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VNDPIDGMVVAITGASSGIGEATARLLGTRGARLVLGARRADRLHTLGGELRAAGAEVATVTTDVTAAGD LERLVGTAVADFGRLDVLVSNAGISAIGPLADADVTGWDAMIDVNLRGVLHGIAAAMPVFRQQGHGHFVT TVSTAGLKIVPTMGVYAATKNAVRTMMEALRQESTDGVIRTTSISPGYVNTELDRSITDVALRNAVRADM DAFGLAPEAVARAIVFAIEQPPEVEIGDLTIRPAVQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3063 | - | - | 100% (248) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_3101 | - | 1e-30 | 38.62% (189) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0852 | - | 6e-29 | 34.30% (242) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 5e-28 | 37.34% (241) | putative short-chain type oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3370 | - | 2e-30 | 38.62% (189) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0484c | - | 9e-28 | 36.93% (241) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-24 | 30.00% (250) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4060 | - | 1e-28 | 34.26% (251) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0810 | - | 2e-28 | 37.04% (243) | short-chain type oxidoreductase |
| M. avium 104 | MAV_2980 | - | 2e-37 | 37.34% (241) | clavaldehyde dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3581 | - | 3e-88 | 69.39% (245) | FabG protein |
| M. thermoresistible (build 8) | TH_2445 | - | 2e-26 | 38.22% (191) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 9e-29 | 34.63% (231) | short-chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3063|M.vanbaalenii_PYR-1 -------MVNDPIDGMVVAITGASSGIGEATARLLGTRGARLVLGARRAD
MSMEG_3581|M.smegmatis_MC2_155 -MSAHEHVHEDSVAGQVVTITGASSGIGEATARLLAARGASVVLGARRTD
Mb0494c|M.bovis_AF2122/97 -------MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRAD
Rv0484c|M.tuberculosis_H37Rv -------MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRAD
MMAR_0810|M.marinum_M -------MTTTDAGNRVAVVTGASSGIGEATARTLAAQGFHVVAVARRAD
MAB_4060|M.abscessus_ATCC_1997 -------MTNPTFDGRVAVVTGASSGIGAATAKSLAALGFHVVVAARRED
MAV_2980|M.avium_104 -------MTTLAHT--AALVTGASSGIGAATATALAAEGAAVALLARRAD
Mflv_3370|M.gilvum_PYR-GCK ----MASTDTAQLSGKVAFVTGGASGIGAALVAKLATAGTEVWIADRQIA
TH_2445|M.thermoresistible__bu ----------MTFAGKHALVTGAGSGIGAALCRALAAAGAEVMCTDIDGA
MLBr_01094|M.leprae_Br4923 ---------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGE
MUL_3160|M.ulcerans_Agy99 MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDT
. :**..**** . * :
Mvan_3063|M.vanbaalenii_PYR-1 RLHTLGGELRAAGAEVATVTTDVTAAGDLERLVGTAVADFGRLDVLVSNA
MSMEG_3581|M.smegmatis_MC2_155 RLDRIVEEIRSTGGAAVAVAVDVTRRADVDNLVATAVREFGRLDVLVNNA
Mb0494c|M.bovis_AF2122/97 RITALANQI---GGTAIVA--DVTDDAAVEALAR----ALSRVDVLVNNA
Rv0484c|M.tuberculosis_H37Rv RITALANQI---GGTAIVA--DVTDDAAVEALAR----ALSRVDVLVNNA
MMAR_0810|M.marinum_M RITALTDQI---GGTPIVA--DVTDGAAVAALAD----GLSRVDVLVNNA
MAB_4060|M.abscessus_ATCC_1997 RVKSLAGEI---GGTAFVL--DVTDADSVAALTQ----SLDRVDVLVNNA
MAV_2980|M.avium_104 RLAELQAEIECSGGTALVVPADVTDAERVAAAVQRTVAEFGRLDILVNNA
Mflv_3370|M.gilvum_PYR-GCK PAEELAAQLRATGAVAHAVELDVRDPAAFAHAVHTAVDTSGRLDYLFNNA
TH_2445|M.thermoresistible__bu AAERTAQSIGGR-----WAALDVTDAAAVQAAVDGVVDRAGRLDLLFNNA
MLBr_01094|M.leprae_Br4923 GLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNA
MUL_3160|M.ulcerans_Agy99 AVADTAQTARGFGHDVITRRVDVSDPEQMTAFADATLGHFGGVDLLVNNA
** . . . :: : .**
Mvan_3063|M.vanbaalenii_PYR-1 G-ISAIGPLADADVTGWDAMIDVNLRGVLHGIAAAMPVFRQQGH------
MSMEG_3581|M.smegmatis_MC2_155 G-IATLGPLADGDTDTWSAVIDVNVRGVLHGIAAATPVFTCQGR------
Mb0494c|M.bovis_AF2122/97 GGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGD------
Rv0484c|M.tuberculosis_H37Rv GGAKGLQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGD------
MMAR_0810|M.marinum_M GGAKGLEPVADADLEHWRWMWETNVLGTLRVTRALLPKLIASGD------
MAB_4060|M.abscessus_ATCC_1997 GGAWGLEPVLEADLEHWRWMWETNVVGTLQVTRALLPKLIDSGD------
MAV_2980|M.avium_104 G-LMQSGPATEASLRDWDRMVAVNVQGVLYATRAALPHLVDAAADSPRGV
Mflv_3370|M.gilvum_PYR-GCK G-IGIGGEVDTLTLDDWTDIIDVNLKGVIHGVHAAYPQMIRQG------S
TH_2445|M.thermoresistible__bu G-IVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAYPLMVRQG------H
MLBr_01094|M.leprae_Br4923 G-IAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSG------D
MUL_3160|M.ulcerans_Agy99 G-VGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIESGR-----G
* : : *.: * * : .
Mvan_3063|M.vanbaalenii_PYR-1 GHFVTTVSTAGLKIVPTMGVYAATKNAVRTMMEALRQESTDGV--IRTTS
MSMEG_3581|M.smegmatis_MC2_155 GHVITVVSTAGLKIVPEMGVYAGTKNAVRTIMEALRQESTDGV--IRTTS
Mb0494c|M.bovis_AF2122/97 GLIVTVTSIAALEVYDGGAGYTAAKHAQGALHRTLRGELLGKP--VRLTE
Rv0484c|M.tuberculosis_H37Rv GLIVTVTSIAAIEVYDGGAGYTAAKHAQGALHRTLRGELLGKP--VRLTE
MMAR_0810|M.marinum_M GLIVTVTSIAALEIYDGGAGYTAAKHAQGALHRTLRGELLGLP--VRLTE
MAB_4060|M.abscessus_ATCC_1997 GLIVTVTSIAALDVYDGGSGYTSAKHAQAALHRTLRGELLGKP--VRLTE
MAV_2980|M.avium_104 ADLVTISSTAGWVARPNTAVYSLTKFGVNAFSEGIRQEVLGKR--VRVGV
Mflv_3370|M.gilvum_PYR-GCK GHIVNTASMAGLITTSAQGGYSATKHAVVALSKTMRVEAATHG--VRVSV
TH_2445|M.thermoresistible__bu GHIVNTASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAAHG--VGVLA
MLBr_01094|M.leprae_Br4923 GHVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTT
MUL_3160|M.ulcerans_Agy99 GHVVNLSSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHR--IGVTA
. .:. * . * :* . : :* * :
Mvan_3063|M.vanbaalenii_PYR-1 ISPGYVNTELDRSITDVALRNAVRADMDAFGLAPEAVARAIVFAIEQPPE
MSMEG_3581|M.smegmatis_MC2_155 ISPGYVRTELGGPPGGPAG-NAARATMDRIGLPPDAVARAIAFAIEQPHD
Mb0494c|M.bovis_AF2122/97 IAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSH
Rv0484c|M.tuberculosis_H37Rv IAPGAVETEFSLVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSH
MMAR_0810|M.marinum_M IAPGAVETEFSLVRFDGDEQRADAVYSGMTPLVAADIAEVIGFVASRPPH
MAB_4060|M.abscessus_ATCC_1997 VAPGAVETEFSVVRFDGDQDRADAVYRGITPLVAEDVAEIIAFVASRPPH
MAV_2980|M.avium_104 VGPGTVDTEIFGHLSEPSREAFERQTAGMVMLRPQDIADAVLFMVTRDRR
Mflv_3370|M.gilvum_PYR-GCK LCPGVVRTPILTGGAFGRNKSVSREDQLKLGEALR-PMDAGVFAQKALRG
TH_2445|M.thermoresistible__bu VCPAAVETPLLDKGAVG---GFLGRDYFIRGQGVRSAYDPDRLASDTLRA
MLBr_01094|M.leprae_Br4923 VYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHT--SPQHAARIILKA
MUL_3160|M.ulcerans_Agy99 ICPGVINTAITKASPIRGAGDTEGRRQRLTVTYQRRGYTPARAARNILRA
: *. : * :
Mvan_3063|M.vanbaalenii_PYR-1 VEIGDLTIRPAVQG------------------------------------
MSMEG_3581|M.smegmatis_MC2_155 VEIGDLTIRPTVQG------------------------------------
Mb0494c|M.bovis_AF2122/97 VNLDQIVIRPRDQASASRRATHPVR-------------------------
Rv0484c|M.tuberculosis_H37Rv VNLDQIVIRPRDQASASRRATHPVR-------------------------
MMAR_0810|M.marinum_M VNLDQIIIRPRDQASATRRANHQV--------------------------
MAB_4060|M.abscessus_ATCC_1997 VNLDQIVVKPRDQASSTRRATRQ---------------------------
MAV_2980|M.avium_104 VAVNHMLVRAAEQTW-----------------------------------
Mflv_3370|M.gilvum_PYR-GCK VLRNEAIIVVPRWWKALWYLERLSPALSMRTAAVALKRTREVQSAVPLQ-
TH_2445|M.thermoresistible__bu VQRNKALLVKPRVAHAGWLFARLAPGLMQRASIRFVERQRAGQRAAQVGR
MLBr_01094|M.leprae_Br4923 VRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR-----
MUL_3160|M.ulcerans_Agy99 VERNKAVAPVAAEAHVMYVLSRIMP-----PLARWVSAQMAKAAK-----
* .