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MLQVHPTMVDELAMSMPERVHLPGSPEYGDAVAIWNGAVTERPAAVVRPTSSGDVRNVVRFAHEQRIPIT VRAGGHDWGGRALNEGGLVIDLSSMRKVYIDPAAREALVEGGATAEDVVQAAERHGLTAAAPNLADVGFT GFTLGGGYGPLNGIAGLGVDNLLEAHVVLADGRSVTANAADEADLLWALRGGGANFGVVTHLRVRLHPVP HLATGVLMFPWEQAADVMRRYDALAPSLPDGLTAQIGVIPAPDGGPVVFVAPYWVGDPDEGDRWVAELRR LGTPVVDQVAPMSPSAQLRLLDPLVPRGRHYEMRTVNVDTLSPGVIDALVAAGSSRTSPASVLALHHFHG ASTRVGLTDTAFGLRTPHFLVEIVAAWDADSDDDGERHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQA DTAYGPNAERLLAAKDRWDAGNVFTAIPLPSRSSTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1746 | - | - | 100% (456) | 6-hydroxy-D-nicotine oxidase |
| M. smegmatis MC2 155 | MSMEG_1964 | - | 7e-45 | 29.93% (451) | mitomycin radical oxidase |
| M. smegmatis MC2 155 | MSMEG_0301 | - | 7e-17 | 34.36% (195) | oxidoreductase, FAD-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 4e-58 | 32.95% (434) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 6e-45 | 34.06% (367) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv1726 | - | 5e-59 | 33.18% (434) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 2e-14 | 28.88% (187) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 1e-29 | 28.64% (433) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_0110 | - | 4e-31 | 28.57% (462) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 3e-34 | 29.32% (457) | FAD binding domain-containing protein |
| M. thermoresistible (build 8) | TH_1540 | - | 2e-23 | 26.68% (401) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 3e-27 | 29.71% (451) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 3e-44 | 31.58% (437) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4651|M.gilvum_PYR-GCK ---------------------------------MTVPTDLRRDEALRSLR
Mvan_1816|M.vanbaalenii_PYR-1 ---------------------------------MTIPTDLTRDDALRILR
Mb1755|M.bovis_AF2122/97 --------------------------------------MTATLTKTLGSL
Rv1726|M.tuberculosis_H37Rv --------------------------------------MTATLTKTLGSL
MSMEG_1746|M.smegmatis_MC2_155 -------------------------------------MLQVHPTMVDELA
MMAR_0110|M.marinum_M -----MAREISRQAFLRGAAGALAAG---AVFGSVRAAAEPNPSGWEGLS
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
TH_1540|M.thermoresistible__bu ------------------------------------------------MA
MLBr_01103|M.leprae_Br4923 ------------------------------------------MGVLTSLI
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALPGE-PGYERCRPWN--VVAPVEPAAVVLATSPEDVAGTVRF
Mvan_1816|M.vanbaalenii_PYR-1 EEVATLVALPGE-PGYERCVPWN--VAAPVTPAAVVLATSAEDVAGTVRF
Mb1755|M.bovis_AF2122/97 DDFRGTLCVPGD-PDYPRVRAIWNGQVAR-EPALIATCHDACDVRTVLRR
Rv1726|M.tuberculosis_H37Rv DDFRGTLCVPGD-PDYPRVRAIWNGQVAR-EPALIATCHDACDVRTVLRR
MSMEG_1746|M.smegmatis_MC2_155 MSMPERVHLPGS-PEYGDAVAIWNGAVTE-RPAAVVRPTSSGDVRNVVRF
MMAR_0110|M.marinum_M SALGGKVLRPDDGPQFATAKQVFNTNYNDFTPAAVVTPTSAADVQKAMAF
MAV_0089|M.avium_104 TALGGKVLLPDS-PQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVRGD-AAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
TH_1540|M.thermoresistible__bu ALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MLBr_01103|M.leprae_Br4923 AGLPDGMVVTDS-AVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRW
. . * :. :* :
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAVG--VGPDT-ILIQTSAMR-HVSVDVVNGTARV
Mvan_1816|M.vanbaalenii_PYR-1 AAAHGFTVTVQATGHGAVG--VGADT-ILVLTAAMK-HCEVDSLNRTARV
Mb1755|M.bovis_AF2122/97 PVDAGMVTAVRGGGHNVAGTALCDGG-VVIDLSAMR-AVSLDPATGRVRV
Rv1726|M.tuberculosis_H37Rv AVDAGMVTAVRGGGHNVAGTALCDGG-VVIDLSAMR-AVSLDPATGRVRV
MSMEG_1746|M.smegmatis_MC2_155 AHEQRIPITVRAGGHDWGGRALNEGG-LVIDLSSMR-KVYIDPAAREALV
MMAR_0110|M.marinum_M ATAHNLKVAPRSGGHSYIGASTANGA-MVLDLRQLPGDINYDAATGQVTV
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYTGASTANGT-MVLDLRQLPGDANYDAATGQVTV
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYIGASTAVGA-MVIDLRGLPGGVNFDAGSGTVTV
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYAAYCIPNDG-LVVDLARMA---AVSVTGTRAVV
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWAASHLRDGG-MLLDVSRLD-HCGIDADRMVAVA
MLBr_01103|M.leprae_Br4923 ASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMR-DITVDPVTRTAVC
. . . * . . . ::: : . .
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLCG--SAPGVGVIGYLTGGGIGPLVRTYGL
Mvan_1816|M.vanbaalenii_PYR-1 GAGARWQDVIDVAAPHGLAPLCG--SSPGVGVVGFLTGGGIGPLVRTVGL
Mb1755|M.bovis_AF2122/97 QGGATLADLDHATVPFARVAPAG--IVTTTGVGGLTLGGGVGWTTRRFGL
Rv1726|M.tuberculosis_H37Rv QGGATLADLDHATVPFARVAPAG--IVTTTGVGGLTLGGGVGWTTRRFGL
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAAP--NLADVGFTGFTLGGGYGPLNGIAGL
MMAR_0110|M.marinum_M TPSTGLYEMHQVLAGAGRGIPTG--TCPSVGAAGHALGGGLGAHSRHAGL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPTG--TCPSVGAAGHALGGGMGAQSRHAGL
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAGL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAGG--SCPTVGIAGLTLGGGVGVLTRRFGL
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPAG--HCEGICLGGYLLQGGYGWNSRVLGP
MLBr_01103|M.leprae_Br4923 QPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGV
. : * .. * *
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAP----DENADLFWGLRGGKA-TLGIVTSA
Mvan_1816|M.vanbaalenii_PYR-1 SSDYVRAFDVVTGEGRLLRATP----DENADLFWGLRGGKA-TLGIVTAV
Mb1755|M.bovis_AF2122/97 SCDNLVAVRLVTAAGDYLSVDD----ERDPELMWGLRGGGG-NFGIVTEF
Rv1726|M.tuberculosis_H37Rv SCDNLVAVRLVTAAGDYLSVDD----ERDPELMWGLRGGGG-NFGIVTEF
MSMEG_1746|M.smegmatis_MC2_155 GVDNLLEAHVVLADGRSVTANA----ADEADLLWALRGGGA-NFGVVTHL
MMAR_0110|M.marinum_M LCDALTSAAVVLPSGQAVTASA----ASNPDLFWALRGGGGGNFGVTTSL
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTAST----ASNPDLFWALRGGGGGNFGVTTSL
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASA----EDHPDLFWALRGGGGGNFGVTTAM
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSA----DTESDLFWAIRGVGGGNFCIATEL
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDD----ETNADLFWAARGSGPGFFAVVTSF
MLBr_01103|M.leprae_Br4923 TGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEV
: : :* * : : : *
Mflv_4651|M.gilvum_PYR-GCK EIDLLPVPEFYGG-AVYFA-ADDVADVLRAWAAWCVDLPETINTSIAIQ-
Mvan_1816|M.vanbaalenii_PYR-1 EIDLPPIPEFYGG-AVYFD-GADTAAVLHAWRSWSVELPETVNTSIAVQ-
Mb1755|M.bovis_AF2122/97 EFATHPFGPVAVAGFVVYR-LDDGPAVLRGYRQFAAAAPEEVTTIVVLR-
Rv1726|M.tuberculosis_H37Rv EFATHPFGPVAVAGFVVYR-LDDGPAVLRGYRQFAAAAPEEVTTIVVLR-
MSMEG_1746|M.smegmatis_MC2_155 RVRLHPVPHLATG-VLMFP-WEQAADVMRRYDALAPSLPDGLTAQIGVI-
MMAR_0110|M.marinum_M TFATFATKDLDAV-NLDFP-PESFAQVLLGWQQWLRTADRNNWALADAT-
MAV_0089|M.avium_104 TFATFPTKDVDAV-NLNFP-PQSFAQVLVGWQNWLRTADPNSWALADAT-
MUL_1431|M.ulcerans_Agy99 TFETFPVADSDVV-RVDFT-PSSAAQVLAGWQTWLAAADRDTWGLVDMS-
MAB_2456|M.abscessus_ATCC_1997 AFETAASTDLTVF-TLDYA-AGEMAPIVHRWLTFMAGAPDELWTTLHAIG
TH_1540|M.thermoresistible__bu HLRLHPRPPVCGSCLYIYP-AEAIDDVYTWALTSGRDVDDRVELQIIASR
MLBr_01103|M.leprae_Br4923 TLRLLPTQNTSSIVVATFASVQAAVDAVLGVAARLRPAMLEFMDSVAINA
. . :
Mflv_4651|M.gilvum_PYR-GCK -QLPPLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTV
Mvan_1816|M.vanbaalenii_PYR-1 -QLPPLSGVPEPLAGRMTVAVRYTAVGDFAEAERLLAPMRAVATPVMDTV
Mb1755|M.bovis_AF2122/97 -HAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VADT
Rv1726|M.tuberculosis_H37Rv -HAPPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VADT
MSMEG_1746|M.smegmatis_MC2_155 -PAP---------DGGPVVFVAPYWVGDPDEGDRWVAELRRLGTP-VVDQ
MMAR_0110|M.marinum_M -VDQ---------MGTHCRILATCPVGSGGSVASAITSAVGVQPIGTDHH
MAV_0089|M.avium_104 -VDA---------MGVHCRILATCPAGSGNSAAAAITQAVGIQPSGVETH
MUL_1431|M.ulcerans_Agy99 -VSA---------AQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIETK
MAB_2456|M.abscessus_ATCC_1997 GAIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLDAMKFM
TH_1540|M.thermoresistible__bu -DLPALG------LNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAI
MLBr_01103|M.leprae_Br4923 VEDTFR-------MGLDREAAAMLVAGSDELGHAGTDEAKLIGAVFAENG
.
Mflv_4651|M.gilvum_PYR-GCK GVLPYAAIGAVHADPVDPMPINED--QALLRELPPEAVEALLAAAGPESG
Mvan_1816|M.vanbaalenii_PYR-1 GVLPYAAIGAVHADPVDPMPTNED--QALLSELPAEAVDALLAVAGPGSG
Mb1755|M.bovis_AF2122/97 VWPTPFLAHQAVLDASNPAGHRYYWKSDYLAELNDEAIDLLVEQTAQLSS
Rv1726|M.tuberculosis_H37Rv VWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEAIDLLVEQTAQLSS
MSMEG_1746|M.smegmatis_MC2_155 VAPMSPSAQLRLLDPLVPRGRHYEMRTVNVDTLSPGVIDALVAAGSSRTS
MMAR_0110|M.marinum_M TFNYLDLVRYLAVGNLNPAPLGYVGGSDVLPTINAGAAKGIASAIDAFPR
MAV_0089|M.avium_104 TFNYMDLVNYLAVGNLNPQPLGYVGGSDVFPTVNAAVAQGIAAAVNAFPR
MUL_1431|M.ulcerans_Agy99 TFNHMELVKYLAGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAVGKSPP
MAB_2456|M.abscessus_ATCC_1997 GGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARIETLLA
TH_1540|M.thermoresistible__bu IKIPYATTDLAGWYGAIMTNYPTGHRYATDNMWTSASPEALLPGIHRIIE
MLBr_01103|M.leprae_Br4923 ATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPLPALGKLVT
Mflv_4651|M.gilvum_PYR-GCK SP-QAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAP---EIAD
Mvan_1816|M.vanbaalenii_PYR-1 SP-QVIVDLRLLGGALVREPQHRSAFCHRDAAFSLAVIGAPTP---ENAA
Mb1755|M.bovis_AF2122/97 PD--SLIGIFQLGGAAARGGE-RSCFPSRHARFMVNYATHWTEAREDD--
Rv1726|M.tuberculosis_H37Rv PD--SLIGIFQLGGAAARGGE-RSCFPSRHARFMVNYATHWTEAREDD--
MSMEG_1746|M.smegmatis_MC2_155 PA--SVLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDADSDDDGE
MMAR_0110|M.marinum_M GAGRALAIMHALDGALATVAPGATAFPWRRQSALVQWYVETP----GSPA
MAV_0089|M.avium_104 NAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVETS----GDPA
MUL_1431|M.ulcerans_Agy99 ASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSS--GQTA
MAB_2456|M.abscessus_ATCC_1997 GKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG----ADPA
TH_1540|M.thermoresistible__bu TLPPAPSHFLMFN--WSPTSTRDNLFYGLEADFNLALYAVWNDP--EDDE
MLBr_01103|M.leprae_Br4923 GIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHR---AFGE
: .
Mflv_4651|M.gilvum_PYR-GCK MVIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTLHWLAGLA
Mvan_1816|M.vanbaalenii_PYR-1 MVAEHARAVTGAVAPWATGGQMPNFAPSYDPARPARAYAPDTLHWLAALA
Mb1755|M.bovis_AF2122/97 LHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLK
Rv1726|M.tuberculosis_H37Rv LHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLK
MSMEG_1746|M.smegmatis_MC2_155 RHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAYG-PNAERLLAAK
MMAR_0110|M.marinum_M AASGWLNTAHQAVQPYSAG-GYVNYLEANQPA---SRYFGPNLSRLSAVR
MAV_0089|M.avium_104 AATNWLASAHQAVQQYSVG-GYVNYLEANQSP---ARYFGPNLSRLSAVR
MUL_1431|M.ulcerans_Agy99 AATKWINSAHQAVQQFSVG-GYVNYLEANTAL---SRYFGSNLSRLTQIR
MAB_2456|M.abscessus_ATCC_1997 VAHERVSQARDGLGDICGPAAYVNYIDPGMPD-WATAYYGDNLPRLRGIA
TH_1540|M.thermoresistible__bu RFSAWPGTNMAALAHLAMG---VGLADENLGRRPARFATDANMARLDGIR
MLBr_01103|M.leprae_Br4923 IMDMAVGLGGTITGEHGVGRLKRPWLDDYLGP--------DVMELNQRIK
Mflv_4651|M.gilvum_PYR-GCK DRYDPARTLATGQVIRTVV--
Mvan_1816|M.vanbaalenii_PYR-1 DRYDPSRVLATGQVVRT----
Mb1755|M.bovis_AF2122/97 NRLDPDNVFRNNHNIRPSA--
Rv1726|M.tuberculosis_H37Rv NRLDPDNVFRNNHNIRPSA--
MSMEG_1746|M.smegmatis_MC2_155 DRWDAGNVFTAIPLPSRSSTS
MMAR_0110|M.marinum_M QKYDPGRVMFSGLNL------
MAV_0089|M.avium_104 QKYDPGRVMFSGLNY------
MUL_1431|M.ulcerans_Agy99 QRYDPSRLMYSGLNF------
MAB_2456|M.abscessus_ATCC_1997 AAYDPKGIFRFAQAVRP----
TH_1540|M.thermoresistible__bu ARRDPAGRFHGWMGRV-----
MLBr_01103|M.leprae_Br4923 HALDPYGILNPGAAI------
*. :