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LTRFIRTQLIIFTIASIVGVAVMLFAYMQVPTLLGLGRITVTLQLPATGGLYQFSNVTYRGSQIGKVTAV ELTETGAEATLSLDRSPKVPADLQAQVRSMSAVGEQYVELLPRKDSGPYLENGSVIPASETTIPQAVGPM LDQLSALVDTIPKDKLSQLLDESYDAFNGTGFDFGSLLDSASTITTDASAVSDQTRALIDDSGPFLDAQA QTADSIRTWARSLAGITGTVSDDDAQIRTVLREGPGFAQETSRLLDGIKPTLPVLLANLTTIGQIAVTYN PSIEQLLVLLPPYVAQIQTYTPTNSPAGLPNGEFSLGLGDPSSCTVGFLPPSAWRSPADESDMDTPDNLY CKLPQDSPVAVRGARNYPCMAHPGKRAPTVELCNDPNGYQPLAQRQHTLGPYPFDPNLIAQGVAPDSRVR PDDKIFGPLQGSPLPPGVTAPPQGPPPAPQPPPNFAGTNPGPMLPGQPIYVDPPVPGQPPAPIRNPEIVP LPPAQLPQATEVPVPHGLTAPPPATDPGAPVAAPSAFDGGKSSGPAVTVAKYNPRNGEYMGADGKLYRQA NLVGNAKSWQDLMPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4785 | - | - | 100% (576) | mce-family protein mce1f |
| M. smegmatis MC2 155 | MSMEG_2860 | - | e-173 | 65.05% (455) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_5895 | - | e-107 | 37.71% (586) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3524c | mce4F | 3e-98 | 36.36% (583) | MCE-family protein MCE4F |
| M. gilvum PYR-GCK | Mflv_2513 | - | 0.0 | 61.25% (578) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3494c | mce4F | 1e-98 | 36.36% (583) | MCE-family protein MCE4F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-81 | 33.33% (579) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 1e-100 | 42.16% (472) | MCE-family protein |
| M. marinum M | MMAR_4705 | - | 0.0 | 56.95% (583) | MCE-family protein |
| M. avium 104 | MAV_0953 | - | 0.0 | 60.07% (586) | mce-family protein mce1f |
| M. thermoresistible (build 8) | TH_2459 | - | 0.0 | 70.43% (585) | PUTATIVE mce-family protein mce1f |
| M. ulcerans Agy99 | MUL_4057 | mce4F | 1e-98 | 36.88% (583) | MCE-family protein Mce4F |
| M. vanbaalenii PYR-1 | Mvan_4145 | - | 0.0 | 61.14% (579) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3524c|M.bovis_AF2122/97 MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
Rv3494c|M.tuberculosis_H37Rv MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGG
MUL_4057|M.ulcerans_Agy99 MIDKLTKIQLSIFAIITVLTLTVMGIFYLRLPATFGIGTYEVSADFVAGG
MAB_4148c|M.abscessus_ATCC_199 -MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVASG
MSMEG_4785|M.smegmatis_MC2_155 MLTRFIRTQLIIFTIASIVGVAVMLFAYMQVPTLLGLGRITVTLQLPATG
TH_2459|M.thermoresistible__bu MLTRFIRTQLILFTIAAIVGVSVMVFAYMQVPMLLGIGRMTVKIELPEAG
Mflv_2513|M.gilvum_PYR-GCK MLTRFVRNQLIIFTIASIVGVAVMIFSYMQVPTLLGIGRLAVTLELPASG
Mvan_4145|M.vanbaalenii_PYR-1 MLTRFVRNQLIIFTIASIVGVAVMLFAYMQVPTLLGVGRLVVTLELPESG
MMAR_4705|M.marinum_M MLTRFVRIQLAIFAIVGMVGVAVMAVWYIQAPTLLGIGKMTVTLELPATG
MAV_0953|M.avium_104 MLTRFVRIQLAIFLIAGTIGVISMVLFYIQAPTLLGIGRMTVTLELPATG
MLBr_02594|M.leprae_Br4923 MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSATG
: : : ** :* : : : . *:: * .*:* :. :: *
Mb3524c|M.bovis_AF2122/97 GLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRS
Rv3494c|M.tuberculosis_H37Rv GLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRS
MUL_4057|M.ulcerans_Agy99 GLYKNANVTYRGVAVGRVESVGLNPNGVTAQMRLNSGTAIPSNVTATVKS
MAB_4148c|M.abscessus_ATCC_199 GLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVKS
MSMEG_4785|M.smegmatis_MC2_155 GLYQFSNVTYRGSQIGKVTAVELTETGAEATLSLDRSPKVPADLQAQVRS
TH_2459|M.thermoresistible__bu GLYRFSNVTYRGTQVGKVQSVTLTDDGVEATMSLVGSAKIPADLRAEVRS
Mflv_2513|M.gilvum_PYR-GCK GLYRFSNVTYRGVQVGKVTEVNLTENGAEAILSLDTSPEIPADLRAEVRS
Mvan_4145|M.vanbaalenii_PYR-1 GLYRFSNVTYRGVQVGKVTGVSLTENGAEATLSLETSPKIPADLQAEVLS
MMAR_4705|M.marinum_M GLYRFSNVTYRGVQIGKVTALGLTSSGAKATLALDASPKIPADLKAEVRS
MAV_0953|M.avium_104 GLYRFSNVTYRGVQLGKVTAVGLTPSGVKATLSLSTSPKVPADLTAEVLS
MLBr_02594|M.leprae_Br4923 GLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVHS
*** :***:** :*:* : . *. * : : :* : * * *
Mb3524c|M.bovis_AF2122/97 VSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLL
Rv3494c|M.tuberculosis_H37Rv VSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLL
MUL_4057|M.ulcerans_Agy99 MSAIGEQYIDLVPPDDPSAGRLHDGSRIERNNTRIGQDVADLLHQAETLV
MAB_4148c|M.abscessus_ATCC_199 VSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGLV
MSMEG_4785|M.smegmatis_MC2_155 MSAVGEQYVELLPRKD-SGPYLENGSVIPASETTIPQAVGPMLDQLSALV
TH_2459|M.thermoresistible__bu MSAVGEQYIELLPRTD-SPPYLENGSVIPRSDTSVPQAVGPMLEQLSTLV
Mflv_2513|M.gilvum_PYR-GCK VSAVGEQYVELLPQTD-DGPFLEDGSRIPVSNTTIPQQVGPMLDQMSALV
Mvan_4145|M.vanbaalenii_PYR-1 VSAVGEQYVDLRPNTD-EGPYLEDGARIPVANTTVPQQVGPMLDQLSALV
MMAR_4705|M.marinum_M ISAVGEYYVDLRPRTD-SPPYLHDGSVIARDRAVIGQPIGPVLDQTSALI
MAV_0953|M.avium_104 VSAVGEQYVDLRPRTN-SPPYLHDGSVIAMRDTKIPQPVGPMLDQVNALV
MLBr_02594|M.leprae_Br4923 VSAVGEQYLDLVSSGN-PGKYLAPGQTITKS--KIPIEIGPALDSVNRGL
:**:** *::* . * * * : :. * . . :
Mb3524c|M.bovis_AF2122/97 GSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQL
Rv3494c|M.tuberculosis_H37Rv GSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQL
MUL_4057|M.ulcerans_Agy99 NSLGDTRLREVLHEAFVATNGSGPELARLVESARLLVDEANADYPQVSQL
MAB_4148c|M.abscessus_ATCC_199 NTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTKL
MSMEG_4785|M.smegmatis_MC2_155 DTIPKDKLSQLLDESYDAFNGTGFDFGSLLDSASTITTDASAVSDQTRAL
TH_2459|M.thermoresistible__bu NTIPKDSLSRLLDESFEAFNDTGYEFGSLLDSSATVTRDANAVADQTRLL
Mflv_2513|M.gilvum_PYR-GCK GSLPKDRIPDLLDETFKAFNGAGPEFGSLLDSATTLAADMNGISEQTRAL
Mvan_4145|M.vanbaalenii_PYR-1 GSLPKDRIPDLLDETFKAFNGAGPDFGSMLDSAATLTNDVNGVSDQMRSL
MMAR_4705|M.marinum_M NSIPKGKLSTLLDESFNAFNGAGYDFGSLFDSSAQLSGDLNGIADRTRTL
MAV_0953|M.avium_104 QSIPKTKLGQLLDESFQGFNGSGYDLGSLIDSSQTLSRDANGVVDRTRAL
MLBr_02594|M.leprae_Br4923 AALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVNDI
:: . : :* *: . .. * : :..*: : . :
Mb3524c|M.bovis_AF2122/97 IDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLAGAPDAI
Rv3494c|M.tuberculosis_H37Rv IDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLADAPDAI
MUL_4057|M.ulcerans_Agy99 IDQAGPFLQAQVRAGGDIKSLADGLARFTAELRQADPGLRNTLATAPDAI
MAB_4148c|M.abscessus_ATCC_199 IDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGAS
MSMEG_4785|M.smegmatis_MC2_155 IDDSGPFLDAQAQTADSIRTWARSLAGITGTVSDDDAQIRTVLREGPGFA
TH_2459|M.thermoresistible__bu AEDAEPFLDAQAQTTDSIRVWAASLAGITDQLDKNDPQIRTVLREGPGFA
Mflv_2513|M.gilvum_PYR-GCK IDDSGPLLESQAETTDAIRTWARSLNGISAQVVQNDPQVRALLQQGPGFA
Mvan_4145|M.vanbaalenii_PYR-1 IDDSGPLIDSQAETADAIRTWAQSLNGISAQVVQNDPQVRALLQQGPAFA
MMAR_4705|M.marinum_M TEDSGPFLDAQAQTTDSIRLWARSLAGVSGQLATNDPQIRTLLERGPGAF
MAV_0953|M.avium_104 TEDTGPLLDTQAQTTDSIRTWARSFAGISDVMVNNDSHFRTILEKGPETA
MLBr_02594|M.leprae_Br4923 IQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPTA
:: *::::* .: . *. . .: .: * .: * ..
Mb3524c|M.bovis_AF2122/97 DEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAII
Rv3494c|M.tuberculosis_H37Rv DEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAII
MUL_4057|M.ulcerans_Agy99 DEANTAFSGIRPSFPALAANLANLGRVGVIYNKSIEQLLVVFPALFAAIT
MAB_4148c|M.abscessus_ATCC_199 EQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSALL
MSMEG_4785|M.smegmatis_MC2_155 QETSRLLDGIKPTLPVLLANLTTIGQIAVTYNPSIEQLLVLLPPYVAQIQ
TH_2459|M.thermoresistible__bu QETAQLLEQARPTLPVLLANMTTFGKIGVSYNPSIEQLLVLVPPFVAQIQ
Mflv_2513|M.gilvum_PYR-GCK QEVSSLLNQVKPTLPILLANMSTVGQTLLTYNPALEQLLVLFPGIIAAQQ
Mvan_4145|M.vanbaalenii_PYR-1 QEVSALLNQVKPTLPILLANLSTVGQTLLTYNPAIEQLLVLFPGIIAAQQ
MMAR_4705|M.marinum_M NEASRLLDQIKPTLPVLLANLTTVGQIAVTYHASVEQILVLLPPFTAAIQ
MAV_0953|M.avium_104 NEASRLLDQIKPTLPVLLANLTTIGQIGITYHPSLEQLLVLLPSAVAIEQ
MLBr_02594|M.leprae_Br4923 DEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIAQ
::. : : ::* *.: . *: .:** **..* :
Mb3524c|M.bovis_AF2122/97 TSAGGVPQDEG-AKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
Rv3494c|M.tuberculosis_H37Rv TSAGGVPQDEG-AKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPR
MUL_4057|M.ulcerans_Agy99 TAAGGVPQDEG-AKLDFKVDLNDPPPCNVGFLPPPLIRSPADETLRELPP
MAB_4148c|M.abscessus_ATCC_199 TVAGGAPMDEG-AKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPR
MSMEG_4785|M.smegmatis_MC2_155 TY-TPTNSPAGLPNGEFSLGLGDPSSCTVGFLPPSAWRSPADESDMDTPD
TH_2459|M.thermoresistible__bu TY-APTTSPNGLPNGEFSLGLGDPAACTVGFLPPSAWRSPADTTVVDTPE
Mflv_2513|M.gilvum_PYR-GCK SFGLPQNSPTGLPTGDFALTISDPNPCTVGFLPSSQWRAPEDETTIDTPD
Mvan_4145|M.vanbaalenii_PYR-1 SFGLPQNSPTGLPMGDFALTISDPNPCTVGFLPSTQWRSPEDETTIDTPD
MMAR_4705|M.marinum_M SF-LGTKSPVGLATGAFNLIISDPPACTVGFLPPSQWRNPADTTIVDTPD
MAV_0953|M.avium_104 AA-AAPNHPEGTAQGDFALTIDDPPICTVGFMPPNTWRSPDDLSDIDTPD
MLBr_02594|M.leprae_Br4923 TASATFP---NMAALDLALSINQPPPCLTGFIPAAEWRSPADTSLQPLPV
: . . : : : :* * .**:*. * * * : *
Mb3524c|M.bovis_AF2122/97 DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNP
Rv3494c|M.tuberculosis_H37Rv DMYCKTAQNDPS-TVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNP
MUL_4057|M.ulcerans_Agy99 DMYCKVAQNDAT-TVRGARNYPCQEFPGKRAPTIQLCRDPKGYFPVGRNP
MAB_4148c|M.abscessus_ATCC_199 DMYCKTAQNDPS-AVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSNP
MSMEG_4785|M.smegmatis_MC2_155 NLYCKLPQDSPV-AVRGARNYPCMAHPGKRAPTVELCNDPNGYQPLAQRQ
TH_2459|M.thermoresistible__bu GLYCKLPQDSPV-AVRGARNYPCMEHPGKRAPTVELCNDPEGYKPVATRQ
Mflv_2513|M.gilvum_PYR-GCK GLYCKLPQDSPM-NVRGARNYPCLEHPGKRAPTVELCNDPRGFVPMAIRQ
Mvan_4145|M.vanbaalenii_PYR-1 GLYCKLPQDSPM-NVRGARNYPCIEHPGKRAPTVELCNDPRGFVPTAIRN
MMAR_4705|M.marinum_M GLYCKLPQDSPI-GVRGARNYPCMGQPGKRAPTVEICESDQPFEPLAMRQ
MAV_0953|M.avium_104 GLYCKLPQDSPL-SVRGARNYPCMGHPGKRAPTVEICNSDQPFMPLAMKQ
MLBr_02594|M.leprae_Br4923 GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTNP
. *** . : . ***:** ** *****.: . *.. . : * . .
Mb3524c|M.bovis_AF2122/97 WRGPPIPYGTEVTDG------------RNILPPNKFPYIPPGADPDPGVP
Rv3494c|M.tuberculosis_H37Rv WRGPPIPYGTEVTDG------------RNILPPNKFPYIPPGADPDPGVP
MUL_4057|M.ulcerans_Agy99 WRGPPVPYDTPVTDG------------LNVLPPNKFPYIPPDSDPDPGTP
MAB_4148c|M.abscessus_ATCC_199 WRGPPAPYDTPVEDP------------RNILPPNKFPNIPPGAEPDPGTP
MSMEG_4785|M.smegmatis_MC2_155 HTLGPYPFDPNLIAQGVAPDSRVRPD-DKIFGPLQGSPLPPGVTAPPQGP
TH_2459|M.thermoresistible__bu HALGPYPFDPNLVSQGVPIDARARLD-DNTFGPVEGTPLPPGVTAPPPRI
Mflv_2513|M.gilvum_PYR-GCK HITGPYPFDPNLVAQGIPIDDRVSGD-ERIHAPVQGTPLPPGAQRAGTPP
Mvan_4145|M.vanbaalenii_PYR-1 HITGPYPFDPNLVSQGVPIDSTVEGP-DRIYLPPEGTPLPPGAVRAGTPP
MMAR_4705|M.marinum_M HIFGTYPLDPNLIAQGIPPDDRANWNRERIFGPVEGTPLPPGVGP-----
MAV_0953|M.avium_104 HVLGPYPLDPNLLAQGVPPDDRVTVN-DRIFGPVEGTPLPPGAVPRGAPA
MLBr_02594|M.leprae_Br4923 WFGDPNQLLTCPAPG------------ARCDQPVKPGLVIPAPTVDNGLN
. . . * : : *
Mb3524c|M.bovis_AF2122/97 IVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQ
Rv3494c|M.tuberculosis_H37Rv IVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQ
MUL_4057|M.ulcerans_Agy99 IVGPPPPGVIPGPPPAPNQPAQPAPPPNDNGPPPPFTSWMPPDYPPQAPQ
MAB_4148c|M.abscessus_ATCC_199 TLPPPSP------------PAPEVPPAGGDVMP-----------------
MSMEG_4785|M.smegmatis_MC2_155 PPAPQPPPNFAGTNPGPMLPG-QPIYVDPPVPGQPPAPIRNPEIVPLPPA
TH_2459|M.thermoresistible__bu PQAPSPPPNFAGTGPGALLPG-QPLYTEPPVSPPGPAQVTEPDIVPAPPA
Mflv_2513|M.gilvum_PYR-GCK VSEPGTPP-FPVGPPGPPAPGVAPAPSQPLFVPPAPPAVLPPGQGPLLPN
Mvan_4145|M.vanbaalenii_PYR-1 VSEPGTPP-FPVGAPAPMVPG-APPPAQPPILPPAP---LLPGQGPLLPG
MMAR_4705|M.marinum_M -PEETVMPPGPLG---PPSPMG-------------EVSPIAPIDVPS---
MAV_0953|M.avium_104 GPRGENPPPGSVGAAVPPVPSSGPPALAPMSRMSADLPPIAPLDVPTP-T
MLBr_02594|M.leprae_Br4923 PAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQP-----------------
Mb3524c|M.bovis_AF2122/97 VPYPATIPPPPPPE--------------------GTGPPPGPAPGPQPQA
Rv3494c|M.tuberculosis_H37Rv VPYPATIPPPPPPE--------------------GTGPPPGPAPGPQPQA
MUL_4057|M.ulcerans_Agy99 IPYPKTLPPPPPPV--------------------GVGP----EPGPQPQA
MAB_4148c|M.abscessus_ATCC_199 ---------------------------------------------VSAQS
MSMEG_4785|M.smegmatis_MC2_155 QLPQATEVPVPHG-----LTAPP---PATDPG-APVAAPSAFDGGKSS-G
TH_2459|M.thermoresistible__bu QLPSATEVPVPPGVNPDDLHLPPGAVPVPGPGSGTVISPSSSSSARDG-G
Mflv_2513|M.gilvum_PYR-GCK QA-----VPAPPG-------------------GAVPAAPSAFGGNASG-G
Mvan_4145|M.vanbaalenii_PYR-1 QA-----VPVAPAS------------------GAVPVAPSAFGSNDSG-V
MMAR_4705|M.marinum_M -----TPPPAPSG--------------------APSAAPSGLGRAAARPG
MAV_0953|M.avium_104 ELPPPPPPPAPAAP-------------DQVDGAAPQAAPSAFAGKASKPA
MLBr_02594|M.leprae_Br4923 -------------------------------------------NTCVYTP
Mb3524c|M.bovis_AF2122/97 SGPAYTIYDQLSGAFADPAGGTGIFAPGMTG--ASSAENWVDLMRDPRQL
Rv3494c|M.tuberculosis_H37Rv SGPAYTIYDQLSGAFADPAGGTGIFAPGMTG--ASSAENWVDLMRDPRQL
MUL_4057|M.ulcerans_Agy99 SGPAYTTYDPLTGVFKDPAGGAGIFVGGISG--ASSAENWVDLMLAPRTM
MAB_4148c|M.abscessus_ATCC_199 GPMAARAYDPKNGVFLDANNQPSVYAPALDR--GTEAETWADLMLGPKPV
MSMEG_4785|M.smegmatis_MC2_155 PAVTVAKYNPRNGEYMGADGKLYRQANLVG-----NAKSWQDLMPS----
TH_2459|M.thermoresistible__bu PTVAFARYNPRTGEYMASDGRLYRQSDLSS-----TPKSWQELMPT----
Mflv_2513|M.gilvum_PYR-GCK PSVATAAYDPNTGQYLSPDGAMHQISNVTPG---GTPKSWKDLLPM----
Mvan_4145|M.vanbaalenii_PYR-1 PTVGTAQYNPQTGEYIAPDGSMNRVTNVASG---ANPKSWKDLLPM----
MMAR_4705|M.marinum_M PSVAFAQYDPHTGSYVAPDGQVYRQTDLIIPDTPKAPRTWKDMLPT----
MAV_0953|M.avium_104 PSVVVAKYDPRTGRYVGPDGKLYQQSDLVT---PKAPKTWKDMLPT----
MLBr_02594|M.leprae_Br4923 SGPPSAVYSPQSGELVGPDGVAYAVENSTKT----GDDGWKEMLAPAG--
*. .* . . * :::