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NHVDALACNRENWDERADIHARSQMYDVEGFLADRSLISSVVRNDLTVLQPHLPSSKISGQSLLHLQCHI GTDTVSWARLGAVNVTGLDLSPNSLRHARRIAEQDGQVITWVQGDARVASSLIDEQFDVVVTSAGTIVWL PELSAWARSIHDLLTPGGVFMIRDDHPILAAMEFQPWTISDDYLSGGGTRTYDDASTYTENTDVVIRQTT NYEWRHDLSEVLTALLEADLRIEAVHELAYMDWPAFPALIPDPRGWTLPADAPRIPLNFAIVARRAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4128 | - | - | 100% (278) | hypothetical protein MSMEG_4128 |
| M. smegmatis MC2 155 | MSMEG_0546 | - | 1e-34 | 35.14% (276) | hypothetical protein MSMEG_0546 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1550 | - | 1e-06 | 31.93% (119) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_4060 | - | 1e-07 | 36.00% (100) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1523 | - | 1e-06 | 31.93% (119) | methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1977 | - | 9e-08 | 28.96% (183) | putative methyltransferase |
| M. marinum M | MMAR_4607 | - | 2e-34 | 33.81% (281) | hypothetical protein MMAR_4607 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4458 | - | 2e-30 | 33.21% (271) | hypothetical protein MUL_4458 |
| M. vanbaalenii PYR-1 | Mvan_2287 | - | 3e-06 | 32.00% (100) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4607|M.marinum_M ---------MDDVSQRPMAASWRSLNLANWESRVPLHTGPNG------YD
MUL_4458|M.ulcerans_Agy99 ---------------------------------MPLHTGPNG------YD
MSMEG_4128|M.smegmatis_MC2_155 ----------------MNHVDALACNRENWDERADIHARSQM------YD
Mb1550|M.bovis_AF2122/97 MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Rv1523|M.tuberculosis_H37Rv MTITALTVTLPLLWRRLTTAGVKYADQGHFVGSAGVPAADAGGRDAASEQ
Mflv_4060|M.gilvum_PYR-GCK -------------------MATVDN-----EDDRALKAKHRA-----LWA
Mvan_2287|M.vanbaalenii_PYR-1 -------------------MSTTATSASAHDADRQLKAKHRA-----LWA
MAB_1977|M.abscessus_ATCC_1997 ----------------MDPAEHARHTRDVYDRLAPVWSATTD--------
: :
MMAR_4607|M.marinum_M LDSFD-DPDFLSAEVRYDLPRLG------RLDGLDIAHLQCHIGTD----
MUL_4458|M.ulcerans_Agy99 LDSFD-DPDFLSAEVRYDLPRLG------RLDGLDIAHLQCHIGTD----
MSMEG_4128|M.smegmatis_MC2_155 VEGFLADRSLISSVVRNDLTVLQPHLPSSKISGQSLLHLQCHIGTD----
Mb1550|M.bovis_AF2122/97 IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Rv1523|M.tuberculosis_H37Rv IARWTQTCTVVLVCGHGPAKWAFRSWCTSRSCDTLPVALRYRLQSNPLVG
Mflv_4060|M.gilvum_PYR-GCK SGDYPAVAAELIPSLGPELVRACG-----VRSGDRVLDVAAGSGNA----
Mvan_2287|M.vanbaalenii_PYR-1 SGDYPAVAAELIAELGPELVRACG-----IQAGDRVLDVAAGSGNA----
MAB_1977|M.abscessus_ATCC_1997 ------DGPFNGLLERPALRSLIPR----PLAGRSVLDAGCGSGAQ----
.
MMAR_4607|M.marinum_M ---TVSLSRLGPRST--------VGLDFSPAALQAARDLAMRARADVGFV
MUL_4458|M.ulcerans_Agy99 ---TVWLSRLGPRST--------VGLDFSPAALQAARDLAMRARADVGFV
MSMEG_4128|M.smegmatis_MC2_155 ---TVSWARLGAVNV--------TGLDLSPNSLRHARRIAEQDGQVITWV
Mb1550|M.bovis_AF2122/97 KLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLY
Rv1523|M.tuberculosis_H37Rv KLTTKYFLPLGTRQVGDHVVFFNFGYEEDPPMALPLSESDEPNRYCIQLY
Mflv_4060|M.gilvum_PYR-GCK ---SIPAAAAGAVVT---------ASDLTPELFDAGRRIAAERGVAVEWV
Mvan_2287|M.vanbaalenii_PYR-1 ---AIPAAEVGAIVT---------ASDLTPELFGAGRRIAAERGVDLEWV
MAB_1977|M.abscessus_ATCC_1997 ---CAWLLGEGADVT---------GLDLSPAMVDQAR---QRCGSAAKLM
*. . . : *
MMAR_4607|M.marinum_M EADVYDAVQALGGERFDLVYTGLGALCWIPSISRWADVVASLLRPGGRLF
MUL_4458|M.ulcerans_Agy99 EADVYDAVQALGGERFDLVYTGLGALCWIPSISRWADVFASLLRPGGRLF
MSMEG_4128|M.smegmatis_MC2_155 QGDAR-VASSLIDEQFDVVVTSAGTIVWLPELSAWARSIHDLLTPGGVFM
Mb1550|M.bovis_AF2122/97 HQTAS-QVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
Rv1523|M.tuberculosis_H37Rv HQTAS-QVDLTGKEVLEVSCGAGGGASYIARNLGPASYTGLDLNPASIDL
Mflv_4060|M.gilvum_PYR-GCK EADAE--ALPFPDDSFDVVMSCVG-AMFAPHHQATADEIVRVTRPGGTLG
Mvan_2287|M.vanbaalenii_PYR-1 EADAE--SLPFADGSFDVVMSCVG-AMFAPHHQATADELIRVCRPGGTIG
MAB_1977|M.abscessus_ATCC_1997 VADLA-DDLPLEPRSFDGVTCSLA-LHYLRDWQVPLASFARILRPGGWVV
:: . : *..
MMAR_4607|M.marinum_M MREGHP--FLWSLSDPRPDGLVVVEYPYFE----TSG-IPFVEHETYAGN
MUL_4458|M.ulcerans_Agy99 MREGHP--FLWSLSDPRPDGLVVVEYPYFE----TSG-IPFVEHETYAGN
MSMEG_4128|M.smegmatis_MC2_155 IRDDHP--ILAAMEFQP----WTISDDYLS----GGGTRTYDDASTYTEN
Mb1550|M.bovis_AF2122/97 CRAKHR--LPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFRGFLAE
Rv1523|M.tuberculosis_H37Rv CRAKHR--LPGLQFVQGDAQNLPFPDESFDAVVNVEASHQYPDFRGFLAE
Mflv_4060|M.gilvum_PYR-GCK LISWTPEGFIGHLFATMKPYAPPPPPGASPPPMWGSENHVEALFGDRVRD
Mvan_2287|M.vanbaalenii_PYR-1 MVNWTPGGFIGNLFATMKPYAPPPPPGANPPPLWGDTDHVTTLFGDRVGD
MAB_1977|M.abscessus_ATCC_1997 ISLDHP-------------FGAPLPD------------QRGGYFQHQLVS
.
MMAR_4607|M.marinum_M GTVASPQI--IHFN--HGLGEIFTALTAAGLMVTGLEEHREVPWNPLGDA
MUL_4458|M.ulcerans_Agy99 GTVASPQI--IHFN--HGLGEIFTALTAAGLMVTGLEEHREVPWNPLGDA
MSMEG_4128|M.smegmatis_MC2_155 TDVVIRQT--TNYEWRHDLSEVLTALLEADLRIEAVHELAYMDWPAFP-A
Mb1550|M.bovis_AF2122/97 VARVLRPG--GHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKR
Rv1523|M.tuberculosis_H37Rv VARVLRPG--GHFLYTDSRRNPVVAEWEAALADAPLRTISQRDIGAQAKR
Mflv_4060|M.gilvum_PYR-GCK LTMRRQTVRFDHCASPLDFREYWKRNYGPTLAAYRFNEDRPERLAELDAA
Mvan_2287|M.vanbaalenii_PYR-1 LTTRRQTVRMDHCADPAGFREYWKRNYGPTIAAYRFNAGHADRIGALDRD
MAB_1977|M.abscessus_ATCC_1997 DTWNKADVEVTQHFWRRPLGQVADAFADAGLLIERISEPR-----PSAEA
: : . : .
MMAR_4607|M.marinum_M MIPSPDYDGEFILAEDRDRIPMTYTVQAIKR-------------------
MUL_4458|M.ulcerans_Agy99 MIPSPDYDGEFILAEDRDRIPMTYTVQAIKR-------------------
MSMEG_4128|M.smegmatis_MC2_155 LIPDP---RGWTLPADAPRIPLNFAIVARRAS------------------
Mb1550|M.bovis_AF2122/97 GLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRGGGFSYRIYLFA
Rv1523|M.tuberculosis_H37Rv GLDANTARSQEAIGRRAPVLLAGLTRCAVRVLDWDLRRGGGFSYRIYLFA
Mflv_4060|M.gilvum_PYR-GCK FLDFLTTWNQADGTDGTAYDAEYLLVTATKR-------------------
Mvan_2287|M.vanbaalenii_PYR-1 FLALLTEWNRGDETN-AFWEAEYLLVTMTRL-------------------
MAB_1977|M.abscessus_ATCC_1997 IRRFPAELRNVVDSPSFIVYRLRYWGAPA---------------------
MMAR_4607|M.marinum_M --
MUL_4458|M.ulcerans_Agy99 --
MSMEG_4128|M.smegmatis_MC2_155 --
Mb1550|M.bovis_AF2122/97 KD
Rv1523|M.tuberculosis_H37Rv KD
Mflv_4060|M.gilvum_PYR-GCK --
Mvan_2287|M.vanbaalenii_PYR-1 --
MAB_1977|M.abscessus_ATCC_1997 --