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MTLTDLPNGTEGLADALDGLRAHVVAPVALPGEAGYERATPWNVAAEVKPAAVVLATSAYDVANTVRYAA SRGLRVTVQATGHGALKVTDDTILIVTSGMTGCTVDPSTRTARVQAGARWQHVIDAAAPHGLAPLCGSSP NVGVVGYLTGGGVGPLVRTVGLSSDHVRSFELVTGKGELLRATPEENAELFWGLRGGKATLGIVTSVEID LPPIPEFYGGAVIFDGADAASVLHAWRTWCVTLPESVNTSISLQNLPPLPGVPEPLAGKLTVAVRYTAIG DFARAERLLAPMRAVATPVLDTVAVHPYAAIGGVHMDPVDPMPCNETHTLLRELPSEAVDVLLAAAGPDT PPVQTIVEIRLFGGALAREPRHRSAFCHRDAAFGVTAIGVPVPPVADTVRAHGAALVDAMAPWSTGGQLP NFAPSDDAGRASRVYDEDTLHWLAALAERHDPAGVYRCGQVVRFVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1964 | - | - | 100% (466) | mitomycin radical oxidase |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 8e-45 | 29.93% (451) | 6-hydroxy-D-nicotine oxidase |
| M. smegmatis MC2 155 | MSMEG_6283 | - | 3e-13 | 33.61% (122) | FAD binding domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 2e-45 | 30.93% (443) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 0.0 | 70.29% (451) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1726 | - | 6e-46 | 31.24% (445) | oxidoreductase |
| M. leprae Br4923 | MLBr_02333 | - | 2e-10 | 27.01% (174) | hypothetical protein MLBr_02333 |
| M. abscessus ATCC 19977 | MAB_2456 | - | 3e-21 | 25.81% (465) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_3461 | - | 3e-24 | 25.82% (457) | hypothetical protein MMAR_3461 |
| M. avium 104 | MAV_0089 | - | 5e-20 | 30.83% (240) | FAD binding domain-containing protein |
| M. thermoresistible (build 8) | TH_1540 | - | 9e-20 | 30.11% (269) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 3e-23 | 32.53% (249) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 0.0 | 72.83% (449) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1755|M.bovis_AF2122/97 ------------------------------MTATLTK--------TLGSL
Rv1726|M.tuberculosis_H37Rv ------------------------------MTATLTK--------TLGSL
Mflv_4651|M.gilvum_PYR-GCK ----------------------------MTVPTDLRR-----DEALRSLR
Mvan_1816|M.vanbaalenii_PYR-1 ----------------------------MTIPTDLTR-----DDALRILR
MSMEG_1964|M.smegmatis_MC2_155 ----------------------------MTL-TDLPNGTEGLADALDGLR
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
MMAR_3461|M.marinum_M ------------------------------MALEACD--------FRTLE
TH_1540|M.thermoresistible__bu --------------------------------------------------
MLBr_02333|M.leprae_Br4923 --------------------------------------------------
Mb1755|M.bovis_AF2122/97 DDFRGTLCVP-GDPDYPRVR--AIWN-GQVAREPALIATCHDACDVRTVL
Rv1726|M.tuberculosis_H37Rv DDFRGTLCVP-GDPDYPRVR--AIWN-GQVAREPALIATCHDACDVRTVL
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALP-GEPGYERCR--PWN--VVAPVEPAAVVLATSPEDVAGTV
Mvan_1816|M.vanbaalenii_PYR-1 EEVATLVALP-GEPGYERCV--PWN--VAAPVTPAAVVLATSAEDVAGTV
MSMEG_1964|M.smegmatis_MC2_155 AHVVAPVALP-GEAGYERAT--PWN--VAAEVKPAAVVLATSAYDVANTV
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAK--QVFNTNYNGSTPAAVVTPTSAADVQKAM
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGK--QVFNSLYNNSNPAAVVTVTSQADVEKAV
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESG--RAFNPLFDVNHPGAVAFCASDQDVARCV
MMAR_3461|M.marinum_M NLCPGRVGAP-GSPLYEAGR--RVFSRAGRIRSPAAVLRPADRNQVAAIM
TH_1540|M.thermoresistible__bu MAALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAV
MLBr_02333|M.leprae_Br4923 ---------------------------MVSVQESALVVYTSGVKRLVASY
. : :
Mb1755|M.bovis_AF2122/97 RRPVDAGMVTAVRGGGHNVAGTALCDGG-VVIDLSAMRAVSLDPATGRVR
Rv1726|M.tuberculosis_H37Rv RRAVDAGMVTAVRGGGHNVAGTALCDGG-VVIDLSAMRAVSLDPATGRVR
Mflv_4651|M.gilvum_PYR-GCK RFAAAHGFRVTVQATGHGAVGVGPDT---ILIQTSAMRHVSVDVVNGTAR
Mvan_1816|M.vanbaalenii_PYR-1 RFAAAHGFTVTVQATGHGAVGVGADT---ILVLTAAMKHCEVDSLNRTAR
MSMEG_1964|M.smegmatis_MC2_155 RYAASRGLRVTVQATGHGALKVTDDT---ILIVTSGMTGCTVDPSTRTAR
MAV_0089|M.avium_104 AFAAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVT
MUL_1431|M.ulcerans_Agy99 AFAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVT
MAB_2456|M.abscessus_ATCC_1997 EFATSARLPIAARGGGHSYAAYCIPNDG---LVVDLARMAAVSVTGTRAV
MMAR_3461|M.marinum_M AWANAAGIRLSIRSGGHSFDGFPVRDDGVLLDLRGLS--AVRYAPSGYLH
TH_1540|M.thermoresistible__bu RYAADNDLRIGVCSGGHSWAASHLRDGG-MLLDVSRLDHCGIDADRMVAV
MLBr_02333|M.leprae_Br4923 RSIPATSPVRLAKPTSNLFRTRAKRDAP-GLDASGLTGVIGIDTEARTAD
.:
Mb1755|M.bovis_AF2122/97 VQGGATLADLDHATVPFARVAPAG-IVTTTGVGGLTLGGGVGWTTRRFGL
Rv1726|M.tuberculosis_H37Rv VQGGATLADLDHATVPFARVAPAG-IVTTTGVGGLTLGGGVGWTTRRFGL
Mflv_4651|M.gilvum_PYR-GCK VGAGARWQDVLDVATPHGLAPLCG-SAPGVGVIGYLTGGGIGPLVRTYGL
Mvan_1816|M.vanbaalenii_PYR-1 VGAGARWQDVIDVAAPHGLAPLCG-SSPGVGVVGFLTGGGIGPLVRTVGL
MSMEG_1964|M.smegmatis_MC2_155 VQAGARWQHVIDAAAPHGLAPLCG-SSPNVGVVGYLTGGGVGPLVRTVGL
MAV_0089|M.avium_104 VTPATSLYTMHRTLAAVGRGVPTG-TCPSVGAAGHALGGGMGAQSRHAGL
MUL_1431|M.ulcerans_Agy99 VPAGVSLTDVHQVLAGAGRAIPTG-SCPTVGVGGLALGGGMGADSRHAGL
MAB_2456|M.abscessus_ATCC_1997 VGAGARLIDVYAGIAGAGRMLAGG-SCPTVGIAGLTLGGGVGVLTRRFGL
MMAR_3461|M.marinum_M AMTGATVGDIARALDGTGRAMPIG-ECPTVGVGGLVLGGGFGQCTRHFGL
TH_1540|M.thermoresistible__bu AGPGKIGSELAGELDKLDLFFPAG-HCEGICLGGYLLQGGYGWNSRVLGP
MLBr_02333|M.leprae_Br4923 VAGMCTYEDLVAATLPYGLLPLVVPQLKTITLGGAVTGLGIESASFRNGL
. : * * *
Mb1755|M.bovis_AF2122/97 SCDNLVAVRLVTAAGDYLSVDDERDPELMWGLRGGG-GNFGIVTEFEFAT
Rv1726|M.tuberculosis_H37Rv SCDNLVAVRLVTAAGDYLSVDDERDPELMWGLRGGG-GNFGIVTEFEFAT
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAPDENADLFWGLRGGK-ATLGIVTSAEIDL
Mvan_1816|M.vanbaalenii_PYR-1 SSDYVRAFDVVTGEGRLLRATPDENADLFWGLRGGK-ATLGIVTAVEIDL
MSMEG_1964|M.smegmatis_MC2_155 SSDHVRSFELVTGKGELLRATPEENAELFWGLRGGK-ATLGIVTSVEIDL
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTASTASNPDLFWALRGGGGGNFGVTTSLTFAT
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASAEDHPDLFWALRGGGGGNFGVTTAMTFET
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSADTESDLFWAIRGVGGGNFCIATELAFET
MMAR_3461|M.marinum_M TSDFLAEATVVTASGQIHVTNAVTNANLFWGLRGGA-GCVGIVTDLVFHT
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDDETNADLFWAARGSGPGFFAVVTSFHLRL
MLBr_02333|M.leprae_Br4923 PHESVLEMDILTGAGELLTVSANQHGDLYRAFPNSY-GTLGYSTRFRISL
: : :: * . :* . . . . * :
Mb1755|M.bovis_AF2122/97 HPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLR------
Rv1726|M.tuberculosis_H37Rv HPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLR------
Mflv_4651|M.gilvum_PYR-GCK LPVPEFYGG-AVYFAADDVADVLRAWAAWCVDLPETINTSIAIQ------
Mvan_1816|M.vanbaalenii_PYR-1 PPIPEFYGG-AVYFDGADTAAVLHAWRSWSVELPETVNTSIAVQ------
MSMEG_1964|M.smegmatis_MC2_155 PPIPEFYGG-AVIFDGADAASVLHAWRTWCVTLPESVNTSISLQ------
MAV_0089|M.avium_104 FPTKDVDAV-NLNFPPQSFAQVLVGWQNWLRTADP--NSWALAD------
MUL_1431|M.ulcerans_Agy99 FPVADSDVV-RVDFTPSSAAQVLAGWQTWLAAADR--DTWGLVD------
MAB_2456|M.abscessus_ATCC_1997 AASTDLTVF-TLDYAAGEMAPIVHRWLTFMAGAPDELWTTLHAIGG----
MMAR_3461|M.marinum_M VPIQQVTGV-TLGWRWDAAVEAILLFTQLMHTAPSELDLQLSIRTTGADR
TH_1540|M.thermoresistible__bu HPRPPVCGSCLYIYP----AEAIDDVYTWALTSGRDVDDRVELQ------
MLBr_02333|M.leprae_Br4923 EPVTPFVALRHIRFH--LLTEMVTAMENIIDTGGHDGVPVDYLDG---VV
. : :
Mb1755|M.bovis_AF2122/97 -HAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARPVADTV
Rv1726|M.tuberculosis_H37Rv -HAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARPVADTV
Mflv_4651|M.gilvum_PYR-GCK -QLPPLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTV
Mvan_1816|M.vanbaalenii_PYR-1 -QLPPLSGVPEPLAGRMTVAVRYTAVGDFAEAERLLAPMRAVATPVMDTV
MSMEG_1964|M.smegmatis_MC2_155 -NLPPLPGVPEPLAGKLTVAVRYTAIGDFARAERLLAPMRAVATPVLDTV
MAV_0089|M.avium_104 -ATVDAMGVHCRILATCPAGSGNSAAAAITQAVGIQP--SGVETHTFNYM
MUL_1431|M.ulcerans_Agy99 -MSVSAAQANCHVLATCPAGAGRGVADAIKSAVGAQP--TGIETKTFNHM
MAB_2456|M.abscessus_ATCC_1997 -AIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLDAMKFM
MMAR_3461|M.marinum_M YADEASAGPADVIPGTPRVRIDGQFLGNQDDARSLMRPLLEHPAALHASI
TH_1540|M.thermoresistible__bu --IIASRDLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAI
MLBr_02333|M.leprae_Br4923 FSANESYLCIGKRTTTPGPVSDYTGQHIYYRSIQHDNEVKEDRLTIHDYV
:
Mb1755|M.bovis_AF2122/97 W---------PTPFLAHQAVLDASNPAGHR----------YYWKSDYLAE
Rv1726|M.tuberculosis_H37Rv W---------PTPFLAHQAVLDASNPAGHR----------YYWKSDHLAE
Mflv_4651|M.gilvum_PYR-GCK G---------VLPYAAIGAVHADPVDPMPI----------NEDQALLREL
Mvan_1816|M.vanbaalenii_PYR-1 G---------VLPYAAIGAVHADPVDPMPT----------NEDQALLSEL
MSMEG_1964|M.smegmatis_MC2_155 A---------VHPYAAIGGVHMDPVDPMPC----------NETHTLLREL
MAV_0089|M.avium_104 D---------LVNYLAVGNLNPQPLGYVGG----------SDVFPTVNAA
MUL_1431|M.ulcerans_Agy99 E---------LVKYLAGGSSASSPRGFVAG----------SDVIGTVNSA
MAB_2456|M.abscessus_ATCC_1997 G---------GCTTLTVAQCHPSWTGPGSGQLK-------REAFVASSRM
MMAR_3461|M.marinum_M R---------EESFFDAVFVSNDFLHDPAPATLRPHRIASDIGRGALGAV
TH_1540|M.thermoresistible__bu I---------KIPYATTDLAGWYGAIMTNYP---------TGHRYATDNM
MLBr_02333|M.leprae_Br4923 WRWDTDWFWCSRAFGAQNQQLRRWWPRRYRRSSVYWKLMAADRRFGIVDR
Mb1755|M.bovis_AF2122/97 LNDEAIDLLVEQTAQLSSPDSLIGIFQLGGAAAR-GGERSCFPSRHARFM
Rv1726|M.tuberculosis_H37Rv LNDEAIDLLVEQTAQLSSPDSLIGIFQLGGAAAR-GGERSCFPSRHARFM
Mflv_4651|M.gilvum_PYR-GCK PPEAVEALLAAAGPESGSPQAIVELRHLGGALAREATHRSAFCHR-NAAF
Mvan_1816|M.vanbaalenii_PYR-1 PAEAVDALLAVAGPGSGSPQVIVDLRLLGGALVREPQHRSAFCHR-DAAF
MSMEG_1964|M.smegmatis_MC2_155 PSEAVDVLLAAAGPDTPPVQTIVEIRLFGGALAREPRHRSAFCHR-DAAF
MAV_0089|M.avium_104 VAQGIAAAVNAFPRNAGRMLAIMHA--LDGALATVAPAATAFPWRRQSAL
MUL_1431|M.ulcerans_Agy99 AAQAIVAAVGKSPPASGWASALVDT--LTGAVGDIDPTATAFPWRRQSAV
MAB_2456|M.abscessus_ATCC_1997 VPHPDVDTARIETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAAC
MMAR_3461|M.marinum_M EAAAIVGQINELQFAPELPGGAVSIEAINGAVAAFTPQETAFFHRGQDFV
TH_1540|M.thermoresistible__bu WTSASPEALLPGIHRIIETLPPAPSHFLMFNWSPTSTRDNLFYGLEADFN
MLBr_02333|M.leprae_Br4923 IEARNGRPLRERVVQDVELPIERTCEFLEWFLGSVPIAPIWLCPLRLRDH
: :
Mb1755|M.bovis_AF2122/97 VNYATHWTEAREDDLHRQWTRDAIEALAPYGLGTAYVNFTADDA---PMH
Rv1726|M.tuberculosis_H37Rv VNYATHWTEAREDDLHRQWTRDAIEALAPYGLGTAYVNFTADDA---PMH
Mflv_4651|M.gilvum_PYR-GCK SLAVIGVPAPEIADMVIAHAGAVTGAVAPWSTGGQMPNFAPSYD---PAR
Mvan_1816|M.vanbaalenii_PYR-1 SLAVIGAPTPENAAMVAEHARAVTGAVAPWATGGQMPNFAPSYD---PAR
MSMEG_1964|M.smegmatis_MC2_155 GVTAIGVPVPPVADTVRAHGAALVDAMAPWSTGGQLPNFAPSDD---AGR
MAV_0089|M.avium_104 VQWYVET--SGDPAAATNWLASAHQAVQQYSVGGYVNYLEANQS---PAR
MUL_1431|M.ulcerans_Agy99 VQWYVETPSSGQTAAATKWINSAHQAVQQFSVGGYVNYLEANTA---LSR
MAB_2456|M.abscessus_ATCC_1997 IQIYHGVG--ADPAVAHERVSQARDGLGDICGPAAYVNYIDPGM---PDW
MMAR_3461|M.marinum_M YHWALGDRLPADAGLAARHDALLQEIRHDLAGVLTGGRYVNYAD---ILD
TH_1540|M.thermoresistible__bu LALYAVWNDPEDDERFSAWPGTNMAALAHLAMG---VGLADENL---GRR
MLBr_02333|M.leprae_Br4923 NSWPLYPIQPDHSYVNVGFWSSVPAGATEGETNRTIEAKVSALDGHKSLY
Mb1755|M.bovis_AF2122/97 VETLYSTTEFSRLVT------LKNRLDPDNVFRNNHNIRPSA-
Rv1726|M.tuberculosis_H37Rv VETLYSTTEFSRLVT------LKNRLDPDNVFRNNHNIRPSA-
Mflv_4651|M.gilvum_PYR-GCK PSRVYTDDTLHWLAG------LADRYDPARTLATGQVIRTVV-
Mvan_1816|M.vanbaalenii_PYR-1 PARAYAPDTLHWLAA------LADRYDPSRVLATGQVVRT---
MSMEG_1964|M.smegmatis_MC2_155 ASRVYDEDTLHWLAA------LAERHDPAGVYRCGQVVRFVS-
MAV_0089|M.avium_104 ----YFGPNLSRLSA------VRQKYDPGRVMFSGLNY-----
MUL_1431|M.ulcerans_Agy99 ----YFGSNLSRLTQ------IRQRYDPSRLMYSGLNF-----
MAB_2456|M.abscessus_ATCC_1997 AT-AYYGDNLPRLRG------IAAAYDPKGIFRFAQAVRP---
MMAR_3461|M.marinum_M TPNDWWGDNTDQLMS------VVQEHDPDRILISRLNP-----
TH_1540|M.thermoresistible__bu PARFATDANMARLDG------IRARRDPAGRFHGWMGRV----
MLBr_02333|M.leprae_Br4923 SDSFYTREEFNELYGGESYNAVKKIYDPDSRLLDLYAKVVQRR
* : **