For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTIPTDLTRDDALRILREEVATLVALPGEPGYERCVPWNVAAPVTPAAVVLATSAEDVAGTVRFAAAHGF TVTVQATGHGAVGVGADTILVLTAAMKHCEVDSLNRTARVGAGARWQDVIDVAAPHGLAPLCGSSPGVGV VGFLTGGGIGPLVRTVGLSSDYVRAFDVVTGEGRLLRATPDENADLFWGLRGGKATLGIVTAVEIDLPPI PEFYGGAVYFDGADTAAVLHAWRSWSVELPETVNTSIAVQQLPPLSGVPEPLAGRMTVAVRYTAVGDFAE AERLLAPMRAVATPVMDTVGVLPYAAIGAVHADPVDPMPTNEDQALLSELPAEAVDALLAVAGPGSGSPQ VIVDLRLLGGALVREPQHRSAFCHRDAAFSLAVIGAPTPENAAMVAEHARAVTGAVAPWATGGQMPNFAP SYDPARPARAYAPDTLHWLAALADRYDPSRVLATGQVVRT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | - | 100% (460) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | 2e-31 | 29.66% (472) | FAD linked oxidase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0156 | - | 4e-22 | 29.48% (251) | FAD linked oxidase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 9e-39 | 28.89% (443) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 0.0 | 81.52% (460) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1726 | - | 4e-39 | 29.12% (443) | oxidoreductase |
| M. leprae Br4923 | MLBr_02333 | - | 2e-09 | 30.70% (114) | hypothetical protein MLBr_02333 |
| M. abscessus ATCC 19977 | MAB_2456 | - | 4e-24 | 26.38% (436) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 5e-30 | 28.03% (421) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 3e-23 | 26.13% (421) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1964 | - | 0.0 | 72.83% (449) | mitomycin radical oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 3e-19 | 28.37% (289) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 7e-29 | 27.96% (422) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1755|M.bovis_AF2122/97 --------MTATLTKTLG-----------SLDDFRGTLCVPGDPDYPRVR
Rv1726|M.tuberculosis_H37Rv --------MTATLTKTLG-----------SLDDFRGTLCVPGDPDYPRVR
Mvan_1816|M.vanbaalenii_PYR-1 ---------MTIPTDLTR-----DDALRILREEVATLVALPGEPGYERCV
Mflv_4651|M.gilvum_PYR-GCK ---------MTVPTDLRR-----DEALRSLRDQVATPVALPGEPGYERCR
MSMEG_1964|M.smegmatis_MC2_155 ---------MTL-TDLPNGTEGLADALDGLRAHVVAPVALPGEAGYERAT
MMAR_1179|M.marinum_M --------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
TH_1540|M.thermoresistible__bu ------------------------------MAALPALSFRRGAQGYEQAR
MLBr_02333|M.leprae_Br4923 --------------------------------------------------
Mb1755|M.bovis_AF2122/97 AIWNG---------------------QVAREPALIATCHDACDVRTVLRR
Rv1726|M.tuberculosis_H37Rv AIWNG---------------------QVAREPALIATCHDACDVRTVLRR
Mvan_1816|M.vanbaalenii_PYR-1 PWN----------------------VAAPVTPAAVVLATSAEDVAGTVRF
Mflv_4651|M.gilvum_PYR-GCK PWN----------------------VVAPVEPAAVVLATSPEDVAGTVRF
MSMEG_1964|M.smegmatis_MC2_155 PWN----------------------VAAEVKPAAVVLATSAYDVANTVRY
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
TH_1540|M.thermoresistible__bu RTTVWN------------------GLLPDRFPDVIVQAVTVDDVVTAVRY
MLBr_02333|M.leprae_Br4923 --------------------------MVSVQESALVVYTSGVKRLVASYR
:. .
Mb1755|M.bovis_AF2122/97 PVDAGMVTAVRGGGHNVAGTALCDGGVVIDLS-AMRAVSLDPATGRVRVQ
Rv1726|M.tuberculosis_H37Rv AVDAGMVTAVRGGGHNVAGTALCDGGVVIDLS-AMRAVSLDPATGRVRVQ
Mvan_1816|M.vanbaalenii_PYR-1 AAAHGFTVTVQATGHGAVGVGADT---ILVLTAAMKHCEVDSLNRTARVG
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAVGVGPDT---ILIQTSAMRHVSVDVVNGTARVG
MSMEG_1964|M.smegmatis_MC2_155 AASRGLRVTVQATGHGALKVTDDT---ILIVTSGMTGCTVDPSTRTARVQ
MMAR_1179|M.marinum_M AAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTVP
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTVP
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVTVT
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYAAYCIPNDGLVVDLA---RMAAVSVTGTRAVVG
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWAASHLRDGGMLLDVS-RLDHCGIDADRMVAVAG
MLBr_02333|M.leprae_Br4923 SIPATSPVRLAKPTSNLFRTRAKRDAPGLDASGLTGVIGIDTEARTADVA
. . : . . .
Mb1755|M.bovis_AF2122/97 GGATLADLDHATVPFARVAPAG-IVTTTGVGGLTLGGGVGWTTRRFGLSC
Rv1726|M.tuberculosis_H37Rv GGATLADLDHATVPFARVAPAG-IVTTTGVGGLTLGGGVGWTTRRFGLSC
Mvan_1816|M.vanbaalenii_PYR-1 AGARWQDVIDVAAPHGLAPLCG-SSPGVGVVGFLTGGGIGPLVRTVGLSS
Mflv_4651|M.gilvum_PYR-GCK AGARWQDVLDVATPHGLAPLCG-SAPGVGVIGYLTGGGIGPLVRTYGLSS
MSMEG_1964|M.smegmatis_MC2_155 AGARWQHVIDAAAPHGLAPLCG-SSPNVGVVGYLTGGGVGPLVRTVGLSS
MMAR_1179|M.marinum_M AGVSLTDVHQVLAGAGRAIPTG-SCPTVGVGGLALGGGMGADSRHAGLTC
MUL_1431|M.ulcerans_Agy99 AGVSLTDVHQVLAGAGRAIPTG-SCPTVGVGGLALGGGMGADSRHAGLTC
MAV_0089|M.avium_104 PATSLYTMHRTLAAVGRGVPTG-TCPSVGAAGHALGGGMGAQSRHAGLLC
MAB_2456|M.abscessus_ATCC_1997 AGARLIDVYAGIAGAGRMLAGG-SCPTVGIAGLTLGGGVGVLTRRFGLTC
TH_1540|M.thermoresistible__bu PGKIGSELAGELDKLDLFFPAG-HCEGICLGGYLLQGGYGWNSRVLGPAC
MLBr_02333|M.leprae_Br4923 GMCTYEDLVAATLPYGLLPLVVPQLKTITLGGAVTGLGIESASFRNGLPH
: * * *
Mb1755|M.bovis_AF2122/97 DNLVAVRLVTAAGDYLSVDDERDPELMWGLRGGG-GNFGIVTEFEFATHP
Rv1726|M.tuberculosis_H37Rv DNLVAVRLVTAAGDYLSVDDERDPELMWGLRGGG-GNFGIVTEFEFATHP
Mvan_1816|M.vanbaalenii_PYR-1 DYVRAFDVVTGEGRLLRATPDENADLFWGLRGGK-ATLGIVTAVEIDLPP
Mflv_4651|M.gilvum_PYR-GCK DHVRSFDVVTGGGRLLRAAPDENADLFWGLRGGK-ATLGIVTSAEIDLLP
MSMEG_1964|M.smegmatis_MC2_155 DHVRSFELVTGKGELLRATPEENAELFWGLRGGK-ATLGIVTSVEIDLPP
MMAR_1179|M.marinum_M DALRSATVVLPSGETVTASAEDHPDLFWALRGGGGGNFGVTTAMTFETFP
MUL_1431|M.ulcerans_Agy99 NALRSATVVLPSGETVTASAEDHPDLFWALRGGGGGNFGVTTAMTFETFP
MAV_0089|M.avium_104 DQLTSASVVLPSGQAVTASTASNPDLFWALRGGGGGNFGVTTSLTFATFP
MAB_2456|M.abscessus_ATCC_1997 DQLISARVVTADGKIRVVSADTESDLFWAIRGVGGGNFCIATELAFETAA
TH_1540|M.thermoresistible__bu ESIVGVDVVTADGEVLYCDDETNADLFWAARGSGPGFFAVVTSFHLRLHP
MLBr_02333|M.leprae_Br4923 ESVLEMDILTGAGELLTVSANQHGDLYRAFPNSY-GTLGYSTRFRISLEP
: : :: * . :* . . . : * : .
Mb1755|M.bovis_AF2122/97 FGPVAVAGFVVYRLDDGPAVLRG-------YRQFAAAAPEEVTTIVVLR-
Rv1726|M.tuberculosis_H37Rv FGPVAVAGFVVYRLDDGPAVLRG-------YRQFAAAAPEEVTTIVVLR-
Mvan_1816|M.vanbaalenii_PYR-1 IPEFYGG-AVYFDGADTAAVLHA-------WRSWSVELPETVNTSIAVQ-
Mflv_4651|M.gilvum_PYR-GCK VPEFYGG-AVYFAADDVADVLRA-------WAAWCVDLPETINTSIAIQ-
MSMEG_1964|M.smegmatis_MC2_155 IPEFYGG-AVIFDGADAASVLHA-------WRTWCVTLPESVNTSISLQ-
MMAR_1179|M.marinum_M VADSDVV-RVDFTPSSAAQVLAG-------WQTWLAAADR--DTWGLVD-
MUL_1431|M.ulcerans_Agy99 VADSDVV-RVDFTPSSAAQVLAG-------WQTWLAAADR--DTWGLVD-
MAV_0089|M.avium_104 TKDVDAV-NLNFPPQSFAQVLVG-------WQNWLRTADP--NSWALAD-
MAB_2456|M.abscessus_ATCC_1997 STDLTVF-TLDYAAGEMAPIVHR-------WLTFMAGAPDELWTTLHAIG
TH_1540|M.thermoresistible__bu RPPVCGSCLYIYP----AEAIDD-------VYTWALTSGRDVDDRVELQI
MLBr_02333|M.leprae_Br4923 VTPFVALRHIRFHLLTEMVTAMENIIDTGGHDGVPVDYLDGVVFSANESY
:
Mb1755|M.bovis_AF2122/97 -HAPPAPWIPVDQRGKPVVM-IGAVHTGSIQTGIEALRPVKSLARPVADT
Rv1726|M.tuberculosis_H37Rv -HAPPAPWIPVDQRGKPVVM-IGAVHTGSIQTGIEALRPVKSLARPVADT
Mvan_1816|M.vanbaalenii_PYR-1 -QLPPLSGVPEPLAGRMTVA-VRYTAVGDFAEAERLLAPMRAVATPVMDT
Mflv_4651|M.gilvum_PYR-GCK -QLPPLPEVPEPLAGRMTVA-VRYAAVGDVDEAEQALAPMRAVATPVLDT
MSMEG_1964|M.smegmatis_MC2_155 -NLPPLPGVPEPLAGKLTVA-VRYTAIGDFARAERLLAPMRAVATPVLDT
MMAR_1179|M.marinum_M -MSVSAAQANCHVLATCPAG-AGRGVADAIKSAVGAQP--TGIETKTFNH
MUL_1431|M.ulcerans_Agy99 -MSVSAAQANCHVLATCPAG-AGRGVADAIKSAVGAQP--TGIETKTFNH
MAV_0089|M.avium_104 -ATVDAMGVHCRILATCPAG-SGNSAAAAITQAVGIQP--SGVETHTFNY
MAB_2456|M.abscessus_ATCC_1997 GAIPQCRIVGCVAQGVNSQD-VIESLRGGIGVRAADSFIAEMTFLDAMKF
TH_1540|M.thermoresistible__bu IASRDLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIKI
MLBr_02333|M.leprae_Br4923 LCIGKRTTTPGPVSDYTGQHIYYRSIQHDNEVKEDRLTIHDYVWRWDTDW
.
Mb1755|M.bovis_AF2122/97 VWPTPFLAHQAVLDASNPAGHR---YYWKSDYLAELNDEAIDLLVE----
Rv1726|M.tuberculosis_H37Rv VWPTPFLAHQAVLDASNPAGHR---YYWKSDHLAELNDEAIDLLVE----
Mvan_1816|M.vanbaalenii_PYR-1 VGVLPYAAIGAVHADPVDPMPT---NEDQALLSELPAEAVDALLAV----
Mflv_4651|M.gilvum_PYR-GCK VGVLPYAAIGAVHADPVDPMPI---NEDQALLRELPPEAVEALLAA----
MSMEG_1964|M.smegmatis_MC2_155 VAVHPYAAIGGVHMDPVDPMPC---NETHTLLRELPSEAVDVLLAA----
MMAR_1179|M.marinum_M MELVKYLAGGSSASSPRGFVAG---SDVIGTVNSAAAQAIVAAVGK----
MUL_1431|M.ulcerans_Agy99 MELVKYLAGGSSASSPRGFVAG---SDVIGTVNSAAAQAIVAAVGK----
MAV_0089|M.avium_104 MDLVNYLAVGNLNPQPLGYVGG---SDVFPTVNAAVAQGIAAAVNA----
MAB_2456|M.abscessus_ATCC_1997 MGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARI----
TH_1540|M.thermoresistible__bu PYATTDLAGWYGAIMTNYPTGHR--YATDNMWTSASPEALLPGIHR----
MLBr_02333|M.leprae_Br4923 FWCSRAFGAQNQQLRRWWPRRYRRSSVYWKLMAADRRFGIVDRIEARNGR
Mb1755|M.bovis_AF2122/97 -------QTAQLSSPDSLIGIFQLGGAAAR-GGERSCFPSRHARFMVNYA
Rv1726|M.tuberculosis_H37Rv -------QTAQLSSPDSLIGIFQLGGAAAR-GGERSCFPSRHARFMVNYA
Mvan_1816|M.vanbaalenii_PYR-1 -------AGPGSGSPQVIVDLRLLGGALVREPQHRSAFCHR-DAAFSLAV
Mflv_4651|M.gilvum_PYR-GCK -------AGPESGSPQAIVELRHLGGALAREATHRSAFCHR-NAAFSLAV
MSMEG_1964|M.smegmatis_MC2_155 -------AGPDTPPVQTIVEIRLFGGALAREPRHRSAFCHR-DAAFGVTA
MMAR_1179|M.marinum_M -------WPPASGRASALVDT--LTGAVGDIDPTATAFPWRRQSAVVQWY
MUL_1431|M.ulcerans_Agy99 -------SPPASGWASALVDT--LTGAVGDIDPTATAFPWRRQSAVVQWY
MAV_0089|M.avium_104 -------FPRNAGRMLAIMHA--LDGALATVAPAATAFPWRRQSALVQWY
MAB_2456|M.abscessus_ATCC_1997 -------ETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIY
TH_1540|M.thermoresistible__bu -------IIETLPPAPSHFLMFNWSPTSTR----DNLFYGLEADFNLALY
MLBr_02333|M.leprae_Br4923 PLRERVVQDVELPIERTCEFLEWFLGSVPIAPIWLCPLRLRDHNSWPLYP
: :
Mb1755|M.bovis_AF2122/97 THWTEAREDDLHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYST
Rv1726|M.tuberculosis_H37Rv THWTEAREDDLHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYST
Mvan_1816|M.vanbaalenii_PYR-1 IGAPTPENAAMVAEHARAVTGAVAPWATGGQMPNFAPSYDPARPARAYAP
Mflv_4651|M.gilvum_PYR-GCK IGVPAPEIADMVIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTD
MSMEG_1964|M.smegmatis_MC2_155 IGVPVPPVADTVRAHGAALVDAMAPWSTGGQLPNFAPSDDAGRASRVYDE
MMAR_1179|M.marinum_M VETPSSGQTAAATKWINSAHQAVQQFSVGGYVNYLEANTAPSR----YFG
MUL_1431|M.ulcerans_Agy99 VETPSSGQTAAATKWINSAHQAVQQFSVGGYVNYLEANTALSR----YFG
MAV_0089|M.avium_104 VET--SGDPAAATNWLASAHQAVQQYSVGGYVNYLEANQSPAR----YFG
MAB_2456|M.abscessus_ATCC_1997 HGVG--ADPAVAHERVSQARDGLGDICGPAAYVNYIDPGMPDWAT-AYYG
TH_1540|M.thermoresistible__bu AVWNDPEDDERFSAWPGTNMAALAHLAMGVGLADENLGRRPAR---FATD
MLBr_02333|M.leprae_Br4923 IQPDHSYVNVGFWSSVPAGATEGETNRTIEAKVSALDGHKSLYSDSFYTR
Mb1755|M.bovis_AF2122/97 TEFSRLVT------LKNRLDPDNVFRNNHNIRPSA-
Rv1726|M.tuberculosis_H37Rv TEFSRLVT------LKNRLDPDNVFRNNHNIRPSA-
Mvan_1816|M.vanbaalenii_PYR-1 DTLHWLAA------LADRYDPSRVLATGQVVRT---
Mflv_4651|M.gilvum_PYR-GCK DTLHWLAG------LADRYDPARTLATGQVIRTVV-
MSMEG_1964|M.smegmatis_MC2_155 DTLHWLAA------LAERHDPAGVYRCGQVVRFVS-
MMAR_1179|M.marinum_M SNLSRLTQ------IRQRYDPSRLMYSGLNF-----
MUL_1431|M.ulcerans_Agy99 SNLSRLTQ------IRQRYDPSRLMYSGLNF-----
MAV_0089|M.avium_104 PNLSRLSA------VRQKYDPGRVMFSGLNY-----
MAB_2456|M.abscessus_ATCC_1997 DNLPRLRG------IAAAYDPKGIFRFAQAVRP---
TH_1540|M.thermoresistible__bu ANMARLDG------IRARRDPAGRFHGWMGRV----
MLBr_02333|M.leprae_Br4923 EEFNELYGGESYNAVKKIYDPDSRLLDLYAKVVQRR
: * : **