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TSKSDLPLAQRPDADLPGHWLLARLGKRVLRPGGVELTTRLLSAAGITGSDVVELGPGLGRTAVDIAAAE PRSYVGVDDNSTTSALLQSAVATSGGRLVAADAAETGLDTGSADVVVGEAMLTMQGEKAKKAIVDEAFRV LRPGGRYAIHELGLMPDDLSDGIKDDIRKEMARAIKVNARPLTVAEWTDLLTSAGFEVRSVDLAPMALLQ PKRVVADEGFLGALRIVFNALTHPAARKRVLGMRRTFNRYRDELTAVAIVAVVPTESK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5310 | - | - | 100% (269) | SAM-dependent methyltransferase |
| M. smegmatis MC2 155 | MSMEG_2350 | - | 1e-07 | 32.67% (150) | hypothetical protein MSMEG_2350 |
| M. smegmatis MC2 155 | MSMEG_1893 | - | 9e-07 | 37.14% (105) | UbiE/COQ5 methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2655 | - | 6e-84 | 62.16% (259) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4299 | - | 1e-110 | 76.63% (261) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2622 | - | 6e-84 | 62.16% (259) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 2e-05 | 29.41% (119) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_2961 | - | 2e-05 | 28.19% (149) | putative menaquinone biosynthesis methyltransferase |
| M. marinum M | MMAR_2078 | - | 2e-84 | 62.03% (266) | methyltransferase |
| M. avium 104 | MAV_3501 | - | 9e-84 | 61.11% (270) | SAM-dependent methyltransferase |
| M. thermoresistible (build 8) | TH_1606 | - | 1e-105 | 71.70% (265) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_3266 | - | 1e-84 | 62.03% (266) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2049 | - | 1e-108 | 75.86% (261) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2655|M.bovis_AF2122/97 --------MANKRGNAGQ-------------------PLPLSDRDDDHMQ
Rv2622|M.tuberculosis_H37Rv --------MANKRGNAGQ-------------------PLPLSDRDDDHMQ
MMAR_2078|M.marinum_M --------MAGTQGESGQ-------------------PLPLSNRSDDHLQ
MUL_3266|M.ulcerans_Agy99 --------MAGTQGESGQ-------------------PLPLSNRSDDHLQ
MAV_3501|M.avium_104 --------MAANELRTGSEP-----------------PLPGSHRADEAVA
Mflv_4299|M.gilvum_PYR-GCK ---------MADS------------------------PLPLAERSDADLP
Mvan_2049|M.vanbaalenii_PYR-1 ---------MADS------------------------PLPLAERSDADLP
TH_1606|M.thermoresistible__bu --------MTAKS------------------------PLPLANRSDADLP
MSMEG_5310|M.smegmatis_MC2_155 --------MTSKS------------------------DLPLAQRPDADLP
MAB_2961|M.abscessus_ATCC_1997 --------MPTTWMDTVVRQ-----------------VRRVGDFPFPRQA
MLBr_00130|M.leprae_Br4923 MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYEEDP
.
Mb2655|M.bovis_AF2122/97 GHWLLARLGKRVLRPGGVELTRTLLARAEVTDADVLELAPGLGRTAAEIL
Rv2622|M.tuberculosis_H37Rv GHWLLARLGKRVLRPGGVELTRTLLARAEVTDADVLELAPGLGRTAAEIL
MMAR_2078|M.marinum_M GHWLLARLGKRVLRPGGVELTRTLLARADVNHADVLELAPGLGRTASEIL
MUL_3266|M.ulcerans_Agy99 GHWLLARLGKRVLRPGGVELTRTLLARADVNHADVLELAPGLGRTASEIL
MAV_3501|M.avium_104 GHWLLARLGKRVLRPGGVELTRTLLSHAQLTGADVVELAPGLGRTATEIV
Mflv_4299|M.gilvum_PYR-GCK GHWLLARLGKRVLRPGGLELTTRLLTAARIQGADVVELGPGLGRTATDIV
Mvan_2049|M.vanbaalenii_PYR-1 GHWLLARLGKRVLRPGGLELTTRLLAAARIGGSDVVELGPGLGRTASDII
TH_1606|M.thermoresistible__bu GHWLLARLGKRVLRPGGLELTRRLLTAARVTGADVVELGPGLGRTATDIV
MSMEG_5310|M.smegmatis_MC2_155 GHWLLARLGKRVLRPGGVELTTRLLSAAGITGSDVVELGPGLGRTAVDIA
MAB_2961|M.abscessus_ATCC_1997 ALVLDNPIHRKFVNPAGVAEQLALHG-----GEHVLEIGPGPGIFSVHIA
MLBr_00130|M.leprae_Br4923 PMALPLEASDEPNR-AHINLYHRTATQVNLSGKRILEVSCGHGGGASYLT
* . . . : ::*:. * * : :
Mb2655|M.bovis_AF2122/97 ARN-PRSYVG-AESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDAS
Rv2622|M.tuberculosis_H37Rv ARN-PRSYVG-AESDPNAANLVRHVLAGRGD----VRVTDAADTGLSDAS
MMAR_2078|M.marinum_M ARH-PRSYVG-AEADPDAANLVRTIVAGHGD----VRVADAADTGLPDSS
MUL_3266|M.ulcerans_Agy99 ARH-PRSYVG-AEADPDAANLVRTIVAGRGD----VRVADAADTGLPDSS
MAV_3501|M.avium_104 ARA-PRSYVG-AEADPDAANVVRGVLGDLGAHNAAVRVADAADTGLPDAS
Mflv_4299|M.gilvum_PYR-GCK AER-PRSYVG-VDDTAAATEQVRSIVAPVGG---KVVVADAASTGLPDGS
Mvan_2049|M.vanbaalenii_PYR-1 AAQ-PRSYVG-VDDTAAATENVKAIVAPVNG---AVVVADASTTGLPDGS
TH_1606|M.thermoresistible__bu AAG-PRSYVG-VDDTAAATEAVRRIVEPVDG---KVVVANAADTGLPSGS
MSMEG_5310|M.smegmatis_MC2_155 AAE-PRSYVG-VDDNSTTSALLQSAVATSGG---RLVAADAAETGLDTGS
MAB_2961|M.abscessus_ATCC_1997 SRL-PSGRLELFDVQPEMLEMVKSKLDRAGYRNAGFHSGDAGN-GLPFSD
MLBr_00130|M.leprae_Br4923 RALHPASYTG-LDLNPAGIKLCQKRHQLPGL---EFVRGDAENLPFDNES
* . : . : . . :* : .
Mb2655|M.bovis_AF2122/97 ADVVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQ
Rv2622|M.tuberculosis_H37Rv ADVVIGEAMLTMQGNAAKHTIVAEAARVLRPGGRYAIHELALVPDDVAEQ
MMAR_2078|M.marinum_M ADVVIGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEE
MUL_3266|M.ulcerans_Agy99 ADVVIGEAMLTMQGDAAKHAIVAEAARVLRPHGRYAIHELALTPDDVPEE
MAV_3501|M.avium_104 GDVVIGEAMLTMQGDAAKRAIVAEAARVLRPGGRYAIHELALTPDTVSAE
Mflv_4299|M.gilvum_PYR-GCK ADVVVGEAMLTMQGEKAKRAIIGEAFRVLRPGGRYAIHELGLSPDDLSQG
Mvan_2049|M.vanbaalenii_PYR-1 ADVVVGEAMLTMQGEKAKRAIIAEAFRVLRPGGRYAIHELGLTPDDLSQD
TH_1606|M.thermoresistible__bu ADVVIGEAMLTMQGDRDKRAIVNEAFRVLRPGGRYAIHELGLQPDSLPQD
MSMEG_5310|M.smegmatis_MC2_155 ADVVVGEAMLTMQGEKAKKAIVDEAFRVLRPGGRYAIHELGLMPDDLSDG
MAB_2961|M.abscessus_ATCC_1997 NTFDVAFLASVIGEVPDKAACVRSLAQVLKPGGRLVFHEIFLDPD-----
MLBr_00130|M.leprae_Br4923 FDVVINIEASHCYPHFPR--FLAEVVRVLRPGGHLAYADLRPSNKVG---
. : : : . :**:* *: . :: .
Mb2655|M.bovis_AF2122/97 VRTDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPR
Rv2622|M.tuberculosis_H37Rv VRTDLRQSLARALKVNARPLTVAEWSHLLAGHGLVVEHVVTASMALLQPR
MMAR_2078|M.marinum_M ISTEVRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPR
MUL_3266|M.ulcerans_Agy99 ISTEVRQALARSIKVNARPLTVAEWSQLLAGHGLVVSHVATAPMALLQPR
MAV_3501|M.avium_104 VSTDIRRALARAIKVNARPLTVAEWSALLAEHGLVVDHVATAPMALLQPR
Mflv_4299|M.gilvum_PYR-GCK IKDDIRRDMSRAIKVNARPLTSAEWTALLTDAGFKIESVDHAPMALLNPA
Mvan_2049|M.vanbaalenii_PYR-1 IKDDIRREMSRAIKVNARPLTIAEWTALLTEAGFQVETVDQAPMALLSPA
TH_1606|M.thermoresistible__bu TKDQIRKDMARAIKVNARPLTASEWVNLLTDAGFEVVSVDHAKMALLNPG
MSMEG_5310|M.smegmatis_MC2_155 IKDDIRKEMARAIKVNARPLTVAEWTDLLTSAGFEVRSVDLAPMALLQPK
MAB_2961|M.abscessus_ATCC_1997 ------------------RLGISELRSLVEPAGFTFAAATGS--------
MLBr_00130|M.leprae_Br4923 -EWEVDFANSRLQQLSQREINAEVLRGIASNSQKSRDLVDRHLPAFLR--
: : .
Mb2655|M.bovis_AF2122/97 RVIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAH
Rv2622|M.tuberculosis_H37Rv RVIADEGLLGALRFAGNLLIHRAARRRVLLMRHTFRRHRERLTAVAIVAH
MMAR_2078|M.marinum_M RIIADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAY
MUL_3266|M.ulcerans_Agy99 RIIADEGLLGALRFAKNLLTQPAARKRVLMMRSTFRKHRDRMAAVAIVAY
MAV_3501|M.avium_104 RLVSDEGLFGALRFARNVLVHRDARKRVLTMRRTFRKHRRQLAAVAIVAH
Mflv_4299|M.gilvum_PYR-GCK RVLADEGPLGALRIVGNLIRRPAARKRVIGMRKTFQRYRRSLTAVAVVGV
Mvan_2049|M.vanbaalenii_PYR-1 RVLADEGLFGALRIVGNMIRRPAARRRVLGMRATFARYRRSLTAVAVVGV
TH_1606|M.thermoresistible__bu RVLADEGLFGALRIVGNLIRRPAARKRVIGMRKTFQRYRHSLTAIAVVGV
MSMEG_5310|M.smegmatis_MC2_155 RVVADEGFLGALRIVFNALTHPAARKRVLGMRRTFNRYRDELTAVAIVAV
MAB_2961|M.abscessus_ATCC_1997 -----------------------RWRDIVEFART----------------
MLBr_00130|M.leprae_Br4923 ----------------------FAGREFIGVQGTQLSRYLEGGELSYRMY
: .: . *
Mb2655|M.bovis_AF2122/97 KPHVDS--
Rv2622|M.tuberculosis_H37Rv KPHVDS--
MMAR_2078|M.marinum_M KPSASGS-
MUL_3266|M.ulcerans_Agy99 KPSASGS-
MAV_3501|M.avium_104 KPTASQTG
Mflv_4299|M.gilvum_PYR-GCK VPGQ----
Mvan_2049|M.vanbaalenii_PYR-1 VPGQ----
TH_1606|M.thermoresistible__bu VPEK----
MSMEG_5310|M.smegmatis_MC2_155 VPTESK--
MAB_2961|M.abscessus_ATCC_1997 --------
MLBr_00130|M.leprae_Br4923 SFAKD---