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NMAETALINSAPRRWLQRVYEVPVLLRFGGRLVPDTQALEIGCGSGYGTQLILERFGAATVDAVDLDPAM IRRAGERLARYGNRVRLVQGSATDLSTALDAGDGSYGAVFDFGIVHHIPDWRNAVAEVARVLAPGGRFYF DEVTAHALARPSYKRLFDHPTEDRFSAEQFSDELAHHGLVVLGSRTRIQGDYLLGVAAKPLPTGCE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2862 | - | - | 100% (207) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_4269 | - | 3e-11 | 34.23% (111) | methyltransferase type 11 |
| M. gilvum PYR-GCK | Mflv_4035 | - | 1e-08 | 36.21% (116) | methyltransferase type 11 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 2e-12 | 35.71% (126) | methyltransferase |
| M. tuberculosis H37Rv | Rv1523 | - | 2e-12 | 35.71% (126) | methyltransferase |
| M. leprae Br4923 | MLBr_01723 | - | 5e-11 | 33.94% (109) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_3381c | - | 2e-11 | 35.14% (111) | hypothetical protein MAB_3381c |
| M. marinum M | MMAR_0694 | - | 1e-16 | 36.02% (161) | hypothetical protein MMAR_0694 |
| M. avium 104 | MAV_3903 | - | 4e-11 | 34.23% (111) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_2329 | - | 4e-11 | 33.33% (111) | methyltransferase, UbiE/COQ5 family protein |
| M. thermoresistible (build 8) | TH_2189 | - | 7e-12 | 36.04% (111) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1900 | - | 5e-11 | 33.94% (109) | hypothetical protein MUL_1900 |
| M. vanbaalenii PYR-1 | Mvan_3244 | - | 5e-91 | 79.21% (202) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu VIRRLMATALTALTTAVLAGCGDAGSWVEAKPAEGWSAQYGDAANSSYTS
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0694|M.marinum_M --------------------------------------------------
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu AAGAEALTLEWSRSVKGELAAQVAVGASGYLAVNAQTPAGCSLMVWEYAN
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0694|M.marinum_M --------------------------------------------------
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu SARQRWCTRLVQGGGRTSPLLDGFDNVYIGQPGAILSFPPTQWIRWRKPV
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0694|M.marinum_M --------------------------------------------------
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu IGMPTTPRILAPGELLVVTHLGQVLLFDAHRGTVTGTPLDLVAGVDPTDS
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0694|M.marinum_M --------------------------------------------------
MAV_3903|M.avium_104 ------------------------------------------MTRST---
MUL_1900|M.ulcerans_Agy99 ------------------------------------------MTRSSEIP
MSMEG_2329|M.smegmatis_MC2_155 ------------------------------------------MTEIRDAA
TH_2189|M.thermoresistible__bu ERGLADCAGARXXXCWPPPRPPSTVTPRARDAARHPTARLPAMTETTEPG
MAB_3381c|M.abscessus_ATCC_199 ------------------------------------------MTEITGLD
MLBr_01723|M.leprae_Br4923 ------------------------------------------MTRSTEIS
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 ------------MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPA
Rv1523|M.tuberculosis_H37Rv ------------MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPA
MMAR_0694|M.marinum_M -----------------------------MLNALSPDAQQESGAACAIPS
MAV_3903|M.avium_104 --------DAVPTPHATAEQVEAARHDS-KLAQVLYHDWEAETYDEKWSI
MUL_1900|M.ulcerans_Agy99 A-------DAAPNPHATAEEVEAARHDS-KLAQVLYHDWEAENYDEKWSI
MSMEG_2329|M.smegmatis_MC2_155 D--------PAPNPHATAEEVEAAMHDS-KLAQVLYHDWEAETYDEKWSI
TH_2189|M.thermoresistible__bu IGSEGAGDLPAPNPHATAEQVEAAMRDS-KLAQILYHDWEAESYDDKWSI
MAB_3381c|M.abscessus_ATCC_199 G---------QPTTKATAEQVAAAFEDN-KLAQILYHDWEAETYDEKWSI
MLBr_01723|M.leprae_Br4923 AN-------AVPNPHATAEQVAAARKDS-KLAQVLYHDWEAENYDEKWSI
Mflv_2862|M.gilvum_PYR-GCK -----------------MNMAETALINS-APRRWLQRVYEVP--------
Mvan_3244|M.vanbaalenii_PYR-1 -----------------MNRAETALINS-PPRRWLQRLYEVP--------
Mb1550|M.bovis_AF2122/97 ADAGGRDAASEQIARWTQTCTVVLVCGH-GPAKWAFRSWCTSRSCDTLPV
Rv1523|M.tuberculosis_H37Rv ADAGGRDAASEQIARWTQTCTVVLVCGH-GPAKWAFRSWCTSRSCDTLPV
MMAR_0694|M.marinum_M SGGAQPQSSTESGGPASHDYTDAMTRDFYDHEDSTYRGFWDPDGSLHWGV
. . . : :
MAV_3903|M.avium_104 SYDQR-----------------------CIDYARGRFDAIVPEHV-----
MUL_1900|M.ulcerans_Agy99 SYDQR-----------------------CVEYARGRFDAIVPAQV-----
MSMEG_2329|M.smegmatis_MC2_155 SYDQR-----------------------CIDYARGRFDAIVPEDE-----
TH_2189|M.thermoresistible__bu SYDQR-----------------------CVDYARGRFDAIVPDHV-----
MAB_3381c|M.abscessus_ATCC_199 SYDQR-----------------------CIDYARGRFDAIVPVED-----
MLBr_01723|M.leprae_Br4923 SYDQR-----------------------CVDYVRHCFDAIVPDEL-----
Mflv_2862|M.gilvum_PYR-GCK --------------------------------VLLRFGGRLVP-------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------VLLRFGGRLPP-------
Mb1550|M.bovis_AF2122/97 ALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLS
Rv1523|M.tuberculosis_H37Rv ALRYRLQSNPLVGKLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLS
MMAR_0694|M.marinum_M FEDDD----------------------TGFIAGCQHWNEQMLRAAR----
:.
MAV_3903|M.avium_104 ------------------LRELPYDRALELGCGTGFFLLNLIQSGVARRG
MUL_1900|M.ulcerans_Agy99 ------------------HADLPYERALELGCGTGFFLLNLIQAGVARRG
MSMEG_2329|M.smegmatis_MC2_155 ------------------QRKLPYDRALELGCGTGFFLLNLIQSGVARRG
TH_2189|M.thermoresistible__bu ------------------QRELPYDNALELGCGTGFFLLNLIQSGVARRG
MAB_3381c|M.abscessus_ATCC_199 ------------------QRELPYDRALELGCGTGFFLLNLMQAGVARRG
MLBr_01723|M.leprae_Br4923 ------------------FTELPYDCALELGCGTGFFLLNLIQSGVARRG
Mflv_2862|M.gilvum_PYR-GCK -----------------------DTQALEIGCGSGYGTQLILERFGAATV
Mvan_3244|M.vanbaalenii_PYR-1 -----------------------GSGALEIGCGSGYGSQLVLQRFGAARI
Mb1550|M.bovis_AF2122/97 ESDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASY
Rv1523|M.tuberculosis_H37Rv ESDEPNRYCIQLYHQTASQVDLTGKEVLEVSCGAGGGASYIARNLGPASY
MMAR_0694|M.marinum_M --------------------IGPQSRVLDLGCGNGTVSAWLARQTGAQVT
.*::.** * : . .
MAV_3903|M.avium_104 SVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYE----DDTFDLVVG
MUL_1900|M.ulcerans_Agy99 SVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYD----DDTFDLVVG
MSMEG_2329|M.smegmatis_MC2_155 SVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYE----DDTFDLVVG
TH_2189|M.thermoresistible__bu SVTDLSPGMVRVATRNGRSLGLDVDGRVADAEGIPYD----DNTFDLVVG
MAB_3381c|M.abscessus_ATCC_199 SVTDLSPGMVKVATRTGQELGLDVDGRVADAERIPYD----DNTFDLVVG
MLBr_01723|M.leprae_Br4923 SVTDLSPGMVKIATRNGQSLGLDINGRVADAEGIPYD----DNTFDLVVG
Mflv_2862|M.gilvum_PYR-GCK DAVDLDPAMIRRAGERLARYGNRVRLVQGSATDLSTALDAGDGSYGAVFD
Mvan_3244|M.vanbaalenii_PYR-1 DAVDLDPAMIERARTRLAPYGDRVHLATGSATDLREALNADDGSYDAVFD
Mb1550|M.bovis_AF2122/97 TGLDLNPASIDLCRAKHRLPG--LQFVQGDAQNLPFP----DESFDAVVN
Rv1523|M.tuberculosis_H37Rv TGLDLNPASIDLCRAKHRLPG--LQFVQGDAQNLPFP----DESFDAVVN
MMAR_0694|M.marinum_M GIDLSAVRIANAQRLAADNPQLQLEFMASSASALPFA----DGTFTHVFS
: ..* : * :: *..
MAV_3903|M.avium_104 HAVLHHIPDVELSLREVIRVLRPGGRFVFAG-------------------
MUL_1900|M.ulcerans_Agy99 HAVLHHIPDVELSLREVMRVLKPGGRFVFAG-------------------
MSMEG_2329|M.smegmatis_MC2_155 HAVLHHIPDVELSLREVVRILKPGGRFVFAG-------------------
TH_2189|M.thermoresistible__bu HAVLHHIPDVELSLREVVRVLRPGGRFVFAG-------------------
MAB_3381c|M.abscessus_ATCC_199 HAVLHHIPDVELSLREVLRVLKPGGRFVFAG-------------------
MLBr_01723|M.leprae_Br4923 HAVLHHIPDVELSLREVLRVLKPGGRFVFAG-------------------
Mflv_2862|M.gilvum_PYR-GCK FGIVHHIPDWRNAVAEVARVLAPGGRFYFDE-------------------
Mvan_3244|M.vanbaalenii_PYR-1 FGIIHHIPDWRAAVAEAARVLIPGGRFYFEE-------------------
Mb1550|M.bovis_AF2122/97 VEASHQYPDFRGFLAEVARVLRPGGHFLYTD-------------------
Rv1523|M.tuberculosis_H37Rv VEASHQYPDFRGFLAEVARVLRPGGHFLYTD-------------------
MMAR_0694|M.marinum_M QAVLYHVHDRERALAEVARVLQPQGLFVFDDLVTPQRPVSALAREVVYDR
:: * . : *. *:* * * * :
MAV_3903|M.avium_104 ---EPTSAGDVYARELSTLTWRIATNVTKLPGLGSWRRPQAELDESSRAA
MUL_1900|M.ulcerans_Agy99 ---EPTTVGNEYARTLSTLTWRIATNVTKLPGLGGWRRPQEELDESSRAA
MSMEG_2329|M.smegmatis_MC2_155 ---EPTTVGNRYARELSTLTWHATTNLTKLPFLSGWRRPQEELDESSRAA
TH_2189|M.thermoresistible__bu ---EPTTVGNSYARALSTLTWHVATTVTRLPGLQGWRRPQAELDESSRAA
MAB_3381c|M.abscessus_ATCC_199 ---EPTTVGNLYARALADLTWKATVQAMKLPGLESWRRPQEELDENSRAA
MLBr_01723|M.leprae_Br4923 ---EPTDVGNRYARVFADLTWKVTIRVVQLPGLSAWRRTQVEIDENSRAA
Mflv_2862|M.gilvum_PYR-GCK ---VTAHA------------------LARPSYKRLFDHPTEDR------F
Mvan_3244|M.vanbaalenii_PYR-1 ---VTAHA------------------LSRPTYRLLFDHPTDDR------F
Mb1550|M.bovis_AF2122/97 ---SRRNP------------------VVAEWEAALADAPLRTISQRDIGA
Rv1523|M.tuberculosis_H37Rv ---SRRNP------------------VVAEWEAALADAPLRTISQRDIGA
MMAR_0694|M.marinum_M LLFEPTFSADDYRKALARHGFVVYETRDLSPHLAQSYKLLADLAEPSCPR
MAV_3903|M.avium_104 ALEAIVDLHTFTPGDLERMAANAGATEVR---------------------
MUL_1900|M.ulcerans_Agy99 ALEAIVDLHTFAPEDLERMAKNAGAIRVE---------------------
MSMEG_2329|M.smegmatis_MC2_155 ALEAVVDLHTFDPADLERMATNAGAVEVR---------------------
TH_2189|M.thermoresistible__bu ALEAVVDLHTFEPSDLERMARNAGAVEVA---------------------
MAB_3381c|M.abscessus_ATCC_199 ALEWVVDLHTFDPADLEKMAANAGAVAVR---------------------
MLBr_01723|M.leprae_Br4923 ALEWVVDLHTFEPKVLETMATNAGAVQVK---------------------
Mflv_2862|M.gilvum_PYR-GCK SAEQFSDELAHH-----------GLVVLG---------------------
Mvan_3244|M.vanbaalenii_PYR-1 TAEDFLDELGRH-----------GLVILG---------------------
Mb1550|M.bovis_AF2122/97 QAKRGLDANTAR-----------SQEAIG---------------------
Rv1523|M.tuberculosis_H37Rv QAKRGLDANTAR-----------SQEAIG---------------------
MMAR_0694|M.marinum_M LATAYRQIPEVIQDAEVGWSFFLGKKVVDRLEWIYNSDPDLSLEQKYDAW
: . :
MAV_3903|M.avium_104 -----------------TVSEEFTAAMFGWPVRTFEASVPPGRLGWGWAK
MUL_1900|M.ulcerans_Agy99 -----------------TASEEFSAAMFGWPVRTFESSVPPGRLGWNWAR
MSMEG_2329|M.smegmatis_MC2_155 -----------------TASEEFTAAMLGWPVRTFEAAVPPGRLGWGWAK
TH_2189|M.thermoresistible__bu -----------------TASEEFTAAMLGWPVRTFEAAVPPGKLGWNWAK
MAB_3381c|M.abscessus_ATCC_199 -----------------TASEEFTAAMLGWPVRTFESTVPPGKLGWGWAK
MLBr_01723|M.leprae_Br4923 -----------------TVTEEFTAAMLGWPLRTFESTMPPSKLGWGWAR
Mflv_2862|M.gilvum_PYR-GCK -----------------SRTRIQGDYLLGVAAKPLPTGCE----------
Mvan_3244|M.vanbaalenii_PYR-1 -----------------SVTRIQGDYLLGVAAKPLAADGGR---------
Mb1550|M.bovis_AF2122/97 -----------------RRAPVLLAGLTRCAVRVLDWDLRRG-GGFSYRI
Rv1523|M.tuberculosis_H37Rv -----------------RRAPVLLAGLTRCAVRVLDWDLRRG-GGFSYRI
MMAR_0694|M.marinum_M AESYDSDLRDNYQENPRRAAALLAAHLPERSAPVLDAGAGTGLVGEELHK
: : . :
MAV_3903|M.avium_104 FAFNGWKTLSWVDANIWRRVVPKGWFYNVMVTGVKPT-------------
MUL_1900|M.ulcerans_Agy99 FAFNGWKALGWMDANVWRHVAPKGWFYNVMVTGVKPS-------------
MSMEG_2329|M.smegmatis_MC2_155 FAFNSWTTLSWVDANVWRKVVPKGWFYNVMVTGVKPS-------------
TH_2189|M.thermoresistible__bu FAFGSWTALSWVDANVWRRVMPKGWFYNVMVTGVKPS-------------
MAB_3381c|M.abscessus_ATCC_199 FAFNGWKALSWVDENVWRHVVPKGWYYNVMITGIKPS-------------
MLBr_01723|M.leprae_Br4923 FAFTSWKTLSWVDANVWRRVIPKSWFYNIIITGVKPS-------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 YLFAKD--------------------------------------------
Rv1523|M.tuberculosis_H37Rv YLFAKD--------------------------------------------
MMAR_0694|M.marinum_M LGYDNLTALDRSLG-MLSHARAKNVYRDVVHGALAAAPTLFPDQRFAAIV
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2329|M.smegmatis_MC2_155 --------------------------------------------------
TH_2189|M.thermoresistible__bu --------------------------------------------------
MAB_3381c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1550|M.bovis_AF2122/97 --------------------------------------------------
Rv1523|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0694|M.marinum_M AVGVFTFAHAGPEDLAALDRVLEPGGWLVIAVRADYLDQHRTLEQTLAKL
MAV_3903|M.avium_104 ----------------------------------
MUL_1900|M.ulcerans_Agy99 ----------------------------------
MSMEG_2329|M.smegmatis_MC2_155 ----------------------------------
TH_2189|M.thermoresistible__bu ----------------------------------
MAB_3381c|M.abscessus_ATCC_199 ----------------------------------
MLBr_01723|M.leprae_Br4923 ----------------------------------
Mflv_2862|M.gilvum_PYR-GCK ----------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 ----------------------------------
Mb1550|M.bovis_AF2122/97 ----------------------------------
Rv1523|M.tuberculosis_H37Rv ----------------------------------
MMAR_0694|M.marinum_M GYRIEARDEYEIFDAEPMVALGCRKPINDDGASR