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MLNARAAVLLDAGADPRLTDVQVRPPVGDELLVEIEAVGICHTDISVAARFRKVPMVFGHEGAGTVIDAG PAAAGRIGERVVLTFASCGVCDRCGAGSPAYCDHSTDLNMRGGRLDETAALRLDGAPVAGEFFGQSSFAT HAISKSRNAVTIPGDLDPALAAPLGCSVQTGVGAVLNVLTPGADDAVVVFGAGAVGLSAVMGARIAGCRT IVAVDPVAGRRALATELGATITIDPTDTDVTRAVLDATGGAACAIDTTARPDVIATAVMALRSRGTLALL GLGALTAELPVALIMGKGLTVRGVVEGDSEPHSFIPALLEHHRRGELPVDKLVTTCPFEEFDRAWAAAKA GEVVKPVLVTRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2034 | - | - | 100% (362) | aryl-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4039 | - | 5e-75 | 46.41% (362) | aryl-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0127 | - | 5e-44 | 34.68% (372) | oxidoreductase, zinc-binding dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 5e-39 | 33.64% (327) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_0725 | - | 1e-78 | 46.78% (357) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 5e-39 | 33.64% (327) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 1e-38 | 29.63% (351) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_4388 | - | 3e-87 | 48.45% (355) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 2e-42 | 33.07% (375) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 3e-45 | 36.21% (348) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_2558 | - | 3e-75 | 45.13% (359) | PUTATIVE putative aryl-alcohol dehydrogenase |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 2e-40 | 30.49% (364) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 2e-39 | 30.22% (364) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
Mflv_0725|M.gilvum_PYR-GCK --------------------MPETTAVLSYAPEDPFSVAEVRVDDPRADE
MAB_4388|M.abscessus_ATCC_1997 ---------------------MKVTAALSASPAAPFTLQELELDEPRSDE
MSMEG_2034|M.smegmatis_MC2_155 --------------------MLNARAAVLLDAGADPRLTDVQVRPPVGDE
TH_2558|M.thermoresistible__bu ---------------------------VLRGETDPYQIEELDLPDPAAHQ
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
MUL_1292|M.ulcerans_Agy99 -------------------MSQTVRGVISRKKGEPVELVDIVVPDPGPGE
Mvan_3767|M.vanbaalenii_PYR-1 -------------------MTQTVRGVISRTKGQPVEVVEIVIPDPGPGE
: :: : * :
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVAV
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGDRVDDLAV
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLAV
Mflv_0725|M.gilvum_PYR-GCK ILVRIEAAGVCHTDLVNRVAGKP-DRPVLLGHEGAGIVERVGDGLQSVKP
MAB_4388|M.abscessus_ATCC_1997 VLVKIHATGLCHTDLT--FKSQV-PIPAVLGHEGAGIVTAVGEAVSGISP
MSMEG_2034|M.smegmatis_MC2_155 LLVEIEAVGICHTDIS--VAARFRKVPMVFGHEGAGTVIDAGPAAAGR-I
TH_2558|M.thermoresistible__bu ILVRIAGTGHCHTDVLPRAGAGFGTPPIVVGHEGSGVVEAVGAAVDTVAV
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREGGINDRYPFLLGHEAAGTVEVVGPGVTAVEP
MUL_1292|M.ulcerans_Agy99 AVVDISACGVCHTDLTYREGGINDEYPFLLGHEAAGTVEAVGPGVTNVEP
Mvan_3767|M.vanbaalenii_PYR-1 VVVDIQACGVCHTDLHYREGGINDEFPFLLGHEAAGTVESVGAGVTNVAP
:* : . * **:*: * :.***.:* * .*
Mb0167c|M.bovis_AF2122/97 GQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RGG
Rv0162c|M.tuberculosis_H37Rv GQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RGG
MMAR_0405|M.marinum_M GQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRIS-RSG
MAV_5022|M.avium_104 GARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS-RAG
Mflv_0725|M.gilvum_PYR-GCK GDRVVLSFRS-CGACTNCRARRPAYCRKAVRLNQFGQRADGTPRVT-VDG
MAB_4388|M.abscessus_ATCC_1997 GDHVVLSYRS-CGGCRSCAAGERAYCSRSMRLNSAGVRADGSPTLS-DNG
MSMEG_2034|M.smegmatis_MC2_155 GERVVLTFAS-CGVCDRCGAGSPAYCDHSTDLNMRGGRLDETAALR-LDG
TH_2558|M.thermoresistible__bu GDHVVLSFDS-CGTCGSCLAAHPAYCDTFLERNLGGPGVDGAAQLTDVDG
MLBr_01784|M.leprae_Br4923 GDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTP----
MUL_1292|M.ulcerans_Agy99 GDFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLTDGTELTP----
Mvan_3767|M.vanbaalenii_PYR-1 GDFVVLNWRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDGTELTP----
* *:* : . ** * * * : .
Mb0167c|M.bovis_AF2122/97 RPVY-HHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
Rv0162c|M.tuberculosis_H37Rv RPVY-HHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
MMAR_0405|M.marinum_M QPIY-HHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAV
MAV_5022|M.avium_104 RPVY-HHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAV
Mflv_0725|M.gilvum_PYR-GCK RSVLDGFFGQSSLAGYALTTQDNTVVVGPDVDPVLAAPLGCGFQTGAGAV
MAB_4388|M.abscessus_ATCC_1997 TPVYGSFFGQSSFAQYALTGADNTVVVDPSIDLAVAAPLGCGFQTGAGAV
MSMEG_2034|M.smegmatis_MC2_155 APVAGEFFGQSSFATHAISKSRNAVTIPGDLDPALAAPLGCSVQTGVGAV
TH_2558|M.thermoresistible__bu QPVAGRWFGQSSFASHAVVDAANAVVVDKDLPLELLGPLGCGVQTGAGAV
MLBr_01784|M.leprae_Br4923 ------ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
MUL_1292|M.ulcerans_Agy99 ------ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
Mvan_3767|M.vanbaalenii_PYR-1 ------ALGIGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAA
:* ..:* .: . . : . ***.. :* **.
Mb0167c|M.bovis_AF2122/97 LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
Rv0162c|M.tuberculosis_H37Rv LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
MMAR_0405|M.marinum_M LNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAE
MAV_5022|M.avium_104 LNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAAR
Mflv_0725|M.gilvum_PYR-GCK LNLMQPAAGSSVAVFGAGAVGLAGVLAALAVDVETVIVVEPSPQRRALAE
MAB_4388|M.abscessus_ATCC_1997 LNVLSPEPDSRLVVFGAGGVGLAAVMAAKAQGVETIIAVDPVASRRAKAT
MSMEG_2034|M.smegmatis_MC2_155 LNVLTPGADDAVVVFGAGAVGLSAVMGARIAGCRTIVAVDPVAGRRALAT
TH_2558|M.thermoresistible__bu LEVLRIGPGESIVITGTGAVGLSAVMAAKVAGASTIIAVDLNTERLALAE
MLBr_01784|M.leprae_Br4923 INTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWAR
MUL_1292|M.ulcerans_Agy99 VNTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDNTKLEWAR
Mvan_3767|M.vanbaalenii_PYR-1 INTGAVNRDDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWAR
:: .. :.: * *.** :.: * :. *: : *
Mb0167c|M.bovis_AF2122/97 ALGAHEIYTP-------QQATAG-GVKAAVVVEAVGHPAALHTAIGLTAP
Rv0162c|M.tuberculosis_H37Rv ALGAHEIYTP-------QQATAG-GVKAAVVVEAVGHPAALHTAIGLTAP
MMAR_0405|M.marinum_M ALGASATYTP-------QQAAAA-GVKADVVIEAAGHPAALETAIGLTAP
MAV_5022|M.avium_104 RLGAHQAYTP-------QQAVEA-RVKAAVVIEAVGHPAALQTAIDLTAP
Mflv_0725|M.gilvum_PYR-GCK SLGVRAALSP-DDHTVRAIREIT-GGGVDYALDTTGRPEVLASAVAALAV
MAB_4388|M.abscessus_ATCC_1997 ELGATQTVDP-AMEDVAAM-----ARGATHALDTTANAGVIATALGLLRQ
MSMEG_2034|M.smegmatis_MC2_155 ELGATITIDP-TDTDVTRAVLDA-TGGAACAIDTTARPDVIATAVMALRS
TH_2558|M.thermoresistible__bu EFGATHTIVANTGELTEQIRAIV-PGGTHYGLDTTGLPAVIAAALEAVAV
MLBr_01784|M.leprae_Br4923 TFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPETWKQAFYARDL
MUL_1292|M.ulcerans_Agy99 AFGATHTVNARELDVVETIQDLTGGFGVDVVIDAVGRPETWKQAFYARDL
Mvan_3767|M.vanbaalenii_PYR-1 EFGATHTINAGELDAVKTIQDLTDGFGADVVIDAVGRPETWKQAFYARDL
:*. . . :::.. . . *.
Mb0167c|M.bovis_AF2122/97 GGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSL
Rv0162c|M.tuberculosis_H37Rv GGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSL
MMAR_0405|M.marinum_M GGRTITVGLPPPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFVSL
MAV_5022|M.avium_104 GGRTITVGLPPPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVEL
Mflv_0725|M.gilvum_PYR-GCK GGTAVAVGLGTGVP--AIDLADLVLRGKTVHGCLEGDSIPSVFIPELLAL
MAB_4388|M.abscessus_ATCC_1997 RGVLVLVGLGAQPG--PIDLNDLMLGGKVIRGCIEGDANPQEFIPELLQM
MSMEG_2034|M.smegmatis_MC2_155 RGTLALLGLGALTA--ELPVALIMGKGLTVRGVVEGDSEPHSFIPALLEH
TH_2558|M.thermoresistible__bu RGTMGLVGVQQGEL--AIGPLALTIG-RTITGILEGDAEPRTFIPRLIEL
MLBr_01784|M.leprae_Br4923 AGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDL
MUL_1292|M.ulcerans_Agy99 AGTVVLVGVPTPDMRLDMPLVDFFSRGGALKSSWYGDCLPERDFPTLIDL
Mvan_3767|M.vanbaalenii_PYR-1 AGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLISL
* :*: : : : . *.. * :* ::
Mb0167c|M.bovis_AF2122/97 WQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
Rv0162c|M.tuberculosis_H37Rv WQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL
MMAR_0405|M.marinum_M WQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF----
MAV_5022|M.avium_104 WRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA--
Mflv_0725|M.gilvum_PYR-GCK HARGRFPIERLVTEFS-HRDVTEALAAQHAGDVVKPVLTWP---
MAB_4388|M.abscessus_ATCC_1997 HARGHFPIESLITTYP-AADIEQAVADARSGAAIKPVLLW----
MSMEG_2034|M.smegmatis_MC2_155 HRRGELPVDKLVTTCP-FEEFDRAWAAAKAGEVVKPVLVTRR--
TH_2558|M.thermoresistible__bu WRAGRFPFDRMIETFP-LSEINTAEQRALAGEIIKPVLIPGA--
MLBr_01784|M.leprae_Br4923 YLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML----
MUL_1292|M.ulcerans_Agy99 YLQGRLPLDKFVSEQIGLGGIEEAFEKMHAGKVLRSVVVL----
Mvan_3767|M.vanbaalenii_PYR-1 YLQGRFPLDKFVSERIGLDQIEDAFDKMHAGEVLRSVVVL----
*.:*. :: . * * :: ::