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SENKIILVTGVTSGIGEAVAIRLAAEGHLVVGGARRADRLAALKRENLHVRRVDVTDRADMAAFVDEAVS EHGRVDAIVNNAGIMPLSRVDTLLVDEWDAMIDVNVRGLLNGIAAALPHFQRQGHGHFVTMASIGAHQVV PTGAVYCATKHAAWAITEGLRLELDPSIRVTTISPGVVESELAQTITDPDAAKAMEIYRAESIPPDAIAR AVSYAVNEPADVDVNEVIVRPARQR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0258 | - | - | 100% (236) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_3581 | - | 1e-46 | 44.96% (238) | FabG protein |
| M. smegmatis MC2 155 | MSMEG_6859 | - | 7e-34 | 39.51% (243) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 2e-30 | 38.24% (238) | putative short-chain type oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0088 | - | 2e-28 | 35.44% (237) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0484c | - | 3e-30 | 38.24% (238) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-22 | 31.08% (251) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 2e-27 | 36.41% (217) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0810 | - | 3e-31 | 38.49% (239) | short-chain type oxidoreductase |
| M. avium 104 | MAV_2980 | - | 1e-33 | 39.92% (243) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_2445 | - | 3e-25 | 40.32% (186) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4554 | - | 2e-31 | 38.49% (239) | short-chain type oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3063 | - | 2e-48 | 43.98% (241) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0258|M.smegmatis_MC2_155 -MS----ENKIILVTGVTSGIGEAVAIRLAAEGHLVVGGARRADRLAALK
Mvan_3063|M.vanbaalenii_PYR-1 -MVNDPIDGMVVAITGASSGIGEATARLLGTRGARLVLGARRADRLHTLG
Mb0494c|M.bovis_AF2122/97 -MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALA
Rv0484c|M.tuberculosis_H37Rv -MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALA
MMAR_0810|M.marinum_M -MTTTDAGNRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALT
MUL_4554|M.ulcerans_Agy99 -MTTTDAGNRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALT
Mflv_0088|M.gilvum_PYR-GCK -MTTPSDARRVAVVTGASAGIGEAIARTLAAQGFHVICVARREGPIKALA
MAV_2980|M.avium_104 ---MTTLAHTAALVTGASSGIGAATATALAAEGAAVALLARRADRLAELQ
TH_2445|M.thermoresistible__bu ----MTFAGKHALVTGAGSGIGAALCRALAAAGAEVMCTDIDGAAAERTA
MLBr_01094|M.leprae_Br4923 ---MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTE
MAB_4335|M.abscessus_ATCC_1997 MGTAVQLAGKVVAVTGGARGIGRAIATAFAAEGAKVAIGDIDKKLCENTA
:** *** * . :. * :
MSMEG_0258|M.smegmatis_MC2_155 REN------LHVRRVDVTDRADMAAFVDEAVSEHGRVDAIVNNAG-IMPL
Mvan_3063|M.vanbaalenii_PYR-1 GELRAAGAEVATVTTDVTAAGDLERLVGTAVADFGRLDVLVSNAG-ISAI
Mb0494c|M.bovis_AF2122/97 NQIGGT-----AIVADVTDDAAVEALAR----ALSRVDVLVNNAGGAKGL
Rv0484c|M.tuberculosis_H37Rv NQIGGT-----AIVADVTDDAAVEALAR----ALSRVDVLVNNAGGAKGL
MMAR_0810|M.marinum_M DQIGGT-----PIVADVTDGAAVAALAD----GLSRVDVLVNNAGGAKGL
MUL_4554|M.ulcerans_Agy99 DQIGGT-----PIVADVTDGAAVAALAD----GLSRVDVLVNNAGGAKEL
Mflv_0088|M.gilvum_PYR-GCK AEIDGT-----AIVADVTDPTAVAALAG----RLDRVDVLVNNAGGARGL
MAV_2980|M.avium_104 AEIECSGGTALVVPADVTDAERVAAAVQRTVAEFGRLDILVNNAG-LMQS
TH_2445|M.thermoresistible__bu QSIGGR-----WAALDVTDAAAVQAAVDGVVDRAGRLDLLFNNAG-IVWG
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG-IAFT
MAB_4335|M.abscessus_ATCC_1997 AEIGNS---AIGLPLDVTDHGSFEAFFDTIAATVGPVDVIVNNAG-IMPI
. *** . . :: : .***
MSMEG_0258|M.smegmatis_MC2_155 SRVDTLLVDEWDAMIDVNVRGLLNGIAAALPHFQRQGH------GHFVTM
Mvan_3063|M.vanbaalenii_PYR-1 GPLADADVTGWDAMIDVNLRGVLHGIAAAMPVFRQQGH------GHFVTT
Mb0494c|M.bovis_AF2122/97 QFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGD------GLIVTV
Rv0484c|M.tuberculosis_H37Rv QFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGD------GLIVTV
MMAR_0810|M.marinum_M EPVADADLEHWRWMWETNVLGTLRVTRALLPKLIASGD------GLIVTV
MUL_4554|M.ulcerans_Agy99 EPVADADLEHWRWMWETNVLGTLRVTRALLPKLIASGD------GLIVTV
Mflv_0088|M.gilvum_PYR-GCK ESISDADVENWRWMWEANVMGTLHVTRALLPKLIDSGD------GLIVTI
MAV_2980|M.avium_104 GPATEASLRDWDRMVAVNVQGVLYATRAALPHLVDAAADSPRGVADLVTI
TH_2445|M.thermoresistible__bu GDTELLTLDQWNAIIDVNIRGVVHGVAAAYPLMVRQGH------GHIVNT
MLBr_01094|M.leprae_Br4923 GDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGD------GHVINI
MAB_4335|M.abscessus_ATCC_1997 TPFDDESLESIQRQLDINVRGVMWGSQLAIKRMKPRGG------GVIVNI
. : * : : . . .:.
MSMEG_0258|M.smegmatis_MC2_155 ASIGAHQVVPTGAVYCATKHAAWAITEGLRLE---LDPSIRVTTISPGVV
Mvan_3063|M.vanbaalenii_PYR-1 VSTAGLKIVPTMGVYAATKNAVRTMMEALRQES--TDGVIRTTSISPGYV
Mb0494c|M.bovis_AF2122/97 TSIAALEVYDGGAGYTAAKHAQGALHRTLRGEL--LGKPVRLTEIAPGAV
Rv0484c|M.tuberculosis_H37Rv TSIAAIEVYDGGAGYTAAKHAQGALHRTLRGEL--LGKPVRLTEIAPGAV
MMAR_0810|M.marinum_M TSIAALEIYDGGAGYTAAKHAQGALHRTLRGEL--LGLPVRLTEIAPGAV
MUL_4554|M.ulcerans_Agy99 TSIAALEIYDGGAGYTAAKHAQGALHRTLRGEL--LGLPVRLTEIAPGAV
Mflv_0088|M.gilvum_PYR-GCK TSIAAVEIYDNGGGYTSAKHAQGVLHRTLRSEL--LGKPVRLTEVAPGMV
MAV_2980|M.avium_104 SSTAGWVARPNTAVYSLTKFGVNAFSEGIRQEV--LGKRVRVGVVGPGTV
TH_2445|M.thermoresistible__bu ASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEA--AAHGVGVLAVCPAAV
MLBr_01094|M.leprae_Br4923 SSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGI
MAB_4335|M.abscessus_ATCC_1997 ASAAGKAGFPGLATYCATKHAVVGLSESLSLEY--EPAGISVVCVMPGMV
* . * :* . : : * : : *. :
MSMEG_0258|M.smegmatis_MC2_155 ESELA--------------------QTITDPD--AAKAMEIYR-AESIPP
Mvan_3063|M.vanbaalenii_PYR-1 NTELD--------------------RSITDVA--LRNAVRADMDAFGLAP
Mb0494c|M.bovis_AF2122/97 ETEFS--------------------LVRFDGD--QQRADAVYAGMTPLVA
Rv0484c|M.tuberculosis_H37Rv ETEFS--------------------LVRFDGD--QQRADAVYAGMTPLVA
MMAR_0810|M.marinum_M ETEFS--------------------LVRFDGD--EQRADAVYSGMTPLVA
MUL_4554|M.ulcerans_Agy99 ETEFS--------------------LVRFDGD--EQRADAVYSGMTPLVA
Mflv_0088|M.gilvum_PYR-GCK KTDFS--------------------LNRFDGD--AERAEKVYEGVTPLVA
MAV_2980|M.avium_104 DTEIF--------------------GHLSEPS--REAFERQTAGMVMLRP
TH_2445|M.thermoresistible__bu ETPLLDKGAVGGFLGRDYFIRGQGVRSAYDPDRLASDTLRAVQRNKALLV
MLBr_01094|M.leprae_Br4923 KTAIARN------------------ATAAEGLDVSKIASRFDTWVAHTSP
MAB_4335|M.abscessus_ATCC_1997 NTELISG-----------LDTHWLLKTVEPEDIANAVVKAVRRGVFPVFV
.: :
MSMEG_0258|M.smegmatis_MC2_155 DAIARAVSYAVNEP---------ADVDVNEVIVRPARQR-----------
Mvan_3063|M.vanbaalenii_PYR-1 EAVARAIVFAIEQP---------PEVEIGDLTIRPAVQG-----------
Mb0494c|M.bovis_AF2122/97 ADVAEVIGFVATRP---------SHVNLDQIVIRPRDQAS-ASRRATHPV
Rv0484c|M.tuberculosis_H37Rv ADVAEVIGFVATRP---------SHVNLDQIVIRPRDQAS-ASRRATHPV
MMAR_0810|M.marinum_M ADIAEVIGFVASRP---------PHVNLDQIIIRPRDQAS-ATRRANHQV
MUL_4554|M.ulcerans_Agy99 ADIAEVIGFVASRP---------PHVNLDQIIIRPRDQAS-ATRRANHQV
Mflv_0088|M.gilvum_PYR-GCK EDIAEVVGFVASRP---------SHVDLDLIVVRPRDQVSGASGSRFHRQ
MAV_2980|M.avium_104 QDIADAVLFMVTRD---------RRVAVNHMLVRAAEQTW----------
TH_2445|M.thermoresistible__bu KPRVAHAGWLFARL---------APGLMQRASIRFVERQRAGQRAAQVGR
MLBr_01094|M.leprae_Br4923 QHAARIILKAVRKKKARV--LVGPDAKVANVVVRFSGGAGYQRLFAQVAS
MAB_4335|M.abscessus_ATCC_1997 PKMFGGMYRTMSVLPRSTGKFLTRKLGIQDFMLNAHGSDARKAYEDRASH
: :.
MSMEG_0258|M.smegmatis_MC2_155 -------
Mvan_3063|M.vanbaalenii_PYR-1 -------
Mb0494c|M.bovis_AF2122/97 R------
Rv0484c|M.tuberculosis_H37Rv R------
MMAR_0810|M.marinum_M -------
MUL_4554|M.ulcerans_Agy99 -------
Mflv_0088|M.gilvum_PYR-GCK S------
MAV_2980|M.avium_104 -------
TH_2445|M.thermoresistible__bu -------
MLBr_01094|M.leprae_Br4923 RLILNQR
MAB_4335|M.abscessus_ATCC_1997 SGPSTE-