For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MAATDCDVIVVGAGPTGLTLACSLRLHGLSVRVLDRAAGPATTSRANFLHARGSEVLNRIGALGTLPDES LRAMRITNYLGDRPVMTLTFGDPGMRTAAPPMVVSQARVEAALRARLAQLGVEPEWGRKVAGVRQAGDRV VADLADGAQVSGQWLVGCDGTSSATREQVGIPFPGVKLSERFLLADIHLDWAVDRGGTTGWIHPDGVVGA MPMPSGDGRNDLWRLFVYDPALNRKPSDSEILQRIEQIVPYRTGRAITIGQPEWLSMFTVHRRLAQSYRR GRVLIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVIRGLAADALIDTYEAERRFLATEVLRGTSAIT RVNVASNPVGRFLRDRVATRIFGLPVVQRWTTYTASQLWVSYRKGPLGGHGRRPRLGDRIGDRPCTRADG AATRLHSELAGRWALLWPRDAPAPGASLLARLGDFGVTLRHDGAEAMLIRPDAHLAWRGAPDDTAGLDHW LAKALGSGAVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1499 | - | - | 100% (501) | oxygenase |
| M. smegmatis MC2 155 | MSMEG_1699 | - | 1e-47 | 34.90% (384) | pentachlorophenol 4-monooxygenase |
| M. smegmatis MC2 155 | MSMEG_2252 | - | 2e-47 | 31.01% (503) | flavin-type hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1170c | - | 4e-09 | 32.18% (174) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_5009 | - | 0.0 | 79.16% (499) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv1138c | - | 4e-09 | 32.18% (174) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 7e-07 | 24.30% (321) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_3483 | - | 3e-51 | 33.20% (512) | hypothetical protein MAB_3483 |
| M. marinum M | MMAR_4271 | - | 9e-47 | 33.40% (521) | hypothetical protein MMAR_4271 |
| M. avium 104 | MAV_2736 | - | 2e-52 | 35.37% (492) | hypothetical protein MAV_2736 |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-163 | 59.22% (510) | PUTATIVE oxygenase |
| M. ulcerans Agy99 | MUL_2358 | - | 2e-08 | 24.52% (363) | FAD-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0779 | - | 0.0 | 72.55% (499) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1170c|M.bovis_AF2122/97 --------MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPID
Rv1138c|M.tuberculosis_H37Rv --------MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPID
MSMEG_1499|M.smegmatis_MC2_155 --------MAATDCDVIVVGAGPTGLTLACSLRLHGLSVRVLDRAAGPAT
Mflv_5009|M.gilvum_PYR-GCK -------MPGAHRSDVVVVGAGPTGLTLACCLRLHGVSVRVLDAAAGPAT
Mvan_0779|M.vanbaalenii_PYR-1 ----------MTDTDVVVVGAGPTGLTLACALRLHGLTVQVVDRAAGPAT
TH_4641|M.thermoresistible__bu -------MARETTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPAT
MMAR_4271|M.marinum_M ----------MADHAVVVVGAGPTGLMLAGELALAGVDVAVVERRVSQDL
MAV_2736|M.avium_104 MRGVRFSERSVRGHAVLVAGAGPTGLMLAGELGLAGVDVALVERRADQQL
MAB_3483|M.abscessus_ATCC_1997 ----------MTEHAVVIAGGGPTGLMLAGELALAGADVAIVERRTTHEL
MUL_2358|M.ulcerans_Agy99 -------------MRVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPN
MLBr_02276|M.leprae_Br4923 -------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFPRD
: : *.* * * * * . :
Mb1170c|M.bovis_AF2122/97 KACGEGLMPGGLAELTSLGVDPVGLPFHGIAYVG-------EHRRVQARF
Rv1138c|M.tuberculosis_H37Rv KACGEGLMPGGLAELTSLGVDPVGLPFHGIAYVG-------EHRRVQARF
MSMEG_1499|M.smegmatis_MC2_155 T-SRANFLHARGSEVLNRIGALGTLPDESLRAMRI-TNYLGDRPVMTLTF
Mflv_5009|M.gilvum_PYR-GCK T-SRANFLHARGSEVLDRMGALGTLPQESLRALRI-TNYLGDRPLATLEF
Mvan_0779|M.vanbaalenii_PYR-1 T-SRANFLHARGSEVLGRIGALGTLPDESLRAMRI-TNYLGDRPLVTLEF
TH_4641|M.thermoresistible__bu T-SRANFLHARGSEVLDRLGALGGLPERSVRAMQI-TTHLGGEPVMRMQF
MMAR_4271|M.marinum_M VGSRAGGLHSRTIEVLDQRGIADRFLAQGTATQ------VARFAAIPLDI
MAV_2736|M.avium_104 IGSRAGGLHARTLEILDQRGIVDRFLAEGQVAQ------VAGFAQIRLDI
MAB_3483|M.abscessus_ATCC_1997 DGSRAAGMTSRTLEVLDQRGILDRFTPQGFSAP------VAHFSALLLDM
MUL_2358|M.ulcerans_Agy99 QGAMIDLFGAG-YEAADAIGILDAIRDVSYPIGDTGLVDELGRRRAGLPY
MLBr_02276|M.leprae_Br4923 KACGDG-LTPRAVAELKRLGLDDWLNTRIRHRGLR-----MSGFGGEVEV
. : :
Mb1170c|M.bovis_AF2122/97 RTGPGR------GVRRTTLHAALAARAKEQDTEWIRSR-VATIQQDAHG-
Rv1138c|M.tuberculosis_H37Rv RTGPGR------GVRRTTLHAALAARAKEQDTEWIRSR-VATIQQDAHG-
MSMEG_1499|M.smegmatis_MC2_155 GDPGMRTAAPPMVVSQARVEAALRARLAQLGVEPEWGRKVAGVRQAGDR-
Mflv_5009|M.gilvum_PYR-GCK GDPGMRTAAPPMVVSQAKVEAALRARLADLDVEPEWGRKVIDVREDADG-
Mvan_0779|M.vanbaalenii_PYR-1 GDPRMRTAAPPMVISQAKVEASLRSRLADLGAEPQWGNGLAALHRNDDT-
TH_4641|M.thermoresistible__bu GDPGMRTAAPPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAST-
MMAR_4271|M.marinum_M SDFPTRHNYG-LALWQNRIERILAEWVAELRVRIYRGCEVTDITQDDNG-
MAV_2736|M.avium_104 SDFPTRHPYG-LALWQNHIERILADWVGELGVPIYRGHRIATCTQDDTG-
MAB_3483|M.abscessus_ATCC_1997 TDQPTRHTFG-LALLQYRIERTLSEWVGEHGVPIYRGREVTGFTSSDDA-
MUL_2358|M.ulcerans_Agy99 GRIAKALEDRLCRITRTDLHKVLLDNLP-TNVDLRFGTSVSEVTHGDDR-
MLBr_02276|M.leprae_Br4923 DWPGPSFPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHDSSRR
: : :. : .
Mb1170c|M.bovis_AF2122/97 -VTAAG-----VRAKWLVAADGLHSAVRRAVG--------IKATAGTPRR
Rv1138c|M.tuberculosis_H37Rv -VTAAG-----VRAKWLVAADGLHSAVRRAVG--------IKATAGTPRR
MSMEG_1499|M.smegmatis_MC2_155 -VVADLADGAQVSGQWLVGCDGTSSATREQVG--------IPFPGVKLSE
Mflv_5009|M.gilvum_PYR-GCK -VVADLADGARVRGQWLVGCDGTTSVVRRQTG--------IEFPGVRLSE
Mvan_0779|M.vanbaalenii_PYR-1 -VVAELDDGTSVEARWLVGCDGTASTTRKLAG--------IGFPGVKLTE
TH_4641|M.thermoresistible__bu -VTAGIGGGGELRGRWLVGCDGTGSSTRKSVG--------IGYPGARLSE
MMAR_4271|M.marinum_M -VDLTLSDGPPLRADYVVGCDGGRSLVRRAVG--------IDFPGWDPTT
MAV_2736|M.avium_104 -VDVVASDGRTLRGQYLVGCDGGRSVIRKAAG--------IDFPGWEATT
MAB_3483|M.abscessus_ATCC_1997 -VRVELSDGSTLRAQYLVGCDGGRSLTRKIAG--------IDFPGWDPST
MUL_2358|M.ulcerans_Agy99 -AVVTLDDGARLDVDLLVGADGIHSTVRALAFG--AEVQYLRYLGFHFAA
MLBr_02276|M.leprae_Br4923 AASVTLADGTEVGCRQLIIADGARSPLGRKLGRSWHQKTVYGVAARGYLT
. : :: .** * .
Mb1170c|M.bovis_AF2122/97 ----YGVRWHYRLPVWSDFVEVHWSRWGEAYVTPVEPD-------LVGVA
Rv1138c|M.tuberculosis_H37Rv ----YGVRWHYRLPVWSDFVEVHWSRWGEAYVTPVEPD-------LVGVA
MSMEG_1499|M.smegmatis_MC2_155 RFLLADIHLDWAVDRGGTTGWIHPDGVVGAMPMPSGDGRNDLWRLFVYDP
Mflv_5009|M.gilvum_PYR-GCK RFLLADIHLDWAVDRAGTTGWIHPDGVVGAMPMPSTDGRDDLWRLFVYDP
Mvan_0779|M.vanbaalenii_PYR-1 RWLLADLHLDWDLDRGGTTGWIHPGGLLGAMPMPDSSGAHDLWRVFAYDP
TH_4641|M.thermoresistible__bu RFLLADVYLDWRLDRSGTTGWIHPDGMVGAMPMPDG-----LWRIIAYDP
MMAR_4271|M.marinum_M SSLIAEVEVAVGSESGPNLGEVRHDALGVHGFTRLPDG--GPLRVVVTER
MAV_2736|M.avium_104 SYLLAEAEMDWRTGQPPQWG-IHHDSLGVHALSETEPA--GGVRVLVTER
MAB_3483|M.abscessus_ATCC_1997 SCLVADVQMTEE----PEWGIHRQGAL--HSIFKFEED--GPVRVLVTEA
MUL_2358|M.ulcerans_Agy99 -FVFDASDMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEP
MLBr_02276|M.leprae_Br4923 TPRSDDLWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSKRP
Mb1170c|M.bovis_AF2122/97 ILSRQRPELAWFPSLAHHLQDASRGHARGCGP--------LRQVVSRRVA
Rv1138c|M.tuberculosis_H37Rv ILSRQRPELAWFPSLAHHLQDASRGHARGCGP--------LRQVVSRRVA
MSMEG_1499|M.smegmatis_MC2_155 ALNRKPSDSEILQRIEQIVPYRTGRAITIGQPEWLSMFTVHRRLAQSYRR
Mflv_5009|M.gilvum_PYR-GCK SLDRKPTDSEILDRISELVPYRTGRRVKIGDAEWLSMFTVHRRLADTYRR
Mvan_0779|M.vanbaalenii_PYR-1 GHTEKPAESEILERMRQVIPQRSGRRVHVGDPEWLSVFTVHRRLADRYRQ
TH_4641|M.thermoresistible__bu GPGDLDQG-----ALERLLYERTGHRVKVTGTVWQSEFRVHRRLADTYRR
MMAR_4271|M.marinum_M QLDAGGEPS--LGDLSAALTAVYGTDYGIHSPTWISRFTDLTRQAATYRQ
MAV_2736|M.avium_104 QLRSAAEPN--LDDLRQALIAVYRTDYGIHSPRWISRFTDAARQAARYRD
MAB_3483|M.abscessus_ATCC_1997 QLGRREEPT--LRDLSEALLSARGTDYGIHSPTWISRFTDVTRQAATYRK
MUL_2358|M.ulcerans_Agy99 PPDARAALRDRFAGMGWLVPEVLERCPPSGDIYFG---QVAQVEMPRWST
MLBr_02276|M.leprae_Br4923 ADLALRSLISYYTDLRRHEWGFSGQPRAVSSALLP-----MGGAVSGVAG
:
Mb1170c|M.bovis_AF2122/97 GRVLLVGDAAGYEDALTGEGISLAVKQAA------------AAVSAIVDD
Rv1138c|M.tuberculosis_H37Rv GRVLLVGDAAGYEDALTGEGISLAVKQAA------------AAVSAIVDD
MSMEG_1499|M.smegmatis_MC2_155 GRVLIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVIRGLAADALIDT
Mflv_5009|M.gilvum_PYR-GCK GRVLIAGDAAHVHAPFGGQGMLTGIGDAENVGFKLALVVRGLAADDLLDT
Mvan_0779|M.vanbaalenii_PYR-1 GRILIAGDAAHAHAPFGGQGMLTGIGDAENLAFKLALVTRGLAADPFVDT
TH_4641|M.thermoresistible__bu GRVFIAGDAAHAHAPFGGQGMLTGLGDAENLAFKLALVIRGYAGPALLDT
MMAR_4271|M.marinum_M GRVLIAGDAAHVHDPVGGQGLNTGVQDAVNLGWKLAQVVNRRSPESLLDT
MAV_2736|M.avium_104 RRVLLAGDAAHIHHPVGGQGLNTGVQDAVNLGWKLALVVGGASPPALLDT
MAB_3483|M.abscessus_ATCC_1997 GRVLLAGDAAHVHFPIGGQGLNTGMQDAVNLGWKLAQVVNGTSPENLLDT
MUL_2358|M.ulcerans_Agy99 NRVVLVGDACSAGSPLTGPGASLALAGAY------------VLSEQLRRT
MLBr_02276|M.leprae_Br4923 PNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQ
. .: ***. .. * * .: . :
Mb1170c|M.bovis_AF2122/97 TPASYEAAWHRITRDYRLVTRGLVLASTPRAAR--RAIVPLCALLPTAFR
Rv1138c|M.tuberculosis_H37Rv TPASYEAAWHRITRDYRLVTRGLVLASTPRAAR--RAIVPLCALLPTAFR
MSMEG_1499|M.smegmatis_MC2_155 YEAERRFLATEVLRGTSAITRVNVASNPVGRFLRDRVATRIFGLPVVQRW
Mflv_5009|M.gilvum_PYR-GCK YEAERRPLATQVLRGTSAITRVNVAGNPIVRFLRDRVAPRVFGLPAVQRW
Mvan_0779|M.vanbaalenii_PYR-1 YEAERRPLATEVLRGTSAVTRVNIAGNPVGRFLRDRVAPKVFGLAPVQRW
TH_4641|M.thermoresistible__bu YEAERRPLATEVLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRR
MMAR_4271|M.marinum_M YHAERHPVAARVLRTTMAQVALRRLDYRKKALS--DTISELLMMDEPRKR
MAV_2736|M.avium_104 YHAERHPVGERVLRNAIAQMALLRPDERTRALR--DLVTELLGMDEPRKR
MAB_3483|M.abscessus_ATCC_1997 YHAERHPVAARVLHNTMAQTALIRPGERVDALR--DIMSDLLTLDMPRRR
MUL_2358|M.ulcerans_Agy99 SSVERALDFYERLWSPTVEEKQE----SARGLRLDAVAVVLTALDSPRRA
MLBr_02276|M.leprae_Br4923 HYGRGFSVARRLALLLTFKRCLPAIGPSAMRSTSLITIAVRVMANLVTDD
.
Mb1170c|M.bovis_AF2122/97 YGVNILAY------------------------------------------
Rv1138c|M.tuberculosis_H37Rv YGVNILAY------------------------------------------
MSMEG_1499|M.smegmatis_MC2_155 TTYTASQLWVSYRKGPLGGHGR---RPRLGDRIGDRPCTRADGAATRLHS
Mflv_5009|M.gilvum_PYR-GCK TTYTASQLWVSYRNGPLGGRGS---KPRPGDRIDDAPCSRPDGTATRLHG
Mvan_0779|M.vanbaalenii_PYR-1 TTYTASQLWVSYRKGPLGGRGP---KPRAGDRIPDVACVRPDGTPSLLHR
TH_4641|M.thermoresistible__bu LTYQTSQLWVTYRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYE
MMAR_4271|M.marinum_M FAAMMSGLDIRYHLGGG--------HPLLGRRMPDLDLTTADGPRRVFTH
MAV_2736|M.avium_104 FAAMISGLDVRYDLGPG--------HPLLGRRMPDLDLVTADGASRVFAL
MAB_3483|M.abscessus_ATCC_1997 IAAMMSGLDIHYDLGPG--------HPLLGRRMPDLEVRTAQGPRCVFTL
MUL_2358|M.ulcerans_Agy99 ALHLAPADQPIR--------------------------------------
MLBr_02276|M.leprae_Br4923 DADWVARVWRSGG-----------WASWLVDRRPPFS-------------
Mb1170c|M.bovis_AF2122/97 --------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1499|M.smegmatis_MC2_155 ELAGRWALLWPRD--APAPG------ASLLAR----LGDFGVTLR---HD
Mflv_5009|M.gilvum_PYR-GCK ELGGRWALLLPRG--VPAVG------AAAVRGPAGYLADHVVTLH---HD
Mvan_0779|M.vanbaalenii_PYR-1 ELSGRWALLAPPD--APAGC------ADVARR---HLGDFVEPLT---FD
TH_4641|M.thermoresistible__bu QLGGRWAVLEPGSGRHHREG------PGLLGTAHTFLGEYVVGLRGAEMR
MMAR_4271|M.marinum_M LHAARPVLLNLAEPGRFDIAGWRHRVLLIDAKYV---GVWELPVLG-AIA
MAV_2736|M.avium_104 LRNARPVLLNFAGAGRRSVAGWADRVRVVDAKCV---ADWELPVLG-RVS
MAB_3483|M.abscessus_ATCC_1997 LREGRGVLLNLGTP-ITGASGWSHRVDVVEAEYLDAEGTFELPVIG-MVE
MUL_2358|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
Mb1170c|M.bovis_AF2122/97 ------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv ------------------------------------------------
MSMEG_1499|M.smegmatis_MC2_155 GAEAMLIRPDAHLAWRGAPDDTAGLDHWLAKALGSGAVR---------
Mflv_5009|M.gilvum_PYR-GCK RDDVMLVRPDAHLAWRGAHDDPTGLDRWLATALHPGGTQ---------
Mvan_0779|M.vanbaalenii_PYR-1 GDEAMLIRPDGHLAWRGDAGDADGVNLWLTRALTTGNAR---------
TH_4641|M.thermoresistible__bu GCDAFLVRPDGHLAWRGR--DATDLADWLKSALTVGRVR---------
MMAR_4271|M.marinum_M APAAALIRPDGYVAWVGDDLTDRGLFDALTAWFGRPAVPSPRLRASAP
MAV_2736|M.avium_104 APPAVLIRPDGHVAWAGD-PNDPGLHDALTTWCGPPAAGG--------
MAB_3483|M.abscessus_ATCC_1997 APHAVLIRPDGYVAWVGN-GTTAGLNGALQRWFGPPRYSGGGS-----
MUL_2358|M.ulcerans_Agy99 ------------------------------------------------
MLBr_02276|M.leprae_Br4923 ------------------------------------------------