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EVTSLREPKMADRVATVLRRMFIRGEITEGTMLPPESELMERFGVSRPTLREAFRVLESESLIQVQRGVR GGARVTRPRRETLARYAGLILEYEGVTVKDVYDARVTLEVPMVEQLAKDRNPKVIAELEQIVERESQLNP GSEAVDQLTDFHAAIARLSGNSTLQIVSDMLHHIIEKANRSLQPTKGTRAEQAVRRSAKTHRMVLDMIKE GDAEKAGELWKRHLQKAEEFVLTGAELSTVVDLLE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2560 | - | - | 100% (246) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_1821 | - | e-122 | 90.24% (246) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_2542 | - | 3e-38 | 35.95% (242) | regulatory protein GntR, HTH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 3e-18 | 27.98% (218) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2114 | - | 2e-43 | 40.33% (243) | GntR domain-containing protein |
| M. tuberculosis H37Rv | Rv3060c | - | 3e-18 | 27.98% (218) | GntR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01188 | - | 1e-07 | 35.06% (77) | hypothetical protein MLBr_01188 |
| M. abscessus ATCC 19977 | MAB_4644c | - | 2e-12 | 28.57% (224) | GntR family transcriptional regulator |
| M. marinum M | MMAR_3975 | - | 1e-28 | 36.67% (240) | FadR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5201 | - | 6e-42 | 38.43% (242) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_2873 | - | 1e-119 | 87.40% (246) | PUTATIVE regulatory protein GntR, HTH |
| M. ulcerans Agy99 | MUL_3832 | - | 9e-29 | 36.67% (240) | FadR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4590 | - | 4e-43 | 39.67% (242) | GntR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2560|M.avium_104 ----------------MEVTSLREPKMADRVATVLRRMFIRGEITEGTML
TH_2873|M.thermoresistible__bu ------------VEDDMEVTSLREPKMADRVATVLRRMFIRGEIPEGTML
Mflv_2114|M.gilvum_PYR-GCK MARSTPLAPMIGPDAVASRTAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
Mvan_4590|M.vanbaalenii_PYR-1 MTRNTPLAPMIGPDAVASRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MSMEG_5201|M.smegmatis_MC2_155 MAGSTPLAPMIGPDAITPRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MMAR_3975|M.marinum_M --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MUL_3832|M.ulcerans_Agy99 --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MLBr_01188|M.leprae_Br4923 -------------------------------------------------M
Mb3086c|M.bovis_AF2122/97 --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Rv3060c|M.tuberculosis_H37Rv --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
MAB_4644c|M.abscessus_ATCC_199 -----------------MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKL
:
MAV_2560|M.avium_104 PPESELMERFGVSRPTLREAFRVLESESLIQVQRGVRGGARVTRPRRETL
TH_2873|M.thermoresistible__bu PPESELMERFGVSRPTLREAFRVLESESLIVVQRGVRGGARVTRPRRETL
Mflv_2114|M.gilvum_PYR-GCK PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
Mvan_4590|M.vanbaalenii_PYR-1 PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MSMEG_5201|M.smegmatis_MC2_155 PNEAELMSHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MMAR_3975|M.marinum_M PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKTSA
MUL_3832|M.ulcerans_Agy99 PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKASA
MLBr_01188|M.leprae_Br4923 PRQEALVEPLNVSLLSFREALQIMDTERLISLRRGNRGSVVVHTPTRTSA
Mb3086c|M.bovis_AF2122/97 GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Rv3060c|M.tuberculosis_H37Rv GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
MAB_4644c|M.abscessus_ATCC_199 PGEVALCEEFGVSRATVREAIRDLKTKGLVSTRQG--AGVFVTSDRP---
: * : ** .***.: :. . : ::* . :
MAV_2560|M.avium_104 ARYAGLILEYEGVTVKDVYDARVTLEVPMVEQLAK--DRNPKVIAELEQI
TH_2873|M.thermoresistible__bu ARYAGLILEYEGVTVKDVYEARVALEVPMVVQLAK--DRNPAVIAELERI
Mflv_2114|M.gilvum_PYR-GCK ARPAGLLLELSGATIADLLTAKSAIEPMAARLLAE--SGSAAAFDELEQL
Mvan_4590|M.vanbaalenii_PYR-1 ARPAGLLLELSGATIADLLTAKSGIEPMAARLLAE--SGSPEAFDELERM
MSMEG_5201|M.smegmatis_MC2_155 ARPVGLLLELSGADIADLLVARSAIEPMAARLLAE--NGTEEQFAELDRM
MMAR_3975|M.marinum_M AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MUL_3832|M.ulcerans_Agy99 AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MLBr_01188|M.leprae_Br4923 AYMLGLLLQSKSIALADLGAALQELEPACAALAAQ---------------
Mb3086c|M.bovis_AF2122/97 TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
Rv3060c|M.tuberculosis_H37Rv TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
MAB_4644c|M.abscessus_ATCC_199 --LGQWDRVLAAAEIDAVVEIRRLLEVQAAGLAAERRNRSDVAAIRRALV
. : : :* . *:
MAV_2560|M.avium_104 VERESQLNPGSEAVDQLT-DFHAAIARLSGNSTLQIVSDMLHHIIEKANR
TH_2873|M.thermoresistible__bu VEAESKLEPGAETVSQLT-DFHGAIARLSGNKTLQIVTDMLHHVIEKANR
Mflv_2114|M.gilvum_PYR-GCK LEELVADSHQSPRLAEATGAFHLRVVQLSGNATLSIVAGMLHEITVRHTA
Mvan_4590|M.vanbaalenii_PYR-1 LEELAADSHKSSRLAEATGLFHLRVVQLSGNATLSIVAGMLHEITVRHTA
MSMEG_5201|M.smegmatis_MC2_155 LEEHIPSDWQSDRLAETTGDFHRRVVELSGNATLGIIAGMLHEITVRHHQ
MMAR_3975|M.marinum_M NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MUL_3832|M.ulcerans_Agy99 NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
Rv3060c|M.tuberculosis_H37Rv RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
MAB_4644c|M.abscessus_ATCC_199 ARAKAESAGDDIEYVDADLEFHRAVVAAVHNPLLDELFDSFSVRMREAML
MAV_2560|M.avium_104 SLQPTKGTRAEQ----AVRRSAKTHRMVLDMIKEGDAEKAGELWKRHLQK
TH_2873|M.thermoresistible__bu SLQPTEGTRAEQ----AVKKSTKTHRMVLDYIKAGDAEKAGELWQKHLQK
Mflv_2114|M.gilvum_PYR-GCK FVFNERRPVSKA----DYETLLRSYRRLLQFLRSRDADGAEAHWRRHLDK
Mvan_4590|M.vanbaalenii_PYR-1 FVFNERRPVSKA----DYDTLLRSYRKLMQFLRAGDAVGAEAHWRKHLDT
MSMEG_5201|M.smegmatis_MC2_155 FLFREHRPVSKS----DYDKLMRSYRKLMQIMRSGDGDAAEAHWRTHLDT
MMAR_3975|M.marinum_M QWADESAARGTYPSLTKRRAVLNTHIKLTETIAEGDVDRARRIAGRHLAD
MUL_3832|M.ulcerans_Agy99 QWADESAARGTYPSLAKRRAVLNAHIKLTETIAEGDVDRARRIAGRHLAD
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 KSGTQSAGEAVE----AAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEA
Rv3060c|M.tuberculosis_H37Rv KSGTQSAGEAVE----AAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEA
MAB_4644c|M.abscessus_ATCC_199 ALLAGSAERPHD---------QEHHQWLFDAIVDGSTRRAVELATDQLQH
MAV_2560|M.avium_104 AE--------------------------EFVLTGAELSTVVDLLE-----
TH_2873|M.thermoresistible__bu AG--------------------------EYLLSGTEMSTVVDLLE-----
Mflv_2114|M.gilvum_PYR-GCK TR--------------------------ELLLAGLESVPVRDVMG-----
Mvan_4590|M.vanbaalenii_PYR-1 TR--------------------------ELLLTGLESVPVRDVMG-----
MSMEG_5201|M.smegmatis_MC2_155 AR--------------------------ALMLQGLESVKVRDVMG-----
MMAR_3975|M.marinum_M TQ--------------------------TYVLSGRAEQRIYALSPQALSR
MUL_3832|M.ulcerans_Agy99 TQ--------------------------TYVLSGRAEQRIYALSPQALSR
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGD
Rv3060c|M.tuberculosis_H37Rv VAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGD
MAB_4644c|M.abscessus_ATCC_199 VRMR----------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3975|M.marinum_M PRDMRRP-------------------------------------------
MUL_3832|M.ulcerans_Agy99 PRDMRRP-------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 DIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPG
Rv3060c|M.tuberculosis_H37Rv DIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPG
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 GGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRR
Rv3060c|M.tuberculosis_H37Rv GGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRR
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 SEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLF
Rv3060c|M.tuberculosis_H37Rv SEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLF
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 LLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCR
Rv3060c|M.tuberculosis_H37Rv LLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCR
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2560|M.avium_104 -------------
TH_2873|M.thermoresistible__bu -------------
Mflv_2114|M.gilvum_PYR-GCK -------------
Mvan_4590|M.vanbaalenii_PYR-1 -------------
MSMEG_5201|M.smegmatis_MC2_155 -------------
MMAR_3975|M.marinum_M -------------
MUL_3832|M.ulcerans_Agy99 -------------
MLBr_01188|M.leprae_Br4923 -------------
Mb3086c|M.bovis_AF2122/97 TRRHLDAAASWWL
Rv3060c|M.tuberculosis_H37Rv TRRHLDAAASWWL
MAB_4644c|M.abscessus_ATCC_199 -------------