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ALEACDFRTLENLCPGRVGAPGSPLYEAGRRVFSRAGRIRSPAAVLRPADRNQVAAIMAWANAAGIRLSI RSGGHSFDGFPVRDDGVLLDLRGLSAVRYAPSGYLHAMTGATVGDIARALDGTGRAMPIGECPTVGVGGL VLGGGFGQCTRHFGLTSDFLAEATVVTASGQIHVTNAVTNANLFWGLRGGAGCVGIVTDLVFHTVPIQQV TGVTLGWRWDAAVEAILLFTQLMHTAPSELDLQLSIRTTGADRYADEASAGPADVIPGTPRVRIDGQFLG NQDDARSLMRPLLEHPAALHASIREESFFDAVFVSNDFLHDPAPATLRPHRIASDIGRGALGAVEAAAIV GQINELQFAPELPGGAVSIEAINGAVAAFTPQETAFFHRGQDFVYHWALGDRLPADAGLAARHDALLQEI RHDLAGVLTGGRYVNYADILDTPNDWWGDNTDQLMSVVQEHDPDRILISRLNP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3461 | - | - | 100% (474) | hypothetical protein MMAR_3461 |
| M. marinum M | MMAR_1179 | - | 6e-43 | 29.40% (466) | oxidoreductase |
| M. marinum M | MMAR_0110 | - | 3e-40 | 29.09% (471) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0064 | - | 7e-37 | 26.83% (477) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4651 | - | 1e-23 | 26.28% (468) | FAD linked oxidase domain-containing protein |
| M. tuberculosis H37Rv | Rv0063 | - | 7e-37 | 26.83% (477) | oxidoreductase |
| M. leprae Br4923 | MLBr_01103 | - | 5e-08 | 23.47% (213) | putative oxidoreductase subunit |
| M. abscessus ATCC 19977 | MAB_2456 | - | 4e-36 | 29.61% (466) | hypothetical protein MAB_2456 |
| M. avium 104 | MAV_0089 | - | 3e-43 | 29.89% (465) | FAD binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_1746 | - | 6e-27 | 31.76% (233) | 6-hydroxy-D-nicotine oxidase |
| M. thermoresistible (build 8) | TH_1540 | - | 4e-17 | 30.54% (203) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1431 | - | 2e-41 | 29.34% (467) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4048 | - | 5e-33 | 30.86% (444) | FAD linked oxidase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0064|M.bovis_AF2122/97 -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
Rv0063|M.tuberculosis_H37Rv -----MAREISRQTFLRGAAGALAAG---AVFGSVRATADPAASGWEALS
MAV_0089|M.avium_104 -----MAREISRQTFLRGAVGALAAG---AMLGAPRVGADPRPSGWEGLS
MUL_1431|M.ulcerans_Agy99 --------MISRQTFLRGAAAATAAGLGSALFGSARAVAEP-VSGWSALA
MAB_2456|M.abscessus_ATCC_1997 MDPQSRPALMTRRTVLSAGAMLALGSTSLIGCSPVLPNEIPAGVRWEDLR
Mvan_4048|M.vanbaalenii_PYR-1 -----------------------------MGGSHATAQPPPTQAALADLT
MMAR_3461|M.marinum_M --------------------------------------MALEACDFRTLE
Mflv_4651|M.gilvum_PYR-GCK ---------------------------------MTVPTDLRRDEALRSLR
MSMEG_1746|M.smegmatis_MC2_155 -------------------------------------MLQVHPTMVDELA
TH_1540|M.thermoresistible__bu ------------------------------------------------MA
MLBr_01103|M.leprae_Br4923 ------------------------------------------MGVLTSLI
:
Mb0064|M.bovis_AF2122/97 SALGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAF
Rv0063|M.tuberculosis_H37Rv SALGGKVLQPDDGPQFATAKQVFNTNYNGYTPAVIVTPTSQLDVQKAMAF
MAV_0089|M.avium_104 TALGGKVLLPDS-PQFAGAKQVFNTNYNGSTPAAVVTPTSAADVQKAMAF
MUL_1431|M.ulcerans_Agy99 SSIGGRVLLPSNGASFTSGKQVFNSLYNNSNPAAVVTVTSQADVEKAVAF
MAB_2456|M.abscessus_ATCC_1997 RSLSGALVVRGDAAMDESGR-AFNPLFDVNHPGAVAFCASDQDVARCVEF
Mvan_4048|M.vanbaalenii_PYR-1 RTLRGSVIGPDG-GRFTELATPRNLRFAATMPRAVVLCADADDVAKTVLW
MMAR_3461|M.marinum_M NLCPGRVGAPGS-PLYEAGRRVFSRAGRIRSPAAVLRPADRNQVAAIMAW
Mflv_4651|M.gilvum_PYR-GCK DQVATPVALPGE-PGYERCR-PWNVVAP-VEPAAVVLATSPEDVAGTVRF
MSMEG_1746|M.smegmatis_MC2_155 MSMPERVHLPGS-PEYGDAVAIWNGAVT-ERPAAVVRPTSSGDVRNVVRF
TH_1540|M.thermoresistible__bu ALPALSFRRGAQGYEQARRTTVWNGLLPDRFPDVIVQAVTVDDVVTAVRY
MLBr_01103|M.leprae_Br4923 AGLPDGMVVTDS-AVTDGYRHDRALDPSAGKPLAVVQPRRTDEVQTVLRW
. * .: :* : :
Mb0064|M.bovis_AF2122/97 AAANNLKVAPRGGGHSYV-GASTANGAMVLDLRQLPGDINYDATTGRVTV
Rv0063|M.tuberculosis_H37Rv AAANNLKVAPRGGGHSYV-GASTANGAMVLDLRQLPGDINYDATTGRVTV
MAV_0089|M.avium_104 AAAHNLKVAPRSGGHSYT-GASTANGTMVLDLRQLPGDANYDAATGQVTV
MUL_1431|M.ulcerans_Agy99 AAANKLKIAPRGGGHSYI-GASTAVGAMVIDLRGLPGGVNFDAGSGTVTV
MAB_2456|M.abscessus_ATCC_1997 ATSARLPIAARGGGHSYA-AYCIPNDGLVVDLARMAAVS---VTGTRAVV
Mvan_4048|M.vanbaalenii_PYR-1 ARNTGTSFAIRGGGHNYA-EASSSRG-VIISTRQMTAATIDGATLRAHAG
MMAR_3461|M.marinum_M ANAAGIRLSIRSGGHSFD-GFPVRDDGVLLDLRGLSAVR--YAPSGYLHA
Mflv_4651|M.gilvum_PYR-GCK AAAHGFRVTVQATGHGAV-GVG--PDTILIQTSAMRHVS-VDVVNGTARV
MSMEG_1746|M.smegmatis_MC2_155 AHEQRIPITVRAGGHDWG-GRALNEGGLVIDLSSMRKVY-IDPAAREALV
TH_1540|M.thermoresistible__bu AADNDLRIGVCSGGHSWA-ASHLRDGGMLLDVSRLDHCG-IDADRMVAVA
MLBr_01103|M.leprae_Br4923 ASANRVPVVARGAGSGLSGGATALDDGIVLSTEKMRDIT-VDPVTRTAVC
* . . * . . :::. :
Mb0064|M.bovis_AF2122/97 TPATGLYAMHQVLAAAGRGIPT--GTCPTVGVAGHALGGGLGANSRHAGL
Rv0063|M.tuberculosis_H37Rv TPATGLYAMHQVLAAAGRGIPT--GTCPTVGVAGHALGGGLGANSRHAGL
MAV_0089|M.avium_104 TPATSLYTMHRTLAAVGRGVPT--GTCPSVGAAGHALGGGMGAQSRHAGL
MUL_1431|M.ulcerans_Agy99 PAGVSLTDVHQVLAGAGRAIPT--GSCPTVGVGGLALGGGMGADSRHAGL
MAB_2456|M.abscessus_ATCC_1997 GAGARLIDVYAGIAGAGRMLAG--GSCPTVGIAGLTLGGGVGVLTRRFGL
Mvan_4048|M.vanbaalenii_PYR-1 VRNADLAALLPQGGGGRLLLPG--GNCPGVGVVGLTLGGGIGPNAPWAGL
MMAR_3461|M.marinum_M MTGATVGDIARALDGTGRAMPI--GECPTVGVGGLVLGGGFGQCTRHFGL
Mflv_4651|M.gilvum_PYR-GCK GAGARWQDVLDVATPHGLAPLC--GSAPGVGVIGYLTGGGIGPLVRTYGL
MSMEG_1746|M.smegmatis_MC2_155 EGGATAEDVVQAAERHGLTAAA--PNLADVGFTGFTLGGGYGPLNGIAGL
TH_1540|M.thermoresistible__bu GPGKIGSELAGELDKLDLFFPA--GHCEGICLGGYLLQGGYGWNSRVLGP
MLBr_01103|M.leprae_Br4923 QPGLFNAEVKKAAAEHGLWYPPDPSSFEICSIGGNVATNAGGLCCVKYGV
: * .. * *
Mb0064|M.bovis_AF2122/97 LCDQLTSASVVLPSGQAVTASATDHPDLF----WALRGGGGGNFGVTTSL
Rv0063|M.tuberculosis_H37Rv LCDQLTSASVVLPSGQAVTASATDHPDLF----WALRGGGGGNFGVTTSL
MAV_0089|M.avium_104 LCDQLTSASVVLPSGQAVTASTASNPDLF----WALRGGGGGNFGVTTSL
MUL_1431|M.ulcerans_Agy99 TCNALRSATVVLPSGETVTASAEDHPDLF----WALRGGGGGNFGVTTAM
MAB_2456|M.abscessus_ATCC_1997 TCDQLISARVVTADGKIRVVSADTESDLF----WAIRGVGGGNFCIATEL
Mvan_4048|M.vanbaalenii_PYR-1 TADRLRKVTMVTAHGDVVTASPTENPDLF----WGLRGGAGGNFGVVTDL
MMAR_3461|M.marinum_M TSDFLAEATVVTASGQIHVTNAVTNANLF----WGLRG-GAGCVGIVTDL
Mflv_4651|M.gilvum_PYR-GCK SSDHVRSFDVVTGGGRLLRAAPDENADLF----WGLRG-GKATLGIVTSA
MSMEG_1746|M.smegmatis_MC2_155 GVDNLLEAHVVLADGRSVTANAADEADLL----WALRG-GGANFGVVTHL
TH_1540|M.thermoresistible__bu ACESIVGVDVVTADGEVLYCDDETNADLF----WAARGSGPGFFAVVTSF
MLBr_01103|M.leprae_Br4923 TGDYVLGIQVVLADGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGIITEV
: : :* * :: . . . : *
Mb0064|M.bovis_AF2122/97 TFATFPS--GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALADATV
Rv0063|M.tuberculosis_H37Rv TFATFPS--GDLDVVNLNFPPQSFAQVLVGWQNWLRTADRGSWALADATV
MAV_0089|M.avium_104 TFATFPT--KDVDAVNLNFPPQSFAQVLVGWQNWLRTADPNSWALADATV
MUL_1431|M.ulcerans_Agy99 TFETFPV--ADSDVVRVDFTPSSAAQVLAGWQTWLAAADRDTWGLVDMSV
MAB_2456|M.abscessus_ATCC_1997 AFETAAS--TDLTVFTLDYAAGEMAPIVHRWLTFMAGAPDELWTTLHAIG
Mvan_4048|M.vanbaalenii_PYR-1 EYELVEVPVRRATTAELSVTGADAATRVALAFQQLRADAERIVTGNLYLG
MMAR_3461|M.marinum_M VFHTVPI--QQVTGVTLGWRWDAAVEAILLFTQLMHTAPSELDLQLSIRT
Mflv_4651|M.gilvum_PYR-GCK EIDLLPVP--EFYGGAVYFAADDVADVLRAWAAWCVDLPETINTSIAIQQ
MSMEG_1746|M.smegmatis_MC2_155 RVRLHPVP--HLATGVLMFPWEQAADVMRRYDALAPSLPDGLTAQIGVIP
TH_1540|M.thermoresistible__bu HLRLHPRP-PVCGSCLYIYPAEAIDDVYTWALTSGRDVDDRVELQIIASR
MLBr_01103|M.leprae_Br4923 TLRLLPTQNTSSIVVATFASVQAAVDAVLGVAARLRPAMLEFMDSVAINA
Mb0064|M.bovis_AF2122/97 DPLGTHCRILATCPA----------------GSGGSVAAAIVSAVG-TQP
Rv0063|M.tuberculosis_H37Rv DPLGTHCRILATCPA----------------GSGGSVAAAIVSAVG-TQP
MAV_0089|M.avium_104 DAMGVHCRILATCPA----------------GSGNSAAAAITQAVG-IQP
MUL_1431|M.ulcerans_Agy99 SAAQANCHVLATCPA----------------GAGRGVADAIKSAVG-AQP
MAB_2456|M.abscessus_ATCC_1997 GAIPQCRIVGCVAQG----------------VNSQDVIESLRGGIG-VRA
Mvan_4048|M.vanbaalenii_PYR-1 HAAGDVEAALTTQLL----------------VDEADARDLLAPLTA-IPG
MMAR_3461|M.marinum_M TGADRYADEASAGPADVIPGTPRVRIDGQFLGNQDDARSLMRPLLEHPAA
Mflv_4651|M.gilvum_PYR-GCK LPPLPEVPEPLAGRMT-------------VAVRYAAVGDVDEAEQALAPM
MSMEG_1746|M.smegmatis_MC2_155 APDGGPVVFVAPYWVG----------------DPDEGDRWVAELRRLGTP
TH_1540|M.thermoresistible__bu DLPALGLNQPSIVVASP------------VFAESESAAAQALAVLGDCPA
MLBr_01103|M.leprae_Br4923 VEDTFRMGLDR---------------------EAAAMLVAGSDELGHAGT
Mb0064|M.bovis_AF2122/97 TGTENHTFNYLD-LVRYLAVGNLNPSPLGYVGGSD-----------VFTT
Rv0063|M.tuberculosis_H37Rv TGTENHTFNYLD-LVRYLAVGNLNPSPLGYVGGSD-----------VFTT
MAV_0089|M.avium_104 SGVETHTFNYMD-LVNYLAVGNLNPQPLGYVGGSD-----------VFPT
MUL_1431|M.ulcerans_Agy99 TGIETKTFNHME-LVKYLAGGSSASSPRGFVAGSD-----------VIGT
MAB_2456|M.abscessus_ATCC_1997 ADSFIAEMTFLD-AMKFMGGCTTLTVAQCHPSWTGPGSGQLKREAFVASS
Mvan_4048|M.vanbaalenii_PYR-1 LTAEITEQPWWG-AYAWYVTPPSPAYPFWDRSLYAD--------QFLSGD
MMAR_3461|M.marinum_M LHASIREESFFD-AVFVSNDFLHDPAPATLRPHRIASDIG-----RGALG
Mflv_4651|M.gilvum_PYR-GCK RAVATPVLDTVG-VLPYAAIGAVHADPVDPMPINED---------QALLR
MSMEG_1746|M.smegmatis_MC2_155 VVDQVAPMSPSA-QLRLLDPLVPRGRHYEMR---------------TVNV
TH_1540|M.thermoresistible__bu VDRAIIKIPYATTDLAGWYGAIMTNYPTGHRYATDN----------MWTS
MLBr_01103|M.leprae_Br4923 DEAKLIGAVFAENGATQVSSTNDPDEGEAFVAARR-----------FCIP
Mb0064|M.bovis_AF2122/97 ITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQS
Rv0063|M.tuberculosis_H37Rv ITPATAQGIASAVDAFPRGAGRMLAIMHALDGALATVSPGATAFPWRRQS
MAV_0089|M.avium_104 VNAAVAQGIAAAVNAFPRNAGRMLAIMHALDGALATVAPAATAFPWRRQS
MUL_1431|M.ulcerans_Agy99 VNSAAAQAIVAAVGKSPPASGWASALVDTLTGAVGDIDPTATAFPWRRQS
MAB_2456|M.abscessus_ATCC_1997 RMVPHPDVDTARIETLLAGKPGLTFIFDSLGGAVRRISPDATAFPHRQAA
Mvan_4048|M.vanbaalenii_PYR-1 ALAAALEVVRRFPAGNDPERYGALGLYGWVGGAVNDVAPDATAYVHRTAR
MMAR_3461|M.marinum_M AVEAAAIVGQINELQFAPELPGGAVSIEAINGAVAAFTPQETAFFHRGQD
Mflv_4651|M.gilvum_PYR-GCK ELPPEAVEALLAAAGPESGSPQAIVELRHLGGALAREATHRSAFCHRNAA
MSMEG_1746|M.smegmatis_MC2_155 DTLSPGVIDALVAAGSSRTSPASVLALHHFHGASTRVGLTDTAFGLRTPH
TH_1540|M.thermoresistible__bu ASPEALLPGIHRIIETLPPAPSHFLMFNWSP-----TSTRDNLFYGLEAD
MLBr_01103|M.leprae_Br4923 AVESKGSLLLEDVGVPLPALGKLVTGIAHISTERNLMISVIAHAGDGNTH
Mb0064|M.bovis_AF2122/97 ALVQWYVET---------SGSPSEATSWLNTAHQAVRAYS-VGGYVNYLE
Rv0063|M.tuberculosis_H37Rv ALVQWYVET---------SGSPSEATSWLNTAHQAVRAYS-VGGYVNYLE
MAV_0089|M.avium_104 ALVQWYVET---------SGDPAAATNWLASAHQAVQQYS-VGGYVNYLE
MUL_1431|M.ulcerans_Agy99 AVVQWYVETP-------SSGQTAAATKWINSAHQAVQQFS-VGGYVNYLE
MAB_2456|M.abscessus_ATCC_1997 ACIQIYHGVG---------ADPAVAHERVSQARDGLGDICGPAAYVNYID
Mvan_4048|M.vanbaalenii_PYR-1 ILVEMSSGWSPAPSGAPVAPIPPDIRDWEDELWETVLPHTTGRSYQNFPD
MMAR_3461|M.marinum_M FVYHWALGDR----LPADAGLAARHDALLQEIRHDLAGVLTGGRYVNYAD
Mflv_4651|M.gilvum_PYR-GCK FSLAVIGVPAP--------EIADMVIAHAGAVTGAVAPWSTGGQMPNFAP
MSMEG_1746|M.smegmatis_MC2_155 FLVEIVAAWDAD-----SDDDGERHRRWAQSTFDALGAHALPGGYPNLIG
TH_1540|M.thermoresistible__bu FNLALYAVWN----------DPEDDERFSAWPGTNMAALAHLAMGVGLAD
MLBr_01103|M.leprae_Br4923 PLIVYNPADAT---------MTERAHRAFGEIMDMAVGLGGTITGEHGVG
Mb0064|M.bovis_AF2122/97 VNQP--PARYFGPN-LSRLSAVRQKYDPSRVMFSGLNF------
Rv0063|M.tuberculosis_H37Rv VNQP--PARYFGPN-LSRLSAVRQKYDPSRVMFSGLNF------
MAV_0089|M.avium_104 ANQS--PARYFGPN-LSRLSAVRQKYDPGRVMFSGLNY------
MUL_1431|M.ulcerans_Agy99 ANTA--LSRYFGSN-LSRLTQIRQRYDPSRLMYSGLNF------
MAB_2456|M.abscessus_ATCC_1997 PGMPDWATAYYGDN-LPRLRGIAAAYDPKGIFRFAQAVRP----
Mvan_4048|M.vanbaalenii_PYR-1 PELADWPRAYYGAN-LDRLTRVKATWDPEDVFRYPQGIPPR---
MMAR_3461|M.marinum_M ILDT--PNDWWGDN-TDQLMSVVQEHDPDRILISRLNP------
Mflv_4651|M.gilvum_PYR-GCK SYDPARPSRVYTDDTLHWLAGLADRYDPARTLATGQVIRTVV--
MSMEG_1746|M.smegmatis_MC2_155 PDQRNQADTAYGPN-AERLLAAKDRWDAGNVFTAIPLPSRSSTS
TH_1540|M.thermoresistible__bu ENLGRRPARFATDANMARLDGIRARRDPAGRFHGWMGRV-----
MLBr_01103|M.leprae_Br4923 RLKRPWLDDYLGPDVMELNQRIKHALDPYGILNPGAAI------
*. :