For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSSVTRRSQAKSDRRSQLIAAAERLVAERGYLAVRLEDIGAAVGVSGPAIYRHFPNKEAMLVELLVGIST RLLDGAREVVETHDDPAKALDALVDFHLDFAFDESDLIRIQDRDLAHLPDTAKRQVRRAQRQYVEIWVSV LTRLRRDLPEEEARVMAHATFGLLNSTPHSVKPAVTKAQSSTAQSRGVLRRMTVAALTATG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4718 | - | - | 100% (201) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0343 | - | 1e-27 | 35.71% (154) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0815 | - | 2e-13 | 29.25% (147) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 8e-72 | 70.05% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2551 | - | 2e-73 | 73.06% (193) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2506 | - | 8e-72 | 70.05% (197) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 3e-08 | 25.81% (155) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 8e-62 | 60.42% (192) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3853 | - | 2e-72 | 72.02% (193) | putative regulatory protein |
| M. avium 104 | MAV_1669 | - | 1e-67 | 68.59% (191) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3291 | - | 4e-14 | 27.17% (184) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3785 | - | 5e-72 | 71.50% (193) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4092 | - | 4e-73 | 73.47% (196) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2551|M.gilvum_PYR-GCK ------------MAPTEI---------SSPRSR--AKSDRRDQLVAAAER
Mvan_4092|M.vanbaalenii_PYR-1 ------------MTTTDA---------TSPRSR--AKSDRRGQLIGAAER
MSMEG_4718|M.smegmatis_MC2_155 ------------MSS------------VTRRSQ--AKSDRRSQLIAAAER
Mb2534|M.bovis_AF2122/97 ------------MTASAPDGRPGQPEATNRRSQ--LKSDRRFQLLAAAER
Rv2506|M.tuberculosis_H37Rv ------------MTASAPDGRPGQPEATNRRSQ--LKSDRRFQLLAAAER
MAV_1669|M.avium_104 -----------------------------------MKSDRRLQLLSAAER
MMAR_3853|M.marinum_M ------------MAASAPDEQTATP---NRRSQ--QKSDRRLQLLSAAER
MUL_3785|M.ulcerans_Agy99 ------------MAASAPDEQTATP---NRRSQ--QKSDRRLQLLSAAER
MAB_4541|M.abscessus_ATCC_1997 ------------MTNLIPESE-----TPNKRER--AKADRRDQLLRAAAR
TH_3291|M.thermoresistible__bu --------------------------VNDEQES--KSAATRARILDAAAH
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
* ::: .*
Mflv_2551|M.gilvum_PYR-GCK LFAEHGYLAVRLEDIGSAAGISGPAVYRHFPNKEALLVELLVG---ISTR
Mvan_4092|M.vanbaalenii_PYR-1 LIAEHGYLAVRLEDIGAAAGISGPAIYRHFPNKEALLVELLVG---ISTR
MSMEG_4718|M.smegmatis_MC2_155 LVAERGYLAVRLEDIGAAVGVSGPAIYRHFPNKEAMLVELLVG---ISTR
Mb2534|M.bovis_AF2122/97 LFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVG---VSAR
Rv2506|M.tuberculosis_H37Rv LFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVG---VSAR
MAV_1669|M.avium_104 LFAERGFLAVRLEDIGASAGVSGPAIYRHFPNKESLLVELLVG---ISTR
MMAR_3853|M.marinum_M LFAERGFLAVRLEDIGAAAGISGPAIYRHFPNKESLLVELLVG---ISSR
MUL_3785|M.ulcerans_Agy99 LFAERGFLAVRLEDIGAAAGISGPAIYRHFPNKESLLVELLVG---ISSR
MAB_4541|M.abscessus_ATCC_1997 LLAMRGYARVRLEDLGSAVGISGPAIYRHFPNKEALLVDLLTD---VSRR
TH_3291|M.thermoresistible__bu VLSVRGYAGLRLTDVAARADIQAPAIYYYYPSREALIEEVMWVGIADTRD
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLER---HMNN
:. :*: : ::. ..:. *.:* ::..: : ::
Mflv_2551|M.gilvum_PYR-GCK LLAGATDVVG-ADDDAASTLENLIDFHLDFALDESDLIRIQDRDLGNLPP
Mvan_4092|M.vanbaalenii_PYR-1 LLAGAVEVVDRAGDDADSALEGLIDFHLDFVFGEPDLIRIQDRDLGNLPP
MSMEG_4718|M.smegmatis_MC2_155 LLDGAREVVE-THDDPAKALDALVDFHLDFAFDESDLIRIQDRDLAHLPD
Mb2534|M.bovis_AF2122/97 LLAGARDVTT-RSANLAAALDGLIEFHLDFALGEADLIRIQDRDLAHLPA
Rv2506|M.tuberculosis_H37Rv LLAGARDVTT-RSANLAAALDGLIEFHLDFALGEADLIRIQDRDLAHLPA
MAV_1669|M.avium_104 LLAGARQVRA-RSADAAAALDGLIDFHLDFALNEPDLIRIQDRDLAYLPK
MMAR_3853|M.marinum_M LLAGARQVTT-NSNDAAAALDGLIDFHLDFALGEPDLIRIQDRDLGHLPA
MUL_3785|M.ulcerans_Agy99 LLAGARQVTT-NSNDAAAALDGLIDFHLDFALGEPDLIRIQDRDLGHLPA
MAB_4541|M.abscessus_ATCC_1997 LLEGGMTVAA-AASSPAEALDGLIDFHLDFALNESDLIRVQDRDLDSLPE
TH_3291|M.thermoresistible__bu QVVAALDALP-DGTPALDRLLTAVATHLQHALEISDYATAAIRNAGQVPL
MLBr_00815|M.leprae_Br4923 LVSSVQQALR-TTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEP
: . . * : .::. : .:
Mflv_2551|M.gilvum_PYR-GCK AAKRQVRRKQRQYVEIWVDVLRRCTPG---LSEADARLMAHGTFGL-LNS
Mvan_4092|M.vanbaalenii_PYR-1 AAKRQVRRKQRQYVEIWVDVLRRRTPG---LTETDARLMAHAAFGL-LNS
MSMEG_4718|M.smegmatis_MC2_155 TAKRQVRRAQRQYVEIWVSVLTRLRRD---LPEEEARVMAHATFGL-LNS
Mb2534|M.bovis_AF2122/97 VAERQVRKAQRQYVEVWVGVLRELNPG---LAEADARLMAHAVFGL-LNS
Rv2506|M.tuberculosis_H37Rv VAERQVRKAQRQYVEVWVGVLRELNPG---LAEADARLMAHAVFGL-LNS
MAV_1669|M.avium_104 PAERQVRKAQRQYVEVWVGVLRELNPE---LAEADARLTAHAVFGL-LNS
MMAR_3853|M.marinum_M AAERQVRKAQRQYVEIWVGVLRQLDPG---LAEADARLMAHAAFGL-LNS
MUL_3785|M.ulcerans_Agy99 AAERQVRKAQRQYVEIWVGVLRQLDPG---LAEADARLMAHAAFGL-LNS
MAB_4541|M.abscessus_ATCC_1997 NARRQVRQYQRRYVEAWVQVLCRSQQG---LDESDARIKAHAAFGL-MNS
TH_3291|M.thermoresistible__bu AIRKRQIREEERYGEVWRRLINDLAREGQLRPELDLYIAQMLILGA-LNW
MLBr_00815|M.leprae_Br4923 RVAAQVRVATESCIDAVFALIS-ADSR---LDPHRARMVAVGLVGISVDC
: . : :: : .* ::
Mflv_2551|M.gilvum_PYR-GCK TAHSMKPGTT--KT--AEAGSRTVLREMTVAALTSAERRRG
Mvan_4092|M.vanbaalenii_PYR-1 TPHGVKPGLN--KA--AEASSRTVLRTMTVAALTSAGRRA-
MSMEG_4718|M.smegmatis_MC2_155 TPHSVKPAVT--KAQSSTAQSRGVLRRMTVAALTATG----
Mb2534|M.bovis_AF2122/97 TPHSMKAADS---KPARTVRARAVLRAMTVAALSAADRCL-
Rv2506|M.tuberculosis_H37Rv TPHSMKAADS---KPARTVRARAVLRAMTVAALSAADRCL-
MAV_1669|M.avium_104 TPHSMKSQDSGRGKPARAARSRAIMRAMTVAALAAGNQCP-
MMAR_3853|M.marinum_M TPHSMKSADT---KSACAPHSRAVMRAMTVAALTVDVGA--
MUL_3785|M.ulcerans_Agy99 TPHSMESADT---KSACAPHSRAVMRAMTVAALTVDVGA--
MAB_4541|M.abscessus_ATCC_1997 TPYSAGRSAP--------SQTRTVLRQMVVAALRS------
TH_3291|M.thermoresistible__bu AAEWWDPRRS------SVETVIANAQTIIKHGITTVE----
MLBr_00815|M.leprae_Br4923 ARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL-----
: : :