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MKATDSKLRQRTDGRLDRTRDPAILDAALAALAENGYAGTNMDDIASRAGVGKAAIYRRWSSKAALITDA LVYWKPALLIDDIPDTGSLEGDLNEIAERAARNADERITYDLILRVAVEAMNDSQLASALDDLTLLRGRR TMTAILKNATARGEIAPDTDWSLVPDVLTAMLLMRAIRGERVDANYVRKVIDTVIVPAVRATAY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0465 | - | - | 100% (204) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5340 | - | 7e-24 | 38.29% (175) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3834 | - | 5e-19 | 37.02% (181) | putative TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1581 | - | 8e-14 | 29.28% (181) | regulatory protein |
| M. gilvum PYR-GCK | Mflv_3225 | - | 7e-18 | 36.31% (179) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1556 | - | 8e-14 | 29.28% (181) | regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3151 | - | 2e-44 | 46.91% (194) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0340 | - | 1e-14 | 35.15% (165) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4754 | - | 5e-75 | 70.05% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_4110 | - | 9e-18 | 33.51% (194) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_4780 | - | 2e-14 | 33.94% (165) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1961 | - | 2e-15 | 31.61% (174) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0465|M.smegmatis_MC2_155 ------MKATDSKLRQRTDGRL-DRTRDPAILDAALAALAENGYAGTNMD
MAV_4754|M.avium_104 MGQPQSQMEPESKLRQRTEGRL-DRSRDPAILDAALAALAEHGYDATNMN
MAB_3151|M.abscessus_ATCC_1997 ------MTKNAATQRQRTSGRL-NRSLDIAILEAAFVTLAEQGYDAMSMD
MMAR_0340|M.marinum_M ------MVADFGRPR--------DPRIDGAVLRATVELLAETGYAGLLVS
MUL_4780|M.ulcerans_Agy99 ------MVADFGRPR--------DPRIDGAVLRATVELLAETGYAGLLVS
Mvan_1961|M.vanbaalenii_PYR-1 ----------MGRPR--------NRAIDDAVLRATVELISESSYAELSLD
Mb1581|M.bovis_AF2122/97 -----MVGAVTQIADRPTDPSP-WSPRETELLAVTLRLLQEHGYDRLTVD
Rv1556|M.tuberculosis_H37Rv -----MVGAVTQIADRPTDPSP-WSPRETELLAVTLRLLQEHGYDRLTVD
Mflv_3225|M.gilvum_PYR-GCK -------MNRRGRPR--------SQATHDAILDAVCDILVTGGYSEVSMD
TH_4110|M.thermoresistible__bu ----VTATDAAATGRAAARGRPRDPALDSAILDAALEIFVEQGISALSIE
. :* .. : . :.
MSMEG_0465|M.smegmatis_MC2_155 DIASRAGVGKAAIYRRWSSKAALITDALVYWKPAL-LIDDIPDT--GSLE
MAV_4754|M.avium_104 DIAARAGVGKAAIYRRWSSKAALMTDALIYWRPEL-LNDDAPDT--GSLA
MAB_3151|M.abscessus_ATCC_1997 NIAARAGVGKAAIYRRWSSKAALTADAILHGRPSLGKLDEVPDT--GSLR
MMAR_0340|M.marinum_M AIAKRAGTSKPAIYRRWPSKAHLVHEAVFPIDAAT----AVPDT--GSPV
MUL_4780|M.ulcerans_Agy99 AIAKRAGTSKPAIYRRWPSKAHLVHEAVFPIDAAT----AVPDT--GSPV
Mvan_1961|M.vanbaalenii_PYR-1 AIAARAGTSKPAIYRRWRGKAHLVHEAVFPVDATI----EIPRT--GSLH
Mb1581|M.bovis_AF2122/97 AVAASARASKATVYRRWPSKAELVLAAFIEGIRQV---AVPPNT--GNLR
Rv1556|M.tuberculosis_H37Rv AVAASARASKATVYRRWPSKAELVLAAFIEGIRQV---AVPPNT--GNLR
Mflv_3225|M.gilvum_PYR-GCK RVATAAGVGKHSLYRRWASKAPLVAEAVMNAYGQQ-SPLLLPDT--GDVE
TH_4110|M.thermoresistible__bu QVARRAGVGKPTIYRRWSDKEQLVADAIEHRVSAELAWPTPAEASVSDPY
:* * ..* ::**** .* * *. . : ..
MSMEG_0465|M.smegmatis_MC2_155 GDLNEIAERAARNADERITYDLILRVAVEAMNDSQLASALDDLTLLRGRR
MAV_4754|M.avium_104 GDLDAIVKRAKRNDNALISNDLVLRVALEAAHDPELATALNDLILFKGRR
MAB_3151|M.abscessus_ATCC_1997 GDLHSLYEARDFGDDQVLTGNLLAGIIAEAVNDPTLAAALDDLLVSQTHK
MMAR_0340|M.marinum_M DDLREMVRRTTAVLSTPAAKAALPGLIGEMAADPTLHSALLVRFGEIFGH
MUL_4780|M.ulcerans_Agy99 DDLREMVRRTTAVLSTPAAKAAQPGLIGEMAADPTLHSALLVRFGEIFGH
Mvan_1961|M.vanbaalenii_PYR-1 GDVREMLRRTLAVLSTPAARAALPGLVGEMASDPTLHAALLERFADVLVR
Mb1581|M.bovis_AF2122/97 DDLLRLGELICREVGQHAS--TIRAVLVEVSRNPALNDVLQHQFVDHRKA
Rv1556|M.tuberculosis_H37Rv DDLLRLGELICREVGQHAS--TIRAVLVEVSRNPALNDVLQHQFVDHRKA
Mflv_3225|M.gilvum_PYR-GCK ADLREWLLGQARYFGVERNAALSRALAVASADDAGDREALDLQLAGPHRD
TH_4110|M.thermoresistible__bu ELVRRNISAAARTAADPAFRGLIAAIYGSAVTHPALLRTYWEHYILPRRT
: : .. .
MSMEG_0465|M.smegmatis_MC2_155 TMTAILKNATARGEIAPDTDWSLVPDVLTAMLLMRAIRG-----ERVDAN
MAV_4754|M.avium_104 VLSAVLAQAADRGEIDPNRDWSLVADVLTAMGLLRAISG-----QRVDGK
MAB_3151|M.abscessus_ATCC_1997 RMELVFARAVERGEITQGRDLSLVYDIPLGLSLTAALKR-----TVIDET
MMAR_0340|M.marinum_M GLTTWLDNAAARGQVRADVTAPELAEAIAGIVLIGLLTRPGELEPGVGDA
MUL_4780|M.ulcerans_Agy99 GLTTWLDNAAARGQVRADVTAPELAEAIAGIVLIGLLTRPGELEPGVGDA
Mvan_1961|M.vanbaalenii_PYR-1 DLNNYLDSAVRRGEVRRGVTAVELAEAVTGMTLLALITR-G---ANVDDA
Mb1581|M.bovis_AF2122/97 LIQYILQQAVDRGEISSAAISDELWDLLPGYLIFRSIIP----NRPPTQD
Rv1556|M.tuberculosis_H37Rv LIQYILQQAVDRGEISSAAISDELWDLLPGYLIFRSIIP----NRPPTQD
Mflv_3225|M.gilvum_PYR-GCK ALLRRLHAAAAGGEIRADTDVEAVTEALIGAMLYRIFNR--AKTVDETIK
TH_4110|M.thermoresistible__bu AAIALLRRARDLGTVAADADLDVLVDMLAGAVTYRVLQP-----EPPSAR
: * * : : : . :
MSMEG_0465|M.smegmatis_MC2_155 YVRKVIDTVIVPAVRATAY--------------
MAV_4754|M.avium_104 FVRRVIDTLILPAVRAAPE--------------
MAB_3151|M.abscessus_ATCC_1997 YMHRMVEEVILPLVQAPTTHT------------
MMAR_0340|M.marinum_M WIDRTTTLLLKGIRKGTPQ--------------
MUL_4780|M.ulcerans_Agy99 WIDRTTTLLLKGIRKGTPQ--------------
Mvan_1961|M.vanbaalenii_PYR-1 WIERTAHLITKGISS------------------
Mb1581|M.bovis_AF2122/97 TVQALVDDVILPSLTRSTG--------------
Rv1556|M.tuberculosis_H37Rv TVQALVDDVILPSLTRSTG--------------
Mflv_3225|M.gilvum_PYR-GCK VFNGILDALMRGVRCAENVESRGAHRPGGDDRC
TH_4110|M.thermoresistible__bu QLRCYLEVAYRQVGLLP----------------
.