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MISRQTFLRGAAAATAAGLGSALFGSARAVAEPVSGWSALASSIGGRVLLPSNGASFTSGKQVFNSLYNN SNPAAVVTVTSQADVEKAVAFAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTV PAGVSLTDVHQVLAGAGRAIPTGSCPTVGVGGLALGGGMGADSRHAGLTCNALRSATVVLPSGETVTASA EDHPDLFWALRGGGGGNFGVTTAMTFETFPVADSDVVRVDFTPSSAAQVLAGWQTWLAAADRDTWGLVDM SVSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIETKTFNHMELVKYLAGGSSASSPRGFVAGSDV IGTVNSAAAQAIVAAVGKSPPASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTAA ATKWINSAHQAVQQFSVGGYVNYLEANTALSRYFGSNLSRLTQIRQRYDPSRLMYSGLNF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1431 | - | - | 100% (480) | oxidoreductase |
| M. ulcerans Agy99 | MUL_3124 | - | 9e-08 | 27.06% (170) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4969 | - | 6e-07 | 30.19% (159) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0064 | - | 1e-176 | 63.54% (480) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 1e-26 | 27.14% (420) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv0063 | - | 1e-176 | 63.54% (480) | oxidoreductase |
| M. leprae Br4923 | MLBr_00109 | - | 4e-07 | 30.27% (185) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2456 | - | 4e-58 | 31.38% (494) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 0.0 | 98.96% (480) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 1e-168 | 61.46% (480) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 4e-27 | 29.71% (451) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 5e-19 | 29.02% (224) | PROBABLE OXIDOREDUCTASE |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | 1e-39 | 30.92% (469) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MMAR_1179|M.marinum_M --------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
Mb0064|M.bovis_AF2122/97 -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
Rv0063|M.tuberculosis_H37Rv -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mvan_4048|M.vanbaalenii_PYR-1 -----------------------------MGGSHATAQPPPTQAALADLT
Mflv_4651|M.gilvum_PYR-GCK -------------------------------------MTVPTDLRRDEAL
MSMEG_1746|M.smegmatis_MC2_155 -------------------------------------MLQVHPTMVDELA
TH_1540|M.thermoresistible__bu -------------------------------------------------M
MLBr_00109|M.leprae_Br4923 --------------------------------------------------
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNN-SNPAAVVTVTSQADVEKAVA
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGKQVFNSLYNN-SNPAAVVTVTSQADVEKAVA
Mb0064|M.bovis_AF2122/97 SALGGKVLQPDDGPQFATAKQVFNTNYNG-YTPAVIVTPTSQLDVQKAMA
Rv0063|M.tuberculosis_H37Rv SALGGKVLQPDDGPQFATAKQVFNTNYNG-YTPAVIVTPTSQLDVQKAMA
MAV_0089|M.avium_104 TALGGKVLLPDS-PQFAGAKQVFNTNYNG-STPAAVVTPTSAADVQKAMA
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVRGDAAMDESGR-AFNPLFDV-NHPGAVAFCASDQDVARCVE
Mvan_4048|M.vanbaalenii_PYR-1 RTLRGSVIGPDG-GRFTELATPRNLRFAA-TMPRAVVLCADADDVAKTVL
Mflv_4651|M.gilvum_PYR-GCK RSLRDQVATPVALPGEPGYERCRPWNVVAPVEPAAVVLATSPEDVAGTVR
MSMEG_1746|M.smegmatis_MC2_155 MSMPERVHLPGS-PEYGDAVAIWNGAVTE--RPAAVVRPTSSGDVRNVVR
TH_1540|M.thermoresistible__bu AALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVR
MLBr_00109|M.leprae_Br4923 ---------MLNMGVSTTATRLTGWGRTAPSVANVLSTPDAELISKVVAR
. .:
MUL_1431|M.ulcerans_Agy99 FAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
MMAR_1179|M.marinum_M FAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
Mb0064|M.bovis_AF2122/97 FAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTV
Rv0063|M.tuberculosis_H37Rv FAAANNLKVAPRGGGHSYVGASTANGAMVLDLRQLPGDINYDATTGRVTV
MAV_0089|M.avium_104 FAAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVTV
MAB_2456|M.abscessus_ATCC_1997 FATSARLPIAARGGGHSYAAYCIPNDGLVVDLARMAAVS---VTGTRAVV
Mvan_4048|M.vanbaalenii_PYR-1 WARNTGTSFAIRGGGHNYAEASSSRG-VIISTRQMTAATIDGATLRAHAG
Mflv_4651|M.gilvum_PYR-GCK FAAAHGFRVTVQATGHGAVGVG--PDTILIQTSAMRHVS-VDVVNGTARV
MSMEG_1746|M.smegmatis_MC2_155 FAHEQRIPITVRAGGHDWGGRALNEGGLVIDLSSMRKVY-IDPAAREALV
TH_1540|M.thermoresistible__bu YAADNDLRIGVCSGGHSWAASHLRDGGMLLDVSRLDHCG-IDADRMVAVA
MLBr_00109|M.leprae_Br4923 VADADGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIHCINTDTKLADV
* . . *:. . :::. :
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPTGS-CPTVGVGGLALGGGMGADSRHAGLT
MMAR_1179|M.marinum_M PAGVSLTDVHQVLAGAGRAIPTGS-CPTVGVGGLALGGGMGADSRHAGLT
Mb0064|M.bovis_AF2122/97 TPATGLYAMHQVLAAAGRGIPTGT-CPTVGVAGHALGGGLGANSRHAGLL
Rv0063|M.tuberculosis_H37Rv TPATGLYAMHQVLAAAGRGIPTGT-CPTVGVAGHALGGGLGANSRHAGLL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPTGT-CPSVGAAGHALGGGMGAQSRHAGLL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAGGS-CPTVGIAGLTLGGGVGVLTRRFGLT
Mvan_4048|M.vanbaalenii_PYR-1 VRNADLAALLPQGGGGRLLLPGGN-CPGVGVVGLTLGGGIGPNAPWAGLT
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLCGS-APGVGVIGYLTGGGIGPLVRTYGLS
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAAPN-LADVGFTGFTLGGGYGPLNGIAGLG
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPAGH-CEGICLGGYLLQGGYGWNSRVLGPA
MLBr_00109|M.leprae_Br4923 DAGVNLNKLMKAALPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSF
: : * . * *
MUL_1431|M.ulcerans_Agy99 CNALRSATVVLPSGETVTASAE-DHPDLFWALRGGGGGNFGVTTAMTFET
MMAR_1179|M.marinum_M CDALRSATVVLPSGETVTASAE-DHPDLFWALRGGGGGNFGVTTAMTFET
Mb0064|M.bovis_AF2122/97 CDQLTSASVVLPSGQAVTASAT-DHPDLFWALRGGGGGNFGVTTSLTFAT
Rv0063|M.tuberculosis_H37Rv CDQLTSASVVLPSGQAVTASAT-DHPDLFWALRGGGGGNFGVTTSLTFAT
MAV_0089|M.avium_104 CDQLTSASVVLPSGQAVTASTA-SNPDLFWALRGGGGGNFGVTTSLTFAT
MAB_2456|M.abscessus_ATCC_1997 CDQLISARVVTADGKIRVVSAD-TESDLFWAIRGVGGGNFCIATELAFET
Mvan_4048|M.vanbaalenii_PYR-1 ADRLRKVTMVTAHGDVVTASPT-ENPDLFWGLRGGAGGNFGVVTDLEYEL
Mflv_4651|M.gilvum_PYR-GCK SDHVRSFDVVTGGGRLLRAAPD-ENADLFWGLRG-GKATLGIVTSAEIDL
MSMEG_1746|M.smegmatis_MC2_155 VDNLLEAHVVLADGRSVTANAA-DEADLLWALRG-GGANFGVVTHLRVRL
TH_1540|M.thermoresistible__bu CESIVGVDVVTADGEVLYCDDE-TNADLFWAARGSGPGFFAVVTSFHLRL
MLBr_00109|M.leprae_Br4923 GNYVRSMDLLTASGEVRRLTPTGKDSELFWATVG-GNGLTGIIMRATIEM
: : :: * ..:*:*. * . . :
MUL_1431|M.ulcerans_Agy99 FPV-------ADSDVVRVDFTPSSAAQVLAGWQTWLAAADRDT---WGLV
MMAR_1179|M.marinum_M FPV-------ADSDVVRVDFTPSSAAQVLAGWQTWLAAADRDT---WGLV
Mb0064|M.bovis_AF2122/97 FPS-------GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGS---WALA
Rv0063|M.tuberculosis_H37Rv FPS-------GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGS---WALA
MAV_0089|M.avium_104 FPT-------KDVDAVNLNFPPQSFAQVLVGWQNWLRTADPNS---WALA
MAB_2456|M.abscessus_ATCC_1997 AAS-------TDLTVFTLDYAAGEMAPIVHRWLTFMAGAPDEL---WTTL
Mvan_4048|M.vanbaalenii_PYR-1 VEVPV-----RRATTAELSVTGADAATRVALAFQQLRADAERI---VTGN
Mflv_4651|M.gilvum_PYR-GCK LPVP-------EFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQ
MSMEG_1746|M.smegmatis_MC2_155 HPVP-------HLATGVLMFPWEQAADVMRRYDALAPSLPDGLT---AQI
TH_1540|M.thermoresistible__bu HPRP------PVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIAS
MLBr_00109|M.leprae_Br4923 MPTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLG
.
MUL_1431|M.ulcerans_Agy99 DMSVSA--AQANCHVLATCPAGAGRGVADAIKSAVGAQPT-GIETKTFNH
MMAR_1179|M.marinum_M DMSVSA--AQANCHVLATCPAGAGRGVADAIKSAVGAQPT-GIETKTFNH
Mb0064|M.bovis_AF2122/97 DATVDP--LGTHCRILATCPAGSGGSVAAAIVSAVGTQPT-GTENHTFNY
Rv0063|M.tuberculosis_H37Rv DATVDP--LGTHCRILATCPAGSGGSVAAAIVSAVGTQPT-GTENHTFNY
MAV_0089|M.avium_104 DATVDA--MGVHCRILATCPAGSGNSAAAAITQAVGIQPS-GVETHTFNY
MAB_2456|M.abscessus_ATCC_1997 HAIGGA--IPQCRIVGCVAQGVNSQDVIESLRGGIGVRAA-DSFIAEMTF
Mvan_4048|M.vanbaalenii_PYR-1 LYLGHA--AGDVEAALTTQLLVDEADARDLLAPLTAIPGL-TAEITEQPW
Mflv_4651|M.gilvum_PYR-GCK QLPPLP--EVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDT
MSMEG_1746|M.smegmatis_MC2_155 GVIPAP--DGGPVVFVAPYWVGDPDEGDRWVAELRRLGTPVVDQVAPMSP
TH_1540|M.thermoresistible__bu RDLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIKIPYA
MLBr_00109|M.leprae_Br4923 RAAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMP
MUL_1431|M.ulcerans_Agy99 MELVKYLAGGSSASSPRGFVAGSD-----------VIGTVNSAAAQAIVA
MMAR_1179|M.marinum_M MELVKYLAGGSSASSPRGFVAGSD-----------VIGTVNSAAAQAIVA
Mb0064|M.bovis_AF2122/97 LDLVRYLAVGNLNPSPLGYVGGSD-----------VFTTITPATAQGIAS
Rv0063|M.tuberculosis_H37Rv LDLVRYLAVGNLNPSPLGYVGGSD-----------VFTTITPATAQGIAS
MAV_0089|M.avium_104 MDLVNYLAVGNLNPQPLGYVGGSD-----------VFPTVNAAVAQGIAA
MAB_2456|M.abscessus_ATCC_1997 LDAMKFMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTA
Mvan_4048|M.vanbaalenii_PYR-1 WGAYAWYVTPPSPAYPFWDRSLYAD--------QFLSGDALAAALEVVRR
Mflv_4651|M.gilvum_PYR-GCK VGVLPYAAIGAVHADPVDPMPINED---------QALLRELPPEAVEALL
MSMEG_1746|M.smegmatis_MC2_155 SAQLRLLDPLVPRGRHYEMR---------------TVNVDTLSPGVIDAL
TH_1540|M.thermoresistible__bu TTDLAGWYGAIMTNYPTGHRYATDN----------MWTSASPEALLPGIH
MLBr_00109|M.leprae_Br4923 IGELWYRKSGTYRGKIQNLTQFYHPLDMFG-----EWNRAYGAAGFLQYQ
MUL_1431|M.ulcerans_Agy99 AVGKSPPASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETP-
MMAR_1179|M.marinum_M AVGKWPPASGRASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETP-
Mb0064|M.bovis_AF2122/97 AVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVET--
Rv0063|M.tuberculosis_H37Rv AVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQSALVQWYVET--
MAV_0089|M.avium_104 AVNAFPRNAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVET--
MAB_2456|M.abscessus_ATCC_1997 RIETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG-
Mvan_4048|M.vanbaalenii_PYR-1 FPAGNDPERYGALGLYGWVGGAVNDVAPDATAYVHRTARILVEMSSGWSP
Mflv_4651|M.gilvum_PYR-GCK AAAGPESGSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAP
MSMEG_1746|M.smegmatis_MC2_155 VAAGSSRTSPASVLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDA
TH_1540|M.thermoresistible__bu RIIETLPPAPSHFLMFNWSP-----TSTRDNLFYGLEADFNLALYAVWN-
MLBr_00109|M.leprae_Br4923 FVIPTEAVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWN-
. :
MUL_1431|M.ulcerans_Agy99 ------SSGQTAAATKWINSAHQAVQQFS-VGGYVNYLEANTA--LSRYF
MMAR_1179|M.marinum_M ------SSGQTAAATKWINSAHQAVQQFS-VGGYVNYLEANTA--PSRYF
Mb0064|M.bovis_AF2122/97 -------SGSPSEATSWLNTAHQAVRAYS-VGGYVNYLEVNQP--PARYF
Rv0063|M.tuberculosis_H37Rv -------SGSPSEATSWLNTAHQAVRAYS-VGGYVNYLEVNQP--PARYF
MAV_0089|M.avium_104 -------SGDPAAATNWLASAHQAVQQYS-VGGYVNYLEANQS--PARYF
MAB_2456|M.abscessus_ATCC_1997 --------ADPAVAHERVSQARDGLGDICGPAAYVNYIDPGMPDWATAYY
Mvan_4048|M.vanbaalenii_PYR-1 APSGAPVAPIPPDIRDWEDELWETVLPHTTGRSYQNFPDPELADWPRAYY
Mflv_4651|M.gilvum_PYR-GCK --------EIADMVIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVY
MSMEG_1746|M.smegmatis_MC2_155 D-----SDDDGERHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAY
TH_1540|M.thermoresistible__bu ---------DPEDDERFSAWPGTNMAALAHLAMGVGLADENLGRRPARFA
MLBr_00109|M.leprae_Br4923 -------ICVDFPIKSGLNEFVNKLDRRVMELGGRLYTAKDSRTTADTFH
:
MUL_1431|M.ulcerans_Agy99 GSN--LSRLTQIRQRYDPSRLMYSGLNF------
MMAR_1179|M.marinum_M GSN--LSRLTQIRQRYDPSRLMYSGLNF------
Mb0064|M.bovis_AF2122/97 GPN--LSRLSAVRQKYDPSRVMFSGLNF------
Rv0063|M.tuberculosis_H37Rv GPN--LSRLSAVRQKYDPSRVMFSGLNF------
MAV_0089|M.avium_104 GPN--LSRLSAVRQKYDPGRVMFSGLNY------
MAB_2456|M.abscessus_ATCC_1997 GDN--LPRLRGIAAAYDPKGIFRFAQAVRP----
Mvan_4048|M.vanbaalenii_PYR-1 GAN--LDRLTRVKATWDPEDVFRYPQGIPPR---
Mflv_4651|M.gilvum_PYR-GCK TDDT-LHWLAGLADRYDPARTLATGQVIRTVV--
MSMEG_1746|M.smegmatis_MC2_155 GPN--AERLLAAKDRWDAGNVFTAIPLPSRSSTS
TH_1540|M.thermoresistible__bu TDAN-MARLDGIRARRDPAGRFHGWMGRV-----
MLBr_00109|M.leprae_Br4923 AMYPRIDEWIAVRRKVDPLRVFSSDMARRLELL-
*. :