANQPMHLSG--AIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGVE
MAB_0181|M.abscessus_ATCC_1997 IANQPLQMAG--AVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVS
MAV_4250|M.avium_104 VANQPTQFAG--CLDINASEKAARFVRTCDCFNIPIIMLVDVPGFLPGTG
:.:: . :. : :* : . :*:::::*..* .
Mb0928c|M.bovis_AF2122/97 AEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----ADRV
Rv0904c|M.tuberculosis_H37Rv AEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----ADRV
MMAR_4626|M.marinum_M AEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----ADRV
MUL_0237|M.ulcerans_Agy99 AEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----ADRV
Mflv_1754|M.gilvum_PYR-GCK AEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----ADRV
Mvan_4993|M.vanbaalenii_PYR-1 AEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----ADRV
MSMEG_5642|M.smegmatis_MC2_155 AEQGGLAGEIARCLAELVTLDTPTVSVLMGQGSGGPALAMVP----ADRV
TH_0091|M.thermoresistible__bu AEQGGLASEIAHCLAELVTLDTATLSVLLGQGSGGPALAMVP----ADRV
MLBr_00102|M.leprae_Br4923 QEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLAADLN
MAB_0181|M.abscessus_ATCC_1997 EEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSADLN
MAV_4250|M.avium_104 QEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVN
* .*: . .: : ...::: :. ** .* . .*
Mb0928c|M.bovis_AF2122/97 LAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTI
Rv0904c|M.tuberculosis_H37Rv LAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTI
MMAR_4626|M.marinum_M LAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIVDVI
MUL_0237|M.ulcerans_Agy99 LAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGIVDVI
Mflv_1754|M.gilvum_PYR-GCK LAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSVDLLRDGIVDAV
Mvan_4993|M.vanbaalenii_PYR-1 LAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSADLLRNGIVDAI
MSMEG_5642|M.smegmatis_MC2_155 LAASNGWLAPLPPEGASAIVYRDTEHAPELAAAQGVRAVDLLRHGIVDVV
TH_0091|M.thermoresistible__bu LAARHGWLAPLPPEGVSAIVHRDLDHAPELAARQGIRSVDLLRHGIVDAI
MLBr_00102|M.leprae_Br4923 FAWPTARIAVIGADGAAQLLMKRFPDPSS---PDVQAIRKTFVDNYNLNM
MAB_0181|M.abscessus_ATCC_1997 YVWPTARIAVIGAEGAAQLLVKRFPDPTA---PEVQKIRADFIEGYNKNL
MAV_4250|M.avium_104 IAWPSAQIAVMGASGAVGFVYRKQLAEAAKKGEDVDALRLQLQQEYEDTL
. . :* : ..*. :: : . : : :
Mb0928c|M.bovis_AF2122/97 VPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGL
Rv0904c|M.tuberculosis_H37Rv VPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGL
MMAR_4626|M.marinum_M VPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRSIGL
MUL_0237|M.ulcerans_Agy99 VPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRSIGL
Mflv_1754|M.gilvum_PYR-GCK VPEHPDAADEPRAFVERLSATIAVELHRLRFAPEAERSASRLERYRRIGL
Mvan_4993|M.vanbaalenii_PYR-1 VPEHPDAADEPQAFTQRLSATIAVELHRLRTVPDEQRLAARLERYRRIGL
MSMEG_5642|M.smegmatis_MC2_155 VAEKPDAADEPRAFTARLSTAIAAELHNLRAVPDDERLQTRLQRYRRIGL
TH_0091|M.thermoresistible__bu VDERPDAADEPMEFTARLADSIAVELHRLREMPAESRLETRLARYRRIGL
MLBr_00102|M.leprae_Br4923 AIPWIAAERGFIDAVVEPHQTRLLLRKSLHLLRDKQQWWRVGRKHGLIPL
MAB_0181|M.abscessus_ATCC_1997 ATPWIAAERGYIDGVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHGLTPI
MAV_4250|M.avium_104 VNPYVAAERGYVDAVIPPSHTRGYIATALRLLERKIAHLPP-KKHGNIPL
. * . : *: :: :
Mb0928c|M.bovis_AF2122/97 PRD-
Rv0904c|M.tuberculosis_H37Rv PRD-
MMAR_4626|M.marinum_M PRDR
MUL_0237|M.ulcerans_Agy99 PRDR
Mflv_1754|M.gilvum_PYR-GCK A---
Mvan_4993|M.vanbaalenii_PYR-1 P---
MSMEG_5642|M.smegmatis_MC2_155 ----
TH_0091|M.thermoresistible__bu PR--
MLBr_00102|M.leprae_Br4923 ----
MAB_0181|M.abscessus_ATCC_1997 ----
MAV_4250|M.avium_104 ----