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TVPTDLRRDEALRSLRDQVATPVALPGEPGYERCRPWNVVAPVEPAAVVLATSPEDVAGTVRFAAAHGFR VTVQATGHGAVGVGPDTILIQTSAMRHVSVDVVNGTARVGAGARWQDVLDVATPHGLAPLCGSAPGVGVI GYLTGGGIGPLVRTYGLSSDHVRSFDVVTGGGRLLRAAPDENADLFWGLRGGKATLGIVTSAEIDLLPVP EFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQLPPLPEVPEPLAGRMTVAVRYAAVGDVDEA EQALAPMRAVATPVLDTVGVLPYAAIGAVHADPVDPMPINEDQALLRELPPEAVEALLAAAGPESGSPQA IVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAPEIADMVIAHAGAVTGAVAPWSTGGQMPNFAPS YDPARPSRVYTDDTLHWLAGLADRYDPARTLATGQVIRTVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4651 | - | - | 100% (462) | FAD linked oxidase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1284 | - | 6e-13 | 34.59% (159) | FAD linked oxidase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2230 | - | 1e-09 | 28.93% (197) | FAD linked oxidase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 6e-45 | 31.07% (457) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1726 | - | 3e-45 | 31.29% (457) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 1e-09 | 29.55% (176) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 3e-26 | 27.63% (485) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 5e-28 | 27.79% (421) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 7e-24 | 25.82% (426) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1964 | - | 0.0 | 70.29% (451) | mitomycin radical oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 3e-21 | 26.59% (455) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 1e-26 | 27.32% (421) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 0.0 | 81.52% (460) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4651|M.gilvum_PYR-GCK ----------------------------MTVPTDLRR-----DEALRSLR
Mvan_1816|M.vanbaalenii_PYR-1 ----------------------------MTIPTDLTR-----DDALRILR
MSMEG_1964|M.smegmatis_MC2_155 ----------------------------MTL-TDLPNGTEGLADALDGLR
MMAR_1179|M.marinum_M --------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
Mb1755|M.bovis_AF2122/97 --------------------------------------MTATLTKTLGSL
Rv1726|M.tuberculosis_H37Rv --------------------------------------MTATLTKTLGSL
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
TH_1540|M.thermoresistible__bu --------------------------------------------------
MLBr_01103|M.leprae_Br4923 ------------------------------------------MGVLTSLI
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALP-GEPGYERCR--PWN--VVAPVEPAAVVLATSPEDVAGTV
Mvan_1816|M.vanbaalenii_PYR-1 EEVATLVALP-GEPGYERCV--PWN--VAAPVTPAAVVLATSAEDVAGTV
MSMEG_1964|M.smegmatis_MC2_155 AHVVAPVALP-GEAGYERAT--PWN--VAAEVKPAAVVLATSAYDVANTV
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGK--QVFNSLYNNSNPAAVVTVTSQADVEKAV
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGK--QVFNSLYNNSNPAAVVTVTSQADVEKAV
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAK--QVFNTNYNGSTPAAVVTPTSAADVQKAM
Mb1755|M.bovis_AF2122/97 DDFRGTLCVP-GDPDYPRVR--AIWNGQVAR-EPALIATCHDACDVRTVL
Rv1726|M.tuberculosis_H37Rv DDFRGTLCVP-GDPDYPRVR--AIWNGQVAR-EPALIATCHDACDVRTVL
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESG--RAFNPLFDVNHPGAVAFCASDQDVARCV
TH_1540|M.thermoresistible__bu MAALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAV
MLBr_01103|M.leprae_Br4923 AGLPDGMVVT-DSAVTDGYR--HDRALDPSAGKPLAVVQPRRTDEVQTVL
: . . * :. :* :
Mflv_4651|M.gilvum_PYR-GCK RFAAAHGFRVTVQATGH---GAVGVGPDTILIQTSAMRHVSVDVVNGTAR
Mvan_1816|M.vanbaalenii_PYR-1 RFAAAHGFTVTVQATGH---GAVGVGADTILVLTAAMKHCEVDSLNRTAR
MSMEG_1964|M.smegmatis_MC2_155 RYAASRGLRVTVQATGH---GALKVTDDTILIVTSGMTGCTVDPSTRTAR
MMAR_1179|M.marinum_M AFAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVT
MUL_1431|M.ulcerans_Agy99 AFAAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVT
MAV_0089|M.avium_104 AFAAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVT
Mb1755|M.bovis_AF2122/97 RRPVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMR-AVSLDPATGRVR
Rv1726|M.tuberculosis_H37Rv RRAVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMR-AVSLDPATGRVR
MAB_2456|M.abscessus_ATCC_1997 EFATSARLPIAARGGGHSYAAYCIPNDGLVVDLARMA---AVSVTGTRAV
TH_1540|M.thermoresistible__bu RYAADNDLRIGVCSGGHSWAASHLRDGGMLLDVSRLD-HCGIDADRMVAV
MLBr_01103|M.leprae_Br4923 RWASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDITVDPVTRTAV
. . . * . :: . .
Mflv_4651|M.gilvum_PYR-GCK VGAGARWQDVLDVATPHGLAPLCG--SAPGVGVIGYLTGGGIGPLVRTYG
Mvan_1816|M.vanbaalenii_PYR-1 VGAGARWQDVIDVAAPHGLAPLCG--SSPGVGVVGFLTGGGIGPLVRTVG
MSMEG_1964|M.smegmatis_MC2_155 VQAGARWQHVIDAAAPHGLAPLCG--SSPNVGVVGYLTGGGVGPLVRTVG
MMAR_1179|M.marinum_M VPAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAG
MUL_1431|M.ulcerans_Agy99 VPAGVSLTDVHQVLAGAGRAIPTG--SCPTVGVGGLALGGGMGADSRHAG
MAV_0089|M.avium_104 VTPATSLYTMHRTLAAVGRGVPTG--TCPSVGAAGHALGGGMGAQSRHAG
Mb1755|M.bovis_AF2122/97 VQGGATLADLDHATVPFARVAPAG--IVTTTGVGGLTLGGGVGWTTRRFG
Rv1726|M.tuberculosis_H37Rv VQGGATLADLDHATVPFARVAPAG--IVTTTGVGGLTLGGGVGWTTRRFG
MAB_2456|M.abscessus_ATCC_1997 VGAGARLIDVYAGIAGAGRMLAGG--SCPTVGIAGLTLGGGVGVLTRRFG
TH_1540|M.thermoresistible__bu AGPGKIGSELAGELDKLDLFFPAG--HCEGICLGGYLLQGGYGWNSRVLG
MLBr_01103|M.leprae_Br4923 CQPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYG
. : . * .. * *
Mflv_4651|M.gilvum_PYR-GCK LSSDHVRSFDVVTGGGRLLRAA----PDENADLFWGLR-GGKATLGIVTS
Mvan_1816|M.vanbaalenii_PYR-1 LSSDYVRAFDVVTGEGRLLRAT----PDENADLFWGLR-GGKATLGIVTA
MSMEG_1964|M.smegmatis_MC2_155 LSSDHVRSFELVTGKGELLRAT----PEENAELFWGLR-GGKATLGIVTS
MMAR_1179|M.marinum_M LTCDALRSATVVLPSGETVTAS----AEDHPDLFWALRGGGGGNFGVTTA
MUL_1431|M.ulcerans_Agy99 LTCNALRSATVVLPSGETVTAS----AEDHPDLFWALRGGGGGNFGVTTA
MAV_0089|M.avium_104 LLCDQLTSASVVLPSGQAVTAS----TASNPDLFWALRGGGGGNFGVTTS
Mb1755|M.bovis_AF2122/97 LSCDNLVAVRLVTAAGDYLSVD----DERDPELMWGLRGGGG-NFGIVTE
Rv1726|M.tuberculosis_H37Rv LSCDNLVAVRLVTAAGDYLSVD----DERDPELMWGLRGGGG-NFGIVTE
MAB_2456|M.abscessus_ATCC_1997 LTCDQLISARVVTADGKIRVVS----ADTESDLFWAIRGVGGGNFCIATE
TH_1540|M.thermoresistible__bu PACESIVGVDVVTADGEVLYCD----DETNADLFWAARGSGPGFFAVVTS
MLBr_01103|M.leprae_Br4923 VTGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITE
: : . :* * : . : : *
Mflv_4651|M.gilvum_PYR-GCK AEIDLLPVPEFYGGA-VYFAADDVADVLRAWAAWCVDLPETINTSIAIQQ
Mvan_1816|M.vanbaalenii_PYR-1 VEIDLPPIPEFYGGA-VYFDGADTAAVLHAWRSWSVELPETVNTSIAVQQ
MSMEG_1964|M.smegmatis_MC2_155 VEIDLPPIPEFYGGA-VIFDGADAASVLHAWRTWCVTLPESVNTSISLQN
MMAR_1179|M.marinum_M MTFETFPVADSDVVR-VDFTPSSAAQVLAGWQTWLAAADRDTWGLVDMS-
MUL_1431|M.ulcerans_Agy99 MTFETFPVADSDVVR-VDFTPSSAAQVLAGWQTWLAAADRDTWGLVDMS-
MAV_0089|M.avium_104 LTFATFPTKDVDAVN-LNFPPQSFAQVLVGWQNWLRTADPNSWALADAT-
Mb1755|M.bovis_AF2122/97 FEFATHPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRH
Rv1726|M.tuberculosis_H37Rv FEFATHPFGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRH
MAB_2456|M.abscessus_ATCC_1997 LAFETAASTDLTVFT-LDYAAGEMAPIVHRWLTFMAGAPDELWTTLHAIG
TH_1540|M.thermoresistible__bu FHLRLHPRPPVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIASR
MLBr_01103|M.leprae_Br4923 VTLRLLPTQNTSSIVVATFAS--VQAAVDAVLGVAARLRPAMLEFMDSVA
: . :
Mflv_4651|M.gilvum_PYR-GCK --LPPLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVATPVLDTV
Mvan_1816|M.vanbaalenii_PYR-1 --LPPLSGVPEPLAGRMTVAVRYTAVGDFAEAERLLAPMRAVATPVMDTV
MSMEG_1964|M.smegmatis_MC2_155 --LPPLPGVPEPLAGKLTVAVRYTAIGDFARAERLLAPMRAVATPVLDTV
MMAR_1179|M.marinum_M ----------VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIETK
MUL_1431|M.ulcerans_Agy99 ----------VSAAQANCHVLATCPAGAGRGVADAIKSAVGAQPTGIETK
MAV_0089|M.avium_104 ----------VDAMGVHCRILATCPAGSGNSAAAAITQAVGIQPSGVETH
Mb1755|M.bovis_AF2122/97 --APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VADT
Rv1726|M.tuberculosis_H37Rv --APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLARP-VADT
MAB_2456|M.abscessus_ATCC_1997 GAIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLDAMKFM
TH_1540|M.thermoresistible__bu -------DLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAI
MLBr_01103|M.leprae_Br4923 ----------INAVEDTFRMGLDREAAAMLVAGSDELGHAGTDEAKLIGA
.
Mflv_4651|M.gilvum_PYR-GCK GVLPYAAIGAVHADPVDPMP--INEDQALLRELPPEAVEALLAAAG--PE
Mvan_1816|M.vanbaalenii_PYR-1 GVLPYAAIGAVHADPVDPMP--TNEDQALLSELPAEAVDALLAVAG--PG
MSMEG_1964|M.smegmatis_MC2_155 AVHPYAAIGGVHMDPVDPMP--CNETHTLLRELPSEAVDVLLAAAG--PD
MMAR_1179|M.marinum_M TFNHMELVKYLAGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAVGKWPP
MUL_1431|M.ulcerans_Agy99 TFNHMELVKYLAGGSSASSPRGFVAGSDVIGTVNSAAAQAIVAAVGKSPP
MAV_0089|M.avium_104 TFNYMDLVNYLAVGNLNPQPLGYVGGSDVFPTVNAAVAQGIAAAVNAFPR
Mb1755|M.bovis_AF2122/97 VWPTPFLAHQAVLDASNPAGHRYYWKSDYLAELNDEAIDLLVEQTAQLSS
Rv1726|M.tuberculosis_H37Rv VWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEAIDLLVEQTAQLSS
MAB_2456|M.abscessus_ATCC_1997 GGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARIETLLA
TH_1540|M.thermoresistible__bu IKIPYATTDLAGWYGAIMTNYPTGHRYATDNMWTSASPEALLPGIHRIIE
MLBr_01103|M.leprae_Br4923 VFAENGATQVSSTNDPDEGEAFVAARRFCIPAVESKGSLLLEDVGVPLPA
Mflv_4651|M.gilvum_PYR-GCK SGSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIGVPAPEIADMV
Mvan_1816|M.vanbaalenii_PYR-1 SGSPQVIVDLRLLGGALVREPQHRSAFCHRDAAFSLAVIGAPTPENAAMV
MSMEG_1964|M.smegmatis_MC2_155 TPPVQTIVEIRLFGGALAREPRHRSAFCHRDAAFGVTAIGVPVPPVADTV
MMAR_1179|M.marinum_M ASGRASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTAAA
MUL_1431|M.ulcerans_Agy99 ASGWASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTAAA
MAV_0089|M.avium_104 NAGRMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVET--SGDPAAA
Mb1755|M.bovis_AF2122/97 PD---SLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDDLH
Rv1726|M.tuberculosis_H37Rv PD---SLIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDDLH
MAB_2456|M.abscessus_ATCC_1997 GKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHGVG--ADPAVA
TH_1540|M.thermoresistible__bu TLPPAPSHFLMFN--WSPTSTRDNLFYGLEADFNLALYAVWNDPEDDERF
MLBr_01103|M.leprae_Br4923 LGKLVTGIAHISTERNLMISVIAHAGDGNTHPLIVYNPADATMTERAHRA
Mflv_4651|M.gilvum_PYR-GCK IAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTLHWLAGLADR
Mvan_1816|M.vanbaalenii_PYR-1 AEHARAVTGAVAPWATGGQMPNFAPSYDPARPARAYAPDTLHWLAALADR
MSMEG_1964|M.smegmatis_MC2_155 RAHGAALVDAMAPWSTGGQLPNFAPSDDAGRASRVYDEDTLHWLAALAER
MMAR_1179|M.marinum_M TKWINSAHQAVQQFSVG-GYVNYLEANT---APSRYFGSNLSRLTQIRQR
MUL_1431|M.ulcerans_Agy99 TKWINSAHQAVQQFSVG-GYVNYLEANT---ALSRYFGSNLSRLTQIRQR
MAV_0089|M.avium_104 TNWLASAHQAVQQYSVG-GYVNYLEANQ---SPARYFGPNLSRLSAVRQK
Mb1755|M.bovis_AF2122/97 RQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLKNR
Rv1726|M.tuberculosis_H37Rv RQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLKNR
MAB_2456|M.abscessus_ATCC_1997 HERVSQARDGLGDICGPAAYVNYIDPGMP-DWATAYYGDNLPRLRGIAAA
TH_1540|M.thermoresistible__bu SAWPGTNMAALAHLAMG---VGLADENLGRRPARFATDANMARLDGIRAR
MLBr_01103|M.leprae_Br4923 FGEIMDMAVGLGGTITG---EHGVGRLKRPWLDDYLGPDVMELNQRIKHA
.: : :
Mflv_4651|M.gilvum_PYR-GCK YDPARTLATGQVIRTVV
Mvan_1816|M.vanbaalenii_PYR-1 YDPSRVLATGQVVRT--
MSMEG_1964|M.smegmatis_MC2_155 HDPAGVYRCGQVVRFVS
MMAR_1179|M.marinum_M YDPSRLMYSGLNF----
MUL_1431|M.ulcerans_Agy99 YDPSRLMYSGLNF----
MAV_0089|M.avium_104 YDPGRVMFSGLNY----
Mb1755|M.bovis_AF2122/97 LDPDNVFRNNHNIRPSA
Rv1726|M.tuberculosis_H37Rv LDPDNVFRNNHNIRPSA
MAB_2456|M.abscessus_ATCC_1997 YDPKGIFRFAQAVRP--
TH_1540|M.thermoresistible__bu RDPAGRFHGWMGRV---
MLBr_01103|M.leprae_Br4923 LDPYGILNPGAAI----
**