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VSRITTDQLRDAVLDEDSFISWDTPPLEVPISESYARDLADVRAATGRDESVLTGEGRVLGRRVAVVACE FDFLAGSIGVAAAERITAAMERATSQRLPLLASPSSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLV YLRHPTTGGVFASWGSLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGVQTAENLQRHGVIDGVVTLDEL RRTLDRALTVLTDAPAPAPAAPAPPAIPDVAAWTSVLASRRPDRPGVEHLLRYGATDRVLLSGTGYGDAA TTLLALARMAGQPMVVLGQQGIGGGIIGPASLREARRGMALAAELRLPLVLVIDTAGPALSADAEQGGLA GQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVPADRVLAAQHGWLAPLPPEGASAIVFRDTTHAAELA AAQGIRSADLLAAGIVDVIVPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYRSIGLP RDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0237 | accD3 | - | 100% (493) | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 |
| M. ulcerans Agy99 | MUL_2632 | accD5 | 6e-15 | 23.42% (427) | propionyl-CoA carboxylase beta chain 5 AccD5 |
| M. ulcerans Agy99 | MUL_1302 | accD6 | 3e-13 | 23.69% (439) | acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0928c | accD3 | 0.0 | 81.41% (495) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. gilvum PYR-GCK | Mflv_1754 | - | 0.0 | 75.66% (489) | carboxyl transferase |
| M. tuberculosis H37Rv | Rv0904c | accD3 | 0.0 | 81.41% (495) | putative acetyl-coenzyme A carboxylase carboxyl transferase |
| M. leprae Br4923 | MLBr_00731 | accD5 | 2e-12 | 22.36% (416) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 2e-13 | 23.29% (498) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_4626 | accD3 | 0.0 | 98.38% (493) | acetyl-coenzyme A carboxylase carboxyl transferase (subunit |
| M. avium 104 | MAV_2190 | - | 5e-15 | 23.95% (430) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_5642 | - | 0.0 | 77.51% (489) | acetyl-coenzyme a carboxylase carboxyl transferase |
| M. thermoresistible (build 8) | TH_0091 | accD3 | 0.0 | 74.19% (492) | PUTATIVE ACETYL-COENZYME A CARBOXYLASE CARBOXYL TRANSFERASE |
| M. vanbaalenii PYR-1 | Mvan_4993 | - | 0.0 | 78.78% (490) | carboxyl transferase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0237|M.ulcerans_Agy99 ------------------MSRITTDQLRDAVLDEDSFISWDTP-------
MMAR_4626|M.marinum_M ------------------MSRITTDQLRDAVLDEGSFISWDTP-------
Mb0928c|M.bovis_AF2122/97 ------------------MSRITTDQLRHAVLDRGSFVSWDSE-------
Rv0904c|M.tuberculosis_H37Rv ------------------MSRITTDQLRHAVLDRGSFVSWDSE-------
Mflv_1754|M.gilvum_PYR-GCK ------------------MSRIGALALRDAVLDEGSFLSWDRP-------
Mvan_4993|M.vanbaalenii_PYR-1 ------------------MSRIRALALRDALLDEGSFVSWDGP-------
MSMEG_5642|M.smegmatis_MC2_155 ------------------MSRIGALALRDAVLDEGSFRSWDTA-------
TH_0091|M.thermoresistible__bu ------------------MSRIGAVQFVETVLDTGSFVSWDDP-------
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
MAB_0181|M.abscessus_ATCC_1997 -------------------MPPHTTAEKLADLRERIALTREPGDAKAIAR
MAV_2190|M.avium_104 ---------------------MTITAP------ETVGESLDPR-------
: .
MUL_0237|M.ulcerans_Agy99 -----------PLEVPISESYARDLADVRAATG----------RDESVLT
MMAR_4626|M.marinum_M -----------PLEVPISESYARDLADARAATG----------RDESVLT
Mb0928c|M.bovis_AF2122/97 -----------PLAVPVADSYARELAAARAATG----------ADESVQT
Rv0904c|M.tuberculosis_H37Rv -----------PLAVPVADSYARELAAARAATG----------ADESVQT
Mflv_1754|M.gilvum_PYR-GCK -----------PIPVVTSAEYRAELAAAADATG----------LDESVVT
Mvan_4993|M.vanbaalenii_PYR-1 -----------PLAVPTSAEYRRELAEAEAATG----------LDESVLT
MSMEG_5642|M.smegmatis_MC2_155 -----------PLDVGADDEYRRELAEASAKTG----------LDESVLT
TH_0091|M.thermoresistible__bu -----------PLAIPADEDYRRELTDAAAVTG----------LDEAVLT
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVT
MAB_0181|M.abscessus_ATCC_1997 RDKKGIPSARARIDALLDKGSFLELDAFARTPG-----DANAPYTDGVVT
MAV_2190|M.avium_104 -------DPLLRLSNFFDDGSVALLHERDRS---------------GVLA
: * .* :
MUL_0237|M.ulcerans_Agy99 GEGRVLGRRVAVVACEFDFLAGSIGVAAAERITAAMERATSQRLPLLASP
MMAR_4626|M.marinum_M GEGRVLGRRVAVVVCEFDFLAGSIGVAAAERITAAVERATRQRLPLLASP
Mb0928c|M.bovis_AF2122/97 GEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASP
Rv0904c|M.tuberculosis_H37Rv GEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASP
Mflv_1754|M.gilvum_PYR-GCK GEGRVFGRRVALIACEFDFLAGSIGVAAAERITAAVQRATAEGLPLLASP
Mvan_4993|M.vanbaalenii_PYR-1 GEGRVFGRRVALIACEFDFLAGSIGVAAAERIIAAVQKATAERLPLLASP
MSMEG_5642|M.smegmatis_MC2_155 GEGTVFGRRVAVVACEFDFLAGSIGVAAAERITAAVQRATAERLPLLASP
TH_0091|M.thermoresistible__bu GEGTIFGRRVALVACEFDFLAGSIGVAAAERIVAAVQRATAERLPLVASP
MLBr_00731|M.leprae_Br4923 GYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
MAB_0181|M.abscessus_ATCC_1997 GLGRIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGIN
MAV_2190|M.avium_104 AAGTVNGVRTIAFCTDGTVMGGAMGIEGCSHIVDAYDTAIEEQSPIVGIW
. * : * . . : . *::* :: : * *::.
MUL_0237|M.ulcerans_Agy99 SSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASW
MMAR_4626|M.marinum_M SSGGTRMQEGTVAFLQMVKIAAAVRLHKQAHLPYLVYLRHPTTGGVFASW
Mb0928c|M.bovis_AF2122/97 SSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASW
Rv0904c|M.tuberculosis_H37Rv SSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASW
Mflv_1754|M.gilvum_PYR-GCK SSGGTRMQEGTVAFLQMVKIAAAVELHKKGNLPYLVYLRHPTTGGVFASW
Mvan_4993|M.vanbaalenii_PYR-1 SSGGTRMQEGTVAFLQMVKIAAAVELHKKAHLPYLVYLRHPTTGGVFASW
MSMEG_5642|M.smegmatis_MC2_155 SSGGTRMQEGTVAFLQMVKIAAAVELHKQAHLPYLVYLRHPTTGGVFASW
TH_0091|M.thermoresistible__bu SSGGTRMQEGTVAFLQMVKIAAAVQLHKLAHLSYLVYLRHPTTGGVFASW
MLBr_00731|M.leprae_Br4923 DGAGARIQEGVVSLGLYSRIFRNNILAS-GVIPQISLIMGAAAGGHVYSP
MAB_0181|M.abscessus_ATCC_1997 DSAGARIQDTATSLAWYAELGRRHELLR-GTVPEISIILGKCAGGAVYSP
MAV_2190|M.avium_104 HSGGARLAEGVKALHAVGLVFEAMIRAS-GYIPQISVVVGFAAGGAAYGP
..*:*: : . :: : . :. : : :** .
MUL_0237|M.ulcerans_Agy99 GSLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGVQTAENLQRHGVIDGV
MMAR_4626|M.marinum_M GSLGHVTVAEPGALIGFLGPRVYELLYDEPFPAGIQTAENLQRHGVIDGV
Mb0928c|M.bovis_AF2122/97 GSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGV
Rv0904c|M.tuberculosis_H37Rv GSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGV
Mflv_1754|M.gilvum_PYR-GCK GSLGHVTAAEPDALIGFLGPRVYEHLYGERFPSGVQTSENLQRHGVIDAV
Mvan_4993|M.vanbaalenii_PYR-1 GSLGHVTAAEPGALIGFLGPRVYEHLYGEPFPAGIQTAENLHRHGVVDAV
MSMEG_5642|M.smegmatis_MC2_155 GSLGHVTAAEPGALIGFLGPRVYEHLYGEPFPSGVQTAENLHAHGVIDGV
TH_0091|M.thermoresistible__bu GSLGHITIAEPNALIGFLGPRVYQHLYGEPFPPGVQTAENLHRHGVIDSV
MLBr_00731|M.leprae_Br4923 ALTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAH
MAB_0181|M.abscessus_ATCC_1997 IQTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQR-GNIH
MAV_2190|M.avium_104 ALTDVVVMAPE-SRVFVTGPDVVRSVTGEDVDMASLGGPETHHKKSGVCH
. :. . . : . ** * . : .: . . . :
MUL_0237|M.ulcerans_Agy99 VTLDELRRTLDRALTVLTDAPAPAPAAPAPP--------AIPDVAAWTSV
MMAR_4626|M.marinum_M VTLDELRRTLDRALTVLTDAPAPAPAAPAPT--------AIPDVPAWTSV
Mb0928c|M.bovis_AF2122/97 VALDRLRPMLDRALTVLIDAPEPLPAPQTPA--------PVPDVPTWDSV
Rv0904c|M.tuberculosis_H37Rv VALDRLRPMLDRALTVLIDAPEPLPAPQTPA--------PVPDVPTWDSV
Mflv_1754|M.gilvum_PYR-GCK VPLEVLRATVDRTLKVVADAPGPPPAAPEPE--------VLPDIPAWDSV
Mvan_4993|M.vanbaalenii_PYR-1 IPPGILRATLDRALRVVSDAPDVPPAAPDAE--------PLPDVPAWESV
MSMEG_5642|M.smegmatis_MC2_155 VPLALLRETLDRTLRVVADPPGPAPAVIETE--------DLPDVPAWDSV
TH_0091|M.thermoresistible__bu VPLPRLRSELDRALRVLVDEPGTPPAPPDVDT-------SQPDVPAWDSV
MLBr_00731|M.leprae_Br4923 YVASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLE
MAB_0181|M.abscessus_ATCC_1997 KVVEDEAAAFQYVRDYLSFLPSNTFDYPP-----IVNPGLEPEITEDDLY
MAV_2190|M.avium_104 IVADDELDAYERGRRLVGLFCQQGHFDRT-------------KAEAGDTD
: : .
MUL_0237|M.ulcerans_Agy99 LASRRPDRP----GVEHLLRYGATDRVLLSGTGYGDAATTLLALARMAGQ
MMAR_4626|M.marinum_M LASRRPDRP----GVEHLLRYGATDRVLLSGTGYGDAATTLLALARMAGQ
Mb0928c|M.bovis_AF2122/97 VASRRPDRP----GVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQ
Rv0904c|M.tuberculosis_H37Rv VASRRPDRP----GVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQ
Mflv_1754|M.gilvum_PYR-GCK EISRRPDRP----GVSFLLRHGATERVLLSGTGQGESATMMLALARFGNQ
Mvan_4993|M.vanbaalenii_PYR-1 EISRRPDRP----GVSALLRYGTTDRVLLSGTGQGEAATTLLALARFGGQ
MSMEG_5642|M.smegmatis_MC2_155 IASRRPDRP----GVGFLLRHGATDQVLLSGTERGEAATTLLALARFGGQ
TH_0091|M.thermoresistible__bu IASRRPDRP----GVGYLLRHGATDTVLLSGSGGGEAATTLLALARFGGQ
MLBr_00731|M.leprae_Br4923 LDTLIPDSPNQPYDMHEVVTRLLDEEE-FLEVQAGYATNIVVGLGRIDDR
MAB_0181|M.abscessus_ATCC_1997 LDTFIPDSDNQGYDMMEILLRIFDDGD-IFEISEQRGPAMITAFARVDGH
MAV_2190|M.avium_104 IHALLPESARRAYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGR
: *: .: :: : : .. : .:.*. .:
MUL_0237|M.ulcerans_Agy99 PMVVLGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPA
MMAR_4626|M.marinum_M PMVVLGQQ-GIGGG--IIGPASLREARRGMALAAELRLPLVLVIDTAGPA
Mb0928c|M.bovis_AF2122/97 PTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPA
Rv0904c|M.tuberculosis_H37Rv PTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPA
Mflv_1754|M.gilvum_PYR-GCK PAVVLGQQRVVGGL---VGPAALREARRGMALAASLKLPLVLVIDTAGPA
Mvan_4993|M.vanbaalenii_PYR-1 PAVVLGQQRVVGGL---VGPAALREARRGMALAAGLKLPLVLVIDTAGPA
MSMEG_5642|M.smegmatis_MC2_155 PAVVLGQRRIVGGL---VGPGALREARRGMALAAGLQLPLVLVIDTAGPA
TH_0091|M.thermoresistible__bu PAVVLGQQRVIGAM---VGPAALREARRGMALAADLQLPLVLVIDTAGPA
MLBr_00731|M.leprae_Br4923 PVGIVANQPIQFAG--CLDINASEKAARFVRVCDCFNIPIVMLVDVPGFL
MAB_0181|M.abscessus_ATCC_1997 PVGVIANQPLQMAG--AVDTDASDKAASFIRFCDAYNLPLVFVVDTPGAL
MAV_2190|M.avium_104 TVGVLANNPLRLGG--CLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYL
. ::.:. . :. : :* : .. :*:*.::*..*
MUL_0237|M.ulcerans_Agy99 LSADAEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----
MMAR_4626|M.marinum_M LSADAEQGGLAGQIAQCLAELVTLGTPTVSVLLGQGSGGPALAMVP----
Mb0928c|M.bovis_AF2122/97 LSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----
Rv0904c|M.tuberculosis_H37Rv LSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLP----
Mflv_1754|M.gilvum_PYR-GCK LSTEAEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----
Mvan_4993|M.vanbaalenii_PYR-1 LSTEAEEGGLAGEIARCLAELVTLDTPTVSVLLGQGSGGPALAMVP----
MSMEG_5642|M.smegmatis_MC2_155 LSTEAEQGGLAGEIARCLAELVTLDTPTVSVLMGQGSGGPALAMVP----
TH_0091|M.thermoresistible__bu LTAEAEQGGLASEIAHCLAELVTLDTATLSVLLGQGSGGPALAMVP----
MLBr_00731|M.leprae_Br4923 PGTEQEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMG
MAB_0181|M.abscessus_ATCC_1997 PGVSEEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLS
MAV_2190|M.avium_104 PGVDQEWGGVVRRGAKLLHAFGEATVPRVTLVTRKTYGGAYIAMNSRSLN
. * .*: . .: : .. :::: : ** .* .
MUL_0237|M.ulcerans_Agy99 ADRVLAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGI
MMAR_4626|M.marinum_M ADRVLAAQHGWLAPLPPEGASAIVFRDTTHAAELAAAQGIRSADLLAAGI
Mb0928c|M.bovis_AF2122/97 ADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGI
Rv0904c|M.tuberculosis_H37Rv ADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGI
Mflv_1754|M.gilvum_PYR-GCK ADRVLAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSVDLLRDGI
Mvan_4993|M.vanbaalenii_PYR-1 ADRVLAALHGWLAPLPPEGASAIVFRDVDHAPELAAAQGIRSADLLRNGI
MSMEG_5642|M.smegmatis_MC2_155 ADRVLAASNGWLAPLPPEGASAIVYRDTEHAPELAAAQGVRAVDLLRHGI
TH_0091|M.thermoresistible__bu ADRVLAARHGWLAPLPPEGVSAIVHRDLDHAPELAARQGIRSVDLLRHGI
MLBr_00731|M.leprae_Br4923 CDVNLAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEY
MAB_0181|M.abscessus_ATCC_1997 ADLNYVWPTARIAVIGAEGAAQLLVKRFPDPTAP---EVQKIRADFIEGY
MAV_2190|M.avium_104 ATKVFAWPDAEVAVMGAKAAVGILHKKKLAAAPEH--EREALHDQLAAEH
. . . :* : .... :: : . : :
MUL_0237|M.ulcerans_Agy99 VDVIVPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYR
MMAR_4626|M.marinum_M VDVIVPELPDAAAEPVEFAQRLSIAIATEVAALREIPDAQRMTARLARYR
Mb0928c|M.bovis_AF2122/97 VDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYR
Rv0904c|M.tuberculosis_H37Rv VDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYR
Mflv_1754|M.gilvum_PYR-GCK VDAVVPEHPDAADEPRAFVERLSATIAVELHRLRFAPEAERSASRLERYR
Mvan_4993|M.vanbaalenii_PYR-1 VDAIVPEHPDAADEPQAFTQRLSATIAVELHRLRTVPDEQRLAARLERYR
MSMEG_5642|M.smegmatis_MC2_155 VDVVVAEKPDAADEPRAFTARLSTAIAAELHNLRAVPDDERLQTRLQRYR
TH_0091|M.thermoresistible__bu VDAIVDERPDAADEPMEFTARLADSIAVELHRLREMPAESRLETRLARYR
MLBr_00731|M.leprae_Br4923 EDTLVNPYIAAERGYVDAVIPPSHTRGYIATALHLLERKIAHLPPK-KHG
MAB_0181|M.abscessus_ATCC_1997 NKNLATPWIAAERGYIDGVIEPHQTRLLLRKSLKLLRDKQKHDRMQRKHG
MAV_2190|M.avium_104 EKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPAR------RGRHK
. : * ::
MUL_0237|M.ulcerans_Agy99 SIGLPRDR
MMAR_4626|M.marinum_M SIGLPRDR
Mb0928c|M.bovis_AF2122/97 RIGLPRD-
Rv0904c|M.tuberculosis_H37Rv RIGLPRD-
Mflv_1754|M.gilvum_PYR-GCK RIGLA---
Mvan_4993|M.vanbaalenii_PYR-1 RIGLP---
MSMEG_5642|M.smegmatis_MC2_155 RIGL----
TH_0091|M.thermoresistible__bu RIGLPR--
MLBr_00731|M.leprae_Br4923 NIPL----
MAB_0181|M.abscessus_ATCC_1997 LTPI----
MAV_2190|M.avium_104 NIPL----
: