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VPQPSETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHASTLRLLDELGLGSQFAQ IPHRLIDTISMKVQGQPVDLDLKHLPGAHQHIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDG PDPGRVVSATYRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPRRPDDPTGLAG IFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEALHRALADLMPWLADRVDALKSFDDVKLLDVQL NRLRRWYCDGALCIGDAAHAMSPVGGVGINLALADAVATARMLAPSLRVGRVSTGQLARVQARRWAPTAF LQGIQRAIHAAIVAVAVTGGPPQPPPVVRLVSRSVPVRRIMGYLVAIGPLPEHAPKYPRRAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3663 | - | - | 100% (412) | hypothetical protein MUL_3663 |
| M. ulcerans Agy99 | MUL_1770 | - | 2e-09 | 24.36% (349) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 1e-106 | 50.61% (407) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_0304 | - | 1e-106 | 52.68% (410) | hypothetical protein Mflv_0304 |
| M. tuberculosis H37Rv | Rv1751 | - | 1e-106 | 50.61% (407) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1646c | - | 1e-132 | 56.25% (416) | hypothetical protein MAB_1646c |
| M. marinum M | MMAR_3720 | - | 0.0 | 97.96% (392) | FAD-dependent oxidoreductase |
| M. avium 104 | MAV_4364 | - | 2e-80 | 44.39% (392) | hypothetical protein MAV_4364 |
| M. smegmatis MC2 155 | MSMEG_4962 | - | 1e-109 | 51.93% (414) | hypothetical protein MSMEG_4962 |
| M. thermoresistible (build 8) | TH_4641 | - | 1e-10 | 28.65% (342) | PUTATIVE oxygenase |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | 1e-103 | 50.24% (412) | hypothetical protein Mvan_0442 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3663|M.ulcerans_Agy99 ---------------------------------------------MPQPS
MMAR_3720|M.marinum_M --------------------------------------------------
MAB_1646c|M.abscessus_ATCC_199 -------------------------------------------MIKPELP
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Mflv_0304|M.gilvum_PYR-GCK -MR----------DDDTVS-------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 -MRKQLGRPSGSCHHDQMN-------------------------------
MSMEG_4962|M.smegmatis_MC2_155 -MT-----------------------------------------------
MAV_4364|M.avium_104 --------------------------------------------------
TH_4641|M.thermoresistible__bu ----------------------------------------------MARE
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
MMAR_3720|M.marinum_M ---------------MLGLLLARAGVDVTVMEKHADFLRDFRGDTVHAST
MAB_1646c|M.abscessus_ATCC_199 QGTTCAIAGGGPAGMMLALLLARAGIDVTVLEKHPDFLRDFRGDTVHAST
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Mflv_0304|M.gilvum_PYR-GCK DTTTCAIVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mvan_0442|M.vanbaalenii_PYR-1 AKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
MSMEG_4962|M.smegmatis_MC2_155 EKTTCAVVGGGPAGMVLGLLLARAGIEVTVFEKHADFLRDFRGDTVHPAT
MAV_4364|M.avium_104 --------------MVHALLLARAGIPVVVLEKHNDFLRDFRGDTVHPTT
TH_4641|M.thermoresistible__bu TTTDVVVVGAGPVGLAVACGLLAHGLDVRVIDKAPAPATTSRANFLHARG
. * *: * :::* *.: :*.
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVDL-DLKHLPGA---HQ
MMAR_3720|M.marinum_M LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVDL-DLKHLPGA---HQ
MAB_1646c|M.abscessus_ATCC_199 LNLIDELGLGPRFAAMPHNLVEQVTVDL-GEQTFRLGDLNRLPGP---HK
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQP---YP
Mflv_0304|M.gilvum_PYR-GCK LRLLDDLGLWPRFADISHSRLDHATVDVGAGRSVTMVDFRRLRQP---HP
Mvan_0442|M.vanbaalenii_PYR-1 LRLIDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQP---HP
MSMEG_4962|M.smegmatis_MC2_155 LRLLDELGLFEKFDALPHSRVERARFDL-GGREVTVVDFGRLNLP---HR
MAV_4364|M.avium_104 LRIMDELGLIDEFLRLPHTKIDTVAFDT-DGSIRTFGNFKVLKRLGFNQP
TH_4641|M.thermoresistible__bu SEVLDRLGALGGLPERSVRAMQITTHLG--GEPVMRMQFGDPGMR---TA
.::* ** : . : ::
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSAT
MMAR_3720|M.marinum_M HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDRGRVVGVT
MAB_1646c|M.abscessus_ATCC_199 HIAMAPQWDFLEMLATAAETEPTFRLRRSTEVTGLLRSGD----RITGIE
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGG----KVTGVR
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLREGG----KVTGVR
Mflv_0304|M.gilvum_PYR-GCK YIAMVPQWDLLNLLADAGRAEPTFTLRMSTEVTGVLREGS----RVTGVR
Mvan_0442|M.vanbaalenii_PYR-1 YIAMVPQWDLLNLLAEAGEAEPTFTLRMCTEATGLIREGG----RVVGVR
MSMEG_4962|M.smegmatis_MC2_155 YIALVPQWDFLDLLADAAKEEPTFTLRMQTEVTGLLKDGD----TVTGVR
MAV_4364|M.avium_104 YIAMMPQWDFLDFIAEKASAYPEFTLIRNAEVTDLILEDD----RVAGVR
TH_4641|M.thermoresistible__bu APPMVISQAEVEAALRNRLAELGGRVELDCPLTGLRQDAS---------T
.: . :: : *.: .
MUL_3663|M.ulcerans_Agy99 YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
MMAR_3720|M.marinum_M YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
MAB_1646c|M.abscessus_ATCC_199 YRTASGETGALKADLTVACDGRGSALRAAAGMRPRQFGVPIDIWWFRLPK
Mb1780|M.bovis_AF2122/97 YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Mflv_0304|M.gilvum_PYR-GCK YETADG-TGELQAGLTVACDGRGSLLREKTGLRTQEFPVGFDVWWFRLPR
Mvan_0442|M.vanbaalenii_PYR-1 YQDPDG-PGELRADLTVGCDGRGSVLRGLAGLQVREFPVSFDAWWFRLPR
MSMEG_4962|M.smegmatis_MC2_155 YHGPDG-PGELRADLTVACDGRTSRVRKEAGLAPREYPVPFDVGWFRIDR
MAV_4364|M.avium_104 TP-----HDEVRADLVIAADGRKSAVRAAAGLRTAQAHSPMDVLWFRLKW
TH_4641|M.thermoresistible__bu VTAGIGGGGELRGRWLVGCDGTGSSTRKSVGIGYPGARLSERFLLADVYL
::. :..** * * *: :
MUL_3663|M.ulcerans_Agy99 -RPDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
MMAR_3720|M.marinum_M -RPDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
MAB_1646c|M.abscessus_ATCC_199 -HPDDPQGPRARVGANRFMVLLDRGDYFQCGYLIGKGTDSQMRSGDVQVL
Mb1780|M.bovis_AF2122/97 -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Rv1751|M.tuberculosis_H37Rv -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Mflv_0304|M.gilvum_PYR-GCK PETDEMYTLFPRLAPGRAMIVIPREGYLQIALLIEKGTDAALRAHGLDAF
Mvan_0442|M.vanbaalenii_PYR-1 PADDSIYTLVPRIAPGKAMIVIPREGYLQIAMLIPKGTDAERRARGLDAF
MSMEG_4962|M.smegmatis_MC2_155 -IKETAYQLTPRISSGQALILIPREGYFQAGCFLPKGGEKQLHARGLEVF
MAV_4364|M.avium_104 -RPGDPRELFGVFRKGLMMAMIYRGDYWQVAYLMPKG--ASPKGGSLEEF
TH_4641|M.thermoresistible__bu DWRLDRSGTTGWIHPDGMVGAMPMPDGLWRIIAYDPGPGDLDQG------
. . : . * :
MUL_3663|M.ulcerans_Agy99 HRALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAH
MMAR_3720|M.marinum_M HRALADLMPWLADRVDALKSLDDVKLLDVQLNRLRRWYCDGALCIGDAAH
MAB_1646c|M.abscessus_ATCC_199 RDRVAEMAPWLAARTNAIASWDDVKLLDIQLNRLRKWYRDGLLFIGDAAH
Mb1780|M.bovis_AF2122/97 RRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Rv1751|M.tuberculosis_H37Rv RRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Mflv_0304|M.gilvum_PYR-GCK HADVLALLPEAAGTVGSIASLDEVKMLDVKLNRLRCWHIEGMLCIGDAAH
Mvan_0442|M.vanbaalenii_PYR-1 RADVLALLPEAATTIETITSLDDVKHLDVRLNRLRRWHTDGLLFIGDAAH
MSMEG_4962|M.smegmatis_MC2_155 RAQVAEAVPEAS--VDRLTSWDDVKVLDVKLNRLRRWYRDGLLCIGDAAH
MAV_4364|M.avium_104 KERIVTAQPRLREHVNDLTSWDDTSELDVRVDRLETWWRTGLLCIGDAAH
TH_4641|M.thermoresistible__bu --ALERLLYERTGHRVKVTGTVWQSEFRVHRRLADTYRRGRVFIAGDAAH
: : . . : :: : : *****
MUL_3663|M.ulcerans_Agy99 AMSPVGGVGINLALADAVATARMLAPSLR---------------------
MMAR_3720|M.marinum_M AMSPVGGVGINLALADAVATARMLAPSLR---------------------
MAB_1646c|M.abscessus_ATCC_199 AMSPVGGVGINLAIADAVATARILAEPLR---------------------
Mb1780|M.bovis_AF2122/97 AMSPVAGVGINLAVQDAVAAATILAEPLR---------------------
Rv1751|M.tuberculosis_H37Rv AMSPVAGVGINLAVQDAVAAATILAEPLR---------------------
Mflv_0304|M.gilvum_PYR-GCK AMSPAGGVGINLAIQDAVAAARLLAEPLR---------------------
Mvan_0442|M.vanbaalenii_PYR-1 AMSPAGGVGINVAIQDAVATARLLADPLR---------------------
MSMEG_4962|M.smegmatis_MC2_155 AMSPVGGVGINLAIADAVAAARILAEPLR---------------------
MAV_4364|M.avium_104 AMSPAGGVGINLAVADAVAAANILCAPLQ---------------------
TH_4641|M.thermoresistible__bu AHAPFGGQGMLTGLGDAENLAFKLALVIRGYAGPALLDTYEAERRPLATE
* :* .* *: .: ** * *. ::
MUL_3663|M.ulcerans_Agy99 ----VGRVSTGQLAR------VQARRWAPTAFLQGIQRAIH----AAIVA
MMAR_3720|M.marinum_M ----VGRVSTGQLAR------VQARRWAPTAFLQGIQRAIH----AAIVA
MAB_1646c|M.abscessus_ATCC_199 ----TGTLTTADLRK------VQLRRWVPTALIQRIQRAVHRRVFSAVDS
Mb1780|M.bovis_AF2122/97 ----EHRVSSRHLAA------VRRRRAFPTAVTQAVQRVLHRRLLGPLLQ
Rv1751|M.tuberculosis_H37Rv ----EHRVSSRHLAA------VRRRRAFPTAVTQAVQRVLHRRLLGPLLQ
Mflv_0304|M.gilvum_PYR-GCK ----RGTVTGRDLAR------VRRRRILPTVVTQALQRLIDRRLLGPIVR
Mvan_0442|M.vanbaalenii_PYR-1 ----RGAVTERDLAA------VRRRRVVPAALTQALQRQIDKRFLRPILD
MSMEG_4962|M.smegmatis_MC2_155 ----TGRVTRRDLAA------VEKRRYVPAAVIQAVQRVLHIGLRRALLG
MAV_4364|M.avium_104 ----QGRVTDRDLAK------VQRRRELPTRIVQAVQVLMQDNAIAPNLN
TH_4641|M.thermoresistible__bu VLRNTSAATKLNIADRGVGRFLRDRVVLPLLALPSVQRRLTYQTSQLWVT
: .: :. * * :* :
MUL_3663|M.ulcerans_Agy99 VAVTGGPPQPPPVVR--LVSRSVPVRRIM---------------------
MMAR_3720|M.marinum_M VAVTGGPPQPPPVVR--LVSRSVPARRIM---------------------
MAB_1646c|M.abscessus_ATCC_199 STTAASNAKIASVLS--IATKYPWLQAVP---------------------
Mb1780|M.bovis_AF2122/97 GRDPTPPAALLGLV-----ERLPWLSAVP---------------------
Rv1751|M.tuberculosis_H37Rv GRDPTPPAALLGLV-----ERLPWLSAVP---------------------
Mflv_0304|M.gilvum_PYR-GCK GGSGGPSPGLIRTV-----ERLPWLTVIP---------------------
Mvan_0442|M.vanbaalenii_PYR-1 GDVTGPPPALVRAI-----ERAPWLTFVP---------------------
MSMEG_4962|M.smegmatis_MC2_155 GEIRQPPERVLKAVGA-VLSRFPGLAKVP---------------------
MAV_4364|M.avium_104 GDLS--PIHVPKIVG------FGPLQAIP---------------------
TH_4641|M.thermoresistible__bu YRGGPLAPRTVSMTTPRPGDRVPDQRCVRDDGHISRLYEQLGGRWAVLEP
:
MUL_3663|M.ulcerans_Agy99 ---------------------GYLVAIG-----------PLPEHAPKYPR
MMAR_3720|M.marinum_M ---------------------GYLVAIG-----------PLPEHAPKYAR
MAB_1646c|M.abscessus_ATCC_199 ---------------------AYGVAIG-----------PLPEHAPDFAR
Mb1780|M.bovis_AF2122/97 ---------------------AYFVGVG-----------VRPEHAPAFAR
Rv1751|M.tuberculosis_H37Rv ---------------------AYFVGVG-----------VRPEHAPAFAR
Mflv_0304|M.gilvum_PYR-GCK ---------------------AYLVGVG-----------VRPERAPRFAR
Mvan_0442|M.vanbaalenii_PYR-1 ---------------------AYLVGVG-----------VRPERAPEFAK
MSMEG_4962|M.smegmatis_MC2_155 ---------------------AYLVGVG-----------PLPEHAPDFAR
MAV_4364|M.avium_104 ---------------------PLVVGRG-----------FRPEHVRTPDV
TH_4641|M.thermoresistible__bu GSGRHHREGPGLLGTAHTFLGEYVVGLRGAEMRGCDAFLVRPDGHLAWRG
*. *:
MUL_3663|M.ulcerans_Agy99 RAR-----------------
MMAR_3720|M.marinum_M RAR-----------------
MAB_1646c|M.abscessus_ATCC_199 RSPID---------------
Mb1780|M.bovis_AF2122/97 RGPGNRKGP-----------
Rv1751|M.tuberculosis_H37Rv RGPGNRKGP-----------
Mflv_0304|M.gilvum_PYR-GCK RRPQ----------------
Mvan_0442|M.vanbaalenii_PYR-1 RRPT----------------
MSMEG_4962|M.smegmatis_MC2_155 RSR-----------------
MAV_4364|M.avium_104 HAR-----------------
TH_4641|M.thermoresistible__bu RDATDLADWLKSALTVGRVR
: