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VEDWRTLNLANWEARVPLHVSPGGYDLDSFSDPRHLSGVVRYDLPRLGDITGLDVVHLQCHIGTDTVSLA RLGPRSVTGLDFSPSAIAAANDLAARAVAAVRFVESDVYDAAVVLGRESCDLVYTGIGALCWLPDIRRWA TVVAQLLRPGGRLFMREGHPMLDTIDETRSDDLLVVHYPYFETAGSPFTETTTYGGEGTVSAPKGVSFNH GLGEVFTALTEAGLTVTALEEHREAPWKALVQGMIESTEFEGEYVLAEHPERLPLTYTIQARKP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0546 | - | - | 100% (275) | hypothetical protein MSMEG_0546 |
| M. smegmatis MC2 155 | MSMEG_4128 | - | 1e-34 | 35.14% (276) | hypothetical protein MSMEG_4128 |
| M. smegmatis MC2 155 | MSMEG_5310 | - | 4e-05 | 31.75% (126) | SAM-dependent methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 3e-08 | 35.58% (104) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_2862 | - | 3e-05 | 32.99% (97) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1523 | - | 3e-08 | 35.58% (104) | methyltransferase |
| M. leprae Br4923 | MLBr_00130 | - | 7e-05 | 28.32% (113) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_0867c | - | 2e-06 | 33.91% (115) | putative transferase |
| M. marinum M | MMAR_4607 | - | 1e-108 | 67.78% (270) | hypothetical protein MMAR_4607 |
| M. avium 104 | MAV_3373 | - | 9e-05 | 26.35% (167) | methyltransferase, UbiE/COQ5 family protein |
| M. thermoresistible (build 8) | TH_1636 | - | 6e-07 | 30.53% (131) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_4458 | - | 1e-100 | 66.28% (258) | hypothetical protein MUL_4458 |
| M. vanbaalenii PYR-1 | Mvan_1774 | - | 6e-05 | 34.23% (111) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
MLBr_00130|M.leprae_Br4923 MAFTRIHS---------------------FLASAG---------------
TH_1636|M.thermoresistible__bu VRESRDQVFR----------------------------------------
MMAR_4607|M.marinum_M --------------------------------------------------
MUL_4458|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0546|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1774|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
MAB_0867c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
MLBr_00130|M.leprae_Br4923 ---------------------------------------------NTSMY
TH_1636|M.thermoresistible__bu -------------------------------------------KLNEKLT
MMAR_4607|M.marinum_M --------------------------------------------------
MUL_4458|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0546|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1774|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3373|M.avium_104 --------------------------------------------------
MAB_0867c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVG-DHVVFFNFGYEEDPPMALPLSESDEPNRYCIQL
Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVG-DHVVFFNFGYEEDPPMALPLSESDEPNRYCIQL
MLBr_00130|M.leprae_Br4923 KRVWRFWYPLMTHKLGTDEIMFINWAYEEDPPMALPLEASDEPNRAHINL
TH_1636|M.thermoresistible__bu QHGQKFIYSYASRRLDDDDVVFLNYGYEEDPPMGLPLSETDEPNRYSIQL
MMAR_4607|M.marinum_M -MDDVSQRPMAASWRSLNLANWESRVPLHTGPNGYDLDSFDDPDFLSAEV
MUL_4458|M.ulcerans_Agy99 -------------------------MPLHTGPNGYDLDSFDDPDFLSAEV
MSMEG_0546|M.smegmatis_MC2_155 ---------MVEDWRTLNLANWEARVPLHVSPGGYDLDSFSDPRHLSGVV
Mflv_2862|M.gilvum_PYR-GCK -------------------MNMAETALINSAPRRWLQRVYEVP----VLL
Mvan_1774|M.vanbaalenii_PYR-1 ----------------------MSVSSPSLWSAGRYDAVGQRIAPIAEQV
MAV_3373|M.avium_104 ---------------MTLDTTTADASVAARHRTVWALGDYALMAEEVMAP
MAB_0867c|M.abscessus_ATCC_199 --------------MGAPTQNIFEDLYRDSLHEGGPIVPWDSKD--AKPR
Mb1550|M.bovis_AF2122/97 YHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
Rv1523|M.tuberculosis_H37Rv YHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
MLBr_00130|M.leprae_Br4923 YHRTATQVNLSGKRILEVSCGHGGGASYLTRALHPASYTGLDLNPAGIKL
TH_1636|M.thermoresistible__bu YHRTAGQADLTGKRVLEVGCGHGGGASYLMRTLGPMSYVGLDLNPAGIEF
MMAR_4607|M.marinum_M RYDLPRLGRLDGLDIAHLQCHIGTDTVSLSR-LGPRSTVGLDFSPAALQA
MUL_4458|M.ulcerans_Agy99 RYDLPRLGRLDGLDIAHLQCHIGTDTVWLSR-LGPRSTVGLDFSPAALQA
MSMEG_0546|M.smegmatis_MC2_155 RYDLPRLGDITGLDVVHLQCHIGTDTVSLAR-LGPRSVTGLDFSPSAIAA
Mflv_2862|M.gilvum_PYR-GCK RFGGR---LVPDTQALEIGCGSGYGTQLILERFGAATVDAVDLDPAMIRR
Mvan_1774|M.vanbaalenii_PYR-1 VDALDRRQPLRGAAVVDLACGTG--SAALAAAARGAQVTGVDLTPELIAI
MAV_3373|M.avium_104 LGPTLVEAAGIGPGVRVLDVAAGSGNITLPAAAAGASVVSTDLTPELLQR
MAB_0867c|M.abscessus_ATCC_199 IKELALLGAIRG-DVLDIGCGLGDNAIYLAQ--QGFNVTGLDFAPSAIEQ
. : * : . *: * :
Mb1550|M.bovis_AF2122/97 CR--AKHRLPGLQFVQGDAQN----LPFPDESFDAVVN--VEASHQYPDF
Rv1523|M.tuberculosis_H37Rv CR--AKHRLPGLQFVQGDAQN----LPFPDESFDAVVN--VEASHQYPDF
MLBr_00130|M.leprae_Br4923 CQ--KRHQLPGLEFVRGDAEN----LPFDNESFDVVIN--IEASHCYPHF
TH_1636|M.thermoresistible__bu CR--KKHRLPGLEFVVGDAQD----LPFGAESFDAVIN--IESSHLYPRF
MMAR_4607|M.marinum_M ARDLAMRARADVGFVEADVYDA--VQALGGERFDLVYTG-LGALCWIPSI
MUL_4458|M.ulcerans_Agy99 ARDLAMRARADVGFVEADVYDA--VQALGGERFDLVYTG-LGALCWIPSI
MSMEG_0546|M.smegmatis_MC2_155 ANDLAARAVAAVRFVESDVYDA--AVVLGRESCDLVYTG-IGALCWLPDI
Mflv_2862|M.gilvum_PYR-GCK AGERLARYGNRVRLVQGSATDLSTALDAGDGSYGAVFD--FGIVHHIPDW
Mvan_1774|M.vanbaalenii_PYR-1 AAG--REGADAVTWRTADASDT----GLPAGAFDAAVSN-MGIIFVDPDR
MAV_3373|M.avium_104 SRDRAAGMGLTIDYREANAQAL----PFGDGEFDAVVSA-IGVQFA-PDH
MAB_0867c|M.abscessus_ATCC_199 AKGRAAAAGVAVDFQVADATT----LDGWDARFDTVIDSGVYHCFDAEGH
. : ... . . .
Mb1550|M.bovis_AF2122/97 RGFLAEVARVLRPGGHFLYTD----------SRRNPVVAEWEAALADAPL
Rv1523|M.tuberculosis_H37Rv RGFLAEVARVLRPGGHFLYTD----------SRRNPVVAEWEAALADAPL
MLBr_00130|M.leprae_Br4923 PRFLAEVVRVLRPGGHLAYAD----------LRPSNKVGEWEVDFANSRL
TH_1636|M.thermoresistible__bu SRFLSEVARVLRPGGHFLYAD----------ARQPHEFAEWEAALAAAPL
MMAR_4607|M.marinum_M SRWADVVASLLRPGGRLFMREGHPFLWSLSDPRPDGLVVVEYPYFETSGI
MUL_4458|M.ulcerans_Agy99 SRWADVFASLLRPGGRLFMREGHPFLWSLSDPRPDGLVVVEYPYFETSGI
MSMEG_0546|M.smegmatis_MC2_155 RRWATVVAQLLRPGGRLFMREGHPMLDTIDETRSDDLLVVHYPYFETAGS
Mflv_2862|M.gilvum_PYR-GCK RNAVAEVARVLAPGGRFYFDEV---------TAHALARPSYKRLFDHPTE
Mvan_1774|M.vanbaalenii_PYR-1 Q--VAEIARLLKPAGRLAFSAWAR-------DADNPFFDPVVAVLGPPPA
MAV_3373|M.avium_104 QRAADELVRVCRPGGRIGLISWTP------EGFFGRMLATIRPYRPSLSH
MAB_0867c|M.abscessus_ATCC_199 TEYASALHRATRPGARWYIWC----------FAQGAVHGVPTPFQNGQRA
. *..:
Mb1550|M.bovis_AF2122/97 RTISQRDIG----AQAKRG-----LDANTARSQEAIGRRAPVLLAGLTRC
Rv1523|M.tuberculosis_H37Rv RTISQRDIG----AQAKRG-----LDANTARSQEAIGRRAPVLLAGLTRC
MLBr_00130|M.leprae_Br4923 QQLSQREIN----AEVLRG-----IASNSQKSRDLVDRHLPAFLRFAGRE
TH_1636|M.thermoresistible__bu DMVSARVIN----AEVVRG-----MEQILPVWEDVIERVAPAFLRRRVRE
MMAR_4607|M.marinum_M PFVEHETYAGNGTVASPQI-----IHFNHGLGEIFTALTAAGLMVTGLEE
MUL_4458|M.ulcerans_Agy99 PFVEHETYAGNGTVASPQI-----IHFNHGLGEIFTALTAAGLMVTGLEE
MSMEG_0546|M.smegmatis_MC2_155 PFTETTTYGGEGTVSAPKG-----VSFNHGLGEVFTALTEAGLTVTALEE
Mflv_2862|M.gilvum_PYR-GCK DRFSAEQFSDELAHHGLVV-----LGSRTRIQGDYLLGVAAKPLPTGCE-
Mvan_1774|M.vanbaalenii_PYR-1 TGFSPDQWGDTDTLTTRLAPFFDDIDVQRARHRWEFESMAAALHFLRSES
MAV_3373|M.avium_104 PVPPAALWGRPGYVRALLGERIGEITTARGMLPVNRFGSAEDVHAYFKQH
MAB_0867c|M.abscessus_ATCC_199 EEIEQ--------VLTTSG------WSVLQINPTTMSAPKAEFLNAIRGS
Mb1550|M.bovis_AF2122/97 AVRVL-DWDLRR---GGGFSYR-IYLFAKD--------------------
Rv1523|M.tuberculosis_H37Rv AVRVL-DWDLRR---GGGFSYR-IYLFAKD--------------------
MLBr_00130|M.leprae_Br4923 FIGVQ-GTQLSRYLEGGELSYR-MYSFAKD--------------------
TH_1636|M.thermoresistible__bu FAPARRAWEELR--TEGSTEYR-MYCFTKPPEHADIP-------------
MMAR_4607|M.marinum_M HREVP--WNPLGDAMIPSPDYDGEFILAEDRDRIPMTYTVQAIKR-----
MUL_4458|M.ulcerans_Agy99 HREVP--WNPLGDAMIPSPDYDGEFILAEDRDRIPMTYTVQAIKR-----
MSMEG_0546|M.smegmatis_MC2_155 HREAP--WKALVQGMIESTEFEGEYVLAEHPERLPLTYTIQARKP-----
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1774|M.vanbaalenii_PYR-1 PMHVA-TFRRAAPAQQDRLAAEFEIALRRHLEPSGAVAFTAPYVVVSATL
MAV_3373|M.avium_104 YGPTIEAYANIGHNRVLAAELDAQLVELAAQHLSDGTMGWEYLLVTAEKR
MAB_0867c|M.abscessus_ATCC_199 YRGDPAVLDRLDQDVTDPLLHVPVYTVIAERM------------------
Mb1550|M.bovis_AF2122/97 --
Rv1523|M.tuberculosis_H37Rv --
MLBr_00130|M.leprae_Br4923 --
TH_1636|M.thermoresistible__bu --
MMAR_4607|M.marinum_M --
MUL_4458|M.ulcerans_Agy99 --
MSMEG_0546|M.smegmatis_MC2_155 --
Mflv_2862|M.gilvum_PYR-GCK --
Mvan_1774|M.vanbaalenii_PYR-1 RA
MAV_3373|M.avium_104 SG
MAB_0867c|M.abscessus_ATCC_199 --