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MTATLTKTLGSLDDFRGTLCVPGDPDYPRVRAIWNGQVAREPALIATCHDACDVRTVLRRAVDAGMVTAV RGGGHNVAGTALCDGGVVIDLSAMRAVSLDPATGRVRVQGGATLADLDHATVPFARVAPAGIVTTTGVGG LTLGGGVGWTTRRFGLSCDNLVAVRLVTAAGDYLSVDDERDPELMWGLRGGGGNFGIVTEFEFATHPFGP VAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRHAPPAPWIPVDQRGKPVVMIGAVHTGSIQTG IEALRPVKSLARPVADTVWPTPFLAHQAVLDASNPAGHRYYWKSDHLAELNDEAIDLLVEQTAQLSSPDS LIGIFQLGGAAARGGERSCFPSRHARFMVNYATHWTEAREDDLHRQWTRDAIEALAPYGLGTAYVNFTAD DAPMHVETLYSTTEFSRLVTLKNRLDPDNVFRNNHNIRPSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1726 | - | - | 100% (461) | PROBABLE OXIDOREDUCTASE |
| M. tuberculosis H37Rv | Rv0063 | - | 3e-27 | 26.04% (457) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1774 | - | 5e-22 | 23.20% (444) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1755 | - | 0.0 | 99.57% (461) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 4e-45 | 31.29% (457) | FAD linked oxidase domain-containing protein |
| M. leprae Br4923 | MLBr_00109 | - | 5e-08 | 27.37% (190) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2456 | - | 1e-33 | 30.38% (474) | hypothetical protein MAB_2456 |
| M. marinum M | MMAR_1179 | - | 5e-33 | 29.03% (434) | oxidoreductase |
| M. avium 104 | MAV_0089 | - | 6e-28 | 25.39% (453) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 7e-59 | 33.18% (434) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 9e-26 | 26.61% (436) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 2e-32 | 28.18% (433) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1816 | - | 6e-39 | 29.12% (443) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1726|M.tuberculosis_H37Rv -----------------------------MTATLTKTLG---------SL
Mb1755|M.bovis_AF2122/97 -----------------------------MTATLTKTLG---------SL
MSMEG_1746|M.smegmatis_MC2_155 ----------------------------MLQVHPTMVDE---------LA
Mflv_4651|M.gilvum_PYR-GCK -----------------------------MTVPTDLRRDE----ALRSLR
Mvan_1816|M.vanbaalenii_PYR-1 -----------------------------MTIPTDLTRDD----ALRILR
MMAR_1179|M.marinum_M -------MISRQTLLRGAAAATAAGLGSALFGSARAVAEP-V-SGWSALA
MUL_1431|M.ulcerans_Agy99 -------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-V-SGWSALA
MAV_0089|M.avium_104 ----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRP-SGWEGLS
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
TH_1540|M.thermoresistible__bu ------------------------------------------------MA
MLBr_00109|M.leprae_Br4923 --------------------------------------------------
Rv1726|M.tuberculosis_H37Rv DDFRGTLCVP-GDPDYPRVRAIWNGQVA-REPALIATCHDACDVRTVLRR
Mb1755|M.bovis_AF2122/97 DDFRGTLCVP-GDPDYPRVRAIWNGQVA-REPALIATCHDACDVRTVLRR
MSMEG_1746|M.smegmatis_MC2_155 MSMPERVHLP-GSPEYGDAVAIWNGAVT-ERPAAVVRPTSSGDVRNVVRF
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALP-GEPGYERCRP-WNVVAP-VEPAAVVLATSPEDVAGTVRF
Mvan_1816|M.vanbaalenii_PYR-1 EEVATLVALP-GEPGYERCVP-WNVAAP-VTPAAVVLATSAEDVAGTVRF
MMAR_1179|M.marinum_M SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAV_0089|M.avium_104 TALGGKVLLP-DSPQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVR-GDAAMDESGRAFNPLFDVNHPGAVAFCASDQDVARCVEF
TH_1540|M.thermoresistible__bu ALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MLBr_00109|M.leprae_Br4923 -------MLNMGVSTTATRLTGWGRTAP-SVANVLSTPDAELISKVVARV
:. . :
Rv1726|M.tuberculosis_H37Rv AVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMR-AVSLDPATGRVRVQ
Mb1755|M.bovis_AF2122/97 PVDAGMVTAVRGGGHNVAGTALCDGGVVIDLSAMR-AVSLDPATGRVRVQ
MSMEG_1746|M.smegmatis_MC2_155 AHEQRIPITVRAGGHDWGGRALNEGGLVIDLSSMR-KVYIDPAAREALVE
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAVG--VGPDTILIQTSAMR-HVSVDVVNGTARVG
Mvan_1816|M.vanbaalenii_PYR-1 AAAHGFTVTVQATGHGAVG--VGADTILVLTAAMK-HCEVDSLNRTARVG
MMAR_1179|M.marinum_M AAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTVP
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYIGASTAVGAMVIDLRGLPGGVNFDAGSGTVTVP
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYTGASTANGTMVLDLRQLPGDANYDAATGQVTVT
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYAAYCIPNDGLVVDLARMA---AVSVTGTRAVVG
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWAASHLRDGGMLLDVSRLD-HCGIDADRMVAVAG
MLBr_00109|M.leprae_Br4923 ADADGRGVIARGLGRSYGDNAQNGGGLVIDMTPLNTIHCINTDTKLADVD
. . *:. . ::: : . . .
Rv1726|M.tuberculosis_H37Rv GGATLADLDHATVPFARVAPAGI-VTTTGVGGLTLGGGVGWTTRRFGLSC
Mb1755|M.bovis_AF2122/97 GGATLADLDHATVPFARVAPAGI-VTTTGVGGLTLGGGVGWTTRRFGLSC
MSMEG_1746|M.smegmatis_MC2_155 GGATAEDVVQAAERHGLTAAAPN-LADVGFTGFTLGGGYGPLNGIAGLGV
Mflv_4651|M.gilvum_PYR-GCK AGARWQDVLDVATPHGLAPLCGS-APGVGVIGYLTGGGIGPLVRTYGLSS
Mvan_1816|M.vanbaalenii_PYR-1 AGARWQDVIDVAAPHGLAPLCGS-SPGVGVVGFLTGGGIGPLVRTVGLSS
MMAR_1179|M.marinum_M AGVSLTDVHQVLAGAGRAIPTGS-CPTVGVGGLALGGGMGADSRHAGLTC
MUL_1431|M.ulcerans_Agy99 AGVSLTDVHQVLAGAGRAIPTGS-CPTVGVGGLALGGGMGADSRHAGLTC
MAV_0089|M.avium_104 PATSLYTMHRTLAAVGRGVPTGT-CPSVGAAGHALGGGMGAQSRHAGLLC
MAB_2456|M.abscessus_ATCC_1997 AGARLIDVYAGIAGAGRMLAGGS-CPTVGIAGLTLGGGVGVLTRRFGLTC
TH_1540|M.thermoresistible__bu PGKIGSELAGELDKLDLFFPAGH-CEGICLGGYLLQGGYGWNSRVLGPAC
MLBr_00109|M.leprae_Br4923 AGVNLNKLMKAALPFGLWIPVLPGTRQVTIGGAIACDIHGKNHHSAGSFG
. : * . * *
Rv1726|M.tuberculosis_H37Rv DNLVAVRLVTAAGDYLSVDDE-RDPELMWGLRGGGG-NFGIVTEFEFATH
Mb1755|M.bovis_AF2122/97 DNLVAVRLVTAAGDYLSVDDE-RDPELMWGLRGGGG-NFGIVTEFEFATH
MSMEG_1746|M.smegmatis_MC2_155 DNLLEAHVVLADGRSVTANAA-DEADLLWALRGGGA-NFGVVTHLRVRLH
Mflv_4651|M.gilvum_PYR-GCK DHVRSFDVVTGGGRLLRAAPD-ENADLFWGLRGGKA-TLGIVTSAEIDLL
Mvan_1816|M.vanbaalenii_PYR-1 DYVRAFDVVTGEGRLLRATPD-ENADLFWGLRGGKA-TLGIVTAVEIDLP
MMAR_1179|M.marinum_M DALRSATVVLPSGETVTASAE-DHPDLFWALRGGGGGNFGVTTAMTFETF
MUL_1431|M.ulcerans_Agy99 NALRSATVVLPSGETVTASAE-DHPDLFWALRGGGGGNFGVTTAMTFETF
MAV_0089|M.avium_104 DQLTSASVVLPSGQAVTASTA-SNPDLFWALRGGGGGNFGVTTSLTFATF
MAB_2456|M.abscessus_ATCC_1997 DQLISARVVTADGKIRVVSAD-TESDLFWAIRGVGGGNFCIATELAFETA
TH_1540|M.thermoresistible__bu ESIVGVDVVTADGEVLYCDDE-TNADLFWAARGSGPGFFAVVTSFHLRLH
MLBr_00109|M.leprae_Br4923 NYVRSMDLLTASGEVRRLTPTGKDSELFWATVGGNG-LTGIIMRATIEMM
: : :: * ..:*:*. * : .
Rv1726|M.tuberculosis_H37Rv P------FGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRH
Mb1755|M.bovis_AF2122/97 P------FGPVAVAGFVVYRLDDGPAVLRGYRQFAAAAPEEVTTIVVLRH
MSMEG_1746|M.smegmatis_MC2_155 P------VPHLATG-VLMFPWEQAADVMRRYDALAPSLPDGLTAQIGVIP
Mflv_4651|M.gilvum_PYR-GCK P------VPEFYGG-AVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQ
Mvan_1816|M.vanbaalenii_PYR-1 P------IPEFYGG-AVYFDGADTAAVLHAWRSWSVELPETVNTSIAVQQ
MMAR_1179|M.marinum_M P------VADSDVV-RVDFTPSSAAQVLAGWQTWLAAADRDTWGLVDMSV
MUL_1431|M.ulcerans_Agy99 P------VADSDVV-RVDFTPSSAAQVLAGWQTWLAAADRDTWGLVDMSV
MAV_0089|M.avium_104 P------TKDVDAV-NLNFPPQSFAQVLVGWQNWLRTADPNSWALADATV
MAB_2456|M.abscessus_ATCC_1997 A------STDLTVF-TLDYAAGEMAPIVHRWLTFMAGAPDELWTTLHAIG
TH_1540|M.thermoresistible__bu P------RPPVCGSCLYIYPAEAIDDVYT----WALTSGRDVDDRVELQI
MLBr_00109|M.leprae_Br4923 PTETAYFIADGDITGSLDETIALHSDGSEADYTYSSAWFDAISASPKLGR
.
Rv1726|M.tuberculosis_H37Rv APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLAR--PVADTV
Mb1755|M.bovis_AF2122/97 APPAPWIPVDQRGKPVVMIGAVHTGSIQTGIEALRPVKSLAR--PVADTV
MSMEG_1746|M.smegmatis_MC2_155 AP---------DGGPVVFVAPYWVGDPDEGDRWVAELRRLGT--PVVDQV
Mflv_4651|M.gilvum_PYR-GCK LPPLPEVPEPLAGRMTVAVRYAAVGDVDEAEQALAPMRAVAT--PVLDTV
Mvan_1816|M.vanbaalenii_PYR-1 LPPLSGVPEPLAGRMTVAVRYTAVGDFAEAERLLAPMRAVAT--PVMDTV
MMAR_1179|M.marinum_M SAAQANCHVLATCPAGAGRGVADAIKSAVG----AQPTGIET--KTFNHM
MUL_1431|M.ulcerans_Agy99 SAAQANCHVLATCPAGAGRGVADAIKSAVG----AQPTGIET--KTFNHM
MAV_0089|M.avium_104 DAMGVHCRILATCPAGSGNSAAAAITQAVG----IQPSGVET--HTFNYM
MAB_2456|M.abscessus_ATCC_1997 GAIPQCRIVGCVAQGVNSQDVIESLRGGIGVRAADSFIAEMTFLDAMKFM
TH_1540|M.thermoresistible__bu IASRDLPALGLNQPSIVVASPVFAESESAAAQALAVLGDCPAVDRAIIKI
MLBr_00109|M.leprae_Br4923 AAVSRGCLARLDQLPAKLRRNPLKFHAPQLLTLPDVFPNGLANKYTFMPI
. . :
Rv1726|M.tuberculosis_H37Rv WPTPFLAHQAVLDASNPAGHR---YYWKSDHLAELNDEAIDLLVEQTAQL
Mb1755|M.bovis_AF2122/97 WPTPFLAHQAVLDASNPAGHR---YYWKSDYLAELNDEAIDLLVEQTAQL
MSMEG_1746|M.smegmatis_MC2_155 APMSPSAQLRLLDPLVPRGRH---YEMRTVNVDTLSPGVIDALVAAGSSR
Mflv_4651|M.gilvum_PYR-GCK GVLPYAAIGAVHADPVDPMPI---NEDQALLRELPPEAVEALLAAAGPES
Mvan_1816|M.vanbaalenii_PYR-1 GVLPYAAIGAVHADPVDPMPT---NEDQALLSELPAEAVDALLAVAGPGS
MMAR_1179|M.marinum_M ELVKYLAGGSSASSPRGFVAG---SDVIGTVNSAAAQAIVAAVGKWPPAS
MUL_1431|M.ulcerans_Agy99 ELVKYLAGGSSASSPRGFVAG---SDVIGTVNSAAAQAIVAAVGKSPPAS
MAV_0089|M.avium_104 DLVNYLAVGNLNPQPLGYVGG---SDVFPTVNAAVAQGIAAAVNAFPRNA
MAB_2456|M.abscessus_ATCC_1997 GGCTTLTVAQCHPSWTGPGSGQLKREAFVASSRMVPHPDVDTARIETLLA
TH_1540|M.thermoresistible__bu PYATTDLAGWYGAIMTNYPTG---HRYATDNMWTSASPEALLPGIHRIIE
MLBr_00109|M.leprae_Br4923 GELWYRKSGTYRGKIQNLTQFYHPLDMFGEWNRAYGAAGFLQYQFVIPTE
Rv1726|M.tuberculosis_H37Rv SSPDSLIGIFQLGGAAARGGE-RSCFPSRHARFMVNYATHWTEAREDD--
Mb1755|M.bovis_AF2122/97 SSPDSLIGIFQLGGAAARGGE-RSCFPSRHARFMVNYATHWTEAREDD--
MSMEG_1746|M.smegmatis_MC2_155 TSPASVLALHHFHGASTRVGLTDTAFGLRTPHFLVEIVAAWDADSDDDGE
Mflv_4651|M.gilvum_PYR-GCK GSPQAIVELRHLGGALAREATHRSAFCHRNAAFSLAVIG---VPAPEIAD
Mvan_1816|M.vanbaalenii_PYR-1 GSPQVIVDLRLLGGALVREPQHRSAFCHRDAAFSLAVIG---APTPENAA
MMAR_1179|M.marinum_M G--RASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA--
MUL_1431|M.ulcerans_Agy99 G--WASALVDTLTGAVGDIDPTATAFPWRRQSAVVQWYVETPSSGQTA--
MAV_0089|M.avium_104 G--RMLAIMHALDGALATVAPAATAFPWRRQSALVQWYVET--SGDPA--
MAB_2456|M.abscessus_ATCC_1997 GKPGLTFIFDSLGGAVRRISPDATAFPHRQAAACIQIYHG----VGADPA
TH_1540|M.thermoresistible__bu TLPPAPSHFLMFN--WSPTSTRDNLFYGLEADFNLALYAVWNDPEDDE--
MLBr_00109|M.leprae_Br4923 AVDKVKRIIGDMQGSGHYSFLNVFKLFGPGNQAPLSFPIPGWNICVDFPI
. : : :
Rv1726|M.tuberculosis_H37Rv LHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLK
Mb1755|M.bovis_AF2122/97 LHRQWTRDAIEALAPYGLGTAYVNFTADDAPMHVETLYSTTEFSRLVTLK
MSMEG_1746|M.smegmatis_MC2_155 RHRRWAQSTFDALGAHALPGGYPNLIGPDQRNQADTAYG-PNAERLLAAK
Mflv_4651|M.gilvum_PYR-GCK MVIAHAGAVTGAVAPWSTGGQMPNFAPSYDPARPSRVYTDDTLHWLAGLA
Mvan_1816|M.vanbaalenii_PYR-1 MVAEHARAVTGAVAPWATGGQMPNFAPSYDPARPARAYAPDTLHWLAALA
MMAR_1179|M.marinum_M AATKWINSAHQAVQQFSVGGYVNYLEANTAPSR----YFGSNLSRLTQIR
MUL_1431|M.ulcerans_Agy99 AATKWINSAHQAVQQFSVGGYVNYLEANTALSR----YFGSNLSRLTQIR
MAV_0089|M.avium_104 AATNWLASAHQAVQQYSVGGYVNYLEANQSPAR----YFGPNLSRLSAVR
MAB_2456|M.abscessus_ATCC_1997 VAHERVSQARDGLGDICGPAAYVNYIDPGMPDWAT-AYYGDNLPRLRGIA
TH_1540|M.thermoresistible__bu RFSAWPGTNMAALAHLAMGVGLADENLGRRPAR---FATDANMARLDGIR
MLBr_00109|M.leprae_Br4923 KSGLNEFVNKLDRRVMELGGRLYTAKDSRTTADT-FHAMYPRIDEWIAVR
Rv1726|M.tuberculosis_H37Rv NRLDPDNVFRNNHNIRPSA--
Mb1755|M.bovis_AF2122/97 NRLDPDNVFRNNHNIRPSA--
MSMEG_1746|M.smegmatis_MC2_155 DRWDAGNVFTAIPLPSRSSTS
Mflv_4651|M.gilvum_PYR-GCK DRYDPARTLATGQVIRTVV--
Mvan_1816|M.vanbaalenii_PYR-1 DRYDPSRVLATGQVVRT----
MMAR_1179|M.marinum_M QRYDPSRLMYSGLNF------
MUL_1431|M.ulcerans_Agy99 QRYDPSRLMYSGLNF------
MAV_0089|M.avium_104 QKYDPGRVMFSGLNY------
MAB_2456|M.abscessus_ATCC_1997 AAYDPKGIFRFAQAVRP----
TH_1540|M.thermoresistible__bu ARRDPAGRFHGWMGRV-----
MLBr_00109|M.leprae_Br4923 RKVDPLRVFSSDMARRLELL-
*. :