For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TTLESAPAVDDFDVGSVIRHDRVHGTVYTSTEIFRREMDTIFKTGWVYVAHESEVSEPGDYLTRMIGHDP VVVARGKDGVVRVMLNRCTHRANKLCNAEKGNANSFRCPYHGWTFGNTGALQGVPMREGYGEEFNKVRSE LGLAQAPRVDSYGGFVFASLAPDGISLTEHLGKATRAIDRLLNLSPTREIDLRANWMKHLHHANWKMVVE NNVDGYHALFTHASVYDAIKPAKVSHVPTKVDVLVRDLGNGHSEIDYSDEYRKLDEEFVWYGRIPRAKLA DYVGALEGAYGPEQAHDALVVGPPHTLIWPNLFLAEMNVMFVEPQAPDRTIAYTTAVLIPGQDALNERTL RRSEGAMGPAGFLIADDGEIGMRNQAGLAAELPEWLMLARGIESDVDDMTGIINRDKSAETPQRGFYSHW ASVVGGRSGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2612 | - | - | 100% (431) | dioxygenase large subunit |
| M. avium 104 | MAV_1901 | - | 0.0 | 89.93% (427) | dioxygenase large subunit |
| M. avium 104 | MAV_5084 | - | e-104 | 44.85% (408) | dioxygenase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-21 | 28.47% (295) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_1355 | - | 1e-51 | 32.03% (434) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 5e-22 | 28.81% (295) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 2e-38 | 27.60% (442) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. marinum M | MMAR_4422 | - | 3e-21 | 29.27% (205) | dioxygenase |
| M. smegmatis MC2 155 | MSMEG_1908 | - | 3e-48 | 31.66% (379) | benzoate 1,2-dioxygenase alpha subunit |
| M. thermoresistible (build 8) | TH_2976 | - | 1e-101 | 44.80% (404) | PUTATIVE dioxygenase large subunit |
| M. ulcerans Agy99 | MUL_3820 | - | 2e-16 | 29.06% (234) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_0539 | - | 3e-41 | 28.94% (432) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3186c|M.bovis_AF2122/97 --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
Rv3161c|M.tuberculosis_H37Rv --------MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQ
MAV_2612|M.avium_104 ---------MTTLESAPAVDDFDVGSVIRHD-----RVHGTVYTSTEIFR
TH_2976|M.thermoresistible__bu --------------------------LIRPD-----RVHGSLYTDPAIFA
Mflv_1355|M.gilvum_PYR-GCK -----MTQTTASPQPRTHLAAVLADAVIDDPEAGVFRANRRIFTDEEIFE
MSMEG_1908|M.smegmatis_MC2_155 ------MTTHLSP---DHLENVLADAVIEDPAAGVYRANRRIFTDDEIFE
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHGGLLDRVIFTDGELYR
Mvan_0539|M.vanbaalenii_PYR-1 ------------------------METIGSKTGSALPIDSSAFYDEAVYQ
MMAR_4422|M.marinum_M ------------------------MTAVRQPSALLPTLGGAYYTSAAVFA
MUL_3820|M.ulcerans_Agy99 -------MDRDQLIDLTRRALKLARDKTTDLAPHQHAVDAREYTSLDRHE
: .
Mb3186c|M.bovis_AF2122/97 LERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHALS
Rv3161c|M.tuberculosis_H37Rv LERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHALS
MAV_2612|M.avium_104 REMDTIFKTGWVYVAHESEVSEPGDYLTRMIGHDPVVVARGKDGVVRVML
TH_2976|M.thermoresistible__bu EELRKIWYRTWVFVGHESEVSQPNDYVRKKLGLQDVIMTRDRDGEIHLLL
Mflv_1355|M.gilvum_PYR-GCK LEMKHIFEGNWIYLAHESQVANPGDYFTTYIGRQPVVITRSKDGSLNCLI
MSMEG_1908|M.smegmatis_MC2_155 LEMKHIFEGNWVYLAHESQVPNPGDYFTTYIGRQPVVITRDRDGDLHCLI
MAB_4370c|M.abscessus_ATCC_199 QELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMDKNRRIRAFL
Mvan_0539|M.vanbaalenii_PYR-1 RELDSIFKRSWLFVGHESMIPKPGDFRTTYMADDAVIVCRDKESRVRVLL
MMAR_4422|M.marinum_M AEQQHVFESMWFCVVRAADLNEPGQFKAVQVGRESVLLVRGRDRRLRAFL
MUL_3820|M.ulcerans_Agy99 RDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRAADRAVRAFD
: : : . .. : : ::: : :. :
Mb3186c|M.bovis_AF2122/97 PICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMAANLDFN
Rv3161c|M.tuberculosis_H37Rv PICRHRLMLMVEPGAGRID-TLTCQYHLWRYGLDGRLRGAPHMAANLDFN
MAV_2612|M.avium_104 NRCTHRANKLCNAEKGNAN-SFRCPYHGWTFGNTGALQGVPMRE-GYGEE
TH_2976|M.thermoresistible__bu NRCSHRGNQVCADAKGNSS-TFRCPYHGWTFRNTGELVGFPFFK-GYGTR
Mflv_1355|M.gilvum_PYR-GCK NACAHRGAMICRRKTDNRM-TLTCPFHGWTFRNDGALLKVKDPD-GAGYP
MSMEG_1908|M.smegmatis_MC2_155 NACAHRGAMICRRKTDNRT-TLTCPFHGWTFRNDGTLLKVKDPD-GAGYP
MAB_4370c|M.abscessus_ATCC_199 NSCRHRGARVCRADYGVTR-GFTCTYHGWAYDLEGKLISVPNEE-GYPDS
Mvan_0539|M.vanbaalenii_PYR-1 NKCRHRGNKVCQFDKGNAN-IFHCSYHGWSYDTAGRLRSVPLAESAYGPQ
MMAR_4422|M.marinum_M NICRHRGALLCTEPEGQVRRNLRCPYHSWTYGLDGTLIAAPNIAELTDTD
MUL_3820|M.ulcerans_Agy99 NVCLHRQSRVATGCGTALR--FTCPYHGWTYDNGGRLVGLPGREGFPGIA
* ** : : * :* * : * *
Mb3186c|M.bovis_AF2122/97 ------RRECRLPQFAVATWNGLVWINLDADAEPIA-AHLDL-----TDD
Rv3161c|M.tuberculosis_H37Rv ------RRECRLPQFAVATWNGLVWINLDADAEPIA-AHLDL-----TDD
MAV_2612|M.avium_104 FNK-VRSELGLAQAPRVDSYGGFVFASLAPDGISLT-EHLGK-ATRAIDR
TH_2976|M.thermoresistible__bu -----KLDLPLGRVPRVDSYGGFVFGSFATEGPTLR-EHLGA-AAGEIDR
Mflv_1355|M.gilvum_PYR-GCK EAFNVNGSHNMTTVARFESYRGFLFGSLNPDVLPLT-EHLGD-ATKIIDM
MSMEG_1908|M.smegmatis_MC2_155 DTFNSNGSHNMTNVARFEGYRGFLFGSLNPDVLPLT-EHLGD-TTTVIDM
MAB_4370c|M.abscessus_ATCC_199 FS---TDDWGLVEVPHVDSYHGLIFGTWNPAPVGLR-ESLGD-MAWYMD-
Mvan_0539|M.vanbaalenii_PYR-1 FD---KASMGLVS-PRVATYKGLIFACWDQSAPPLE-EYLGEGLLWYLDN
MMAR_4422|M.marinum_M GAS-IDRHRYGLVAVALREWLGYAWVCLAEDPPSFEDDVVGSVTARLGDV
MUL_3820|M.ulcerans_Agy99 VG------SDGLTELPATEFAGFLWVSLHPAARLDVPAHLGP-----LAG
: * : :.
Mb3186c|M.bovis_AF2122/97 EFAGYRLGEMVQVESWS-HEWRANWKVAAEN-GHENYHVLGLHRQTLEPF
Rv3161c|M.tuberculosis_H37Rv EFAGYRLGEMVQVESWS-HEWRANWKVAAEN-GHENYHVLGLHRQTLEPF
MAV_2612|M.avium_104 LLNLSPTREIDLRANWMKHLHHANWKMVVEN-NVDGYHALFTHASVYDAI
TH_2976|M.thermoresistible__bu LLRLSPEGKVALDAGWLRHRTRANWKLLVEN-ETDGYHPQFVHGGIFGVT
Mflv_1355|M.gilvum_PYR-GCK LVDQSPDG-LEVLRGSSTYTYDGNWKVQAEN-GADGYHVTATHWN-YAAT
MSMEG_1908|M.smegmatis_MC2_155 LVDQSPDG-LEVLRGASTYTYDGNWKVQAEN-GADGYHVTATHWN-YAAT
MAB_4370c|M.abscessus_ATCC_199 AMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHASALMVM
Mvan_0539|M.vanbaalenii_PYR-1 FLLDCDPNGLQVVPGLHRYLMPVNWKLLAENFGGDQYHFAATHGSVSALS
MMAR_4422|M.marinum_M SAIDTYRIEALQVGRRVSYDVAANWKLIVEN-FMECYHCATIHPELTRVI
MUL_3820|M.ulcerans_Agy99 ELQSWGIGRWSPL-GEKVLGSPIDWKLATDT-FAENYHFATVHRRTFATI
:**: .: : ** *
Mb3186c|M.bovis_AF2122/97 VP----------------------GGGDLDVRQYSRWALRLRVPFTVPVE
Rv3161c|M.tuberculosis_H37Rv VP----------------------GGGDLDVRQYSRWALRLRVPFTVPVE
MAV_2612|M.avium_104 KPAKVSHVP---TKVDVLVRDLGNGHSEIDYSDEYRKLDEEFVWYGRIPR
TH_2976|M.thermoresistible__bu GSTIGPLYS---DSSTAVTRDLGGGHSENDLRPEFRKFAEPLRWFG-TTE
Mflv_1355|M.gilvum_PYR-GCK TSRRGTGES---KNETKALDAGGWGKSGGGYWSFPHGHLCLWTWAANPQD
MSMEG_1908|M.smegmatis_MC2_155 TSRRTCGES---KNDTKALDAGSWGKSGGGYWSFPHGHLCLWTWAANPQD
MAB_4370c|M.abscessus_ATCC_199 APQGKAPKDEIVHRTGRQYVDPNGHGAG--FPVHPKNRFDARVVHQWTDY
Mvan_0539|M.vanbaalenii_PYR-1 KAGQTARINFSIDEGQHYSVVLDGCAPHGLLQLAVGKNFYQDDLAQAETL
MMAR_4422|M.marinum_M PEFARG----------------QAAQRSVGRGAEFGSAVAGFTVDGRAGF
MUL_3820|M.ulcerans_Agy99 ARSN--------------------CTVFDSYGPHHRLIFPLNTILELENV
Mb3186c|M.bovis_AF2122/97 AKSLQLNEVQKSNLVVLWTFPNSALAIAGERVVWFG--------------
Rv3161c|M.tuberculosis_H37Rv AKSLQLNEVQKSNLVVLWTFPNSALAIAGERVVWFG--------------
MAV_2612|M.avium_104 AKLADYVGALEGAYGP--EQAHDALVVGPPHTLIWPNLFLA----EMN--
TH_2976|M.thermoresistible__bu SRVPDYVAAMRARYG---AEADQILIEGSPHVMIFPNLFIA----EIQ--
Mflv_1355|M.gilvum_PYR-GCK RPLWDKLDELKATHG---DAKGEFMVKGSRNLCVYPNVYVM----DQFST
MSMEG_1908|M.smegmatis_MC2_155 RPLWDRLDELKARFG---DAKGEFMVKGSRNLCLYPNVYVM----DQFST
MAB_4370c|M.abscessus_ATCC_199 G-------ALRERLGEARVQG----PLTNGHATVFPNLSYLPVNGSVR--
Mvan_0539|M.vanbaalenii_PYR-1 GTEAVDWLTERQRLQDERLATSPVQPYSFHVANIFPNFSMIGMGTAFYGR
MMAR_4422|M.marinum_M TALPGIRPEQDRRYFAITVKPTVFINLVPDHAIIHR--------------
MUL_3820|M.ulcerans_Agy99 PE--GQWDPFHHMVVIYALFPNVVLSVTIANGELFRIYPGD---------
Mb3186c|M.bovis_AF2122/97 ----FIPQSIDRVQVLGGVLTTPELAADAAATAQTS----QFVMAMINDE
Rv3161c|M.tuberculosis_H37Rv ----FIPQSIDRVQVLGGVLTTPELAADAAATAQTS----QFVMAMINDE
MAV_2612|M.avium_104 -VMFVEPQAPDRTIAYTTAVLIPGQDALN-ERTLRRSEGAMGPAGFLIAD
TH_2976|M.thermoresistible__bu -VFNIQPVAVNECVQYSTAVQLVGAPELN-RRMVSQCIGSVGPAGMLLAD
Mflv_1355|M.gilvum_PYR-GCK QIRHFRPIAPDKTEVTIYCIAPKSESAQARANRIRQYEDFFNASGMATPD
MSMEG_1908|M.smegmatis_MC2_155 QIRHFRPIAPDKTEVTIYCIAPKGESAAARAHRIRQYEDFFNASGMATPD
MAB_4370c|M.abscessus_ATCC_199 ---IWHPKGPDKMEVWAWTIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQD
Mvan_0539|M.vanbaalenii_PYR-1 GFIMWQPRGPRLTEVWEWCLVESSAPRAVKERMVFVLSQRQSAAGLVTPD
MMAR_4422|M.marinum_M ----MFPIAADRTIVECDWLYAPEVAAAG------DIAHSVELFHRVNEQ
MUL_3820|M.ulcerans_Agy99 -----RPGSSITVHQNSTPLDLSDESVATGAQAVFD-----YAHATVRDE
* . : :
Mb3186c|M.bovis_AF2122/97 DRLGLEAVQVGAGSRFAERGHLSSK-------------------------
Rv3161c|M.tuberculosis_H37Rv DRLGLEAVQVGAGSRFAERGHLSSK-------------------------
MAV_2612|M.avium_104 DGEIGMRNQAGLAAELPEWLMLARG--------------IESDVDDMTGI
TH_2976|M.thermoresistible__bu DTEMYERNQQGLEALTPEWLDIRRG--------------LNREHVDDHGF
Mflv_1355|M.gilvum_PYR-GCK DLEEFRSCQLTFRAEAAPWNDMSRGAQHWLDGPDDVARSLGLDAVISAGV
MSMEG_1908|M.smegmatis_MC2_155 DLEEFRSCQLTFRAQAAPWNDMSRGAQHWLSGPDPVAESLGMHGIVSSGL
MAB_4370c|M.abscessus_ATCC_199 DGENWSEVQSISRGFVTNSVALNYQ--------------MGLDSERED--
Mvan_0539|M.vanbaalenii_PYR-1 DHENFERLSDALDTGVARDVPFNYS--------------LGEDVEPMESL
MMAR_4422|M.marinum_M DFDACQRTQPAMSSRAYRTGGVLVP-------------------------
MUL_3820|M.ulcerans_Agy99 DYRLAETLQTNLESGARQRLVFGRN-------------------------
* . .
Mb3186c|M.bovis_AF2122/97 ------------EWPGMLAFYRNLAMALVGDHPGAS--
Rv3161c|M.tuberculosis_H37Rv ------------EWPGMLAFYRNLAMALVGDHPGAS--
MAV_2612|M.avium_104 INRDKS------AETPQRGFYSHWASVVGGRSGA----
TH_2976|M.thermoresistible__bu TVGGPT------DETGMRAFWSEYRRLMEAE-------
Mflv_1355|M.gilvum_PYR-GCK KNEDEG------LYPVQHGYWLETMRAAAQKEAR----
MSMEG_1908|M.smegmatis_MC2_155 RNEDEG------LYPVQHGYWLETLRRAVTSNPTEH--
MAB_4370c|M.abscessus_ATCC_199 -GRHPGLTSELYSDAAGRSFYARWRDLMNTKAWHEEHV
Mvan_0539|M.vanbaalenii_PYR-1 VAELPGNVRPQISEAYQREFYRHWHRTMTEPA------
MMAR_4422|M.marinum_M ------------AEHHIAEFHQWVIARIGTPAVTG---
MUL_3820|M.ulcerans_Agy99 -------------EPGLQHRHITWAQALETPG------