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MSEDVSEIHRSARENRLKPNALGLTSVVFMVVATAAPITAITSNMPIMVGLGTGVGTPAGFLLATVTLSI FSVGFVAIARHVTSAGAFYGFISRGLGRIVGLGSGLLTTASYMMFEVTLVALFGVFTKETMAAELGVDLP WWVYTFTLIAVIAVLTYFEIELTAKVLGIALAAEVLILAAIALAVLANGGGPEGISAAPLSPAEAFAGPS VGLGLFFAFWCWMGFESTALYGEESKNPRRTVPVATFIVVIGVGLFYAFVSWMIMSGNGIEQTAALAASD SPFETVFAPTREFLGEWAVLIFRWLLLTGTFACAMAFHNCASRYLYALGRERILPGVLGRTHPRYGSPWV ASIVQSAFVVIVTLCYWSSGLDPYVGQYTLSALLGTMGIIVVQALCSLAVTAYFWRYPDKRPHFLVWVVA PILGALAMIGAVLLLVLNMDAAAGGPAASTLLFRLIPWIVGAVFIAGCVLAVWLRKSAPQRYELIGHLDV VAPGGVENGPEGTKSFPAAMN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1118 | - | - | 100% (511) | amino acid permease |
| M. smegmatis MC2 155 | MSMEG_0279 | - | e-141 | 50.51% (487) | amino acid permease |
| M. smegmatis MC2 155 | MSMEG_0781 | - | e-132 | 47.77% (494) | amino acid permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2347c | rocE | 2e-12 | 22.51% (422) | cationic amino acid transport integral membrane protein RocE |
| M. gilvum PYR-GCK | Mflv_1244 | - | 1e-139 | 49.18% (490) | amino acid permease-associated region |
| M. tuberculosis H37Rv | Rv2320c | rocE | 2e-12 | 22.51% (422) | cationic amino acid transport integral membrane protein RocE |
| M. leprae Br4923 | MLBr_01974 | - | 3e-10 | 24.10% (332) | putative permease |
| M. abscessus ATCC 19977 | MAB_0950c | - | 1e-135 | 49.39% (492) | putative amino acid permease family protein |
| M. marinum M | MMAR_0869 | - | 2e-20 | 22.97% (444) | amino acid permease |
| M. avium 104 | MAV_2087 | - | 2e-13 | 22.09% (421) | amino acid transporter |
| M. thermoresistible (build 8) | TH_0471 | - | 9e-14 | 24.95% (457) | POSSIBLE CATIONIC AMINO ACID TRANSPORT INTEGRAL MEMBRANE |
| M. ulcerans Agy99 | MUL_2787 | - | 5e-19 | 22.73% (440) | hypothetical protein MUL_2787 |
| M. vanbaalenii PYR-1 | Mvan_5564 | - | 1e-137 | 48.01% (502) | amino acid permease-associated region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2347c|M.bovis_AF2122/97 --------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2087|M.avium_104 --------------------------------------------------
TH_0471|M.thermoresistible__bu --------------------------------------------------
Mflv_1244|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5564|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0950c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1118|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0869|M.marinum_M --------------------------------------------------
MLBr_01974|M.leprae_Br4923 MFLSADVSCIEIVDINCSELRNDRRIPPQLALFCTNAANKAESAVTSHGQ
MUL_2787|M.ulcerans_Agy99 --------------------------------------------------
Mb2347c|M.bovis_AF2122/97 ---------------------------MPTTSMSLRELMLRRRPVSGAPV
Rv2320c|M.tuberculosis_H37Rv ---------------------------MPTTSMSLRELMLRRRPVSGAPV
MAV_2087|M.avium_104 -------------------------------------------------M
TH_0471|M.thermoresistible__bu ----------------------------------MTDRLRVKSVEQSIAD
Mflv_1244|M.gilvum_PYR-GCK ----------------------------------MTESAERTAP--GQTT
Mvan_5564|M.vanbaalenii_PYR-1 -------------------------------------MTEDVVP--RQTA
MAB_0950c|M.abscessus_ATCC_199 -------------------------------------MSDTIDPPVGTTT
MSMEG_1118|M.smegmatis_MC2_155 -------------------------------------MSEDVSE----IH
MMAR_0869|M.marinum_M -----------------------------------------------MAV
MLBr_01974|M.leprae_Br4923 LPIMANRRWAPHTRRQSGRATSTCSSLMRFSASESRAHSRFECYTLVRWS
MUL_2787|M.ulcerans_Agy99 -----------------------MGHLDADKKTNHQPIEGDCVSQGEATS
Mb2347c|M.bovis_AF2122/97 ASGASGNLKRSFGTFQLTMFGVGATIG--TGIFFVLAQAVP-----EAGP
Rv2320c|M.tuberculosis_H37Rv ASGASGNLKRSFGTFQLTMFGVGATIG--TGIFFVLAQAVP-----EAGP
MAV_2087|M.avium_104 APGTADHLRRGIGTFQLTMFGVGSTIG--TGIFFVMSQAVP-----EAGP
TH_0471|M.thermoresistible__bu TDEPDSRLRKDLSWWDLTVFGVSVVIG--AGIFTVTASTAGN----ITGP
Mflv_1244|M.gilvum_PYR-GCK PTASVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGF----GNGS
Mvan_5564|M.vanbaalenii_PYR-1 PTDSVQRLKRNAVGTFGVIFMAVATAAPITAMVGNVPIAVGF----GNGS
MAB_0950c|M.abscessus_ATCC_199 EPDSMQRLKPNAVGLIGVLFMAVATAAPITAMVGNVPMAVGF----GNGA
MSMEG_1118|M.smegmatis_MC2_155 RSARENRLKPNALGLTSVVFMVVATAAPITAITSNMPIMVGL----GTGV
MMAR_0869|M.marinum_M TTGARSELQKALGQRSAVLFGLAYMTP---IIVLGIFGVIAE----RSKG
MLBr_01974|M.leprae_Br4923 IRGQGGRAISKLGFWSVVMLGINSIIG---AGIFMTPGEVIK----IAGP
MUL_2787|M.ulcerans_Agy99 VAVEGKGLKGGAVGLLSSVVIGTASTAPAYSLAATLGLIVASRGELLCGV
:.
Mb2347c|M.bovis_AF2122/97 GVIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVA
Rv2320c|M.tuberculosis_H37Rv GVIVSFIIAGIAAGLAAICYAELASAVPISGSAYSYAYTTLGEAVAMVVA
MAV_2087|M.avium_104 AVIVSFLLAGVAAGLAAVCYAELASAVPVSGSSYSYAYTTLGEVVAMGVA
TH_0471|M.thermoresistible__bu AISVSFIIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFVAWIIG
Mflv_1244|M.gilvum_PYR-GCK HAPAGYLVATIVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASG
Mvan_5564|M.vanbaalenii_PYR-1 HAPAGYLVATVVLGLFAIGYATMAKHITATGAFYGYISHGLGRVMGMASG
MAB_0950c|M.abscessus_ATCC_199 YAPAGYLVATIVLTLFAIGYAAMSRHIVATGAFYGYISHGLGRVVGLGSG
MSMEG_1118|M.smegmatis_MC2_155 GTPAGFLLATVTLSIFSVGFVAIARHVTSAGAFYGFISRGLGRIVGLGSG
MMAR_0869|M.marinum_M ASAGSYLLATVAMLFTAQSYGVMARHFPVAGSAYTYVRKALDARVGFMVG
MLBr_01974|M.leprae_Br4923 FAPIAYTLAGIFAAVLAIVFATAAKYVKTNGSSYAYTTAAFGHRIGIYVG
MUL_2787|M.ulcerans_Agy99 KAPAIVLLSFIPMYMIAVAYQELNKAEPDCGTTFTWASRAFGPVTGWLGG
:: : . : : *: : : :. . .
Mb2347c|M.bovis_AF2122/97 ACLLLEYGVATAAVAVGWS--------GYVNKLLSNLFGFQMPHVLSAAP
Rv2320c|M.tuberculosis_H37Rv ACLLLEYGVATAAVAVGWS--------GYVNKLLSNLFGFQMPHVLSAAP
MAV_2087|M.avium_104 ACLLLEYGVATAAVSVNWS--------GYLNKLLSNVVGFQLPHALSAAP
TH_0471|M.thermoresistible__bu WDLILEFSVAAAVVAKGWS--------SYLGEVFE----------FAGAT
Mflv_1244|M.gilvum_PYR-GCK LIITLAYIVFEASLIGIFA--------FFFQNFLSSQLGITIHWLVPALL
Mvan_5564|M.vanbaalenii_PYR-1 GIITMAYVVFEASLIGIFA--------FFFQNFLSSQFGFDIHWLIPALL
MAB_0950c|M.abscessus_ATCC_199 FLITLAYMVFEASLVGIFS--------FFANDLFQTFFQVDVPWVVFAVA
MSMEG_1118|M.smegmatis_MC2_155 LLTTASYMMFEVTLVALFG--------VFTKETMAAELGVDLPWWVYTFT
MMAR_0869|M.marinum_M WAVLLDYLFLPLVIWLIGG--------SYLQDRFP-----TVPFWTWIVG
MLBr_01974|M.leprae_Br4923 VTHAITASIAWGVLASSFVST--LLRVAFPEKIWADNDELISVKTLTFLV
MUL_2787|M.ulcerans_Agy99 WGIIAADVIVMANLAQIAGAYSFTFVGELGWQSASNLAHSTLWSTVAGVA
. : .
Mb2347c|M.bovis_AF2122/97 WDTHPGWVNLPAVILIGLCALLLIRGASESARVNAIMVL----IKLGVLG
Rv2320c|M.tuberculosis_H37Rv WDTHPGWVNLPAVILIGLCALLLIRGASESARVNAIMVL----IKLGVLG
MAV_2087|M.avium_104 WDAQPGYVNLPAVMLIGMCALLLIRGASESAKVNAIMVM----VKLGVLV
TH_0471|M.thermoresistible__bu TRLGPITLDWGALLIIGFVTVLLATGTKLSANVSLAITV----IKVGVVL
Mflv_1244|M.gilvum_PYR-GCK MLVLNSILTYFDVNLTAKVLGVFLITEIFMLALGAVAVA----VKGGGPD
Mvan_5564|M.vanbaalenii_PYR-1 MLALNCILTYFDVNLTAKVLGVFLVTEIVMLSLGAIAVA----VKGGGPD
MAB_0950c|M.abscessus_ATCC_199 MLATNAVLTYFDLNLAARVLGVFLVTEILMLSLLALSVL----FAGGGPQ
MSMEG_1118|M.smegmatis_MC2_155 LIAVIAVLTYFEIELTAKVLGIALAAEVLILAAIALAVL----ANGGGPE
MMAR_0869|M.marinum_M FAALTTVLNLIGLKVADRANFILMTFQLLILAFFVALTIG---YLVGDSR
MLBr_01974|M.leprae_Br4923 FIAVLLAINIFGNLVIRWANGISALGKIFALSVFIAGGLW---TIITQHV
MUL_2787|M.ulcerans_Agy99 WIVVMTCICYRGTDVSARMQYVLLSVELVVLVALAAVALARVYTNHGDVG
: : :
Mb2347c|M.bovis_AF2122/97 MFMIIAFSAYSADHLKDFVP---------------------------FGV
Rv2320c|M.tuberculosis_H37Rv MFMIIAFSAYSADHLKDFVP---------------------------FGV
MAV_2087|M.avium_104 VFGILAFTAFDMHHLDDFAP---------------------------FGV
TH_0471|M.thermoresistible__bu LVVIVGAFFIKAANYTPFIPPAEAGGEAGRSLDQSLFSLITGAEGSSYGW
Mflv_1244|M.gilvum_PYR-GCK GFAIAETLNPVGAFQ-----------------------------PAAIAG
Mvan_5564|M.vanbaalenii_PYR-1 GFAVGEILNPVGAFQ-----------------------------PAAIAG
MAB_0950c|M.abscessus_ATCC_199 GWSWGS-LNPLNGFHDLGGVVQGPAG------------------PLAVAG
MSMEG_1118|M.smegmatis_MC2_155 GISAAP-LSPAEAFA----------------------------------G
MMAR_0869|M.marinum_M SLLSLTPFTGNGGFT-----------------------------------
MLBr_01974|M.leprae_Br4923 NNYVTSRSAYQPTTYSLLGVTEIG----------------------KSTA
MUL_2787|M.ulcerans_Agy99 SLRPSLSWLWPSGLD---------------------------------FG
Mb2347c|M.bovis_AF2122/97 AGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYV
Rv2320c|M.tuberculosis_H37Rv AGIGSAAGTIFFSYIGLDAVSTAGDEVKDPQKTMPRALIAALVVVTGVYV
MAV_2087|M.avium_104 AGVGTAAGTIFFSYIGLDAVSTAGDEVTNPQKTMPRALIAALLTVTGVYV
TH_0471|M.thermoresistible__bu YGLLAGASIVFFAFIGFDIIATTAEETKNPQRDVARGIMATLGIVTVLYV
Mflv_1244|M.gilvum_PYR-GCK ASAGLGLFFAFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGIFYV
Mvan_5564|M.vanbaalenii_PYR-1 ASAGLGLFFAFWSWVGFESTAMYGEESKDPKRIIPRATMIAVLGVGLFYV
MAB_0950c|M.abscessus_ATCC_199 -SAGVGLFFAFWSWVGFESSAMYAEESKNPKKIIPIAIVTSVVGVGLFYV
MSMEG_1118|M.smegmatis_MC2_155 PSVGLGLFFAFWCWMGFESTALYGEESKNPRRTVPVATFIVVIGVGLFYA
MMAR_0869|M.marinum_M -AITAGAAVAAYSFLGFDAVSTLTEETHDAERTIPRAIVLIALIGGAIFV
MLBr_01974|M.leprae_Br4923 ASMTLATIVALYAFTGFESIANAAEEMNTPDRTLPKAIPLTILTVGVIYI
MUL_2787|M.ulcerans_Agy99 TQMAPALLITIFIYWGFDTAVACNDETDDPGRTLGRAAVISTFLLLATYA
. : : *:: :* . : : . :
Mb2347c|M.bovis_AF2122/97 LVALAALG----TQPWQDFAEQ-ETAGLAIILDNVTHGE-----WASTIL
Rv2320c|M.tuberculosis_H37Rv LVALAALG----TQPWQDFAEQ-ETAGLAIILDNVTHGE-----WASTIL
MAV_2087|M.avium_104 FVALAALG----TQPWQDFGGQ-QEAGLATILDHVTHGS-----WASTIL
TH_0471|M.thermoresistible__bu AVSLVLTG----MVHYTELRAAGENANLATAFA-ANGID-----WAAKVI
Mflv_1244|M.gilvum_PYR-GCK FVSWMAIAGTGPQQAVELAQSADTSSEIFFAPVRDTYGE-----WAITLF
Mvan_5564|M.vanbaalenii_PYR-1 FVSWMAIAGTGPKQAVELAQSADTSSEIFFAPVRTTYGE-----WAITLF
MAB_0950c|M.abscessus_ATCC_199 LVSWLAIVGTGPENAVALAQDSSTAGNIFFGPVQSHLGV-----WAVNLF
MSMEG_1118|M.smegmatis_MC2_155 FVSWMIMSGNGIEQTAALAAS-DSPFETVFAPTREFLGE-----WAVLIF
MMAR_0869|M.marinum_M TVAYVVSL-------VAPGSSFPDADSLSEGVARTIGGN-----LFAAVF
MLBr_01974|M.leprae_Br4923 LALVVAML---------LGSDKIVATNHTVKLAAAVGNN-----TFRTII
MUL_2787|M.ulcerans_Agy99 VVTVASIAFAGVGVDGIGLGNPDNSNDVFAAVGPALFGDGVLGKIGLLLL
. ::
Mb2347c|M.bovis_AF2122/97 AAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA---RFAKVNPRTMTPV
Rv2320c|M.tuberculosis_H37Rv AAGAVVSIFTVTLVTMYGQTRILFAMGRDGLLPA---RFAKVNPRTMTPV
MAV_2087|M.avium_104 AAGAVISIFSVTLVTMYGITRILFAMGRDGLLPP---RFARVNPRTMTPV
TH_0471|M.thermoresistible__bu SIGALAGLTTVVIVLVLGQTRVLFAMSRDGLLPR---PLSKTGPR-GTPV
Mflv_1244|M.gilvum_PYR-GCK NILLVTGSFACGMAFHNCASRYLYALGREGLSTGLQKTLGATHKTHGSPY
Mvan_5564|M.vanbaalenii_PYR-1 NILLVSGSFACGMAFHNCASRYLYALGREGLSTRLQDTLGATHKTHGSPH
MAB_0950c|M.abscessus_ATCC_199 KVLLMTGSFACGMAFHNCAARYLYALGRENVIPGMRKTIGSTHSTHGSPH
MSMEG_1118|M.smegmatis_MC2_155 RWLLLTGTFACAMAFHNCASRYLYALGRERILPG---VLGRTHPRYGSPW
MMAR_0869|M.marinum_M LAALIIGQFTSGLAAQAAVSRLLYAMGRDGVLPR--RVFGVVSAKFHTPM
MLBr_01974|M.leprae_Br4923 VVGALVSMFGINVAASFGAPRLWTALSDGRILPT----RLSSKNRFGVPI
MUL_2787|M.ulcerans_Agy99 SASILTSASASTQTTILPTARTTLSMAVYKALPAS---FAKIHPRYLTPT
: . . .* ::. . *
Mb2347c|M.bovis_AF2122/97 HNTVIVAIFASTLAAFIPLDSL------ADMVSIGTLTAFSVVAVGVIVL
Rv2320c|M.tuberculosis_H37Rv HNTVIVAIFASTLAAFIPLDSL------ADMVSIGTLTAFSVVAVGVIVL
MAV_2087|M.avium_104 NNTVIVAVAAATLAAFIPLQNL------ADMVSIGTLTAFVVVSVGVIVL
TH_0471|M.thermoresistible__bu RITVLVGALVAIAASVFPVGNL------EEMVNIGTLFAFALVSAGVIVL
Mflv_1244|M.gilvum_PYR-GCK IASFVQSGIALVLVLAFFFAGM------DPYIHMYTLLAILGTMAILIVQ
Mvan_5564|M.vanbaalenii_PYR-1 IASFVQTGITLVLILAFFAAGM------DPYIHMYTLLAILGTMAILIVQ
MAB_0950c|M.abscessus_ATCC_199 VAGFVQTAFATVVVLFFAATGR------DPYTGLYGLMALLGTTAILIVQ
MSMEG_1118|M.smegmatis_MC2_155 VASIVQSAFVVIVTLCYWSSGL------DPYVGQYTLSALLGTMGIIVVQ
MMAR_0869|M.marinum_M FN-IMLTGAVGMAAILLSVATS------TSFINFGAFTAFTLVNVSVVVY
MLBr_01974|M.leprae_Br4923 VAFGITAFLTLAFPLSLRFDSLNL----TGLAVIARFIQFIIVPIALFAL
MUL_2787|M.ulcerans_Agy99 VSTIAMGAVSILFYVLFTLVSRNLLSALIGSVGLVIAFYYGLTGYACAHY
.
Mb2347c|M.bovis_AF2122/97 RVR-------------EPDLPRGFKVPGYPVTPVLSVLACGYILAS----
Rv2320c|M.tuberculosis_H37Rv RVR-------------EPDLPRGFKVPGYPVTPVLSVLACGYILAS----
MAV_2087|M.avium_104 RVR-------------EPDLPRGFRVPGYPVTPVLSIMACGYILAS----
TH_0471|M.thermoresistible__bu RRT-------------RPDLKRGFRVPFVPWLPLAAIAACLWLMLN----
Mflv_1244|M.gilvum_PYR-GCK SLCAFSVVAYFHFHKNHPSSAHWFKTFLAPLTGGIGMLYVVYLLWEHKES
Mvan_5564|M.vanbaalenii_PYR-1 SLCAFSVIAYFHFHKNHPSSAHWFKTFLAPLLGGIGMLYVVYLLWEHKES
MAB_0950c|M.abscessus_ATCC_199 ALTAFAVISYFHVLRHHPETAHWFRTLVAPLLGGLGMVYVVYLLAKHASF
MSMEG_1118|M.smegmatis_MC2_155 ALCSLAVTAYFWRYPDK--RPHFLVWVVAPILGALAMIGAVLLLVLNMDA
MMAR_0869|M.marinum_M FVR---------------ERGAGLPRWRYLVLPVIGAAVDIYLLAH----
MLBr_01974|M.leprae_Br4923 ARSR-----------TTNSVYVKRNVFTDKVLPITAVVVSAGLMVS----
MUL_2787|M.ulcerans_Agy99 YRATLTKSLRNFVMRGVVPLTGGVVLTVVFIFGLIEYAKRDWLVENGHNV
::
Mb2347c|M.bovis_AF2122/97 --------------LHWYTWLAFSGWVAVAVIFYLMWGRH---HSALNEE
Rv2320c|M.tuberculosis_H37Rv --------------LHWYTWLAFSGWVAVAVIFYLMWGRH---HSALNEE
MAV_2087|M.avium_104 --------------LHWYTWIAFSGWVLLALIFYFVWGRH---HSALNDA
TH_0471|M.thermoresistible__bu --------------LTGLTWVRFLGWMALGLVLYFFYGRH---HSMLGRG
Mflv_1244|M.gilvum_PYR-GCK AAG-AASGTLLFKLTPWIVVGVFAFGAAMALYFKFKDKRR---YELIGRI
Mvan_5564|M.vanbaalenii_PYR-1 AAG-AASGTLLFKLTPWIVVGLFALGAAMALYFKFNDKRR---YELIGRI
MAB_0950c|M.abscessus_ATCC_199 AAG-TASNDWVFTAIPWVVAAAGIGGIALALTLKYTAPHR---YDDLGRT
MSMEG_1118|M.smegmatis_MC2_155 AAGGPAASTLLFRLIPWIVGAVFIAGCVLAVWLRKSAPQR---YELIGHL
MMAR_0869|M.marinum_M --------------LASDALIVGLSWAAIGFLYLLWLTRG---LTRQPPD
MLBr_01974|M.leprae_Br4923 -----------FDYRSIFLTRGGPNYFSISLIAITFIGIP---AVAYLHY
MUL_2787|M.ulcerans_Agy99 TIFGFGAVAVVGVGSMLLGVVVMLIWWAISPGFFRGRTLRRHSADLLLEP
:.
Mb2347c|M.bovis_AF2122/97 VP------------------------------------------------
Rv2320c|M.tuberculosis_H37Rv VP------------------------------------------------
MAV_2087|M.avium_104 AVDPSGQER-----------------------------------------
TH_0471|M.thermoresistible__bu MTDISARRTG----------------------------------------
Mflv_1244|M.gilvum_PYR-GCK -VYDDSEVRD----------------------------------------
Mvan_5564|M.vanbaalenii_PYR-1 -VYDDSEIRD----------------------------------------
MAB_0950c|M.abscessus_ATCC_199 -VLEEAHER-----------------------------------------
MSMEG_1118|M.smegmatis_MC2_155 DVVAPGGVENGPEGTKSFPAAMN---------------------------
MMAR_0869|M.marinum_M LAGAAERG------------------------------------------
MLBr_01974|M.leprae_Br4923 YRTSGIK-------------------------------------------
MUL_2787|M.ulcerans_Agy99 AVSPPAHLALPDSGDMQTVIAADLSNLPAGETAVNPQTGQHLTKDTSGAS